Minocycline attenuates the development of diabetic neuropathy by modulating DREAM and BDNF protein expression in rat spinal cord
Aim This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats. Methods The rats were divided into four groups ( n = 16): non-diabetic control, diabetic c...
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| Published in | Journal of diabetes and metabolic disorders Vol. 18; no. 1; pp. 181 - 190 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cham
Springer International Publishing
01.06.2019
BioMed Central Ltd Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2251-6581 2251-6581 |
| DOI | 10.1007/s40200-019-00411-4 |
Cover
| Abstract | Aim
This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats.
Methods
The rats were divided into four groups (
n
= 16): non-diabetic control, diabetic control and diabetic rats receiving minocycline (80 μg/day or 160 μg/day). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (60 mg/kg STZ). Tactile allodynia was assessed on day-0 (baseline), day-14 (pre-intervention) and day-22 (post-intervention). Minocycline at doses of 80 μg and 160 μg were given intrathecally from day-15 until day-21. On day-23, formalin test was conducted to assess nociceptive behaviour response. The spinal expression of OX-42 and level of BDNF and DREAM proteins were detected by immunohistochemistry and western blot analyses.
Results
Diabetes rats showed significant tactile allodynia and nociceptive behaviour. These were accompanied by augmented expression of spinal OX-42, BDNF and DREAM protein levels. Both doses of minocycline attenuated tactile allodynia and nociceptive behaviour and also suppressed the diabetic-induced increase in spinal expressions of OX-42, BDNF and DREAM proteins.
Conclusion
This study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions. |
|---|---|
| AbstractList | This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats. The rats were divided into four groups (n = 16): non-diabetic control, diabetic control and diabetic rats receiving minocycline (80 [mu]g/day or 160 [mu]g/day). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (60 mg/kg STZ). Tactile allodynia was assessed on day-0 (baseline), day-14 (pre-intervention) and day-22 (post-intervention). Minocycline at doses of 80 [mu]g and 160 [mu]g were given intrathecally from day-15 until day-21. On day-23, formalin test was conducted to assess nociceptive behaviour response. The spinal expression of OX-42 and level of BDNF and DREAM proteins were detected by immunohistochemistry and western blot analyses. Diabetes rats showed significant tactile allodynia and nociceptive behaviour. These were accompanied by augmented expression of spinal OX-42, BDNF and DREAM protein levels. Both doses of minocycline attenuated tactile allodynia and nociceptive behaviour and also suppressed the diabetic-induced increase in spinal expressions of OX-42, BDNF and DREAM proteins. This study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions. Aim This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats. Methods The rats were divided into four groups (n = 16): non-diabetic control, diabetic control and diabetic rats receiving minocycline (80 [mu]g/day or 160 [mu]g/day). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (60 mg/kg STZ). Tactile allodynia was assessed on day-0 (baseline), day-14 (pre-intervention) and day-22 (post-intervention). Minocycline at doses of 80 [mu]g and 160 [mu]g were given intrathecally from day-15 until day-21. On day-23, formalin test was conducted to assess nociceptive behaviour response. The spinal expression of OX-42 and level of BDNF and DREAM proteins were detected by immunohistochemistry and western blot analyses. Results Diabetes rats showed significant tactile allodynia and nociceptive behaviour. These were accompanied by augmented expression of spinal OX-42, BDNF and DREAM protein levels. Both doses of minocycline attenuated tactile allodynia and nociceptive behaviour and also suppressed the diabetic-induced increase in spinal expressions of OX-42, BDNF and DREAM proteins. Conclusion This study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions. Keywords: Diabetic neuropathic pain, DREAM, BDNF, Minocycline, Spinal cord This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats.AIMThis study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats.The rats were divided into four groups (n = 16): non-diabetic control, diabetic control and diabetic rats receiving minocycline (80 μg/day or 160 μg/day). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (60 mg/kg STZ). Tactile allodynia was assessed on day-0 (baseline), day-14 (pre-intervention) and day-22 (post-intervention). Minocycline at doses of 80 μg and 160 μg were given intrathecally from day-15 until day-21. On day-23, formalin test was conducted to assess nociceptive behaviour response. The spinal expression of OX-42 and level of BDNF and DREAM proteins were detected by immunohistochemistry and western blot analyses.METHODSThe rats were divided into four groups (n = 16): non-diabetic control, diabetic control and diabetic rats receiving minocycline (80 μg/day or 160 μg/day). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (60 mg/kg STZ). Tactile allodynia was assessed on day-0 (baseline), day-14 (pre-intervention) and day-22 (post-intervention). Minocycline at doses of 80 μg and 160 μg were given intrathecally from day-15 until day-21. On day-23, formalin test was conducted to assess nociceptive behaviour response. The spinal expression of OX-42 and level of BDNF and DREAM proteins were detected by immunohistochemistry and western blot analyses.Diabetes rats showed significant tactile allodynia and nociceptive behaviour. These were accompanied by augmented expression of spinal OX-42, BDNF and DREAM protein levels. Both doses of minocycline attenuated tactile allodynia and nociceptive behaviour and also suppressed the diabetic-induced increase in spinal expressions of OX-42, BDNF and DREAM proteins.RESULTSDiabetes rats showed significant tactile allodynia and nociceptive behaviour. These were accompanied by augmented expression of spinal OX-42, BDNF and DREAM protein levels. Both doses of minocycline attenuated tactile allodynia and nociceptive behaviour and also suppressed the diabetic-induced increase in spinal expressions of OX-42, BDNF and DREAM proteins.This study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions.CONCLUSIONThis study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions. AimThis study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats.MethodsThe rats were divided into four groups (n = 16): non-diabetic control, diabetic control and diabetic rats receiving minocycline (80 μg/day or 160 μg/day). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (60 mg/kg STZ). Tactile allodynia was assessed on day-0 (baseline), day-14 (pre-intervention) and day-22 (post-intervention). Minocycline at doses of 80 μg and 160 μg were given intrathecally from day-15 until day-21. On day-23, formalin test was conducted to assess nociceptive behaviour response. The spinal expression of OX-42 and level of BDNF and DREAM proteins were detected by immunohistochemistry and western blot analyses.ResultsDiabetes rats showed significant tactile allodynia and nociceptive behaviour. These were accompanied by augmented expression of spinal OX-42, BDNF and DREAM protein levels. Both doses of minocycline attenuated tactile allodynia and nociceptive behaviour and also suppressed the diabetic-induced increase in spinal expressions of OX-42, BDNF and DREAM proteins.ConclusionThis study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions. This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats. The rats were divided into four groups ( = 16): non-diabetic control, diabetic control and diabetic rats receiving minocycline (80 μg/day or 160 μg/day). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (60 mg/kg STZ). Tactile allodynia was assessed on day-0 (baseline), day-14 (pre-intervention) and day-22 (post-intervention). Minocycline at doses of 80 μg and 160 μg were given intrathecally from day-15 until day-21. On day-23, formalin test was conducted to assess nociceptive behaviour response. The spinal expression of OX-42 and level of BDNF and DREAM proteins were detected by immunohistochemistry and western blot analyses. Diabetes rats showed significant tactile allodynia and nociceptive behaviour. These were accompanied by augmented expression of spinal OX-42, BDNF and DREAM protein levels. Both doses of minocycline attenuated tactile allodynia and nociceptive behaviour and also suppressed the diabetic-induced increase in spinal expressions of OX-42, BDNF and DREAM proteins. This study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions. Aim This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM proteins in diabetic neuropathic pain (DNP) rats. Methods The rats were divided into four groups ( n = 16): non-diabetic control, diabetic control and diabetic rats receiving minocycline (80 μg/day or 160 μg/day). The diabetic rat model was induced by intraperitoneal injection of streptozotocin (60 mg/kg STZ). Tactile allodynia was assessed on day-0 (baseline), day-14 (pre-intervention) and day-22 (post-intervention). Minocycline at doses of 80 μg and 160 μg were given intrathecally from day-15 until day-21. On day-23, formalin test was conducted to assess nociceptive behaviour response. The spinal expression of OX-42 and level of BDNF and DREAM proteins were detected by immunohistochemistry and western blot analyses. Results Diabetes rats showed significant tactile allodynia and nociceptive behaviour. These were accompanied by augmented expression of spinal OX-42, BDNF and DREAM protein levels. Both doses of minocycline attenuated tactile allodynia and nociceptive behaviour and also suppressed the diabetic-induced increase in spinal expressions of OX-42, BDNF and DREAM proteins. Conclusion This study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions. |
| Audience | General |
| Author | Aziz, Che Badariah Abd Ismail, Che Aishah Nazariah Suppian, Rapeah Long, Idris |
| Author_xml | – sequence: 1 givenname: Che Aishah Nazariah surname: Ismail fullname: Ismail, Che Aishah Nazariah organization: Physiology Department, School of Medical Sciences, Universiti Sains Malaysia Health Campus – sequence: 2 givenname: Rapeah surname: Suppian fullname: Suppian, Rapeah organization: School of Health Sciences, Universiti Sains Malaysia Health Campus – sequence: 3 givenname: Che Badariah Abd surname: Aziz fullname: Aziz, Che Badariah Abd organization: Physiology Department, School of Medical Sciences, Universiti Sains Malaysia Health Campus – sequence: 4 givenname: Idris orcidid: 0000-0002-6828-1908 surname: Long fullname: Long, Idris email: idriskk@usm.my organization: School of Health Sciences, Universiti Sains Malaysia Health Campus |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31275889$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jpain.2010.01.268 10.1146/annurev.biochem.72.121801.161629 10.1007/978-1-62703-459-3_14 10.1517/14656560802498149 10.1016/j.fitote.2015.07.011 10.3344/kjp.2013.26.3.255 10.1016/S0006-8993(99)01186-5 10.1016/j.neulet.2008.11.009 10.1073/pnas.96.16.9385 10.3892/mmr.2015.3735 10.1016/S0092-8674(01)00629-8 10.1016/j.pneurobio.2008.04.004 10.1016/j.ejphar.2007.01.013 10.1083/jcb.200305134 10.1016/j.pain.2005.02.009 10.1016/S0165-6147(03)00025-7 10.5114/aoms.2015.56342 10.1155/2014/674987 10.1111/jdi.12379 10.1016/j.ejphar.2014.01.057 10.2337/dc10-1303 10.1016/j.bbi.2010.09.025 10.1016/j.ejphar.2011.04.014 10.1038/18044 10.1007/s00702-011-0713-7 10.1523/JNEUROSCI.3686-05.2006 10.1523/JNEUROSCI.23-27-09097.2003 10.1097/ACO.0b013e32830edbdf 10.1016/S0892-0362(02)00220-9 10.1038/nature04223 10.1111/ejn.12516 10.1016/S0092-8674(02)00640-2 10.1016/j.neuropharm.2014.08.001 10.1046/j.1471-4159.1995.64031231.x 10.1111/j.1463-1326.2010.01333.x 10.1111/j.1471-4159.2010.06863.x 10.1016/j.expneurol.2010.01.003 10.1016/j.ejpain.2010.06.003 |
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| References | Sun, Yang, Zhang, Huang, Li, Zhang (CR29) 2015; 12 Merighi, Salio, Ghirri, Lossi, Ferrini, Betelli, Bardoni (CR10) 2008; 85 Nitta, Murai, Suzuki, Ito, Nomoto, Katoh, Furukawa, Furukawa (CR12) 2002; 24 Ledeboer, Sloane, Milligan, Frank, Mahony, Maier (CR20) 2005; 115 Zhang, Xu, Wang, Zhou, Pu, Jiang, Du (CR22) 2012; 119 Cheng, Pitcher, Laviolette, Whishaw, Tong, Kockeritz, Wada, Joza, Crackower, Goncalves, Sarosi, Woodgett, Oliveira-dos-Santos, Ikura, van der Kooy, Salter, Penninger (CR17) 2002; 108 Long, Suppiah, Ismail (CR27) 2013; 26 Guo, Robbins, Wei, Zou, Dubner, Ren (CR5) 2006; 26 Mika, Osikowicz, Makuch, Przewlocka (CR28) 2007; 560 Fu, Tan, Sung, Mao (CR30) 2009; 449 Morgado, Pereira-Terra, Cruz, Tavares (CR33) 2011; 13 Bathina, Das (CR38) 2015; 11 CR11 Ren, Dubner (CR14) 2008; 21 Fu, Light, Matsushima, Maixner (CR26) 1999; 825 Mannion, Costigan, Decosterd, Amaya, Ma, Holstege (CR6) 1999; 96 Rowjeska, Makuch, Przewlocka, Mika (CR39) 2014; 86 Pabreja, Dua, Sharma, Padi, Kulkarni (CR19) 2011; 661 Wang, Couture, Hong (CR1) 2014; 728 Malcangio, Lessmann (CR7) 2003; 24 Tsuda (CR36) 2016; 7 Du, Feng, Zaitsev, Je, Liu, Lu (CR9) 2003; 163 Chen, Walwyn, Ennes, Kim, McRoberts, Marvizón (CR32) 2014; 39 Zhou, Yang, Wei, Liu, Xin, Chen, Pang, Zang, Li, Liu (CR37) 2011; 25 Huang, Reichardt (CR8) 2003; 72 Coull, Beggs, Boudreau, Boivin, Tsuda, Inoue (CR13) 2005; 438 Lu, Schmidtko (CR21) 2013; 1020 Fernyhough, Diemel, Brewster, Tomlinson (CR34) 1995; 64 Tesfaye, Boulton, Dyck, Freeman, Horowitz, Kempler (CR2) 2010; 33 Liliehook, Bozdagi, Yao, Gomez-Ramirez, Zaidi, Wasco (CR18) 2003; 23 Hayati, Zalina, Myo, Badariah, Azhar, Idris (CR25) 2008; 6 Cao, Byun, Chen, Cai, Pan (CR35) 2010; 114 Sandireddy, Yerra, Areti, Komirishetty, Kumar (CR4) 2014; 2014 Carrion, Link, Ledo, Mellström, Naranjo (CR15) 1999; 398 Daulhac, Maffre, Mallet, Etienne, Privat, Kowalski-Chavuvel (CR24) 2011; 15 Constigan, Woolf (CR16) 2002; 108 Tavakoli, Malik (CR3) 2008; 9 Zulazmi, Gopalsamy, Farouk, Sulaiman, Bharatham, Perimal (CR23) 2015; 105 Lin, Lin, Light, AR (CR31) 2010; 11 J Du (411_CR9) 2003; 163 S Tesfaye (411_CR2) 2010; 33 M Tavakoli (411_CR3) 2008; 9 KY Fu (411_CR26) 1999; 825 M Tsuda (411_CR36) 2016; 7 W Guo (411_CR5) 2006; 26 R Mannion (411_CR6) 1999; 96 C Liliehook (411_CR18) 2003; 23 S Bathina (411_CR38) 2015; 11 E Rowjeska (411_CR39) 2014; 86 JS Sun (411_CR29) 2015; 12 AM Carrion (411_CR15) 1999; 398 KY Fu (411_CR30) 2009; 449 M Constigan (411_CR16) 2002; 108 J