Identification of Protein Coding Regions in the Human Genome by Quadratic Discriminant Analysis
A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discrimin...
Saved in:
| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 94; no. 2; pp. 565 - 568 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences of the United States of America
21.01.1997
National Acad Sciences National Academy of Sciences The National Academy of Sciences of the USA |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0027-8424 1091-6490 1091-6490 |
| DOI | 10.1073/pnas.94.2.565 |
Cover
| Abstract | A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons. |
|---|---|
| AbstractList | A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons.A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons. A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons. A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: hexon [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156–5163] (based on linear discriminant analysis) and grail 2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261–11265] (based on neural networks). A computer program called mzef is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons. Zhang developed a new method for predicting internal exons in genomic DNA sequences. This method is based on a prediction algorithm. A computer program called MZEF allows users to output alternative overlapping exons. A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: hexon [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156–5163] (based on linear discriminant analysis) and grail 2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261–11265] (based on neural networks). A computer program called mzef is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons. |
| Author | Zhang, M. Q. |
| AuthorAffiliation | Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724 |
| AuthorAffiliation_xml | – name: Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724 |
| Author_xml | – sequence: 1 givenname: M. Q. surname: Zhang fullname: Zhang, M. Q. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9012824$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkl1rFDEYhYNU6rZ66Y0ohILezZjPzQx4U1ZtCwU_0OuQyWS2WWaSNclo99-bcYdVC9qrQJ5zwnnPmxNw5LwzADzFqMRI0Ndbp2JZs5KUfMkfgAVGNS6WrEZHYIEQEUXFCHsETmLcIIRqXqFjcFwjTCrCFkBetcYl21mtkvUO-g5-DD4Z6-DKt9at4WezziDCfJNuDLwcB-XghXF-MLDZwU-jakP2avjWRh3sYJ1yCZ471e-ijY_Bw0710TyZz1Pw9f27L6vL4vrDxdXq_LrQXLBUcCNYnbNVrFvWgnW4WRKqVY7ZdIZhirBgpGuQMlqrlghMKMsTdNwonlFDT0G5f3d0W7X7ofpebnMYFXYSIzkVJaeiZM0kkbmobHizN2zHZjCtzi0E9dvklZV_E2dv5Np_l7jmnGb7q9ke_LfRxCSHPL7pe-WMH6MUVYUQZeReIeYVFRRPgc7uCDd-DLnGKAnClAuCJtGLP1Mf4s77zLzYcx18jMF097ZA7-i1Tb9-Qp7Z9v90vZxTTNeHDDOW3dj3ydymrHv-H13Gz_Z4E5MPB54Xyyj9CQba49I |
| CitedBy_id | crossref_primary_10_1038_ng780 crossref_primary_10_1093_nar_gkq007 crossref_primary_10_1093_hmg_8_12_2325 crossref_primary_10_1006_bbrc_2000_2685 crossref_primary_10_1016_j_jprot_2010_02_007 crossref_primary_10_1002_0471250953_bi0209s10 crossref_primary_10_1007_BF02882396 crossref_primary_10_1016_j_jtbi_2007_03_038 crossref_primary_10_1371_journal_pcbi_0030054 crossref_primary_10_15302_J_QB_021_0245 crossref_primary_10_3389_fnins_2021_733423 crossref_primary_10_1016_S0378_1119_02_01052_1 crossref_primary_10_1177_00368504241266588 crossref_primary_10_1016_S0168_9525_01_02229_6 crossref_primary_10_1016_j_mbs_2005_03_005 