Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements - Cadamuro, Janne; Dieplinger, Benjamin; Felder, Thomas; Kedenko, Igor; Mueller, Thomas; Haltmayer, Meinhard; Patsch, Wolfgang; Oberkofler, Hannes (European journal of clinical pharmacology, 2010)
Keywords: Acenocoumarol - administration & dosage; Acenocoumarol - adverse effects; Acenocoumarol - pharmacokinetics; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants - administration & dosage; Anticoagulants - adverse effects; Anticoagulants - pharmacokinetics; Apolipoproteins E - genetics; Apolipoproteins E - metabolism; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Carbon-Carbon Ligases - genetics; Carbon-Carbon Ligases - metabolism; Chi-Square Distribution; Coagulation; Cytochrome P-450 CYP2C9; Drug dosages; Female; Gene Frequency; Genetics; Genotype; Hemorrhage - chemically induced; Heterozygote; Homozygote; Humans; Male; Medical sciences; Middle Aged; Mixed Function Oxygenases - genetics; Mixed Function Oxygenases - metabolism; Pharmacogenetics; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Phenotype; Phenprocoumon - administration & dosage; Phenprocoumon - adverse effects; Phenprocoumon - pharmacokinetics; Polymorphism, Single Nucleotide; Preventive medicine; Regression Analysis; Vitamin K Epoxide Reductases; Young Adult; Pharmacogenetics; Single nucleotide polymorphisms; Phenprocoumon; Acenocoumarol; Human; Genetic variability; Coumarine derivatives; Genotype; Anticoagulant; Genetic determinism; Antivitamin K; Genetics; Single nucleotide polymorphism; Dose