Integrative transcriptomic profiling uncovers immune and functional responses to bisphenol a across multiple tissues in male mice

• Published in: Animal cells and systems Vol. 28; no. 1; pp. 519 - 535
• Main Authors: Park, Yejee, Jang, Min-Jae, Ryu, Do-Yeal, Lim, Byeonghwi, Pathak, Rajesh Kumar, Pang, Myung-Geol, Kim, Jun-Mo
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2024; Taylor & Francis Ltd; Taylor & Francis Group; 한국통합생물학회
• Subjects: adverse effects; animals; Biological effects; Bisphenol A; Bisphenol A (BPA); Cell activation; Cell differentiation; Cell migration; colon; differentially expressed gene (DEG) analysis; Differentiation (biology); Endocrine disorders; Endocrine disruptors; Exposure; Fertility; gene co-expression network (GCN); Gene expression; gene expression regulation; genes; Health risks; Hepatocytes; Immune response; Immune system; Impact analysis; kidneys; liver; Lymphocytes T; Males; Medical research; Network analysis; Side effects; spermatozoa; T-lymphocytes; Thymus; Thymus gland; tissue-specific gene (TSG) analysis; transcriptome; transcriptome analysis; Transcriptomes; Transcriptomics; 생물학; gene co-expression network (GCN); transcriptome analysis; Bisphenol A (BPA); tissue-specific gene (TSG) analysis; differentially expressed gene (DEG) analysis
• ISSN: 1976-8354; 2151-2485; 2151-2485
• DOI: 10.1080/19768354.2024.2419473

Bisphenol A (BPA), an endocrine-disrupting substance commonly found in plastics and receipts, is associated with adverse effects, including endocrine disorders, reduced fertility, and metabolic issues. To gain insights into its effects on biological systems, we observed the adverse effects of BPA in male Institute of Cancer Research (ICR) mice exposed to BPA at the lowest observed adverse effect level for 6 weeks, in comparison with the control groups. We constructed a comprehensive transcriptome profile using 20 different tissues to analyze the changes in the whole-body systems. This involved employing differential gene expression, tissue-specific gene, and gene co-expression network analyses. The study revealed that BPA exposure led to significant differences in the transcriptome in the thymus, suggesting activation of T-cell differentiation and maturation in response to BPA treatment. Furthermore, various tissues exhibited immune response activation, potentially due to the migration of immune cells from the thymus. BPA exposure also caused immune-related functional changes in the colon, liver, and kidney, as well as abnormal signaling responses in the sperm. The transcriptome analysis serves as a valuable resource for understanding the functional impact of BPA, providing profound insights into the effects of BPA exposure and emphasizing the need for further research on potential associated health risks.