crossref_primary_10_1093_genetics_157_3_1321 crossref_primary_10_1002_0471250953_bi0402s00 crossref_primary_10_1371_journal_pone_0163088 crossref_primary_10_1093_genetics_162_4_1995 crossref_primary_10_1093_nar_gkl625 crossref_primary_10_1007_s11707_022_1011_4 crossref_primary_10_1016_j_ygeno_2003_09_024 crossref_primary_10_1016_j_jtbi_2015_06_030 crossref_primary_10_1101_gr_9_2_189 crossref_primary_10_1002__SICI_1097_0061_19980615_14_8_701__AID_YEA247_3_0_CO_2 crossref_primary_10_1002__SICI_1097_0061_20000115_16_1_71__AID_YEA505_3_0_CO_2_5 crossref_primary_10_1007_s10441_013_9203_7 crossref_primary_10_1016_j_jbi_2015_12_001 crossref_primary_10_1016_j_mimet_2009_03_013 crossref_primary_10_1016_j_gene_2012_09_061 crossref_primary_10_1007_s11517_021_02443_6 crossref_primary_10_1006_geno_1999_5852 crossref_primary_10_1006_jmbi_1998_2451 crossref_primary_10_1086_321277 crossref_primary_10_1007_s12064_010_0114_8 crossref_primary_10_1016_j_jtbi_2011_10_004 crossref_primary_10_1038_79189 crossref_primary_10_1016_j_neucom_2007_07_019 crossref_primary_10_1093_bioinformatics_bti796 crossref_primary_10_1016_S0981_9428_01_01242_6 crossref_primary_10_1016_j_patcog_2011_08_016 crossref_primary_10_1002_0471142905_hg0606s29 crossref_primary_10_1006_geno_2002_6692 crossref_primary_10_1016_j_ygeno_2007_03_013 crossref_primary_10_1016_j_jmsy_2018_04_001 crossref_primary_10_1016_j_bbrc_2004_05_094 crossref_primary_10_1146_annurev_genom_7_080505_115745 crossref_primary_10_1186_s12864_018_5350_1 crossref_primary_10_1007_s11042_021_10619_3 crossref_primary_10_1371_journal_pone_0047843 crossref_primary_10_1016_S0022_5193_03_00082_1 crossref_primary_10_1016_S0375_9601_01_00819_2 crossref_primary_10_1016_S0959_440X_98_80069_9 crossref_primary_10_1002_mas_20291 crossref_primary_10_1155_2010_287070 crossref_primary_10_1006_geno_2002_7018 crossref_primary_10_3390_app7030299 crossref_primary_10_1016_j_ygeno_2018_07_013 crossref_primary_10_1101_gr_8_10_1060 crossref_primary_10_1101_gr_147901 crossref_primary_10_1016_S0378_1119_99_00104_3 crossref_primary_10_1101_gr_313703 crossref_primary_10_1088_0953_8984_21_3_034108 crossref_primary_10_1186_gb_2005_6_11_r95 crossref_primary_10_1007_s10616_005_1719_5 crossref_primary_10_5187_jast_2022_e64 crossref_primary_10_1006_jmbi_1997_1523 crossref_primary_10_1088_1555_6611_ac5b77 crossref_primary_10_1099_0022_1317_83_4_819 crossref_primary_10_1139_g04_021 crossref_primary_10_1002_0471250953_bi0407s01 crossref_primary_10_1016_j_compbiolchem_2008_07_001 crossref_primary_10_1016_j_vibspec_2018_06_009 crossref_primary_10_1186_1471_2105_7_263 crossref_primary_10_1006_meth_1997_0575 crossref_primary_10_1016_j_jprot_2009_08_004 crossref_primary_10_1016_j_asr_2024_05_045 crossref_primary_10_1046_j_1432_1327_2001_02341_x crossref_primary_10_1101_gr_186901 crossref_primary_10_1006_geno_1999_6044 crossref_primary_10_1142_S1793524514500521 crossref_primary_10_1093_bioinformatics_bti639 crossref_primary_10_1016_S1672_0229_04_02022_4 crossref_primary_10_1146_annurev_genom_4_070802_110300 crossref_primary_10_1016_S0378_1119_01_00846_0 crossref_primary_10_1016_S1369_5266_03_00003_7 crossref_primary_10_1007_s10529_011_0525_8 crossref_primary_10_1016_S0168_9452_03_00034_7 crossref_primary_10_1101_gr_10_6_758 crossref_primary_10_1038_78182 crossref_primary_10_12720_jomb_2_2_80_83 crossref_primary_10_1016_j_patcog_2005_02_019 