Bi-allelic NRXN1α deletion in microglia derived from iPSC of an autistic patient increases interleukin-6 production and impairs supporting function on neuronal networking - Bose, Raj; Posada-Pérez, Mercedes; Karvela, Eleni; Skandik, Martin; Keane, Lily; Falk, Anna; Spulber, Stefan; Joseph, Bertrand; Ceccatelli, Sandra (Brain, behavior, and immunity, 2025)
Keywords: Alleles; Autism Spectrum Disorder; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - metabolism; Autistic Disorder - genetics; Autistic Disorder - metabolism; Basic Medicine; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Cell Adhesion Molecules, Neuronal - genetics; Cell Adhesion Molecules, Neuronal - metabolism; Cytokines; Gene Deletion; Humans; Induced pluripotent stem cells; Induced Pluripotent Stem Cells - metabolism; Interleukin-6 - genetics; Interleukin-6 - metabolism; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Microglia - metabolism; Nerve Net - metabolism; Neural Cell Adhesion Molecules - genetics; Neural Cell Adhesion Molecules - metabolism; Neuroepithelial stem cells; Neuronal network; Neurons - metabolism; Neurosciences; Neurovetenskaper; Neuronal network; Autism Spectrum Disorder; Cytokines; Neuroepithelial stem cells; Induced pluripotent stem cells