Definitions of neonatal abstinence syndrome in clinical studies of mothers and infants: an expert literature review
Neonatal abstinence syndrome (NAS) results from discontinuation of in utero exposures to opioids/substances. The rising incidence of NAS has prompted an increased need for accurate research and public health data. To examine how NAS has been defined in clinical studies of opioid-exposed mothers and...
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| Published in | Journal of perinatology Vol. 41; no. 6; pp. 1364 - 1371 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.06.2021
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0743-8346 1476-5543 1476-5543 |
| DOI | 10.1038/s41372-020-00893-8 |
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| Abstract | Neonatal abstinence syndrome (NAS) results from discontinuation of in utero exposures to opioids/substances. The rising incidence of NAS has prompted an increased need for accurate research and public health data. To examine how NAS has been defined in clinical studies of opioid-exposed mothers and infants, a review process was developed based on the RAND/UCLA Appropriateness Method, yielding 888 abstracts. Per inclusion criteria, 57 abstracts underwent full-text review. To define NAS, studies cited using modified versions of the Finnegan NAS scoring tool (
n
= 21; 37%), ICD-9/10 coding (
n
= 17; 30%), original Finnegan tool (
n
= 16; 28%), Eat Sleep Console (
n
= 3; 5%), and Lipsitz (
n
= 3; 5%) tools, (3 cited 2+ tools). Most studies utilized subjective NAS scoring/assessment algorithms and neonatal coding as key elements defining NAS. While most cited opioid exposure as integral to their inclusion criteria, 26% did not. These approaches highlight the need for a more refined and standardized definition of NAS. |
|---|---|
| AbstractList | Neonatal abstinence syndrome (NAS) results from discontinuation of in utero exposures to opioids/substances. The rising incidence of NAS has prompted an increased need for accurate research and public health data. To examine how NAS has been defined in clinical studies of opioid-exposed mothers and infants, a review process was developed based on the RAND/UCLA Appropriateness Method, yielding 888 abstracts. Per inclusion criteria, 57 abstracts underwent full-text review. To define NAS, studies cited using modified versions of the Finnegan NAS scoring tool (
n
= 21; 37%), ICD-9/10 coding (
n
= 17; 30%), original Finnegan tool (
n
= 16; 28%), Eat Sleep Console (
n
= 3; 5%), and Lipsitz (
n
= 3; 5%) tools, (3 cited 2+ tools). Most studies utilized subjective NAS scoring/assessment algorithms and neonatal coding as key elements defining NAS. While most cited opioid exposure as integral to their inclusion criteria, 26% did not. These approaches highlight the need for a more refined and standardized definition of NAS. Neonatal abstinence syndrome (NAS) results from discontinuation of in utero exposures to opioids/substances. The rising incidence of NAS has prompted an increased need for accurate research and public health data. To examine how NAS has been defined in clinical studies of opioid-exposed mothers and infants, a review process was developed based on the RAND/UCLA Appropriateness Method, yielding 888 abstracts. Per inclusion criteria, 57 abstracts underwent full-text review. To define NAS, studies cited using modified versions of the Finnegan NAS scoring tool (n = 21; 37%), ICD-9/10 coding (n = 17; 30%), original Finnegan tool (n = 16; 28%), Eat Sleep Console (n = 3; 5%), and Lipsitz (n = 3; 5%) tools, (3 cited 2+ tools). Most studies utilized subjective NAS scoring/assessment algorithms and neonatal coding as key elements defining NAS. While most cited opioid exposure as integral to their inclusion criteria, 26% did not. These approaches highlight the need for a more refined and standardized definition of NAS. Neonatal abstinence syndrome (NAS) results from discontinuation of in utero exposures to opioids/substances. The rising incidence of NAS has prompted an increased need for accurate research and public health data. To examine how NAS has been defined in clinical studies of opioid-exposed mothers and infants, a review process was developed based on the RAND/UCLA Appropriateness Method, yielding 888 abstracts. Per inclusion criteria, 57 abstracts underwent full-text review. To define NAS, studies cited using modified versions of the Finnegan NAS scoring tool (n = 21; 37%), ICD-9/10 coding (n = 17; 30%), original Finnegan tool (n = 16; 28%), Eat Sleep Console (n = 3; 5%), and Lipsitz (n = 