ACTH和槐杞黄治疗频复发肾病综合征患儿的疗效观察
目的观察促肾上腺皮质激素（ACTH）联合槐杞黄对频复发肾病综合征（FRNS）患儿的疗效及安全性。方法55例FRNS患儿分为糖皮质激素（GC）维持治疗的对照组（A组,10例）、槐杞黄组（B组,17例）、ACTH组（C组,14例）和ACTH联合槐杞黄组（联合治疗组,D组,14例）,连续治疗12个月。分别记录治疗6个月和12个月时各组GC使用量、肾上腺皮质基础分泌水平及肾上腺皮质储备水平,同时记录各组患儿复发率及不良反应情况。结果治疗6个月后,C、D组的GC用量明显低于A、B组（P〈0.05）,A-D组肾上腺皮质储备水平依次升高（P〈0.05）。治疗12个月后,C、D组与A、B组相比较,GC用量降低...
Saved in:
| Published in | 天津医药 Vol. 45; no. 1; pp. 54 - 57 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
天津市儿童医院肾内科 邮编300134%天津医科大学研究生院
2017
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-9896 |
| DOI | 10.11958/20160184 |
Cover
| Abstract | 目的观察促肾上腺皮质激素（ACTH）联合槐杞黄对频复发肾病综合征（FRNS）患儿的疗效及安全性。方法55例FRNS患儿分为糖皮质激素（GC）维持治疗的对照组（A组,10例）、槐杞黄组（B组,17例）、ACTH组（C组,14例）和ACTH联合槐杞黄组（联合治疗组,D组,14例）,连续治疗12个月。分别记录治疗6个月和12个月时各组GC使用量、肾上腺皮质基础分泌水平及肾上腺皮质储备水平,同时记录各组患儿复发率及不良反应情况。结果治疗6个月后,C、D组的GC用量明显低于A、B组（P〈0.05）,A-D组肾上腺皮质储备水平依次升高（P〈0.05）。治疗12个月后,C、D组与A、B组相比较,GC用量降低,肾上腺皮质基础分泌水平和储备水平均升高（P〈0.05）,而C、D组间上述指标差异无统计学意义（P〉0.05）。在治疗6个月和12个月后,C、D组患儿复发率均低于A、B组（P〈0.05）。结论单纯应用ACTH以及联合槐杞黄均可减轻FRNS患儿长期服用GC对下丘脑-垂体-肾上腺轴的抑制作用。 |
|---|---|
| AbstractList | 目的观察促肾上腺皮质激素（ACTH）联合槐杞黄对频复发肾病综合征（FRNS）患儿的疗效及安全性。方法55例FRNS患儿分为糖皮质激素（GC）维持治疗的对照组（A组,10例）、槐杞黄组（B组,17例）、ACTH组（C组,14例）和ACTH联合槐杞黄组（联合治疗组,D组,14例）,连续治疗12个月。分别记录治疗6个月和12个月时各组GC使用量、肾上腺皮质基础分泌水平及肾上腺皮质储备水平,同时记录各组患儿复发率及不良反应情况。结果治疗6个月后,C、D组的GC用量明显低于A、B组（P〈0.05）,A-D组肾上腺皮质储备水平依次升高（P〈0.05）。治疗12个月后,C、D组与A、B组相比较,GC用量降低,肾上腺皮质基础分泌水平和储备水平均升高（P〈0.05）,而C、D组间上述指标差异无统计学意义（P〉0.05）。在治疗6个月和12个月后,C、D组患儿复发率均低于A、B组（P〈0.05）。结论单纯应用ACTH以及联合槐杞黄均可减轻FRNS患儿长期服用GC对下丘脑-垂体-肾上腺轴的抑制作用。 R692%R586; 目的：观察促肾上腺皮质激素（ACTH）联合槐杞黄对频复发肾病综合征（FRNS）患儿的疗效及安全性。方法55例FRNS患儿分为糖皮质激素（GC）维持治疗的对照组（A组，10例）、槐杞黄组（B组，17例）、ACTH组（C组，14例）和ACTH联合槐杞黄组（联合治疗组，D组，14例），连续治疗12个月。分别记录治疗6个月和12个月时各组GC使用量、肾上腺皮质基础分泌水平及肾上腺皮质储备水平，同时记录各组患儿复发率及不良反应情况。结果治疗6个月后，C、D组的GC用量明显低于A、B组（P<0.05），A~D组肾上腺皮质储备水平依次升高（P<0.05）。治疗12个月后，C、D组与A、B组相比较，GC用量降低，肾上腺皮质基础分泌水平和储备水平均升高（P<0.05），而C、D组间上述指标差异无统计学意义（P>0.05）。在治疗6个月和12个月后，C、D组患儿复发率均低于A、B组（P<0.05）。结论单纯应用ACTH以及联合槐杞黄均可减轻FRNS患儿长期服用GC对下丘脑-垂体-肾上腺轴的抑制作用。 |
| Abstract_FL | Objective To observe the effects and safety of adrenocorticotropic hormone (ACTH) combined with Huaiqihuang on frequent relapse nephrotic syndrome (FRNS) in children. Methods Fifty-five child patients with FRNS were divided into control group, which was given glucocorticoid (GC) to maintain the treatment (group A, n=10), Huaiqihuang group (group B, n=17), ACTH group (group C, n=14) and ACTH combined with Huaiqihuang group (combined treatment group, group D, n=14). Continuous treatment was for 12 months. The GC treatment doses, the levels of basal secretion of adrenal cortex