crossref_primary_10_1029_2019JE006304 crossref_primary_10_1016_j_cell_2004_11_039 crossref_primary_10_1111_jfpe_13982 crossref_primary_10_1002_bip_10054 crossref_primary_10_1016_S0378_4347_99_00012_2 crossref_primary_10_1146_annurev_genom_1_1_251 crossref_primary_10_1006_geno_1999_6051 crossref_primary_10_1089_cmb_2011_0078 crossref_primary_10_1101_gr_703903 crossref_primary_10_1186_s12859_017_1874_7 crossref_primary_10_1016_j_gene_2004_06_014 crossref_primary_10_1086_338450 crossref_primary_10_1109_5254_747907 crossref_primary_10_1007_BF02900313 crossref_primary_10_1103_PhysRevE_61_1812 crossref_primary_10_1210_mend_15_9_0687 crossref_primary_10_1016_S0006_3495_01_75825_0 crossref_primary_10_1038_2503 crossref_primary_10_1016_j_procs_2015_07_350 crossref_primary_10_1007_s00239_004_0053_4 crossref_primary_10_1101_gr_9_8_681 crossref_primary_10_1115_1_4031677 crossref_primary_10_1101_gr_9_2_158 crossref_primary_10_1016_j_gene_2004_10_024 crossref_primary_10_1128_MCB_20_17_6414_6425_2000 crossref_primary_10_1073_pnas_95_7_3764 crossref_primary_10_1016_S0168_9525_00_02127_2 crossref_primary_10_1016_S0168_9525_01_02525_2 crossref_primary_10_4018_jamc_2012010104 crossref_primary_10_1038_35080529 crossref_primary_10_1007_s10577_010_9160_9 crossref_primary_10_1016_S0378_1119_99_00079_7 crossref_primary_10_1080_07391102_2003_10506908 crossref_primary_10_1101_gr_8_3_319 crossref_primary_10_1103_PhysRevE_67_061916 crossref_primary_10_1103_PhysRevE_61_5624 crossref_primary_10_1016_S0097_8485_02_00010_4 crossref_primary_10_1155_2014_261362 crossref_primary_10_1006_geno_1999_5942 crossref_primary_10_1007_s00726_008_0089_7 crossref_primary_10_1038_81664 crossref_primary_10_1109_JSTSP_2008_923854 crossref_primary_10_1038_nrg890 crossref_primary_10_1080_07391102_2002_10506807 crossref_primary_10_1109_TCBB_2005_27 crossref_primary_10_1186_1745_6150_8_23 crossref_primary_10_1016_S0378_1119_98_00509_5 crossref_primary_10_1007_s10577_012_9328_6 crossref_primary_10_1109_JSTSP_2008_923851 crossref_primary_10_1016_j_bbrc_2005_04_159 crossref_primary_10_1016_S0378_1119_01_00897_6 crossref_primary_10_1007_BF02715832 crossref_primary_10_1006_geno_2000_6466 crossref_primary_10_1006_jtbi_2000_2144 crossref_primary_10_1186_1471_2164_5_44 crossref_primary_10_1093_nar_gkl1026 crossref_primary_10_1006_geno_2001_6681 crossref_primary_10_1007_BF02745861 crossref_primary_10_3390_app11030943 crossref_primary_10_1016_j_mbs_2011_04_007 |
| Cites_doi | 10.1126/science.1925538 10.1093/nar/20.24.6441 10.1006/geno.1996.0298 10.1093/nar/20.19.5173 10.1089/cmb.1995.2.87 10.1002/0471725293 10.1006/jmbi.1995.0198 10.1093/nar/22.24.5156 10.1006/geno.1993.1374 10.1093/nar/21.22.5198 10.1006/geno.1994.1545 10.1073/pnas.88.24.11261 10.1016/0092-8674(91)90193-3 10.1126/science.8211127 10.1038/378789a0 10.1038/ng0393-266 10.1038/ng1192-180 10.1093/hmg/2.7.901 10.1016/S0168-9525(00)89003-4 10.1038/355632a0 10.1111/j.1469-1809.1936.tb02137.x 10.1073/pnas.88.9.4005 10.1016/0092-8674(95)90151-5 |
| ContentType | Journal Article |
| Copyright | Copyright 1997 National Academy of Sciences Copyright National Academy of Sciences Jan 21, 1997 Copyright © 1997, The National Academy of Sciences of the USA 1997 |
| Copyright_xml | – notice: Copyright 1997 National Academy of Sciences – notice: Copyright National Academy of Sciences Jan 21, 1997 – notice: Copyright © 1997, The National Academy of Sciences of the USA 1997 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 5PM ADTOC UNPAY |
