Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

In this Perspective, MacMicking and colleagues discuss the roles of interferon-induced guanylate-binding proteins in directing inflammasome responses and their effects on immunity to a wide variety of microbial pathogens. Traditional views of the inflammasome highlight the assembly of pre-existing c...

Full description

Saved in:
Bibliographic Details
Published inNature immunology Vol. 17; no. 5; pp. 481 - 489
Main Authors Kim, Bae-Hoon, Chee, Jonathan D, Bradfield, Clinton J, Park, Eui-Soon, Kumar, Pradeep, MacMicking, John D
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.05.2016
Nature Publishing Group
Subjects
631/250/127/1212
631/250/2499
631/250/256/2177
Animals
Binding proteins
Biomedicine
Disease Resistance - genetics
Disease Resistance - immunology
Genetic aspects
GTP-Binding Proteins - classification
GTP-Binding Proteins - genetics
GTP-Binding Proteins - immunology
Host-Pathogen Interactions - immunology
Humans
Immune response
Immunology
Infection - immunology
Infection - microbiology
Infection - parasitology
Infectious Diseases
Inflammasomes - genetics
Inflammasomes - immunology
Inflammasomes - metabolism
Interferons - immunology
Interferons - metabolism
Listeria monocytogenes - immunology
Listeria monocytogenes - physiology
Mice
Models, Immunological
perspective
Phylogeny
Properties
Signal Transduction - genetics
Signal Transduction - immunology
Toxoplasma - immunology
Toxoplasma - physiology
Online AccessGet full text
ISSN1529-2908
1529-2916
1529-2916
DOI10.1038/ni.3440

Cover

Abstract In this Perspective, MacMicking and colleagues discuss the roles of interferon-induced guanylate-binding proteins in directing inflammasome responses and their effects on immunity to a wide variety of microbial pathogens. Traditional views of the inflammasome highlight the assembly of pre-existing core components shortly after infection or tissue damage. Emerging work, however, suggests that the inflammasome machinery is also subject to 'tunable' or inducible signals that might accelerate its autocatalytic properties and dictate where inflammasome assembly takes place in the cell. Many of these signals operate downstream of interferon receptors to elicit inflammasome regulators, including a new family of interferon-induced GTPases called 'guanylate-binding proteins' (GBPs). Here we investigate the critical roles of interferon-induced GBPs in directing inflammasome subtype–specific responses and their consequences for cell-autonomous immunity to a wide variety of microbial pathogens. We discuss emerging mechanisms of action and the potential effect of these GBPs on predisposition to sepsis and other infectious or inflammatory diseases.
AbstractList Traditional views of the inflammasome highlight the assembly of pre-existing core components shortly after infection or tissue damage. Emerging work, however, suggests that the inflammasome machinery is also subject to 'tunable' or inducible signals that might accelerate its autocatalytic properties and dictate where inflammasome assembly takes place in the cell. Many of these signals operate downstream of interferon receptors to elicit inflammasome regulators, including a new family of interferon-induced GTPases called 'guanylate-binding proteins' (GBPs). Here we investigate the critical roles of interferon-induced GBPs in directing inflammasome subtype-specific responses and their consequences for cell-autonomous immunity to a wide variety of microbial pathogens. We discuss emerging mechanisms of action and the potential effect of these GBPs on predisposition to sepsis and other infectious or inflammatory diseases.
In this Perspective, MacMicking and colleagues discuss the roles of interferon-induced guanylate-binding proteins in directing inflammasome responses and their effects on immunity to a wide variety of microbial pathogens. Traditional views of the inflammasome highlight the assembly of pre-existing core components shortly after infection or tissue damage. Emerging work, however, suggests that the inflammasome machinery is also subject to 'tunable' or inducible signals that might accelerate its autocatalytic properties and dictate where inflammasome assembly takes place in the cell. Many of these signals operate downstream of interferon receptors to elicit inflammasome regulators, including a new family of interferon-induced GTPases called 'guanylate-binding proteins' (GBPs). Here we investigate the critical roles of interferon-induced GBPs in directing inflammasome subtype–specific responses and their consequences for cell-autonomous immunity to a wide variety of microbial pathogens. We discuss emerging mechanisms of action and the potential effect of these GBPs on predisposition to sepsis and other infectious or inflammatory diseases.
Traditional views of the inflammasome highlight the assembly of pre-existing core components shortly after infection or tissue damage. Emerging work, however, suggests that the inflammasome machinery is also subject to 'tunable' or inducible signals that might accelerate its autocatalytic properties and dictate where inflammasome assembly takes place in the cell. Many of these signals operate downstream of interferon receptors to elicit inflammasome regulators, including a new family of interferon-induced GTPases called 'guanylate-binding proteins' (GBPs). Here we investigate the critical roles of interferon-induced GBPs in directing inflammasome subtype-specific responses and their consequences for cell-autonomous immunity to a wide variety of microbial pathogens. We discuss emerging mechanisms of action and the potential effect of these GBPs on predisposition to sepsis and other infectious or inflammatory diseases.Traditional views of the inflammasome highlight the assembly of pre-existing core components shortly after infection or tissue damage. Emerging work, however, suggests that the inflammasome machinery is also subject to 'tunable' or inducible signals that might accelerate its autocatalytic properties and dictate where inflammasome assembly takes place in the cell. Many of these signals operate downstream of interferon receptors to elicit inflammasome regulators, including a new family of interferon-induced GTPases called 'guanylate-binding proteins' (GBPs). Here we investigate the critical roles of interferon-induced GBPs in directing inflammasome subtype-specific responses and their consequences for cell-autonomous immunity to a wide variety of microbial pathogens. We discuss emerging mechanisms of action and the potential effect of these GBPs on predisposition to sepsis and other infectious or inflammatory diseases.
Audience Academic
Author Park, Eui-Soon
Chee, Jonathan D
Kim, Bae-Hoon
Bradfield, Clinton J
Kumar, Pradeep
MacMicking, John D
Author_xml – sequence: 1
  givenname: Bae-Hoon
  surname: Kim
  fullname: Kim, Bae-Hoon
  organization: Howard Hughes Medical Institute, Yale University School of Medicine, Department of Microbial Pathogenesis, Yale University School of Medicine
– sequence: 2
  givenname: Jonathan D
  surname: Chee
  fullname: Chee, Jonathan D
  organization: Department of Microbial Pathogenesis, Yale University School of Medicine
– sequence: 3
  givenname: Clinton J
  surname: Bradfield
  fullname: Bradfield, Clinton J
  organization: Department of Microbial Pathogenesis, Yale University School of Medicine
– sequence: 4
  givenname: Eui-Soon
  surname: Park
  fullname: Park, Eui-Soon
  organization: Department of Microbial Pathogenesis, Yale University School of Medicine
– sequence: 5
  givenname: Pradeep
  surname: Kumar
  fullname: Kumar, Pradeep
  organization: Department of Microbial Pathogenesis, Yale University School of Medicine
– sequence: 6
  givenname: John D
  surname: MacMicking
  fullname: MacMicking, John D
  email: john.macmicking@yale.edu
  organization: Howard Hughes Medical Institute, Yale University School of Medicine, Department of Microbial Pathogenesis, Yale University School of Medicine, Department of Immunobiology, Yale University School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27092805$$D View this record in MEDLINE/PubMed
BookMark eNqN0ltrFDEYBuBBKvag-A9kwAv1YtYcJ5PLUqwuFAQPF16FTObLmjKTrEmmuv--WVtbdykoCSSEJyF5vxxXBz54qKrnGC0wot1b7xaUMfSoOsKcyIZI3B7czVF3WB2ndIkQZqJlT6pDIpAkHeJH1belzxAtxOAb54fZwFCvZu03o87Q9GXJ-VW9jiGD86l2vnQ76mnSKUxQa5Pdlc4u-Fr7of4eUq4HsOATPK0eWz0meHY7nlRfz999OfvQXHx8vzw7vWgMFzw3hEgNBlsjKXBhdCt5zxkmcqAd9LIlgiAEA2AkDGGoAMtF21uupUXQUnpSvb45d_Zrvfmpx1Gto5t03CiM1DYd5Z3apnNPy3t-zJCymlwyMI7aQ5iTwqITUlDG2f9QShlupSz05R69DHP05c1bRQihpKP3aqVHUCXEkKM220PVKeO0VEkQXtTiAVXaAJMzpebWlfWdDW92NhST4Vde6Tkltfz8ade-uL3o3E8w3MX05zcU0NwAE0NKEawyLv-ubrmFGx_I89We_2fyqQi_gvhXRnv0Grx43Ug
CitedBy_id crossref_primary_10_1042_BST20200900
crossref_primary_10_1186_s12929_021_00716_8
crossref_primary_10_1038_s41556_021_00672_3
crossref_primary_10_1016_j_dci_2020_103874
crossref_primary_10_1016_j_jmb_2017_11_006
crossref_primary_10_1038_s41590_020_0727_0