and adrenal cortex reserve were recorded at 6-month and 12-month respectively. And the recurrence rate and adverse reactions were observed in four groups. Results After 6-month treatment, the doses of GC were significantly lower in group C and group D than those in group A and group B (P<0.05). The levels of basal secretion of adrenal cortex were increased in turn in group A~D (P<0.05). After 12-month treatment, the doses of GC were significantly decreased in group C and group D than those in group A and group B, while the level of basal secretion of adrenal cortex and adrenal cortex reserve were increased (P<0.05). There were no significant differences in the doses of GC between group C and group D (P>0.05). After treatment for 6 months and 12 months, the recurrence rates of nephrotic syndrome were significantly lower in group C and group D than those of group A and group B (P<0.05). Conclusion The simple application of ACTH and the combination of Huaiqihuang can relieve the inhibition of long-term using GC on hypothalamic pituitary adrenal axis in FRNS patients. |
| Author | 王文红 张碧丽 刘艳 刘妍 赵林胜 杨丽潇 |
| AuthorAffiliation | 天津市儿童医院肾内科,300134 天津医科大学研究生院 |
| AuthorAffiliation_xml | – name: 天津市儿童医院肾内科 邮编300134%天津医科大学研究生院 |
| Author_FL | ZHAO Lin-sheng WANG Wen-hong ZHANG Bi-li YANG Li-xiao LIU Yan |
| Author_FL_xml | – sequence: 1 fullname: WANG Wen-hong – sequence: 2 fullname: ZHANG Bi-li – sequence: 3 fullname: LIU Yan – sequence: 4 fullname: ZHAO Lin-sheng – sequence: 5 fullname: YANG Li-xiao |
| Author_xml | – sequence: 1 fullname: 王文红 张碧丽 刘艳 刘妍 赵林胜 杨丽潇 |
| BookMark | eNotz09LAkEYBvA5GGTmoa8QdNx6352ZnZ2jLJWB0MW7zP4ZU2otLcJjYuDBSIMSggoq8Bh0NezTzK5-ixbs9MLDj-fh3SC5uBVHhGwh7CJK7u7ZgA6gy3IkDzanlnSls06KnU7DBxRMCCYxT7ySVy2bh2EyHSUvr8tZP_mepU-T5fvYfN6Z-_GiN08nt-nsx4wGZn6T9D5M_zd97mcmeRwspj3z9bZJ1rQ67UTF_1sg1YP9qle2KseHR16pYgVcMEtpP2IcGejQR-naEWcy0FwrFFEYgKC-gBAoCLRZKITmMpA-0zyLIBAqpAWys6q9VrFWcb3WbF2142ywdtnsdrN3BSAgy9z2ygUnrbh-0cjkebtxptrdmiPQcTmlnP4BA5trrA |
| ClassificationCodes | R692%R586 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.11958/20160184 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | The effects of ACTH and Huaiqihuang on the treatment of recurrence nephrotic syndrome in children |
| DocumentTitle_FL | The effects of ACTH and Huaiqihuang on the treatment of recurrence nephrotic syndrome in children |
| EndPage | 57 |
| ExternalDocumentID | tjyy201701014 671685335 |
| GrantInformation_xml | – fundername: 天津市中医药管理局中医、中西医结合科研专项课题 funderid: (13127) |