| DOI | 10.1073/pnas.94.2.565 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts Ecology Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Entomology Abstracts Genetics Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE CrossRef Genetics Abstracts Virology and AIDS Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 1091-6490 |
| EndPage | 568 |
| ExternalDocumentID | oai:pubmedcentral.nih.gov:19553 PMC19553 11156336 9012824 10_1073_pnas_94_2_565 94_2_565 41243 |
| Genre | Research Support, U.S. Gov't, P.H.S Journal Article Feature |
| GrantInformation_xml | – fundername: NHGRI NIH HHS grantid: KO1 HG00010-04 – fundername: Intramural NIH HHS grantid: Z01 HG000010 |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29P 2AX 2FS 2WC 3O- 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACHIC ACIWK ACKIV ACNCT ACPRK ADQXQ ADULT ADXHL AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM AS~ BKOMP CS3 D0L DCCCD DIK DU5 E3Z EBS EJD F5P FRP GX1 H13 HGD HH5 HQ3 HTVGU HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JST KQ8 L7B LU7 MVM N9A NEJ NHB N~3 O9- OK1 P-O PNE PQQKQ R.V RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR VOH W8F WH7 WHG WOQ WOW X7M XSW Y6R YBH YKV YSK ZCA ZCG ~02 ~KM - 02 08R 0R 1AW 55 AAPBV ABFLS ABPTK ADACO ADZLD AFDAS AJYGW AS ASUFR DNJUQ DOOOF DWIUU DZ F20 GJ JSODD KM OHM PQEST RHF VQA X XFK XHC ZA5 AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 5PM 692 6TJ 79B AAYJJ ADTOC AFHIN AFQQW UNPAY |
| ID | FETCH-LOGICAL-c574t-5e74995884f6974f1b623ca901bfe41301742fb0aeccad271234128f5ea5174b3 |
| IEDL.DBID | UNPAY |
| ISSN | 0027-8424 1091-6490 |
| IngestDate | Sun Oct 26 04:13:32 EDT 2025 Tue Sep 30 16:47:20 EDT 2025 Fri Sep 05 14:06:37 EDT 2025 Sun Aug 24 04:13:07 EDT 2025 Wed Oct 29 12:21:37 EDT 2025 Fri May 30 10:48:37 EDT 2025 Thu Apr 24 23:09:10 EDT 2025 Wed Oct 01 01:21:05 EDT 2025 Wed May 29 08:07:29 EDT 2019 Wed Nov 11 00:29:03 EST 2020 Thu May 29 08:42:53 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c574t-5e74995884f6974f1b623ca901bfe41301742fb0aeccad271234128f5ea5174b3 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-2 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 James D. Watson, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://www.ncbi.nlm.nih.gov/pmc/articles/19553 |
| PMID | 9012824 |
| PQID | 201357205 |
| PQPubID | 42026 |
| PageCount | 4 |
| ParticipantIDs | jstor_primary_41243 unpaywall_primary_10_1073_pnas_94_2_565 pubmed_primary_9012824 crossref_citationtrail_10_1073_pnas_94_2_565 pnas_primary_94_2_565_fulltext proquest_miscellaneous_78800342 proquest_miscellaneous_15837315 proquest_journals_201357205 crossref_primary_10_1073_pnas_94_2_565 pubmedcentral_primary_oai_pubmedcentral_nih_gov_19553 pnas_primary_94_2_565 |
| ProviderPackageCode | RNA PNE CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1997-01-21 |
| PublicationDateYYYYMMDD | 1997-01-21 |
| PublicationDate_xml | – month: 01 year: 1997 text: 1997-01-21 day: 21 |
| PublicationDecade | 1990 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Washington |
| PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
| PublicationTitleAlternate | Proc Natl Acad Sci U S A |
| PublicationYear | 1997 |