crossref_primary_10_3389_fimmu_2023_1065181
crossref_primary_10_1002_cti2_1404
crossref_primary_10_1128_microbiolspec_MCHD_0050_2016
crossref_primary_10_3389_fimmu_2018_00130
crossref_primary_10_1016_j_lfs_2018_02_014
crossref_primary_10_1038_s41564_018_0298_0
crossref_primary_10_1073_pnas_1615771114
crossref_primary_10_1002_bies_201700231
crossref_primary_10_3389_fimmu_2017_01375
crossref_primary_10_1016_j_it_2017_04_005
crossref_primary_10_1128_mBio_01188_17
crossref_primary_10_1038_s41598_024_65778_8
crossref_primary_10_1038_nature24467
crossref_primary_10_1038_srep36107
crossref_primary_10_1186_s12864_019_5777_z
crossref_primary_10_1016_j_chom_2017_07_005
crossref_primary_10_1007_s00345_022_03996_3
crossref_primary_10_3389_fimmu_2017_01147
crossref_primary_10_4110_in_2018_18_e33
crossref_primary_10_1111_cmi_13184
crossref_primary_10_1371_journal_ppat_1006630
crossref_primary_10_1016_j_heliyon_2024_e36598
crossref_primary_10_1016_j_ijmm_2017_10_013
crossref_primary_10_1073_pnas_2022269118
crossref_primary_10_1007_s00281_024_01018_5
crossref_primary_10_1189_jlb_4MR0516_223R
crossref_primary_10_1002_JLB_4MR0119_013R
crossref_primary_10_1016_j_clim_2024_109892
crossref_primary_10_1111_febs_14459
crossref_primary_10_1016_j_isci_2022_104583
crossref_primary_10_3389_fncel_2020_00190
crossref_primary_10_1002_bies_201700215
crossref_primary_10_1111_cmi_13375
crossref_primary_10_1016_j_jff_2024_106225
crossref_primary_10_1002_art_41611
crossref_primary_10_1016_j_clim_2025_110472
crossref_primary_10_1111_cas_15584
crossref_primary_10_1155_2019_2471215
crossref_primary_10_1016_j_dci_2018_02_007
crossref_primary_10_1016_j_cell_2016_09_012
crossref_primary_10_1016_j_mam_2020_100924
crossref_primary_10_1155_2021_3236384
crossref_primary_10_1371_journal_pntd_0007949
crossref_primary_10_3389_fimmu_2024_1303089
crossref_primary_10_1038_s41422_023_00790_7
crossref_primary_10_1371_journal_ppat_1006696
crossref_primary_10_1186_s12870_020_02520_2
crossref_primary_10_1530_JOE_18_0573
crossref_primary_10_1111_cmi_12791
crossref_primary_10_1038_s41564_019_0623_2
crossref_primary_10_1084_jem_20190459
crossref_primary_10_3390_cells8080901
crossref_primary_10_3390_jcm8101615
crossref_primary_10_1002_eji_201847556
crossref_primary_10_1084_jem_20182031
crossref_primary_10_1371_journal_pone_0237034
crossref_primary_10_1126_science_aan4526
crossref_primary_10_1152_ajplung_00353_2023
crossref_primary_10_3389_fimmu_2020_01895
crossref_primary_10_4049_jimmunol_2000337
crossref_primary_10_4049_jimmunol_1801303
crossref_primary_10_1128_IAI_00778_16
crossref_primary_10_1002_JLB_4MR0118_038R
crossref_primary_10_1038_s42003_020_01492_1
crossref_primary_10_1126_science_abm9903
crossref_primary_10_1038_s41586_021_03572_6
crossref_primary_10_1016_j_tips_2019_01_001
crossref_primary_10_1016_j_molimm_2022_07_008
crossref_primary_10_3390_ijms24119701
crossref_primary_10_1016_j_jdiacomp_2017_03_002
crossref_primary_10_1038_s41590_019_0368_3
crossref_primary_10_4049_jimmunol_1700725
crossref_primary_10_1128_mBio_01464_20
crossref_primary_10_1016_j_freeradbiomed_2022_11_037
crossref_primary_10_1371_journal_ppat_1011976
crossref_primary_10_1016_j_gene_2022_146347
crossref_primary_10_1128_mBio_01979_17
crossref_primary_10_1016_j_coi_2023_102373
crossref_primary_10_1016_j_coi_2019_04_017
crossref_primary_10_3389_fimmu_2020_01879
crossref_primary_10_1038_s12276_022_00919_5
crossref_primary_10_1038_s41467_022_32218_y
crossref_primary_10_3389_fimmu_2022_752186
crossref_primary_10_3389_fimmu_2016_00652
crossref_primary_10_1038_nature24157
crossref_primary_10_1371_journal_ppat_1007876
crossref_primary_10_3389_ebm_2024_10070
crossref_primary_10_1007_s00401_018_1806_2
crossref_primary_10_1038_s41598_018_19401_2
crossref_primary_10_1016_j_mam_2022_101100
crossref_primary_10_1016_j_micinf_2018_09_001
crossref_primary_10_15252_embj_201798089
crossref_primary_10_1371_journal_pcbi_1007193
crossref_primary_10_1016_j_devcel_2023_11_013
crossref_primary_10_1371_journal_pntd_0007980
crossref_primary_10_1097_MD_0000000000026582
crossref_primary_10_1126_science_abf8113
crossref_primary_10_1074_jbc_RA118_003998
crossref_primary_10_1007_s12094_020_02392_w
crossref_primary_10_1016_j_micpath_2022_105655
crossref_primary_10_3389_fimmu_2022_857455
crossref_primary_10_1002_JLB_4RI0917_358R
crossref_primary_10_3389_fimmu_2018_01954
crossref_primary_10_1016_j_celrep_2020_107667
Cites_doi 10.1126/science.1230751
10.1126/science.1240988
10.1371/journal.ppat.1003414
10.1038/nchembio.1236
10.1073/pnas.1211521110
10.1111/j.1742-4658.2012.08637.x
10.1038/nature11419
10.1016/j.jmb.2008.12.060
10.1038/nature11290
10.1074/jbc.M114.579961
10.1177/1753425912441956
10.1016/j.chom.2012.09.007
10.1016/j.chom.2014.07.002
10.1016/0042-6822(84)90016-3
10.1074/jbc.M112.379636
10.1126/science.aac5489
10.1073/pnas.1205635110
10.1128/mBio.01157-15
10.1016/j.chom.2011.04.008
10.1016/j.it.2004.08.010
10.4049/jimmunol.164.3.1286
10.1126/science.1240248
10.1038/ni.2639
10.1016/j.chom.2010.11.007
10.1016/j.immuni.2012.06.009
10.1038/nature13683
10.1038/ni.1631
10.1016/j.celrep.2014.06.028
10.1146/annurev-immunol-032712-095944
10.1126/science.1217141
10.4049/jimmunol.1203326
10.1126/science.291.5507.1279
10.1038/ni.3119
10.1172/JCI79100
10.1371/journal.pone.0024434
10.1038/nri3552
10.1002/eji.201040425
10.1089/jir.2006.26.328
10.1371/journal.ppat.1003320
10.1126/science.1088063
10.1084/jem.20062665
10.1146/annurev-genet-110711-155522
10.1038/ni.1864
10.1111/j.1742-4658.2010.07586.x
10.1016/j.immuni.2013.05.016
10.1016/j.cell.2014.01.063
10.4049/jimmunol.1302822
10.1038/nature15541
10.1074/jbc.M115.683011
10.1073/pnas.1003738107
10.1126/science.aac5789
10.1002/eji.201344091
10.1016/j.imbio.2007.09.018
10.1038/ni.1759
10.1371/journal.pone.0014246
10.1371/journal.pone.0006499
10.1016/j.jid.2015.12.022
10.1038/ni.3118
10.1126/science.1201711
10.1073/pnas.1421699112
10.1073/pnas.1515966112
10.4049/jimmunol.0900173
10.1038/nature04510
10.1128/IAI.00416-13
10.1073/pnas.1321700111
10.1016/j.chom.2015.07.016
10.1016/0092-8674(95)90085-3
10.1371/journal.ppat.0010024
10.1107/S1744309113015558
10.1016/j.immuni.2011.02.006
10.4049/jimmunol.179.11.7729
10.1038/nature07710
10.1126/science.1233028
10.1016/j.cell.2012.07.007
10.1002/eji.201243187
10.1016/j.celrep.2015.09.005
10.1146/annurev-pathol-012414-040431
10.1128/IAI.01437-07
10.1126/scitranslmed.3002001
10.1038/nri3850
10.1128/IAI.00856-15
10.1016/j.cell.2014.04.007
10.1038/nature07725
10.1038/nature13157
10.1038/nri3210
10.1038/nature10558
10.1038/nature15514
10.1074/jbc.M207852200
10.1038/nri3757
10.1038/nri3452
10.1016/j.cell.2014.02.008
10.1038/nm0697-678
ContentType Journal Article
Copyright Springer Nature America, Inc. 2016
COPYRIGHT 2016 Nature Publishing Group
Copyright Nature Publishing Group May 2016
Copyright_xml – notice: Springer Nature America, Inc. 2016
– notice: COPYRIGHT 2016 Nature Publishing Group
– notice: Copyright Nature Publishing Group May 2016
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
ISR
3V.
7QP
7QR
7T5
7TK
7TM
7U9
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7N
M7P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
7X8
ADTOC
UNPAY
DOI 10.1038/ni.3440
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Science
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
Unpaywall for CDI: Periodical Content
Unpaywall
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
ProQuest Public Health
ProQuest SciTech Collection
ProQuest Medical Library
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList ProQuest Central Student
MEDLINE


MEDLINE - Academic
AIDS and Cancer Research Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1529-2916
EndPage 489
ExternalDocumentID oai:pubmedcentral.nih.gov:4961213
4028365081
A453290725
27092805
10_1038_ni_3440
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIAID NIH HHS
  grantid: R01 AI108834-02
– fundername: NIAID NIH HHS
  grantid: R01 AI068041-10
– fundername: Howard Hughes Medical Institute
– fundername: NIAID NIH HHS
  grantid: R01 AI108834
– fundername: NIAID NIH HHS
  grantid: R01 AI068041
GroupedDBID ---
.55
0R~
123
29M
2FS
36B
39C
3V.
4.4
53G
5BI
5RE
70F
7X7
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8R4
8R5
AAEEF
AAHBH
AARCD
AAYZH
AAZLF
ABAWZ
ABDBF
ABJNI
ABLJU
ABNNU
ABOCM
ABUWG
ACBWK
ACGFS
ACIWK
ACPRK
ACRPL
ACUHS
ADBBV
ADNMO
AENEX
AEUYN
AFBBN
AFKRA
AFRAH
AFSHS
AGAYW
AGGDT
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
AIYXT
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CCPQU
CS3
DB5
DU5
EAD
EAP
EAS
EBS
EE.
EJD
EMB
EMK
EMOBN
ESX
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
HCIFZ
HMCUK
HVGLF
HZ~
IAO
IHR
INH
INR
ISR
ITC
L-9
LK8
M1P
M7P
N9A
NNMJJ
O9-
ODYON
P2P
PQQKQ
PROAC
PSQYO
Q2X
RNT
RNTTT
SHXYY
SIXXV
SNYQT
SOJ
SV3
TAOOD
TBHMF
TDRGL
TSG
TUS
UKHRP
WH7
X7M
Y6R
ZXP
AAYXX
AFANA
ALPWD
ATHPR
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
PUEGO
CGR
CUY
CVF
ECM
EIF
NPM
AGSTI
7QP
7QR
7T5
7TK
7TM
7U9
7XB
8FD
8FK
AZQEC
DWQXO
FR3
GNUQQ
H94
K9.
