Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors - Pien, Gary C.; Basner-Tschakarjan, Etiena; Hui, Daniel J.; Mentlik, Ashley N.; Finn, Jonathan D.; Hasbrouck, Nicole C.; Zhou, Shangzhen; Murphy, Samuel L.; Maus, Marcela V.; Mingozzi, Federico; Orange, Jordan S.; High, Katherine A. (The Journal of clinical investigation, 2009)
Keywords: Antigen presentation; Antigen Presentation - immunology; Biomedical research; Capsid Proteins - immunology; Capsid Proteins - metabolism; Care and treatment; Cell Line; Clinical trials; Cloning; Cytotoxicity, Immunologic - immunology; Dependovirus - genetics; Flow cytometry; Gene therapy; Genetic aspects; Genetic transformation; Genetic Vectors - genetics; Health aspects; Hemophilia; Hepatocytes - cytology; Hepatocytes - immunology; Hepatocytes - metabolism; Histocompatibility Antigens - immunology; Humans; Liver cells; Lymphocytes; Methods; Microscopy; Peptides; Physiological aspects; Protein Multimerization; Reagents; Receptors, Antigen, T-Cell - immunology; Risk factors; Solubility; Substrate Specificity; T cells; T-Lymphocytes, Cytotoxic - immunology; United States