A genetic perspective on granulomatous diseases with an emphasis on mycobacterial infections

Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Gu...

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Published inSeminars in immunopathology Vol. 38; no. 2; pp. 199 - 212
Main Authors Wu, Un-In, Holland, Steven M.
Format Journal Article Book Review
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2016
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Genetic Association Studies
Genetic Diseases, Inborn - complications
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - metabolism
Genetic Predisposition to Disease
Granuloma - etiology
Granuloma - metabolism
Granuloma - pathology
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humans
Immune System - immunology
Immune System - metabolism
Immune System - microbiology
Immune System - pathology
Immunology
Interferon-gamma - deficiency
Interferon-gamma - genetics
Interferon-gamma - metabolism
Interleukin-12 - deficiency
Interleukin-12 - genetics
Interleukin-12 - metabolism
Internal Medicine
Mycobacterium
Mycobacterium - immunology
Mycobacterium Infections - complications
Mycobacterium Infections - genetics
Mycobacterium Infections - immunology
Mycobacterium Infections - microbiology
Review
Risk Factors
Sequence Deletion
Signal Transduction
Nontuberculous
IFN-γ
Tuberculosis
IL-12
Mycobacteria
Online AccessGet full text
ISSN1863-2297
1863-2300
1863-2300
DOI10.1007/s00281-015-0552-y

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Abstract Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guérin (BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathways and can adduce mechanism. We also describe the clinical, immunological, and pathological features that may steer clinical investigation in the appropriate directions.
AbstractList Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guerin (BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN- gamma pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathways and can adduce mechanism. We also describe the clinical, immunological, and pathological features that may steer clinical investigation in the appropriate directions.
Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guérin (BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathways and can adduce mechanism. We also describe the clinical, immunological, and pathological features that may steer clinical investigation in the appropriate directions.Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guérin (BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathways and can adduce mechanism. We also describe the clinical, immunological, and pathological features that may steer clinical investigation in the appropriate directions.
Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guérin (BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathways and can adduce mechanism. We also describe the clinical, immunological, and pathological features that may steer clinical investigation in the appropriate directions.
Issue Title: Immunopathology of Mycobacterial Diseases Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guérin (BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathways and can adduce mechanism. We also describe the clinical, immunological, and pathological features that may steer clinical investigation in the appropriate directions.
Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guérin (BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathways and can adduce mechanism. We also describe the clinical, immunological, and pathological features that may steer clinical investigation in the appropriate directions.
Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guérin ( BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathway and can adduce mechanism. We also describe the clinical, immunological and pathological features that may steer clinical investigation in the appropriate directions.
Author Holland, Steven M.
Wu, Un-In
AuthorAffiliation 2 Laboratory of Clinical Infectious Diseases National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA
1 Division of Infectious Diseases, National Taiwan University Hospital, Taipei, Taiwan ( uninwu@gmail.com )
AuthorAffiliation_xml – name: 1 Division of Infectious Diseases, National Taiwan University Hospital, Taipei, Taiwan ( uninwu@gmail.com )
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  email: smh@nih.gov
  organization: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26733044$$D View this record in MEDLINE/PubMed
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crossref_primary_10_1007_s00281_015_0552_y
crossref_citationtrail_10_1007_s00281_015_0552_y
springer_journals_10_1007_s00281_015_0552_y
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-03-01
PublicationDateYYYYMMDD 2016-03-01
PublicationDate_xml – month: 03
  year: 2016
  text: 2016-03-01
  day: 01
PublicationDecade 2010
PublicationPlace Berlin/Heidelberg
PublicationPlace_xml – name: Berlin/Heidelberg
– name: Germany
– name: Dordrecht
PublicationTitle Seminars in immunopathology
PublicationTitleAbbrev Semin Immunopathol
PublicationTitleAlternate Semin Immunopathol
PublicationYear 2016
Publisher Springer Berlin Heidelberg
Springer Nature B.V
Publisher_xml – name: Springer Berlin Heidelberg
– name: Springer Nature B.V
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Snippet Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the...
Issue Title: Immunopathology of Mycobacterial Diseases Identification of the genetic factors predisposing to mycobacterial infections has been a subject of...
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SubjectTerms Animals
Biomedical and Life Sciences
Biomedicine
Genetic Association Studies
Genetic Diseases, Inborn - complications
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - metabolism
Genetic Predisposition to Disease
Granuloma - etiology
Granuloma - metabolism
Granuloma - pathology
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humans
Immune System - immunology
Immune System - metabolism
Immune System - microbiology
Immune System - pathology
Immunology
Interferon-gamma - deficiency
Interferon-gamma - genetics
Interferon-gamma - metabolism
Interleukin-12 - deficiency
Interleukin-12 - genetics
Interleukin-12 - metabolism
Internal Medicine
Mycobacterium
Mycobacterium - immunology
Mycobacterium Infections - complications
Mycobacterium Infections - genetics
Mycobacterium Infections - immunology
Mycobacterium Infections - microbiology
Review
Risk Factors
Sequence Deletion
Signal Transduction
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Title A genetic perspective on granulomatous diseases with an emphasis on mycobacterial infections
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