M7N
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
7X8
ABFSG
ACSTC
ADTOC
AEZWR
AFHIU
AGQPQ
AHWEU
AIXLP
NFIDA
UNPAY
ID FETCH-LOGICAL-c575t-229aec1fc93e57ca695b54129d38eb9627200ede107c240ca6f576bf5a9f0e633
IEDL.DBID BENPR
ISSN 1529-2908
1529-2916
IngestDate Sun Oct 26 04:05:12 EDT 2025
Thu Oct 02 19:58:00 EDT 2025
Thu Sep 04 15:34:56 EDT 2025
Tue Oct 07 05:18:48 EDT 2025
Mon Oct 20 21:48:50 EDT 2025
Mon Oct 20 16:38:00 EDT 2025
Thu Oct 16 14:44:25 EDT 2025
Thu Jan 02 22:18:22 EST 2025
Thu Apr 24 22:57:17 EDT 2025
Wed Oct 01 03:46:53 EDT 2025
Fri Feb 21 02:39:03 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c575t-229aec1fc93e57ca695b54129d38eb9627200ede107c240ca6f576bf5a9f0e633
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://proxy.k.utb.cz/login?url=https://www.ncbi.nlm.nih.gov/pmc/articles/4961213
PMID 27092805
PQID 1782223283
PQPubID 45782
PageCount 9
ParticipantIDs unpaywall_primary_10_1038_ni_3440
proquest_miscellaneous_1787973454
proquest_miscellaneous_1783341699
proquest_journals_1782223283
gale_infotracmisc_A453290725
gale_infotracacademiconefile_A453290725
gale_incontextgauss_ISR_A453290725
pubmed_primary_27092805
crossref_citationtrail_10_1038_ni_3440
crossref_primary_10_1038_ni_3440
springer_journals_10_1038_ni_3440
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-05-01
PublicationDateYYYYMMDD 2016-05-01
PublicationDate_xml – month: 05
  year: 2016
  text: 2016-05-01
  day: 01
PublicationDecade 2010
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: United States
PublicationTitle Nature immunology
PublicationTitleAbbrev Nat Immunol
PublicationTitleAlternate Nat Immunol
PublicationYear 2016
Publisher Nature Publishing Group US
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group US
– name: Nature Publishing Group
References Franchi, Eigenbrod, Núñez (CR43) 2009; 183
Kravets (CR80) 2012; 287
Knodler (CR28) 2014; 16
Aachoui (CR13) 2013; 339
Muñoz-Planillo (CR41) 2013; 38
Jeremiah (CR92) 2014; 124
Randow, MacMicking, James (CR63) 2013; 340
Shenoy (CR53) 2007; 212
Lamkanfi, Dixit (CR4) 2014; 157
Jin, Huang, Smith, Jiang, Xiao (CR50) 2013; 69
Hornung (CR40) 2009; 458
Niedelman, Sprokholt, Clough, Frickel, Saeij (CR76) 2013; 81
Schauvliege, Vanrobaeys, Schotte, Beyaert (CR45) 2002; 277
Abdullah, Srinivasan, Modiano, Cresswell, Sau (CR69) 2009; 386
Lee, Smith, Gimeno, Gertner, Levy (CR44) 2000; 164
Rupper, Cardelli (CR58) 2008; 76
Tiwari, Choi, Matsuzawa, Pypaert, MacMicking (CR83) 2009; 10
Man (CR22) 2015; 16
Crow, Manel (CR91) 2015; 15
Meunier (CR23) 2015; 16
Aravind, Dixit, Koonin (CR2) 2001; 291
Wehner, Herrmann (CR66) 2010; 277
Virreira Winter (CR74) 2011; 6
Kayagaki (CR30) 2013; 341
He, Franchi, Núñez (CR47) 2013; 43
Degrandi (CR52) 2007; 179
Fernandes-Alnemri, Yu, Datta, Wu, Alnemri (CR39) 2009; 458
Yamamoto (CR65) 2012; 37
Kim, Shenoy, Kumar, Bradfield, MacMicking (CR24) 2012; 12
Degrandi (CR71) 2013; 110
Hagar, Powell, Aachoui, Ernst, Miao (CR15) 2013; 341
Broderick, De Nardo, Franklin, Hoffman, Latz (CR90) 2015; 10
Sheedy (CR61) 2013; 14
Ohtsuka (CR85) 2014; 44
Broz, von Moltke, Jones, Vance, Monack (CR33) 2010; 8
Selleck (CR72) 2013; 9
Rathinam (CR8) 2010; 11
Lee (CR75) 2015; 13
Staeheli, Prochazka, Steigmeier, Haller (CR56) 1984; 137
MacMicking, Taylor, McKinney (CR54) 2003; 302
Kerur (CR10) 2011; 9
Aachoui (CR19) 2015; 18
Broz (CR34) 2012; 490
Pierini (CR64) 2013; 191
Syguda (CR68) 2012; 279
Pilla (CR17) 2014; 111
Jones (CR7) 2010; 107
Kayagaki (CR21) 2015; 526
Casson (CR32) 2015; 112
Cai (CR36) 2014; 156
Daugherty, Malik (CR1) 2012; 46
von Moltke, Ayres, Kofoed, Chavarría-Smith, Vance (CR26) 2013; 31
Haldar (CR86) 2015; 112
Strittmatter (CR16) 2016; 136
Ghosh, Praefcke, Renault, Wittinghofer, Herrmann (CR67) 2006; 440
Tietzel, El-Haibi, Carabeo (CR73) 2009; 4
Dombrowski (CR9) 2011; 3
Case (CR14) 2013; 110
Britzen-Laurent (CR70) 2010; 5
Lu (CR35) 2014; 156
Martens (CR55) 2005; 1
Shi (CR81) 2015; 526
Hu (CR37) 2015; 350
Lu (CR46) 2012; 488
Rathinam (CR11) 2012; 150
MacMicking (CR88) 1995; 81
Meunier (CR18) 2014; 509
Shenoy (CR12) 2012; 336
Kayagaki (CR29) 2011; 479
Zhang (CR38) 2015; 350
Kim (CR57) 2010; 40
Henry, Brotcke, Weiss, Thompson, Monack (CR6) 2007; 204
MacMicking (CR82) 2004; 25
Latz, Xiao, Stutz (CR25) 2013; 13
Finethy (CR20) 2015; 83
Shi (CR31) 2014; 514
Haldar (CR84) 2013; 9
Döcke (CR89) 1997; 3
Hornung (CR60) 2008; 9
Hotchkiss, Monneret, Payen (CR87) 2013; 13
Marty-Roix (CR59) 2016; 291
MacMicking (CR3) 2012; 12
Olszewski, Gray, Vestal (CR51) 2006; 26
Okada, Matsuzawa, Yoshimura, Ichijo (CR62) 2014; 289
Selleck (CR78) 2015; 6
Guarda (CR42) 2011; 34
Kagan, Magupalli, Wu (CR79) 2014; 14
Hett (CR48) 2013; 9
Kim (CR49) 2011; 332
Angosto (CR5) 2012; 18
Chen (CR27) 2014; 8
Ohshima (CR77) 2014; 192
E Meunier (BFni3440_CR18) 2014; 509
S Martens (BFni3440_CR55) 2005; 1
V Hornung (BFni3440_CR40) 2009; 458
L Franchi (BFni3440_CR43) 2009; 183
D Degrandi (BFni3440_CR71) 2013; 110
J von Moltke (BFni3440_CR26) 2013; 31
R Schauvliege (BFni3440_CR45) 2002; 277
S Kim (BFni3440_CR57) 2010; 40
R Finethy (BFni3440_CR20) 2015; 83
M Okada (BFni3440_CR62) 2014; 289
W Niedelman (BFni3440_CR76) 2013; 81
M Yamamoto (BFni3440_CR65) 2012; 37
I Tietzel (BFni3440_CR73) 2009; 4
CN Casson (BFni3440_CR32) 2015; 112
T Fernandes-Alnemri (BFni3440_CR39) 2009; 458
A Syguda (BFni3440_CR68) 2012; 279
A Ghosh (BFni3440_CR67) 2006; 440
EM Selleck (BFni3440_CR72) 2013; 9
N Kayagaki (BFni3440_CR21) 2015; 526
VA Rathinam (BFni3440_CR8) 2010; 11
F Randow (BFni3440_CR63) 2013; 340
G Guarda (BFni3440_CR42) 2011; 34
DM Pilla (BFni3440_CR17) 2014; 111
D Angosto (BFni3440_CR5) 2012; 18
B Lu (BFni3440_CR46) 2012; 488
P Staeheli (BFni3440_CR56) 1984; 137
N Abdullah (BFni3440_CR69) 2009; 386
S Ohtsuka (BFni3440_CR85) 2014; 44
JW Jones (BFni3440_CR7) 2010; 107
L Zhang (BFni3440_CR38) 2015; 350
Y He (BFni3440_CR47) 2013; 43
YJ Crow (BFni3440_CR91) 2015; 15
SM Man (BFni3440_CR22) 2015; 16
JD MacMicking (BFni3440_CR88) 1995; 81
L Aravind (BFni3440_CR2) 2001; 291
AC Rupper (BFni3440_CR58) 2008; 76
CL Case (BFni3440_CR14) 2013; 110
S Virreira Winter (BFni3440_CR74) 2011; 6
X Cai (BFni3440_CR36) 2014; 156
AR Shenoy (BFni3440_CR53) 2007; 212
T Jin (BFni3440_CR50) 2013; 69
JC Kagan (BFni3440_CR79) 2014; 14
JD MacMicking (BFni3440_CR54) 2003; 302
N Kerur (BFni3440_CR10) 2011; 9
JD MacMicking (BFni3440_CR3) 2012; 12
D Degrandi (BFni3440_CR52) 2007; 179
N Jeremiah (BFni3440_CR92) 2014; 124
Y Aachoui (BFni3440_CR13) 2013; 339
CK Lee (BFni3440_CR44) 2000; 164
E Latz (BFni3440_CR25) 2013; 13
Y Aachoui (BFni3440_CR19) 2015; 18
M Wehner (BFni3440_CR66) 2010; 277
N Kayagaki (BFni3440_CR29) 2011; 479
AK Haldar (BFni3440_CR84) 2013; 9
MD Daugherty (BFni3440_CR1) 2012; 46
R Marty-Roix (BFni3440_CR59) 2016; 291
R Pierini (BFni3440_CR64) 2013; 191
LA Knodler (BFni3440_CR28) 2014; 16
MA Olszewski (BFni3440_CR51) 2006; 26
V Hornung (BFni3440_CR60) 2008; 9
WD Döcke (BFni3440_CR89) 1997; 3
T Henry (BFni3440_CR6) 2007; 204
A Lu (BFni3440_CR35) 2014; 156
L Broderick (BFni3440_CR90) 2015; 10
R Muñoz-Planillo (BFni3440_CR41) 2013; 38
AR Shenoy (BFni3440_CR12) 2012; 336
E Meunier (BFni3440_CR23) 2015; 16
FJ Sheedy (BFni3440_CR61) 2013; 14
JA Hagar (BFni3440_CR15) 2013; 341
KW Chen (BFni3440_CR27) 2014; 8
EM Selleck (BFni3440_CR78) 2015; 6
BH Kim (BFni3440_CR24) 2012; 12
N Britzen-Laurent (BFni3440_CR70) 2010; 5
N Kayagaki (BFni3440_CR30) 2013; 341
J Ohshima (BFni3440_CR77) 2014; 192
BH Kim (BFni3440_CR49) 2011; 332