Mika (411_CR28) 2007; 560 411_CR11 X Zhang (411_CR22) 2012; 119 M Malcangio (411_CR7) 2003; 24 C Morgado (411_CR33) 2011; 13 P Fernyhough (411_CR34) 1995; 64 D Wang (411_CR1) 2014; 728 NA Zulazmi (411_CR23) 2015; 105 XH Cao (411_CR35) 2010; 114 A Nitta (411_CR12) 2002; 24 K Lin (411_CR31) 2010; 11 R Sandireddy (411_CR4) 2014; 2014 HYM Cheng (411_CR17) 2002; 108 A Ledeboer (411_CR20) 2005; 115 AA Hayati (411_CR25) 2008; 6 K Pabreja (411_CR19) 2011; 661 I Long (411_CR27) 2013; 26 L Daulhac (411_CR24) 2011; 15 JA Coull (411_CR13) 2005; 438 A Merighi (411_CR10) 2008; 85 R Lu (411_CR21) 2013; 1020 EJ Huang (411_CR8) 2003; 72 K Ren (411_CR14) 2008; 21 W Chen (411_CR32) 2014; 39 LJ Zhou (411_CR37) 2011; 25 |
| References_xml | – volume: 11 start-page: 1056 issue: 11 year: 2010 end-page: 1065 ident: CR31 article-title: Peripheral formalin injury induces 2 stages of microglial activation in the spinal cord publication-title: J Pain doi: 10.1016/j.jpain.2010.01.268 – volume: 6 start-page: Doc05 year: 2008 ident: CR25 article-title: Modulation of formalin-induced fos-like immunoreactivity in the spinal cord by swim stress-induced analgesia, morphine and ketamine publication-title: Ger Med Sci – volume: 72 start-page: 609 year: 2003 end-page: 642 ident: CR8 article-title: Trk receptors: roles in neuronal signal transduction publication-title: Annu Rev Biochem doi: 10.1146/annurev.biochem.72.121801.161629 – volume: 1020 start-page: 215 year: 2013 end-page: 221 ident: CR21 article-title: Direct intrathecal drug delivery in mice for detecting in vivo effects of cGMP on pain processing publication-title: Methods Mol Biol doi: 10.1007/978-1-62703-459-3_14 – volume: 9 start-page: 2969 year: 2008 end-page: 2978 ident: CR3 article-title: Management of painful diabetic neuropathy publication-title: Expert Opin Pharmacother doi: 10.1517/14656560802498149 – volume: 105 start-page: 215 year: 2015 end-page: 221 ident: CR23 article-title: Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain publication-title: Fitoterapia doi: 10.1016/j.fitote.2015.07.011 – volume: 26 start-page: 255 issue: 3 year: 2013 end-page: 264 ident: CR27 article-title: The effects of pre-emptive administration of ketamine and norBNI on pain behavior, c-Fos, and prodynorphin protein expression in the rat spinal cord after formalin-induced pain is modulated by the DREAM protein publication-title: Korean J Pain doi: 10.3344/kjp.2013.26.3.255 – volume: 825 start-page: 59 issue: 1–2 year: 1999 end-page: 67 ident: CR26 article-title: Microglial reactions after subcutaneous formalin injection into the rat hind paw publication-title: Brain Res doi: 10.1016/S0006-8993(99)01186-5 – volume: 449 start-page: 234 issue: 3 year: 2009 end-page: 239 ident: CR30 article-title: Peripheral formalin injection induces unique spinal cord microglial phenotypic changes publication-title: Neurosci Lett doi: 10.1016/j.neulet.2008.11.009 – volume: 96 start-page: 9385 issue: 16 year: 1999 end-page: 9390 ident: CR6 article-title: Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.96.16.9385 – volume: 12 start-page: 2677 issue: 2 year: 2015 end-page: 2682 ident: CR29 article-title: Minocycline attenuates pain by inhibiting spinal microglia activation in diabetic rats publication-title: Mol Med Rep doi: 10.3892/mmr.2015.3735 – volume: 108 start-page: 31 issue: 1 year: 2002 end-page: 43 ident: CR17 article-title: DREAM is a critical transcriptional repressor for pain modulation publication-title: Cell doi: 10.1016/S0092-8674(01)00629-8 – volume: 85 start-page: 297 issue: 3 year: 2008 end-page: 317 ident: CR10 article-title: BDNF as a pain modulator publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2008.04.004 – volume: 560 start-page: 142 issue: 2–3 year: 2007 end-page: 149 ident: CR28 article-title: Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2007.01.013 – volume: 163 start-page: 385 issue: 2 year: 2003 end-page: 395 ident: CR9 article-title: Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca influx publication-title: J Cell Biol doi: 10.1083/jcb.200305134 – volume: 115 start-page: 71 issue: 1–2 year: 2005 end-page: 83 ident: CR20 article-title: Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation publication-title: Pain doi: 10.1016/j.pain.2005.02.009 – volume: 24 start-page: 116 issue: 3 year: 2003 end-page: 121 ident: CR7 article-title: A common thread for pain and memory synapses? Brain-derived neurotrophic factor and TrkB receptors publication-title: Trends Pharmacol Sci doi: 10.1016/S0165-6147(03)00025-7 – volume: 15 start-page: 169 e1 issue: 2 year: 2011 end-page: 169e12 ident: CR24 article-title: Phosphorylation of spinal N-methyl-D-aspartate receptor NR1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetes-induced painful neuropathy publication-title: Eur J Pain – volume: 11 start-page: 1164 issue: 6 year: 2015 end-page: 1174 ident: CR38 article-title: Brain-derived neurotrophic factor and its clinical implications publication-title: Arch Med Sci doi: 10.5114/aoms.2015.56342 – volume: 2014 start-page: 1 year: 2014 end-page: 10 ident: CR4 article-title: Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets publication-title: Int J Endocrinol doi: 10.1155/2014/674987 – volume: 7 start-page: 17 year: 2016 end-page: 26 ident: CR36 article-title: Microglia in the spinal cord and neuropathic pain publication-title: J Diabetes Invest doi: 10.1111/jdi.12379 – volume: 728 start-page: 59 year: 2014 end-page: 66 ident: CR1 article-title: Activated microglia in the spinal cord underlies diabetic neuropathic pain publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2014.01.057 – volume: 33 start-page: 2285 issue: 10 year: 2010 end-page: 2293 ident: CR2 article-title: Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments publication-title: Diabetes Care doi: 10.2337/dc10-1303 – volume: 25 start-page: 322 issue: 2 year: 2011 end-page: 334 ident: CR37 article-title: Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2010.09.025 – volume: 661 start-page: 15 issue: 1–3 year: 2011 end-page: 21 ident: CR19 article-title: Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2011.04.014 – volume: 398 start-page: 80 issue: 6722 year: 1999 end-page: 84 ident: CR15 article-title: DREAM is a Ca2+−regulated transcriptional repressor publication-title: Nature doi: 10.1038/18044 – volume: 119 start-page: 329 issue: 3 year: 2012 end-page: 336 ident: CR22 article-title: The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia spinal nerve ligated rats publication-title: J Neural Transm doi: 10.1007/s00702-011-0713-7 – volume: 26 start-page: 126 issue: 1 year: 2006 end-page: 137 ident: CR5 article-title: Supraspinal brain-derived neurotrophic factor signalling: a novel mechanism for descending pain facilitation publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3686-05.2006 – volume: 23 start-page: 9097 issue: 27 year: 2003 end-page: 9106 ident: CR18 article-title: Altered Aβ formation and long-term potentiation in a calsenilin knock-out publication-title: J Neurosci doi: 10.1523/JNEUROSCI.23-27-09097.2003 – volume: 21 start-page: 570 issue: 5 year: 2008 end-page: 579 ident: CR14 article-title: Neuron-glia crosstalk gets serious: role in pain hypersensitivity publication-title: Curr Opin Anaesthesiol doi: 10.1097/ACO.0b013e32830edbdf – ident: CR11 – volume: 