| GroupedDBID | -05 2B. 2C~ 2RA 5XA 5XF 92F 92I 92L ABDBF ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CIEJG CQIGP CW9 EOJEC F5P OBODZ TCJ TGQ U1G U5O W91 ~WA 4A8 93N ABJNI ACUHS PSX |
| ID | FETCH-LOGICAL-c574-afbe45140fdb1982e549cf5fa17edc073b70d0307124d77f59c9b4f50300c7ad3 |
| ISSN | 0253-9896 |
| IngestDate | Thu May 29 04:06:52 EDT 2025 Wed Feb 14 10:03:31 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | 皮质醇 肾病综合征 下丘脑-垂体-肾上腺轴 Huaiqihuang 肾上腺皮质激素类 糖皮质激素类 槐杞黄 adrenal cortex hormones 氢化可的松 nephrotic syndrome cortisol hypothalamic pituitary adrenal axis hydrocortisone glucocorticoids |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c574-afbe45140fdb1982e549cf5fa17edc073b70d0307124d77f59c9b4f50300c7ad3 |
| Notes | Objective To observe the effects and safety of adrenocorticotropic hormone（ACTH） combined withHuaiqihuang on frequent relapse nephrotic syndrome（FRNS） in children. Methods Fifty-five child patients with FRNSwere divided into control group, which was given glucocorticoid（GC） to maintain the treatment（group A, n=10）, Huaiqihuanggroup（group B, n=17）, ACTH group（group C, n=14） and ACTH combined with Huaiqihuang group（combined treatmentgroup, group D, n=14）. Continuous treatment was for 12 months. The GC treatment doses, the levels of basal secretion ofadrenal cortex and adrenal cortex reserve were recorded at 6-month and 12-month respectively. And the recurrence rate andadverse reactions were observed in four groups. Results After 6-month treatment, the doses of GC were significantly lowerin group C and group D than those in group A and group B（P 〈 0.05）. The levels of basal secretion of adrenal cortex wereincreased in turn in group A~D（P 〈 0.05）. After 12-month treatment, the doses of GC were significantly decre |
| PageCount | 4 |
| ParticipantIDs | wanfang_journals_tjyy201701014 chongqing_primary_671685335 |
| PublicationCentury | 2000 |
| PublicationDate | 2017 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationTitle | 天津医药 |
| PublicationTitleAlternate | Tianjin Medical Journal |
| PublicationYear | 2017 |
| Publisher | 天津市儿童医院肾内科 邮编300134%天津医科大学研究生院 |
| Publisher_xml | – name: 天津市儿童医院肾内科 邮编300134%天津医科大学研究生院 |
| SSID | ssib017477491 ssib001104050 ssib002263120 ssj0051502 ssib051371343 ssib039893103 ssib058494496 |
| Score | 2.0860689 |
| Snippet | 目的观察促肾上腺皮质激素（ACTH）联合槐杞黄对频复发肾病综合征（FRNS）患儿的疗效及安全性。方法55例FRNS患儿分为糖皮质激素（GC）维持治疗的对照组（A组,10例）、槐杞黄... R692%R586; 目的：观察促肾上腺皮质激素（ACTH）联合槐杞黄对频复发肾病综合征（FRNS）患儿的疗效及安全性。方法55例FRNS患儿分为糖皮质激素（GC）维持治疗的对照组（A... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 54 |
| SubjectTerms | 下丘脑-垂体-肾上腺轴 槐杞黄 氢化可的松 皮质醇 糖皮质激素类 肾上腺皮质激素类 肾病综合征 |