Y Dombrowski (BFni3440_CR9) 2011; 3
S Tiwari (BFni3440_CR83) 2009; 10
Z Hu (BFni3440_CR37) 2015; 350
E Kravets (BFni3440_CR80) 2012; 287
P Broz (BFni3440_CR33) 2010; 8
Y Lee (BFni3440_CR75) 2015; 13
VA Rathinam (BFni3440_CR11) 2012; 150
RS Hotchkiss (BFni3440_CR87) 2013; 13
M Lamkanfi (BFni3440_CR4) 2014; 157
J Shi (BFni3440_CR81) 2015; 526
J Shi (BFni3440_CR31) 2014; 514
GE Strittmatter (BFni3440_CR16) 2016; 136
P Broz (BFni3440_CR34) 2012; 490
AK Haldar (BFni3440_CR86) 2015; 112
EC Hett (BFni3440_CR48) 2013; 9
JD MacMicking (BFni3440_CR82) 2004; 25
26320999 - Cell Host Microbe. 2015 Sep 9;18(3):320-32
23215645 - Annu Rev Immunol. 2013;31:73-106
22607347 - FEBS J. 2012 Jul;279(14):2544-54
25288801 - J Biol Chem. 2014 Nov 21;289(47):32926-36
25359439 - Nat Rev Immunol. 2014 Dec;14 (12 ):821-6
19652711 - PLoS One. 2009 Aug 04;4(8):e6499
23145935 - Annu Rev Genet. 2012;46:677-700
24031018 - Science. 2013 Sep 13;341(6151):1250-3
23702978 - Nat Rev Immunol. 2013 Jun;13(6):397-411
24855941 - Cell. 2014 May 22;157(5):1013-22
21147462 - Cell Host Microbe. 2010 Dec 16;8(6):471-83
23785284 - PLoS Pathog. 2013;9(6):e1003414
23401008 - Eur J Immunol. 2013 May;43(5):1147-52
23812099 - Nat Immunol. 2013 Aug;14 (8):812-20
26739094 - J Invest Dermatol. 2016 Mar;136(3):610-20
10640742 - J Immunol. 2000 Feb 1;164(3):1286-92
18025219 - J Immunol. 2007 Dec 1;179(11):7729-40
26440898 - Cell Rep. 2015 Oct 13;13(2):223-33
19620982 - Nat Immunol. 2009 Aug;10(8):907-17
21931713 - PLoS One. 2011;6(9):e24434
23348507 - Science. 2013 Feb 22;339(6122):975-8
18604214 - Nat Immunol. 2008 Aug;9(8):847-56
22801494 - Nature. 2012 Aug 30;488(7413):670-4
21151871 - PLoS One. 2010 Dec 07;5(12):e14246
23661752 - Science. 2013 May 10;340(6133):701-6
23887873 - Science. 2013 Sep 13;341(6151):1246-9
19542372 - J Immunol. 2009 Jul 15;183(2):792-6
22002608 - Nature. 2011 Oct 16;479(7371):117-21
20180847 - FEBS J. 2010 Apr;277(7):1597-605
15489189 - Trends Immunol. 2004 Nov;25(11):601-9
22895188 - Nature. 2012 Oct 11;490(7419):288-91
24739961 - Nature. 2014 May 15;509(7500):366-70
16689661 - J Interferon Cytokine Res. 2006 May;26(5):328-52
11181990 - Science. 2001 Feb 16;291(5507):1279-84
23248289 - Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):294-9
23975862 - J Immunol. 2013 Oct 1;191(7):3847-57
24563254 - J Immunol. 2014 Apr 1;192(7):3328-35
24715728 - Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6046-51
25423351 - Annu Rev Pathol. 2015;10:395-424
25774716 - Nat Immunol. 2015 May;16(5):476-84
26375259 - Nature. 2015 Oct 29;526(7575):666-71
26052098 - Nat Rev Immunol. 2015 Jul;15(7):429-40
22531325 - Nat Rev Immunol. 2012 Apr 25;12(5):367-82
19158676 - Nature. 2009 Mar 26;458(7237):509-13
24630723 - Cell. 2014 Mar 13;156(6):1207-22
26555265 - J Biol Chem. 2016 Jan 15;291(3):1123-36
22795875 - Immunity. 2012 Aug 24;37(2):302-13
18086378 - Immunobiology. 2007;212(9-10):771-84
16304607 - PLoS Pathog. 2005 Nov;1(3):e24
21562230 - Sci Transl Med. 2011 May 11;3(82):82ra38
18362138 - Infect Immun. 2008 Jun;76(6):2304-15
22819539 - Cell. 2012 Aug 3;150(3):606-19
20333626 - Eur J Immunol. 2010 Jun;40(6):1545-51
14576437 - Science. 2003 Oct 24;302(5645):654-9
22730319 - J Biol Chem. 2012 Aug 10;287(33):27452-66
23633952 - PLoS Pathog. 2013;9(4):e1003320
6089411 - Virology. 1984 Aug;137(1):135-42
24042117 - Infect Immun. 2013 Dec;81(12 ):4341-9
25121752 - Cell Host Microbe. 2014 Aug 13;16(2):249-56
21349431 - Immunity. 2011 Feb 25;34(2):213-23
26449474 - Science. 2015 Oct 23;350(6259):404-9
25964352 - Proc Natl Acad Sci U S A. 2015 May 26;112(21):6688-93
17452523 - J Exp Med. 2007 May 14;204(5):987-94
21551061 - Science. 2011 May 6;332(6030):717-21
9176497 - Nat Med. 1997 Jun;3(6):678-81
19158675 - Nature. 2009 Mar 26;458(7237):514-8
25043180 - Cell Rep. 2014 Jul 24;8(2):570-82
26350966 - MBio. 2015 Sep 08;6(5):e01157-15
23809161 - Immunity. 2013 Jun 27;38(6):1142-53
22461501 - Science. 2012 Apr 27;336(6080):481-5
23084913 - Cell Host Microbe. 2012 Oct 18;12(4):432-44
23908027 - Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug;69(Pt 8):855-60
26417105 - Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5628-37
20351692 - Nat Immunol. 2010 May;11(5):395-402
23603659 - Nat Chem Biol. 2013 Jun;9(6):398-405
24630722 - Cell. 2014 Mar 13;156(6):1193-206
26416908 - Infect Immun. 2015 Dec;83(12 ):4740-9
23307811 - Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1851-6
24232462 - Nat Rev Immunol. 2013 Dec;13(12):862-74
26375003 - Nature. 2015 Oct 29;526(7575):660-5
7538909 - Cell. 1995 May 19;81(4):641-50
25401470 - J Clin Invest. 2014 Dec;124(12):5516-20
26449475 - Science. 2015 Oct 23;350(6259):399-404
12198138 - J Biol Chem. 2002 Nov 1;277(44):41624-30
21575908 - Cell Host Microbe. 2011 May 19;9(5):363-75
24374573 - Eur J Immunol. 2014 Apr;44(4):1084-92
19150356 - J Mol Biol. 2009 Feb 27;386(3):690-703
22456941 - Innate Immun. 2012 Dec;18(6):815-24
25119034 - Nature. 2014 Oct 9;514(7521):187-92
16511497 - Nature. 2006 Mar 2;440(7080):101-4
20457908 - Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6
25774715 - Nat Immunol. 2015 May;16(5):467-75
References_xml – volume: 339
  start-page: 975
  year: 2013
  end-page: 978
  ident: CR13
  article-title: Caspase-11 protects against bacteria that escape the vacuole
  publication-title: Science
  doi: 10.1126/science.1230751
– volume: 341
  start-page: 1250
  year: 2013
  end-page: 1253
  ident: CR15
  article-title: Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock
  publication-title: Science
  doi: 10.1126/science.1240988
– volume: 9
  start-page: e1003414
  year: 2013
  ident: CR84
  article-title: IRG and GBP host resistance factors target aberrant, “non-self” vacuoles characterized by the missing of “self” IRGM proteins
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1003414
– volume: 9
  start-page: 398
  year: 2013
  end-page: 405
  ident: CR48
  article-title: Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.1236
– volume: 110
  start-page: 1851
  year: 2013
  end-page: 1856
  ident: CR14
  article-title: Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1211521110
– volume: 279
  start-page: 2544
  year: 2012
  end-page: 2554
  ident: CR68
  article-title: Tetramerization of human guanylate-binding protein 1 is mediated by coiled-coil formation of the C-terminal α-helices
  publication-title: FEBS J.
  doi: 10.1111/j.1742-4658.2012.08637.x
– volume: 490
  start-page: 288
  year: 2012
  end-page: 291
  ident: CR34
  article-title: Caspase-11 increases susceptibility to salmonella infection in the absence of caspase-1
  publication-title: Nature
  doi: 10.1038/nature11419
– volume: 386
  start-page: 690
  year: 2009
  end-page: 703
  ident: CR69
  article-title: Role of individual domains and identification of internal gap in human guanylate binding protein-1
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2008.12.060
– volume: 488
  start-page: 670
  year: 2012
  end-page: 674
  ident: CR46
  article-title: Novel role of PKR in inflammasome activation and HMGB1 release
  publication-title: Nature
  doi: 10.1038/nature11290
– volume: 289
  start-page: 32926
  year: 2014
  end-page: 32936
  ident: CR62
  article-title: The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.579961
– volume: 18
  start-page: 815
  year: 2012
  end-page: 824
  ident: CR5
  article-title: Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β
  publication-title: Innate Immun.