| Publisher | National Academy of Sciences of the United States of America National Acad Sciences National Academy of Sciences The National Academy of Sciences of the USA |
| Publisher_xml | – name: National Academy of Sciences of the United States of America – name: National Acad Sciences – name: National Academy of Sciences – name: The National Academy of Sciences of the USA |
| References | e_1_3_2_26_2 e_1_3_2_27_2 Stormo G D (e_1_3_2_24_2) 1987 e_1_3_2_20_2 e_1_3_2_22_2 e_1_3_2_23_2 e_1_3_2_25_2 e_1_3_2_9_2 e_1_3_2_15_2 e_1_3_2_8_2 e_1_3_2_16_2 e_1_3_2_7_2 e_1_3_2_17_2 e_1_3_2_6_2 e_1_3_2_18_2 e_1_3_2_19_2 e_1_3_2_10_2 e_1_3_2_5_2 e_1_3_2_11_2 e_1_3_2_4_2 e_1_3_2_12_2 e_1_3_2_3_2 e_1_3_2_13_2 e_1_3_2_2_2 e_1_3_2_14_2 Krzanowski W J (e_1_3_2_21_2) 1993 Anonymous (e_1_3_2_1_2) 1995; 13 Proc Natl Acad Sci U S A 1997 May 13;94(10):5495 |
| References_xml | – ident: e_1_3_2_23_2 doi: 10.1126/science.1925538 – ident: e_1_3_2_25_2 doi: 10.1093/nar/20.24.6441 – ident: e_1_3_2_17_2 doi: 10.1006/geno.1996.0298 – ident: e_1_3_2_6_2 doi: 10.1093/nar/20.19.5173 – ident: e_1_3_2_16_2 doi: 10.1089/cmb.1995.2.87 – ident: e_1_3_2_18_2 doi: 10.1002/0471725293 – ident: e_1_3_2_26_2 doi: 10.1006/jmbi.1995.0198 – ident: e_1_3_2_20_2 doi: 10.1093/nar/22.24.5156 – ident: e_1_3_2_7_2 doi: 10.1006/geno.1993.1374 – ident: e_1_3_2_10_2 doi: 10.1093/nar/21.22.5198 – ident: e_1_3_2_12_2 doi: 10.1006/geno.1994.1545 – ident: e_1_3_2_27_2 doi: 10.1073/pnas.88.24.11261 – ident: e_1_3_2_11_2 doi: 10.1016/0092-8674(91)90193-3 – ident: e_1_3_2_4_2 doi: 10.1126/science.8211127 – ident: e_1_3_2_22_2 – ident: e_1_3_2_2_2 doi: 10.1038/378789a0 – start-page: 347 volume-title: Principles of Multivariate Analysis year: 1993 ident: e_1_3_2_21_2 – ident: e_1_3_2_15_2 doi: 10.1038/ng0393-266 – ident: e_1_3_2_13_2 doi: 10.1038/ng1192-180 – start-page: 231 volume-title: Nucleic Acid and Protein Sequence Analysis year: 1987 ident: e_1_3_2_24_2 – ident: e_1_3_2_8_2 doi: 10.1093/hmg/2.7.901 – volume: 13 start-page: 1 year: 1995 ident: e_1_3_2_1_2 publication-title: Nat Genet – ident: e_1_3_2_5_2 doi: 10.1016/S0168-9525(00)89003-4 – ident: e_1_3_2_14_2 doi: 10.1038/355632a0 – ident: e_1_3_2_19_2 doi: 10.1111/j.1469-1809.1936.tb02137.x – ident: e_1_3_2_9_2 doi: 10.1073/pnas.88.9.4005 – ident: e_1_3_2_3_2 doi: 10.1016/0092-8674(95)90151-5 – reference: - Proc Natl Acad Sci U S A 1997 May 13;94(10):5495 |
| SSID | ssj0009580 |
| Score | 2.0128162 |
| Snippet | A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the... Zhang developed a new method for predicting internal exons in genomic DNA sequences. This method is based on a prediction algorithm. A computer program called... |
| SourceID | unpaywall pubmedcentral proquest pubmed crossref pnas jstor |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 565 |
| SubjectTerms | Algorithms Base Sequence Biological Sciences Deoxyribonucleic acid Discriminant analysis Discriminants DNA Exons Genes Genomes Genomics Human Genome Project Humans Linear discriminant analysis Molecular Sequence Data Multivariate Analysis Murals Nucleic acids Pattern recognition Proteins - genetics Sequence Analysis, DNA - methods Software |
| Title | Identification of Protein Coding Regions in the Human Genome by Quadratic Discriminant Analysis |
| URI | https://www.jstor.org/stable/41243 http://www.pnas.org/content/94/2/565.abstract https://www.ncbi.nlm.nih.gov/pubmed/9012824 https://www.proquest.com/docview/201357205 https://www.proquest.com/docview/15837315 https://www.proquest.com/docview/78800342 https://pubmed.ncbi.nlm.nih.gov/PMC19553 https://www.ncbi.nlm.nih.gov/pmc/articles/19553 |