| Title | ACTH和槐杞黄治疗频复发肾病综合征患儿的疗效观察 |
| URI | http://lib.cqvip.com/qk/92492X/201701/671685335.html https://d.wanfangdata.com.cn/periodical/tjyy201701014 |
| Volume | 45 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCO - Academic Search Ultimate issn: 0253-9896 databaseCode: ABDBF dateStart: 20140601 customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn isFulltext: true dateEnd: 99991231 titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn omitProxy: true ssIdentifier: ssj0051502 providerName: EBSCOhost |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9RAFB_6AeJF_MRaLT04J4lmMjPJzDHZzVKEelqht2Xz1eJh68f20N5cKvSg2ApaEFRQoRdB8Fqpf0122__C9ybZ7C4Wvy7hZea9md97L8m8CTNvCLkpkrbD0zi1PJVElkjtzNKpSiydZIy5uh1HJnfn8j136b64uyJXpqa_jK1a2uhGt-OtU_eV_I9XoQz8irtk_8GzVaNQADT4F67gYbj-lY_9WnOJhpJqh6oaDV3qe1TbSOg61SENNQ0CqgSWBA7SITBArYdVvkM1Q3Ef4sk6EqphShRVwBwaZo8qiQTIBjXTl02VQgIYFMOWgdnnRlzQoGGkfNNp1RdcpZFSiBD4sVPoa2JNYYnE1wYtENK0WTOwFSL0q1XI2LaC_gPTNkDwDEYfdBqxSETs21gDqkLHIeBTNKiPswAqbYApsBU_pQZAQfv18b8jxTZQ8ySfDjpQpZKVRfxgUh9NtXHAyNZQ5Za2Ri-yW8iEpjV-AE00pi1jXFBH_tZUpfyQxzNEHbXAKptq4xmQDUwJ3OpGBWhsXHAkt7QqDgIeDmJFTs6Jl7UYkYoU3WVsU-QC_3XU1BK3gjiYbZApMQoNqgWb3Qebm2hec7TzNJl18O_XDJn1g3rQGIXfMLe35fi-apez0XSEA2g81m54LxnHncyjeyW0EJj-sYikINQ2a4YrhcvMYAj3zhAs5kRZW--sPoJIz2y862TtzupYjNg8T86Vk7tFv3hTL5CprbWL5MxyuXzlEqnhC5u_et4_2O2_e39yuN3_djh4s3_ycS___CJ_uXfcOxrsPxscfs93d_Kjp_3ep3z7x-DtNvD0X-8cH_Tyrx8uk2YjbNaWrPIUEyuWnrDaWZQKmJXYWRIxrZxUCh1nMmszL01iGGAjz05wpIVAO_G8TOpYRyKTUGTHXjvhV8hMZ72TXiWLdsS5G2VStCMGcbeOOMvcNBWOHXNbCGeOzFemaD0sktW0XI-5EJJzOUcWSuO0yk_Yk9aEW6_9iWGenEW6-AF5ncx0H2-kNyAk70YL5ZPwEy9hp9g |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=ACTH%E5%92%8C%E6%A7%90%E6%9D%9E%E9%BB%84%E6%B2%BB%E7%96%97%E9%A2%91%E5%A4%8D%E5%8F%91%E8%82%BE%E7%97%85%E7%BB%BC%E5%90%88%E5%BE%81%E6%82%A3%E5%84%BF%E7%9A%84%E7%96%97%E6%95%88%E8%A7%82%E5%AF%9F&rft.jtitle=%E5%A4%A9%E6%B4%A5%E5%8C%BB%E8%8D%AF&rft.au=%E7%8E%8B%E6%96%87%E7%BA%A2&rft.au=%E5%BC%A0%E7%A2%A7%E4%B8%BD&rft.au=%E5%88%98%E8%89%B3&rft.au=%E5%88%98%E5%A6%8D&rft.date=2017&rft.pub=%E5%A4%A9%E6%B4%A5%E5%B8%82%E5%84%BF%E7%AB%A5%E5%8C%BB%E9%99%A2%E8%82%BE%E5%86%85%E7%A7%91+%E9%82%AE%E7%BC%96300134%25%E5%A4%A9%E6%B4%A5%E5%8C%BB%E7%A7%91%E5%A4%A7%E5%AD%A6%E7%A0%94%E7%A9%B6%E7%94%9F%E9%99%A2&rft.issn=0253-9896&rft.volume=45&rft.issue=1&rft.spage=54&rft.epage=57&rft_id=info:doi/10.11958%2F20160184&rft.externalDocID=tjyy201701014 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F92492X%2F92492X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Ftjyy%2Ftjyy.jpg |