  doi: 10.1177/1753425912441956
– volume: 12
  start-page: 432
  year: 2012
  end-page: 444
  ident: CR24
  article-title: IFN-inducible GTPases in host cell defense
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2012.09.007
– volume: 16
  start-page: 249
  year: 2014
  end-page: 256
  ident: CR28
  article-title: Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2014.07.002
– volume: 137
  start-page: 135
  year: 1984
  end-page: 142
  ident: CR56
  article-title: Genetic control of interferon action: mouse strain distribution and inheritance of an induced protein with guanylate-binding property
  publication-title: Virology
  doi: 10.1016/0042-6822(84)90016-3
– volume: 287
  start-page: 27452
  year: 2012
  end-page: 27466
  ident: CR80
  article-title: The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.379636
– volume: 350
  start-page: 399
  year: 2015
  end-page: 404
  ident: CR37
  article-title: Structural and biochemical basis for induced self-propagation of NLRC4
  publication-title: Science
  doi: 10.1126/science.aac5489
– volume: 110
  start-page: 294
  year: 2013
  end-page: 299
  ident: CR71
  article-title: Murine guanylate binding protein 2 (mGBP2) controls replication
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1205635110
– volume: 6
  start-page: e01157
  year: 2015
  end-page: e15
  ident: CR78
  article-title: A noncanonical autophagy pathway restricts growth in a strain-specific manner in IFN-γ-activated human cells
  publication-title: MBio
  doi: 10.1128/mBio.01157-15
– volume: 9
  start-page: 363
  year: 2011
  end-page: 375
  ident: CR10
  article-title: IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma-associated herpesvirus infection
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2011.04.008
– volume: 25
  start-page: 601
  year: 2004
  end-page: 609
  ident: CR82
  article-title: IFN-inducible GTPases and immunity to intracellular pathogens
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2004.08.010
– volume: 164
  start-page: 1286
  year: 2000
  end-page: 1292
  ident: CR44
  article-title: STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.164.3.1286
– volume: 341
  start-page: 1246
  year: 2013
  end-page: 1249
  ident: CR30
  article-title: Noncanonical inflammasome activation by intracellular LPS independent of TLR4
  publication-title: Science
  doi: 10.1126/science.1240248
– volume: 14
  start-page: 812
  year: 2013
  end-page: 820
  ident: CR61
  article-title: CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2639
– volume: 8
  start-page: 471
  year: 2010
  end-page: 483
  ident: CR33
  article-title: Differential requirement for caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2010.11.007
– volume: 37
  start-page: 302
  year: 2012
  end-page: 313
  ident: CR65
  article-title: A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.06.009
– volume: 514
  start-page: 187
  year: 2014
  end-page: 192
  ident: CR31
  article-title: Inflammatory caspases are innate immune receptors for intracellular LPS
  publication-title: Nature
  doi: 10.1038/nature13683
– volume: 9
  start-page: 847
  year: 2008
  end-page: 856
  ident: CR60
  article-title: Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1631
– volume: 8
  start-page: 570
  year: 2014
  end-page: 582
  ident: CR27
  article-title: The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.06.028
– volume: 31
  start-page: 73
  year: 2013
  end-page: 106
  ident: CR26
  article-title: Recognition of bacteria by inflammasomes
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032712-095944
– volume: 336
  start-page: 481
  year: 2012
  end-page: 485
  ident: CR12
  article-title: GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals
  publication-title: Science
  doi: 10.1126/science.1217141
– volume: 191
  start-page: 3847
  year: 2013
  end-page: 3857
  ident: CR64
  article-title: ASC controls IFN-γ levels in an IL-18-dependent manner in caspase-1-deficient mice infected with
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1203326
– volume: 291
  start-page: 1279
  year: 2001
  end-page: 1284
  ident: CR2
  article-title: Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons
  publication-title: Science
  doi: 10.1126/science.291.5507.1279
– volume: 16
  start-page: 476
  year: 2015
  end-page: 484
  ident: CR23
  article-title: Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3119
– volume: 124
  start-page: 5516
  year: 2014
  end-page: 5520
  ident: CR92
  article-title: Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI79100
– volume: 6
  start-page: e24434
  year: 2011
  ident: CR74
  article-title: Determinants of GBP recruitment to vacuoles and the parasitic factors that control it
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0024434
– volume: 13
  start-page: 862
  year: 2013
  end-page: 874
  ident: CR87
  article-title: Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3552
– volume: 40
  start-page: 1545
  year: 2010
  end-page: 1551
  ident: CR57
  article-title: is sensed by the NLRP3 and AIM2 inflammasome
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201040425
– volume: 26
  start-page: 328
  year: 2006
  end-page: 352
  ident: CR51
  article-title: genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters
  publication-title: J. Interferon Cytokine Res.
  doi: 10.1089/jir.2006.26.328
– volume: 9
  start-page: e1003320
  year: 2013
  ident: CR72
  article-title: Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1003320
– volume: 302
  start-page: 654
  year: 2003
  end-page: 659
  ident: CR54
  article-title: Immune control of tuberculosis by IFN-γ-inducible LRG-47
  publication-title: Science
  doi: 10.1126/science.1088063
– volume: 204
  start-page: 987
  year: 2007
  end-page: 994
  ident: CR6
  article-title: Type I interferon signaling is required for activation of the inflammasome during infection
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20062665
– volume: 46
  start-page: 677
  year: 2012
  end-page: 700
  ident: CR1
  article-title: Rules of engagement: molecular insights from host-virus arms races
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev-genet-110711-155522
– volume: 11
  start-page: 395
  year: 2010
  end-page: 402
  ident: CR8
  article-title: The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1864
– volume: 277
  start-page: 1597
  year: 2010
  end-page: 1605
  ident: CR66
  article-title: Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant
  publication-title: FEBS J.
  doi: 10.1111/j.1742-4658.2010.07586.x
– volume: 38
  start-page: 1142
  year: 2013
  end-page: 1153
  ident: CR41
  article-title: K efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.05.016
– volume: 156
  start-page: 1207
  year: 2014
  end-page: 1222
  ident: CR36
  article-title: Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation
  publication-title: Cell
  doi: 10.1016/j.cell.2014.01.063
– volume: 192
  start-page: 3328
  year: 2014
  end-page: 3335
  ident: CR77
  article-title: Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1302822
– volume: 526
  start-page: 666
  year: 2015
  end-page: 671
  ident: CR21
  article-title: Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
  publication-title: Nature
  doi: 10.1038/nature15541
– volume: 291
  start-page: 1123
  year: 2016
  end-page: 1136
  ident: CR59
  article-title: Identification of QS-21 as an inflammasome-activating molecular component of saponin adjuvants
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.683011
– volume: 107
  start-page: 9771
  year: 2010
  end-page: 9776
  ident: CR7
  article-title: Absent in melanoma 2 is required for innate immune recognition of
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1003738107
– volume: 350
  start-page: 404
  year: 2015
  end-page: 409
  ident: CR38
  article-title: Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
  publication-title: Science
  doi: 10.1126/science.aac5789
– volume: 44
  start-page: 1084
  year: 2014
  end-page: 1092
  ident: CR85
  article-title: SQSTM1/p62/A170 regulates the severity of pneumonia by modulating inflammasome activity
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201344091
– volume: 212
  start-page: 771
  year: 2007
  end-page: 784
  ident: CR53
  article-title: Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2007.09.018
– volume: 10
  start-page: 907
  year: 2009
  end-page: 917
  ident: CR83
  article-title: Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P and PtdIns(3,4,5)P promotes immunity to mycobacteria
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1759
– volume: 5
  start-page: e14246
  year: 2010
  ident: CR70
  article-title: Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0014246
– volume: 4
  start-page: e6499
  year: 2009
  ident: CR73
  article-title: Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-γ
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0006499
– volume: 136
  start-page: 610
  year: 2016
  end-page: 620
  ident: CR16
  article-title: IFN-γ primes keratinocytes for HSV-1-induced inflammasome activation
  publication-title: J. Invest. Dermatol.
  doi: 10.1016/j.jid.2015.12.022
– volume: 16
  start-page: 467
  year: 2015
  end-page: 475
  ident: CR22
  article-title: The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by infection
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3118
– volume: 332
  start-page: 717
  year: 2011
  end-page: 721
  ident: CR49
  article-title: A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection
  publication-title: Science
  doi: 10.1126/science.1201711
– volume: 112
  start-page: 6688
  year: 2015
  end-page: 6693
  ident: CR32
  article-title: Human caspase-4 mediates noncanonical inflammasome activation against Gram-negative bacterial pathogens
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1421699112
– volume: 112
  start-page: E5628
  year: 2015
  end-page: E5637
  ident: CR86
  article-title: Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1515966112
– volume: 183
  start-page: 792
  year: 2009
  end-page: 796
  ident: CR43
  article-title: Cutting edge: TNF-α mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0900173
– volume: 440
  start-page: 101
  year: 2006
  end-page: 104
  ident: CR67
  article-title: How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP
  publication-title: Nature
  doi: 10.1038/nature04510
– volume: 81
  start-page: 4341
  year: 2013
  end-page: 4349
  ident: CR76
  article-title: Cell death of γ interferon-stimulated human fibroblasts upon infection induces early parasite egress and limits parasite replication
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.00416-13
– volume: 111
  start-page: 6046
  year: 2014
  end-page: 6051
  ident: CR17
  article-title: Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1321700111
– volume: 18
  start-page: 320
  year: 2015
  end-page: 332
  ident: CR19
  article-title: Canonical inflammasomes drive IFN-γ to prime caspase-11 in defense against a cytosol-invasive bacterium
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2015.07.016
– volume: 81
  start-page: 641
  year: 1995
  end-page: 650
  ident: CR88
  article-title: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90085-3
– volume: 1
  start-page: e24
  year: 2005
  ident: CR55
  article-title: Disruption of parasitophorous vacuoles by the mouse p47-resistance GTPases
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.0010024
– volume: 69
  start-page: 855
  year: 2013
  end-page: 860
  ident: CR50
  article-title: Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein
  publication-title: Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
  doi: 10.1107/S1744309113015558
– volume: 34
  start-page: 213
  year: 2011
  end-page: 223
  ident: CR42
  article-title: Type I interferon inhibits interleukin-1 production and inflammasome activation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.02.006
– volume: 179
  start-page: 7729
  year: 2007
  end-page: 7740
  ident: CR52
  article-title: Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.11.7729
– volume: 458
  start-page: 509
  year: 2009
  end-page: 513
  ident: CR39
  article-title: AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
  publication-title: Nature
  doi: 10.1038/nature07710
– volume: 340
  start-page: 701
  year: 2013
  end-page: 706
  ident: CR63
  article-title: Cellular self-defense: how cell-autonomous immunity protects against pathogens
  publication-title: Science
  doi: 10.1126/science.1233028
– volume: 150
  start-page: 606
  year: 2012
  end-page: 619
  ident: CR11
  article-title: TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria
  publication-title: Cell
  doi: 10.1016/j.cell.2012.07.007
– volume: 43
  start-page: 1147
  year: 2013
  end-page: 1152
  ident: CR47
  article-title: The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201243187
– volume: 13
  start-page: 223
  year: 2015
  end-page: 233
  ident: CR75
  article-title: p62 plays a specific role in interferon-γ-induced presentation of a toxoplasma vacuolar antigen
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.09.005
– volume: 10
  start-page: 395
  year: 2015
  end-page: 424
  ident: CR90
  article-title: The inflammasomes and autoinflammatory syndromes
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathol-012414-040431
– volume: 76
  start-page: 2304
  year: 2008
  end-page: 2315
  ident: CR58
  article-title: Induction of guanylate binding protein 5 by γ interferon increases susceptibility to serovar -induced pyroptosis in RAW 264.7 cells
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.01437-07
– volume: 3
  start-page: 82ra38
  year: 2011
  ident: CR9
  article-title: Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3002001
– volume: 15
  start-page: 429
  year: 2015
  end-page: 440
  ident: CR91
  article-title: Aicardi-Goutières syndrome and the type I interferonopathies
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3850
– volume: 83
  start-page: 4740
  year: 2015
  end-page: 4749
  ident: CR20
  article-title: Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in chlamydia-infected macrophages
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.00856-15
– volume: 157
  start-page: 1013
  year: 2014
  end-page: 1022
  ident: CR4
  article-title: Mechanisms and functions of inflammasomes
  publication-title: Cell
  doi: 10.1016/j.cell.2014.04.007
– volume: 458
  start-page: 514
  year: 2009
  end-page: 518
  ident: CR40
  article-title: AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
  publication-title: Nature
  doi: 10.1038/nature07725
– volume: 509
  start-page: 366
  year: 2014
  end-page: 370
  ident: CR18
  article-title: Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
  publication-title: Nature
  doi: 10.1038/nature13157
– volume: 12
  start-page: 367
  year: 2012
  end-page: 382
  ident: CR3
  article-title: Interferon-inducible effector mechanisms in cell-autonomous immunity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3210
– volume: 479
  start-page: 117
  year: 2011
  end-page: 121
  ident: CR29
  article-title: Non-canonical inflammasome activation targets caspase-11
  publication-title: Nature
  doi: 10.1038/nature10558
– volume: 526
  start-page: 660
  year: 2015
  end-page: 665
  ident: CR81
  article-title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
  publication-title: Nature
  doi: 10.1038/nature15514
– volume: 277
  start-page: 41624
  year: 2002
  end-page: 41630
  ident: CR45
  article-title: Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-κB and signal transducer and activator of transcription (STAT) 1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M207852200
– volume: 14
  start-page: 821
  year: 2014
  end-page: 826
  ident: CR79
  article-title: SMOCs: supramolecular organizing centres that control innate immunity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3757
– volume: 13
  start-page: 397
  year: 2013
  end-page: 411
  ident: CR25
  article-title: Activation and regulation of the inflammasomes
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3452
– volume: 156
  start-page: 1193
  year: 2014
  end-page: 1206
  ident: CR35
  article-title: Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
  publication-title: Cell
  doi: 10.1016/j.cell.2014.02.008
– volume: 3
  start-page: 678
  year: 1997
  end-page: 681
  ident: CR89
  article-title: Monocyte deactivation in septic patients: restoration by IFN-γ treatment
  publication-title: Nat. Med.