24 start-page: 695 issue: 5 year: 2002 end-page: 701 ident: CR12 article-title: Diabetic neuropathies in brain are induced by deficiency of BDNF publication-title: Neurotoxicol Teratol doi: 10.1016/S0892-0362(02)00220-9 – volume: 438 start-page: 1017 issue: 7070 year: 2005 end-page: 1021 ident: CR13 article-title: BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain publication-title: Nature doi: 10.1038/nature04223 – volume: 39 start-page: 1439 year: 2014 end-page: 1454 ident: CR32 article-title: BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals publication-title: Eur J Neurosci doi: 10.1111/ejn.12516 – volume: 108 start-page: 297 issue: 3 year: 2002 end-page: 300 ident: CR16 article-title: No DREAM, no pain: closing the spinal gate publication-title: Cell doi: 10.1016/S0092-8674(02)00640-2 – volume: 86 start-page: 301 year: 2014 end-page: 310 ident: CR39 article-title: Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2014.08.001 – volume: 64 start-page: 1231 issue: 3 year: 1995 end-page: 1237 ident: CR34 article-title: Altered neurotrophin mRNA levels in peripheral nerve and skeletal muscle of experimentally diabetic rats publication-title: J Neurochem doi: 10.1046/j.1471-4159.1995.64031231.x – volume: 13 start-page: 150 issue: 2 year: 2011 end-page: 159 ident: CR33 article-title: Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cord publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2010.01333.x – volume: 114 start-page: 1460 issue: 5 year: 2010 end-page: 1475 ident: CR35 article-title: Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor publication-title: J Neurochem – volume: 115 start-page: 71 issue: 1–2 year: 2005 ident: 411_CR20 publication-title: Pain doi: 10.1016/j.pain.2005.02.009 – volume: 108 start-page: 31 issue: 1 year: 2002 ident: 411_CR17 publication-title: Cell doi: 10.1016/S0092-8674(01)00629-8 – volume: 825 start-page: 59 issue: 1–2 year: 1999 ident: 411_CR26 publication-title: Brain Res doi: 10.1016/S0006-8993(99)01186-5 – volume: 85 start-page: 297 issue: 3 year: 2008 ident: 411_CR10 publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2008.04.004 – volume: 12 start-page: 2677 issue: 2 year: 2015 ident: 411_CR29 publication-title: Mol Med Rep doi: 10.3892/mmr.2015.3735 – volume: 114 start-page: 1460 issue: 5 year: 2010 ident: 411_CR35 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2010.06863.x – volume: 26 start-page: 126 issue: 1 year: 2006 ident: 411_CR5 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3686-05.2006 – volume: 661 start-page: 15 issue: 1–3 year: 2011 ident: 411_CR19 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2011.04.014 – volume: 449 start-page: 234 issue: 3 year: 2009 ident: 411_CR30 publication-title: Neurosci Lett doi: 10.1016/j.neulet.2008.11.009 – ident: 411_CR11 doi: 10.1016/j.expneurol.2010.01.003 – volume: 24 start-page: 695 issue: 5 year: 2002 ident: 411_CR12 publication-title: Neurotoxicol Teratol doi: 10.1016/S0892-0362(02)00220-9 – volume: 163 start-page: 385 issue: 2 year: 2003 ident: 411_CR9 publication-title: J Cell Biol doi: 10.1083/jcb.200305134 – volume: 21 start-page: 570 issue: 5 year: 2008 ident: 411_CR14 publication-title: Curr Opin Anaesthesiol doi: 10.1097/ACO.0b013e32830edbdf – volume: 64 start-page: 1231 issue: 3 year: 1995 ident: 411_CR34 publication-title: J Neurochem doi: 10.1046/j.1471-4159.1995.64031231.x – volume: 2014 start-page: 1 year: 2014 ident: 411_CR4 publication-title: Int J Endocrinol doi: 10.1155/2014/674987 – volume: 1020 start-page: 215 year: 2013 ident: 411_CR21 publication-title: Methods Mol Biol doi: 10.1007/978-1-62703-459-3_14 – volume: 96 start-page: 9385 issue: 