| UnpaywallVersion | submittedVersion |
| Volume | 94 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 1091-6490 dateEnd: 20250503 omitProxy: true ssIdentifier: ssj0009580 issn: 0027-8424 databaseCode: HH5 dateStart: 19150101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1091-6490 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0009580 issn: 0027-8424 databaseCode: KQ8 dateStart: 19150101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1091-6490 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0009580 issn: 0027-8424 databaseCode: KQ8 dateStart: 19150115 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1091-6490 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0009580 issn: 0027-8424 databaseCode: DIK dateStart: 19150101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1091-6490 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0009580 issn: 0027-8424 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1091-6490 dateEnd: 20250503 omitProxy: true ssIdentifier: ssj0009580 issn: 0027-8424 databaseCode: RPM dateStart: 19150101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Pb9MwFH7augNcgI1NhEHxAfFDImni2PFynBBjQmLagUrlFNmuo1W0bqGJ0Dhx5d_kL-E5cbINxgRX-1Vq6s_-PjfvfQ_gqchVzmNNw1TnKmQGz0EppAoPqFRTIyWymqtGfn-SHY_ZuwmfbMCoq4Vpkva1mkV2vojs7KzJrVwt9KjLExslOefpJmxlHMX3ALbGJ6eHH9tEDjxvWdvGFlkwzFgee1dNxPFoZeU6yllEI-6Y5BILtYmIzt0UQ65Tmn8mTN6q7Uqef5Xz-SU2OroLp91ztEkon6K6UpH-9pvF43886D2445UpOWwntmHD2B3Y9nt_TV54g-qX90G21b2l_7uPLEvS2D3MLNFLx4XEtXtAOBMcQYFJmkaAxNnBLgxR5-RzLacOeZq4ouC2sZitfn7_Ib1Fyi6Mj958eH0c-lYNoeaCVSE3Aq9Orui1zPCGUiYKZZWWKDZUaRxP4sWHliqWDjFTKpAvGTJjyY10Vtkq3YOBXVrzAMhUxkykSuDFs2S50rmkmWSSca0FNbEI4FW3dIX2Puaunca8aN6ni7Rwy1jkrKAFrnQAz_rwVWvg8bfAnQYHfZTry50GsNtEdYMX0cNrx4vS5-wEsN_hqPDHwrpAtZVyQWP8-JN-Fveze0kjrVnW6yLhB6lIkxsiBB65zrgxgL0WlRdfwqkNygLgV-Dazzsr8aszCLzGUrzBWgDPe1jf_Fs9_OfIfbjdGv4mIU0ewaD6UpvHKOMqNYTNt5Nk6DfwL3CCTHc |
| linkProvider | Unpaywall |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Pb9MwFH4a3QEuwMYmssHwAfFDImni2PVynBDThMS0A5XGybJdR6to07ImQuPElX-Tv4Tn2Mk2GBNc7VepqT_7-9y89z2A56LQBU8NjXNT6JhZPAeVUDrep0pPrFLIaq4a-cPx6GjM3p_y0zUYdrUwbdK-0dOkms2TanrW5lYu52bY5YkNs4Lz_A6sjziK7wGsj49PDj75RA48b5lvY4ssGI9YkQZXTcTxcFmpVVKwhCbcMckVFvKJiM7dFENuUpp_JkzebaqluviqZrMrbHT4AE665_BJKJ-TptaJ-fabxeN_POhDuB-UKTnwExuwZqtN2Ah7f0VeBYPq149A-ereMvzdRxYlae0ephUxC8eFxLV7QDgTHEGBSdpGgMTZwc4t0RfkS6MmDnmGuKJg31isqn9-_6GCRcoWjA_ffXx7FIdWDbHhgtUxtwKvTq7otRzhDaXMNMoqo1Bs6NI6nsSLDy11qhxiJlQgXzJkxpJb5ayydb4Ng2pR2cdAJiplItcCL54lK7QpFB0pphg3RlCbigjedEsnTfAxd-00ZrJ9ny5y6ZZRFkxSiSsdwYs-fOkNPP4WuNnioI9yfbnzCLbaqG7wMnrvxnFZhpydCHY7HMlwLKwkqq2cC5rix5_1s7if3UsaVdlFs5IZ389Fnt0SIfDIdcaNEWx7VF5-Cac2KIuAX4NrP--sxK_PIPBaS_EWaxG87GF9-2-188-Ru3DPG_5mMc2ewKA-b-xTlHG13gtb9xerYkuG |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+protein+coding+regions+in+the+human+genome+by+quadratic+discriminant+analysis&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Zhang%2C+M+Q&rft.date=1997-01-21&rft.issn=0027-8424&rft.volume=94&rft.issue=2&rft.spage=565&rft.epage=568&rft_id=info:doi/10.1073%2Fpnas.94.2.565&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F94%2F2.cover.gif |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F94%2F2.cover.gif |