  doi: 10.1038/nm0697-678
– volume: 9
  start-page: 363
  year: 2011
  ident: BFni3440_CR10
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2011.04.008
– volume: 302
  start-page: 654
  year: 2003
  ident: BFni3440_CR54
  publication-title: Science
  doi: 10.1126/science.1088063
– volume: 479
  start-page: 117
  year: 2011
  ident: BFni3440_CR29
  publication-title: Nature
  doi: 10.1038/nature10558
– volume: 490
  start-page: 288
  year: 2012
  ident: BFni3440_CR34
  publication-title: Nature
  doi: 10.1038/nature11419
– volume: 112
  start-page: 6688
  year: 2015
  ident: BFni3440_CR32
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1421699112
– volume: 526
  start-page: 666
  year: 2015
  ident: BFni3440_CR21
  publication-title: Nature
  doi: 10.1038/nature15541
– volume: 458
  start-page: 509
  year: 2009
  ident: BFni3440_CR39
  publication-title: Nature
  doi: 10.1038/nature07710
– volume: 76
  start-page: 2304
  year: 2008
  ident: BFni3440_CR58
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.01437-07
– volume: 9
  start-page: 398
  year: 2013
  ident: BFni3440_CR48
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.1236
– volume: 9
  start-page: e1003320
  year: 2013
  ident: BFni3440_CR72
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1003320
– volume: 15
  start-page: 429
  year: 2015
  ident: BFni3440_CR91
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3850
– volume: 191
  start-page: 3847
  year: 2013
  ident: BFni3440_CR64
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1203326
– volume: 386
  start-page: 690
  year: 2009
  ident: BFni3440_CR69
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2008.12.060
– volume: 43
  start-page: 1147
  year: 2013
  ident: BFni3440_CR47
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201243187
– volume: 112
  start-page: E5628
  year: 2015
  ident: BFni3440_CR86
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1515966112
– volume: 350
  start-page: 399
  year: 2015
  ident: BFni3440_CR37
  publication-title: Science
  doi: 10.1126/science.aac5489
– volume: 440
  start-page: 101
  year: 2006
  ident: BFni3440_CR67
  publication-title: Nature
  doi: 10.1038/nature04510
– volume: 124
  start-page: 5516
  year: 2014
  ident: BFni3440_CR92
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI79100
– volume: 14
  start-page: 821
  year: 2014
  ident: BFni3440_CR79
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3757
– volume: 5
  start-page: e14246
  year: 2010
  ident: BFni3440_CR70
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0014246
– volume: 156
  start-page: 1207
  year: 2014
  ident: BFni3440_CR36
  publication-title: Cell
  doi: 10.1016/j.cell.2014.01.063
– volume: 12
  start-page: 432
  year: 2012
  ident: BFni3440_CR24
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2012.09.007
– volume: 111
  start-page: 6046
  year: 2014
  ident: BFni3440_CR17
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1321700111
– volume: 13
  start-page: 862
  year: 2013
  ident: BFni3440_CR87
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3552
– volume: 9
  start-page: e1003414
  year: 2013
  ident: BFni3440_CR84
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1003414
– volume: 18
  start-page: 320
  year: 2015
  ident: BFni3440_CR19
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2015.07.016
– volume: 341
  start-page: 1246
  year: 2013
  ident: BFni3440_CR30
  publication-title: Science
  doi: 10.1126/science.1240248
– volume: 458
  start-page: 514
  year: 2009
  ident: BFni3440_CR40
  publication-title: Nature
  doi: 10.1038/nature07725
– volume: 40
  start-page: 1545
  year: 2010
  ident: BFni3440_CR57
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201040425
– volume: 279
  start-page: 2544
  year: 2012
  ident: BFni3440_CR68
  publication-title: FEBS J.
  doi: 10.1111/j.1742-4658.2012.08637.x
– volume: 69
  start-page: 855
  year: 2013
  ident: BFni3440_CR50
  publication-title: Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
  doi: 10.1107/S1744309113015558
– volume: 340
  start-page: 701
  year: 2013
  ident: BFni3440_CR63
  publication-title: Science
  doi: 10.1126/science.1233028
– volume: 14
  start-page: 812
  year: 2013
  ident: BFni3440_CR61
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2639
– volume: 136
  start-page: 610
  year: 2016
  ident: BFni3440_CR16
  publication-title: J. Invest. Dermatol.
  doi: 10.1016/j.jid.2015.12.022
– volume: 204
  start-page: 987
  year: 2007
  ident: BFni3440_CR6
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20062665
– volume: 16
  start-page: 467
  year: 2015
  ident: BFni3440_CR22
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3118
– volume: 164
  start-page: 1286
  year: 2000
  ident: BFni3440_CR44
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.164.3.1286
– volume: 350
  start-page: 404
  year: 2015
  ident: BFni3440_CR38
  publication-title: Science
  doi: 10.1126/science.aac5789
– volume: 46
  start-page: 677
  year: 2012
  ident: BFni3440_CR1
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev-genet-110711-155522
– volume: 83
  start-page: 4740
  year: 2015
  ident: BFni3440_CR20
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.00856-15
– volume: 37
  start-page: 302
  year: 2012
  ident: BFni3440_CR65
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.06.009
– volume: 81
  start-page: 4341
  year: 2013
  ident: BFni3440_CR76
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.00416-13
– volume: 16
  start-page: 476
  year: 2015
  ident: BFni3440_CR23
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3119
– volume: 156
  start-page: 1193
  year: 2014
  ident: BFni3440_CR35
  publication-title: Cell
  doi: 10.1016/j.cell.2014.02.008
– volume: 289
  start-page: 32926
  year: 2014
  ident: BFni3440_CR62
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.579961
– volume: 81
  start-page: 641
  year: 1995
  ident: BFni3440_CR88
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90085-3
– volume: 341
  start-page: 1250
  year: 2013
  ident: BFni3440_CR15
  publication-title: Science
  doi: 10.1126/science.1240988
– volume: 44
  start-page: 1084
  year: 2014
  ident: BFni3440_CR85
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201344091
– volume: 336
  start-page: 481
  year: 2012
  ident: BFni3440_CR12
  publication-title: Science
  doi: 10.1126/science.1217141
– volume: 526
  start-page: 660
  year: 2015
  ident: BFni3440_CR81
  publication-title: Nature
  doi: 10.1038/nature15514
– volume: 291
  start-page: 1279
  year: 2001
  ident: BFni3440_CR2
  publication-title: Science
  doi: 10.1126/science.291.5507.1279
– volume: 212
  start-page: 771
  year: 2007
  ident: BFni3440_CR53
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2007.09.018
– volume: 192
  start-page: 3328
  year: 2014
  ident: BFni3440_CR77
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1302822
– volume: 157
  start-page: 1013
  year: 2014
  ident: BFni3440_CR4
  publication-title: Cell
  doi: 10.1016/j.cell.2014.04.007
– volume: 150
  start-page: 606
  year: 2012
  ident: BFni3440_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2012.07.007
– volume: 11
  start-page: 395
  year: 2010
  ident: BFni3440_CR8
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1864
– volume: 509
  start-page: 366
  year: 2014
  ident: BFni3440_CR18
  publication-title: Nature
  doi: 10.1038/nature13157
– volume: 137
  start-page: 135
  year: 1984
  ident: BFni3440_CR56
  publication-title: Virology
  doi: 10.1016/0042-6822(84)90016-3
– volume: 13
  start-page: 223
  year: 2015
  ident: BFni3440_CR75
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.09.005
– volume: 10
  start-page: 907
  year: 2009
  ident: BFni3440_CR83
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1759
– volume: 6
  start-page: e01157
  year: 2015
  ident: BFni3440_CR78
  publication-title: MBio
  doi: 10.1128/mBio.01157-15
– volume: 31
  start-page: 73
  year: 2013
  ident: BFni3440_CR26
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032712-095944
– volume: 10
  start-page: 395
  year: 2015
  ident: BFni3440_CR90
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathol-012414-040431
– volume: 18
  start-page: 815
  year: 2012
  ident: BFni3440_CR5
  publication-title: Innate Immun.
  doi: 10.1177/1753425912441956
– volume: 277
  start-page: 41624
  year: 2002
  ident: BFni3440_CR45
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M207852200
– volume: 107
  start-page: 9771
  year: 2010
  ident: BFni3440_CR7
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1003738107
– volume: 291
  start-page: 1123
  year: 2016
  ident: BFni3440_CR59
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.683011
– volume: 38
  start-page: 1142
  year: 2013
  ident: BFni3440_CR41
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.05.016
– volume: 6
  start-page: e24434
  year: 2011
  ident: BFni3440_CR74
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0024434
– volume: 8
  start-page: 570
  year: 2014
  ident: BFni3440_CR27
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.06.028
– volume: 13
  start-page: 397
  year: 2013
  ident: BFni3440_CR25
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3452
– volume: 3
  start-page: 678
  year: 1997
  ident: BFni3440_CR89
  publication-title: Nat. Med.