16 year: 1999 ident: 411_CR6 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.96.16.9385 – volume: 11 start-page: 1056 issue: 11 year: 2010 ident: 411_CR31 publication-title: J Pain doi: 10.1016/j.jpain.2010.01.268 – volume: 7 start-page: 17 year: 2016 ident: 411_CR36 publication-title: J Diabetes Invest doi: 10.1111/jdi.12379 – volume: 11 start-page: 1164 issue: 6 year: 2015 ident: 411_CR38 publication-title: Arch Med Sci doi: 10.5114/aoms.2015.56342 – volume: 33 start-page: 2285 issue: 10 year: 2010 ident: 411_CR2 publication-title: Diabetes Care doi: 10.2337/dc10-1303 – volume: 25 start-page: 322 issue: 2 year: 2011 ident: 411_CR37 publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2010.09.025 – volume: 398 start-page: 80 issue: 6722 year: 1999 ident: 411_CR15 publication-title: Nature doi: 10.1038/18044 – volume: 23 start-page: 9097 issue: 27 year: 2003 ident: 411_CR18 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.23-27-09097.2003 – volume: 119 start-page: 329 issue: 3 year: 2012 ident: 411_CR22 publication-title: J Neural Transm doi: 10.1007/s00702-011-0713-7 – volume: 26 start-page: 255 issue: 3 year: 2013 ident: 411_CR27 publication-title: Korean J Pain doi: 10.3344/kjp.2013.26.3.255 – volume: 728 start-page: 59 year: 2014 ident: 411_CR1 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2014.01.057 – volume: 560 start-page: 142 issue: 2–3 year: 2007 ident: 411_CR28 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2007.01.013 – volume: 9 start-page: 2969 year: 2008 ident: 411_CR3 publication-title: Expert Opin Pharmacother doi: 10.1517/14656560802498149 – volume: 438 start-page: 1017 issue: 7070 year: 2005 ident: 411_CR13 publication-title: Nature doi: 10.1038/nature04223 – volume: 6 start-page: Doc05 year: 2008 ident: 411_CR25 publication-title: Ger Med Sci – volume: 39 start-page: 1439 year: 2014 ident: 411_CR32 publication-title: Eur J Neurosci doi: 10.1111/ejn.12516 – volume: 108 start-page: 297 issue: 3 year: 2002 ident: 411_CR16 publication-title: Cell doi: 10.1016/S0092-8674(02)00640-2 – volume: 13 start-page: 150 issue: 2 year: 2011 ident: 411_CR33 publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2010.01333.x – volume: 105 start-page: 215 year: 2015 ident: 411_CR23 publication-title: Fitoterapia doi: 10.1016/j.fitote.2015.07.011 – volume: 72 start-page: 609 year: 2003 ident: 411_CR8 publication-title: Annu Rev Biochem doi: 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This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM... This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM... Aim This study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM... AimThis study investigates the effects of minocycline (an inhibitor of microglial activation) administration on the expression level of spinal BDNF and DREAM... |
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| StartPage | 181 |
| SubjectTerms | Antibiotics Development and progression Diabetes Diabetic neuropathies Diabetic neuropathy Endocrinology Formaldehyde Gene expression Hyperglycemia Immunohistochemistry Laboratory rats Medicine Medicine & Public Health Metabolic Diseases Minocycline Proteins Research Article Rodents Spinal cord Streptozocin |
| Title | Minocycline attenuates the development of diabetic neuropathy by modulating DREAM and BDNF protein expression in rat spinal cord |
| URI | https://link.springer.com/article/10.1007/s40200-019-00411-4 https://www.ncbi.nlm.nih.gov/pubmed/31275889 https://www.proquest.com/docview/2242862746 https://www.proquest.com/docview/2253283381 https://pubmed.ncbi.nlm.nih.gov/PMC6582076 |
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