3; 5%) tools, (3 cited 2+ tools). Most studies utilized subjective NAS scoring/assessment algorithms and neonatal coding as key elements defining NAS. While most cited opioid exposure as integral to their inclusion criteria, 26% did not. These approaches highlight the need for a more refined and standardized definition of NAS.Neonatal abstinence syndrome (NAS) results from discontinuation of in utero exposures to opioids/substances. The rising incidence of NAS has prompted an increased need for accurate research and public health data. To examine how NAS has been defined in clinical studies of opioid-exposed mothers and infants, a review process was developed based on the RAND/UCLA Appropriateness Method, yielding 888 abstracts. Per inclusion criteria, 57 abstracts underwent full-text review. To define NAS, studies cited using modified versions of the Finnegan NAS scoring tool (n = 21; 37%), ICD-9/10 coding (n = 17; 30%), original Finnegan tool (n = 16; 28%), Eat Sleep Console (n = 3; 5%), and Lipsitz (n = 3; 5%) tools, (3 cited 2+ tools). Most studies utilized subjective NAS scoring/assessment algorithms and neonatal coding as key elements defining NAS. While most cited opioid exposure as integral to their inclusion criteria, 26% did not. These approaches highlight the need for a more refined and standardized definition of NAS. |
| Audience | Academic |
| Author | Jilani, Shahla M. Jordan, Chloe J. Davis, Jonathan M. Jansson, Lauren M. |
| Author_xml | – sequence: 1 givenname: Shahla M. orcidid: 0000-0001-5089-1129 surname: Jilani fullname: Jilani, Shahla M. email: Shahla.jilani@hhs.gov organization: Office of the Assistant Secretary for Health, U.S. Department of Health and Human Services – sequence: 2 givenname: Chloe J. orcidid: 0000-0002-1843-227X surname: Jordan fullname: Jordan, Chloe J. organization: Division of Extramural Research, National Institute on Drug Abuse – sequence: 3 givenname: Lauren M. surname: Jansson fullname: Jansson, Lauren M. organization: Johns Hopkins University School of Medicine, Department of Pediatrics, Center for Addiction and Pregnancy – sequence: 4 givenname: Jonathan M. surname: Davis fullname: Davis, Jonathan M. organization: Division of Newborn Medicine, Tufts Children’s Hospital, The Tufts Clinical and Translational Science Institute, Tufts University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33514878$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jpeds_2021_12_021 crossref_primary_10_1017_cts_2022_431 crossref_primary_10_1038_s41372_024_01953_z crossref_primary_10_1111_jcpp_13761 crossref_primary_10_1007_s00204_023_03563_8 crossref_primary_10_1542_hpeds_2023_007546 crossref_primary_10_1016_j_ntt_2021_107020 crossref_primary_10_1016_S2352_4642_24_00076_2 crossref_primary_10_1080_15401383_2024_2413631 crossref_primary_10_1111_add_16022 crossref_primary_10_1371_journal_pone_0284040 crossref_primary_10_1016_j_siny_2021_101218 crossref_primary_10_3389_fped_2024_1349102 crossref_primary_10_1177_00333549231162375 crossref_primary_10_3389_fgene_2023_1140400 crossref_primary_10_1002_jcph_1928 crossref_primary_10_1093_fampra_cmab121 crossref_primary_10_1016_j_nwh_2022_03_001 |
| Cites_doi | 10.1001/jama.2018.2640 10.1038/s41572-018-0045-0 10.1056/NEJMoa1005359 10.1097/JPN.0000000000000056 10.1097/JPN.0000000000000043 10.1097/MOP.0000000000000589 10.1097/ADM.0000000000000463 10.1097/ADM.0000000000000308 10.1542/peds.2013-3524 10.1016/j.pcl.2018.12.006 10.1542/peds.2011-3212 10.2105/AJPH.2019.305170 10.1097/ADM.0000000000000207 10.1542/peds.2017-4183 10.1056/NEJMra1600879 10.1001/jama.2012.3951 10.1542/peds.2017-3520 |
| ContentType | Journal Article |
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| Snippet | Neonatal abstinence syndrome (NAS) results from discontinuation of in utero exposures to opioids/substances. The rising incidence of NAS has prompted an... |
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| SubjectTerms | 692/1807 706/648 Algorithms Coding Criteria Drug withdrawal Exposure Female Humans Infant, Newborn Infants Literature reviews Medicine Medicine & Public Health Mother and infant Mothers Narcotics Neonatal abstinence syndrome Neonatal Abstinence Syndrome - diagnosis Neonatal Abstinence Syndrome - epidemiology Neonates Newborn babies Opioids Pediatric research Pediatric Surgery Pediatrics Public health |
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| Title | Definitions of neonatal abstinence syndrome in clinical studies of mothers and infants: an expert literature review |
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