  doi: 10.1038/nm0697-678
– volume: 9
  start-page: 847
  year: 2008
  ident: BFni3440_CR60
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1631
– volume: 339
  start-page: 975
  year: 2013
  ident: BFni3440_CR13
  publication-title: Science
  doi: 10.1126/science.1230751
– volume: 488
  start-page: 670
  year: 2012
  ident: BFni3440_CR46
  publication-title: Nature
  doi: 10.1038/nature11290
– volume: 25
  start-page: 601
  year: 2004
  ident: BFni3440_CR82
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2004.08.010
– volume: 26
  start-page: 328
  year: 2006
  ident: BFni3440_CR51
  publication-title: J. Interferon Cytokine Res.
  doi: 10.1089/jir.2006.26.328
– volume: 110
  start-page: 294
  year: 2013
  ident: BFni3440_CR71
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1205635110
– volume: 3
  start-page: 82ra38
  year: 2011
  ident: BFni3440_CR9
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3002001
– volume: 110
  start-page: 1851
  year: 2013
  ident: BFni3440_CR14
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1211521110
– volume: 1
  start-page: e24
  year: 2005
  ident: BFni3440_CR55
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.0010024
– volume: 8
  start-page: 471
  year: 2010
  ident: BFni3440_CR33
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2010.11.007
– volume: 34
  start-page: 213
  year: 2011
  ident: BFni3440_CR42
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.02.006
– volume: 183
  start-page: 792
  year: 2009
  ident: BFni3440_CR43
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0900173
– volume: 179
  start-page: 7729
  year: 2007
  ident: BFni3440_CR52
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.11.7729
– volume: 16
  start-page: 249
  year: 2014
  ident: BFni3440_CR28
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2014.07.002
– volume: 514
  start-page: 187
  year: 2014
  ident: BFni3440_CR31
  publication-title: Nature
  doi: 10.1038/nature13683
– volume: 12
  start-page: 367
  year: 2012
  ident: BFni3440_CR3
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3210
– volume: 287
  start-page: 27452
  year: 2012
  ident: BFni3440_CR80
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.379636
– volume: 332
  start-page: 717
  year: 2011
  ident: BFni3440_CR49
  publication-title: Science
  doi: 10.1126/science.1201711
– volume: 277
  start-page: 1597
  year: 2010
  ident: BFni3440_CR66
  publication-title: FEBS J.
  doi: 10.1111/j.1742-4658.2010.07586.x
– volume: 4
  start-page: e6499
  year: 2009
  ident: BFni3440_CR73
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0006499
– reference: 23401008 - Eur J Immunol. 2013 May;43(5):1147-52
– reference: 23084913 - Cell Host Microbe. 2012 Oct 18;12(4):432-44
– reference: 25774715 - Nat Immunol. 2015 May;16(5):467-75
– reference: 23975862 - J Immunol. 2013 Oct 1;191(7):3847-57
– reference: 18604214 - Nat Immunol. 2008 Aug;9(8):847-56
– reference: 24232462 - Nat Rev Immunol. 2013 Dec;13(12):862-74
– reference: 9176497 - Nat Med. 1997 Jun;3(6):678-81
– reference: 26555265 - J Biol Chem. 2016 Jan 15;291(3):1123-36
– reference: 25423351 - Annu Rev Pathol. 2015;10:395-424
– reference: 21931713 - PLoS One. 2011;6(9):e24434
– reference: 19542372 - J Immunol. 2009 Jul 15;183(2):792-6
– reference: 26052098 - Nat Rev Immunol. 2015 Jul;15(7):429-40
– reference: 26375259 - Nature. 2015 Oct 29;526(7575):666-71
– reference: 26375003 - Nature. 2015 Oct 29;526(7575):660-5
– reference: 23215645 - Annu Rev Immunol. 2013;31:73-106
– reference: 25964352 - Proc Natl Acad Sci U S A. 2015 May 26;112(21):6688-93
– reference: 25359439 - Nat Rev Immunol. 2014 Dec;14 (12 ):821-6
– reference: 22819539 - Cell. 2012 Aug 3;150(3):606-19
– reference: 23348507 - Science. 2013 Feb 22;339(6122):975-8
– reference: 21562230 - Sci Transl Med. 2011 May 11;3(82):82ra38
– reference: 23908027 - Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug;69(Pt 8):855-60
– reference: 24374573 - Eur J Immunol. 2014 Apr;44(4):1084-92
– reference: 26449474 - Science. 2015 Oct 23;350(6259):404-9
– reference: 22461501 - Science. 2012 Apr 27;336(6080):481-5
– reference: 23785284 - PLoS Pathog. 2013;9(6):e1003414
– reference: 25401470 - J Clin Invest. 2014 Dec;124(12):5516-20
– reference: 22456941 - Innate Immun. 2012 Dec;18(6):815-24
– reference: 21147462 - Cell Host Microbe. 2010 Dec 16;8(6):471-83
– reference: 10640742 - J Immunol. 2000 Feb 1;164(3):1286-92
– reference: 23633952 - PLoS Pathog. 2013;9(4):e1003320
– reference: 23248289 - Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):294-9
– reference: 26739094 - J Invest Dermatol. 2016 Mar;136(3):610-20
– reference: 19652711 - PLoS One. 2009 Aug 04;4(8):e6499
– reference: 19620982 - Nat Immunol. 2009 Aug;10(8):907-17
– reference: 19150356 - J Mol Biol. 2009 Feb 27;386(3):690-703
– reference: 23661752 - Science. 2013 May 10;340(6133):701-6
– reference: 23145935 - Annu Rev Genet. 2012;46:677-700
– reference: 26320999 - Cell Host Microbe. 2015 Sep 9;18(3):320-32
– reference: 24739961 - Nature. 2014 May 15;509(7500):366-70
– reference: 17452523 - J Exp Med. 2007 May 14;204(5):987-94
– reference: 23307811 - Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1851-6
– reference: 20180847 - FEBS J. 2010 Apr;277(7):1597-605
– reference: 20457908 - Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6
– reference: 18025219 - J Immunol. 2007 Dec 1;179(11):7729-40
– reference: 22801494 - Nature. 2012 Aug 30;488(7413):670-4
– reference: 23812099 - Nat Immunol. 2013 Aug;14 (8):812-20
– reference: 20351692 - Nat Immunol. 2010 May;11(5):395-402
– reference: 21151871 - PLoS One. 2010 Dec 07;5(12):e14246
– reference: 16689661 - J Interferon Cytokine Res. 2006 May;26(5):328-52
– reference: 18086378 - Immunobiology. 2007;212(9-10):771-84
– reference: 24031018 - Science. 2013 Sep 13;341(6151):1250-3
– reference: 7538909 - Cell. 1995 May 19;81(4):641-50
– reference: 25119034 - Nature. 2014 Oct 9;514(7521):187-92
– reference: 19158676 - Nature. 2009 Mar 26;458(7237):509-13
– reference: 16511497 - Nature. 2006 Mar 2;440(7080):101-4
– reference: 14576437 - Science. 2003 Oct 24;302(5645):654-9
– reference: 23809161 - Immunity. 2013 Jun 27;38(6):1142-53
– reference: 23603659 - Nat Chem Biol. 2013 Jun;9(6):398-405
– reference: 23702978 - Nat Rev Immunol. 2013 Jun;13(6):397-411
– reference: 26350966 - MBio. 2015 Sep 08;6(5):e01157-15
– reference: 26440898 - Cell Rep. 2015 Oct 13;13(2):223-33
– reference: 23887873 - Science. 2013 Sep 13;341(6151):1246-9
– reference: 25774716 - Nat Immunol. 2015 May;16(5):476-84
– reference: 26449475 - Science. 2015 Oct 23;350(6259):399-404
– reference: 22002608 - Nature. 2011 Oct 16;479(7371):117-21
– reference: 22895188 - Nature. 2012 Oct 11;490(7419):288-91
– reference: 25043180 - Cell Rep. 2014 Jul 24;8(2):570-82
– reference: 22531325 - Nat Rev Immunol. 2012 Apr 25;12(5):367-82
– reference: 26417105 - Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5628-37
– reference: 18362138 - Infect Immun. 2008 Jun;76(6):2304-15
– reference: 11181990 - Science. 2001 Feb 16;291(5507):1279-84
– reference: 21551061 - Science. 2011 May 6;332(6030):717-21
– reference: 26416908 - Infect Immun. 2015 Dec;83(12 ):4740-9
– reference: 24855941 - Cell. 2014 May 22;157(5):1013-22
– reference: 24715728 - Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6046-51
– reference: 21349431 - Immunity. 2011 Feb 25;34(2):213-23
– reference: 24630722 - Cell. 2014 Mar 13;156(6):1193-206
– reference: 22730319 - J Biol Chem. 2012 Aug 10;287(33):27452-66
– reference: 25121752 - Cell Host Microbe. 2014 Aug 13;16(2):249-56
– reference: 22795875 - Immunity. 2012 Aug 24;37(2):302-13
– reference: 24630723 - Cell. 2014 Mar 13;156(6):1207-22
– reference: 21575908 - Cell Host Microbe. 2011 May 19;9(5):363-75
– reference: 15489189 - Trends Immunol. 2004 Nov;25(11):601-9
– reference: 16304607 - PLoS Pathog. 2005 Nov;1(3):e24
– reference: 24042117 - Infect Immun. 2013 Dec;81(12 ):4341-9
– reference: 25288801 - J Biol Chem. 2014 Nov 21;289(47):32926-36
– reference: 6089411 - Virology. 1984 Aug;137(1):135-42
– reference: 24563254 - J Immunol. 2014 Apr 1;192(7):3328-35
– reference: 20333626 - Eur J Immunol. 2010 Jun;40(6):1545-51
– reference: 19158675 - Nature. 2009 Mar 26;458(7237):514-8
– reference: 12198138 - J Biol Chem. 2002 Nov 1;277(44):41624-30
– reference: 22607347 - FEBS J. 2012 Jul;279(14):2544-54
SSID ssj0014764
Score 2.5449507
SecondaryResourceType review_article
Snippet In this Perspective, MacMicking and colleagues discuss the roles of interferon-induced guanylate-binding proteins in directing inflammasome responses and their...
Traditional views of the inflammasome highlight the assembly of pre-existing core components shortly after infection or tissue damage. Emerging work, however,...
SourceID unpaywall
proquest
gale
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 481
SubjectTerms 631/250/127/1212
631/250/2499
631/250/256/2177
Animals
Binding proteins
Biomedicine
Disease Resistance - genetics
Disease Resistance - immunology
Genetic aspects
GTP-Binding Proteins - classification
GTP-Binding Proteins - genetics
GTP-Binding Proteins - immunology
Host-Pathogen Interactions - immunology
Humans
Immune response
Immunology
Infection - immunology
Infection - microbiology
Infection - parasitology
Infectious Diseases
Inflammasomes - genetics
Inflammasomes - immunology
Inflammasomes - metabolism
Interferons - immunology
Interferons - metabolism
Listeria monocytogenes - immunology
Listeria monocytogenes - physiology
Mice
Models, Immunological
perspective
Phylogeny
Properties
Signal Transduction - genetics
Signal Transduction - immunology
Toxoplasma - immunology
Toxoplasma - physiology
SummonAdditionalLinks – databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFD4anbg9cBm3wEApQvCUNBfbiR8rxDSQNqFBpe0pchx7RKROtTZC49dznEvVFoFA6kMkf0lP4mP7O_a5ALwRglGiNfHCVBQeSVXqpZHieJWEJEkpYdoGCp-csuMZ-XROz_cgHGJhWqd9mZe-qea-Kb-1vpWLuZwMfmITwm3Sq_gG7DOK9HsE-7PTz9OLNi9qxL2It1Xo-uuQdYGyNg34xJR-TOwux8YKtDsPbyxE65PRu3C7MQtx_UNU1cbic3QfzgaxO5-T736zyn35cyej43-91wO411NRd9o1PYQ9ZQ7gZlec8voAbp30x-6P4KLdN9TqqjYe2vCoDYV72eA0UiFTtba1XQDdNuVDaZZuafCnUdXmYlnPlWtjJ7qdX1eYwrVxJW6hNBrQ6jHMjj58fX_s9TUZPInEbuVFERdKhlryWNFECsZpTgmShiJOVW4r-eCwU4VCq1IiWUCARosm11RwHSgWx09gZGqjnoErhRScamQcgSRpKLhkgoVM6oRIGSS5A2-Hfspkn7Dc1s2osvbgPE4zU2a2Qx181gBcdDk6foe8th2d2YwXxrrUXIpmucw-fjnLpoTGqDRJRB1414N0jX9k5WsjFFBcmyRrC3m4hcQhKbebB33K-ilhmYUdF0M658B43WzvtG5uRtVNi4mRVjDO_4pJeBITShx42unq-q2jJOBRGqAA40F5NwTY_STjtVb_6bM9_wfMC7iDJJJ1TqCHMFpdNeolErVV_qofmr8Aca87gw
  priority: 102
  providerName: Unpaywall
Title Interferon-induced guanylate-binding proteins in inflammasome activation and host defense
URI https://link.springer.com/article/10.1038/ni.3440
https://www.ncbi.nlm.nih.gov/pubmed/27092805
https://www.proquest.com/docview/1782223283
https://www.proquest.com/docview/1783341699
https://www.proquest.com/docview/1787973454
https://www.ncbi.nlm.nih.gov/pmc/articles/4961213
UnpaywallVersion submittedVersion
Volume 17
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1529-2916
  dateEnd: 20241101
  omitProxy: true
  ssIdentifier: ssj0014764
  issn: 1529-2908
  databaseCode: 7X7
  dateStart: 20000701
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 1529-2916
  dateEnd: 20241101
  omitProxy: true
  ssIdentifier: ssj0014764
  issn: 1529-2908
  databaseCode: BENPR
  dateStart: 20000701
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Public Health Database
  customDbUrl:
  eissn: 1529-2916
  dateEnd: 20191231
  omitProxy: true
  ssIdentifier: ssj0014764
  issn: 1529-2908
  databaseCode: 8C1
  dateStart: 20000701
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/publichealth
  providerName: ProQuest
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ZaxsxEB4Sh14PpU0vt2lYl9I-bbOHtJIeSnFDQlqICWkNztMia6VgcLRubFPy7zuzh2unNGBsw47XWmmkb0aj-QbgvdYZZ86xMJa6CJm0MpSJVfhNxExIzjJHicKng-xkyL6P-GgLBm0uDB2rbNfEaqEuSkN75AdxDWWIhl9mv0KqGkXR1baEhm5KKxSfK4qxbdhJiBmrAztfjwZn56u4AhMVoRSClgoTFck6jZZIwg_85FPKaA9kDZ9ur9JrMLWKmz6CB0s_0ze_9XS6Bk3HT-BxY1MG_VoJnsKW9btwr64yebML90-b-PkzuKg2AJ29Ln2IzjgOaxFcLnE9mKLJSU4yIVlQcTdM_DyYeHw51JkrPS-vbEBJEPUWbqB9EVCCSFBYh56wfQ7D46OfhydhU1whNGihLcIkUdqa2BmVWi6MzhQfc4boX6TSjqkkD84fW1h0Dw2iPgo4dE3GjmvlIpul6Qvo-NLbVxAYbbTiDk2HyDAZa2UyncWZcYIZE4lxFz60XZqbhnmcCmBM8yoCnsrcT3Lq-y7eqxWc1WQb_4q8ozHJibrC09mYS72cz_NvP87zPuMpjqlIeBc-NkKuxD-i9lWpBthcYrvakNzbkMS5ZTYvt0OfN3N7nv_VxC70Vpfpl3RezdtyWcmkaB9kSt0pI5RIGWddeFmr1eqpExGpREbYgF6rZ2sNuN0lvZUC_q_bXt_9IG_gIRqCWX2Qcw86i-ulfYvG1mK8D9tiJPBdHsb7zWzCz-HgrH_xB4eNKrc
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqIigcEJRXoEAW8TiF5mEn9gGhqlDt0m4P0ErtKTiOXa20dZZmo2r_FL-RmbzYLaK3SntYKZNdezyebzyeByFvpYwZNYZ6AZe5R7nmHg-1gG9JQBPOaGwwUXh8GA-P6bcTdrJGfne5MBhW2enEWlHnhUIf-XbQQBmg4efZLw-7RuHtatdCoxGLfb24hCNb-Wn0Bdb3XRjufT3aHXptVwFPgWky98JQSK0Co0SkWaJkLFjGKMBeHnGdYS8aEBydazgXKYA7IDBgk2eGSWF8HaMDFFT-LRqFCSoCvtuHlMDk6nJVAInCC4XPmyRdLEG-bScfI4oeliX0u4oBSyDY38reIxuVncnFpZxOl4Bv7wG531qs7k4jYg_Jmrab5HbTw3KxSe6M29v5R-S0di8afVFYD476IDS5e1aBtpmCQYtHcMRJt64MMbGlO7HwMSCR57IszrWLKRaNg9iVNncx_cTNtYFztn5Mjm-EyU_Iui2sfkZcJZUUzIBh4ivKAylULOMgViahSvlJ5pD3HUtT1dY1x_Ya07S-X494aicp8t6B3-oIZ00pj39J3uCapFgYw2LkzZmsyjId_fie7lAWwZomIXPIh5bIFPBHOL46kQGGi7W0Vii3Vihh56rVx93Sp63mKNO_cu6QQf8Y38RoOKuLqqaJwPqIhbiWJhFJRBl1yNNGrPpZh4kvQu7DAAadnC0N4CpLBr0A_o9tz6-fyGuyMTwaH6QHo8P9F-QumJxxEzK6RdbnF5V-CWbdPHtV7yWX_LzpzfsHYt1dTA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELemIQY8IBhfgQEp4uMpNB92HD8gNDGqlbEJAZPKU3Ace6rUOWVpNPVf46_jLl-0Q-xtUh8q5dLa57N_d-f7IOSllDGjxlAvSGTu0UQnXhJqAd94QHnCaGwwUfjwKN4_pp8mbLJBfne5MBhW2Z2J9UGdFwp95MOggTJAw6FpwyK-7I3ez3952EEKb1q7dhqNiBzo5TmYb-W78R6s9aswHH38_mHfazsMeArUlIUXhkJqFRglIs24krFgGaMAgXmU6Az70oAQ6VyDjaQA-oDAgH6eGSaF8XWMzlA4_q_xKBIYTsgnvbEHE61LVwE8Ci8UftIk7GI58qGdvo0oeltWkPAiHqwAYn9De4vcqOxcLs_lbLYCgqM75Harvbq7jbjdJRvabpPrTT_L5TbZOmxv6u-RH7Wr0eizwnpg9oMA5e5JBSfPDJRbNMcRM926SsTUlu7UwseAdJ7KsjjVLqZbNM5iV9rcxVQUN9cGbG59nxxfCZMfkE1bWP2IuEoqKZgBJcVXNAmkULGMg1gZTpXyeeaQ1x1LU9XWOMdWG7O0vmuPktROU-S9A7_VEc6bsh7_krzANUmxSIZFcTuRVVmm429f013KIlhTHjKHvGmJTAF_hOOrkxpguFhXa41yZ40SdrFaf9wtfdqeImX6V-YdMugf45sYGWd1UdU0EWgisRCX0nDBI8qoQx42YtXPOuS-CBMfBjDo5GxlABdZMugF8H9se3z5RJ6TLdi26efx0cETchO0z7iJHt0hm4uzSj8FDW-RPau3kkt-XvXe_QNEHGG7
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFD4anbg9cBm3wEApQvCUNBfbiR8rxDSQNqFBpe0pchx7RKROtTZC49dznEvVFoFA6kMkf0lP4mP7O_a5ALwRglGiNfHCVBQeSVXqpZHieJWEJEkpYdoGCp-csuMZ-XROz_cgHGJhWqd9mZe-qea-Kb-1vpWLuZwMfmITwm3Sq_gG7DOK9HsE-7PTz9OLNi9qxL2It1Xo-uuQdYGyNg34xJR-TOwux8YKtDsPbyxE65PRu3C7MQtx_UNU1cbic3QfzgaxO5-T736zyn35cyej43-91wO411NRd9o1PYQ9ZQ7gZlec8voAbp30x-6P4KLdN9TqqjYe2vCoDYV72eA0UiFTtba1XQDdNuVDaZZuafCnUdXmYlnPlWtjJ7qdX1eYwrVxJW6hNBrQ6jHMjj58fX_s9TUZPInEbuVFERdKhlryWNFECsZpTgmShiJOVW4r-eCwU4VCq1IiWUCARosm11RwHSgWx09gZGqjnoErhRScamQcgSRpKLhkgoVM6oRIGSS5A2-Hfspkn7Dc1s2osvbgPE4zU2a2Qx181gBcdDk6foe8th2d2YwXxrrUXIpmucw-fjnLpoTGqDRJRB1414N0jX9k5WsjFFBcmyRrC3m4hcQhKbebB33K-ilhmYUdF0M658B43WzvtG5uRtVNi4mRVjDO_4pJeBITShx42unq-q2jJOBRGqAA40F5NwTY_STjtVb_6bM9_wfMC7iDJJJ1TqCHMFpdNeolErVV_qofmr8Aca87gw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interferon-induced+guanylate-binding+proteins+in+inflammasome+activation+and+host+defense&rft.jtitle=Nature+immunology&rft.au=Kim%2C+Bae-Hoon&rft.au=Chee%2C+Jonathan+D&rft.au=Bradfield%2C+Clinton+J&rft.au=Park%2C+Eui-Soon&rft.date=2016-05-01&rft.issn=1529-2908&rft.eissn=1529-2916&rft.volume=17&rft.issue=5&rft.spage=481&rft.epage=489&rft_id=info:doi/10.1038%2Fni.3440&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_ni_3440
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1529-2908&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1529-2908&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1529-2908&client=summon