Effect of VKORC1 – 1639 G > A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients - Yoshizawa, Misa; Hayashi, Hideki; Tashiro, Yoshio; Sakawa, Sonoko; Moriwaki, Hideaki; Akimoto, Takehide; Doi, Osamu; Kimura, Midori; Kawarasaki, Yoshinori; Inoue, Kazuyuki; Itoh, Kunihiko (Thrombosis research, 2009)
Keywords: Adult; Aged; Aged, 80 and over; Algorithms; Alleles; Anticoagulants - administration & dosage; Anticoagulants - therapeutic use; Aryl Hydrocarbon Hydroxylases; Biological and medical sciences; Blood and lymphatic vessels; Blood. Blood coagulation. Reticuloendothelial system; Body Weight - genetics; Cardiology. Vascular system; CYP2C9; Cytochrome P-450 CYP2C9; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dosing algorithm; Female; Gene Frequency; Genetic polymorphisms; Genotype; Hematology, Oncology and Palliative Medicine; Humans; Japan - epidemiology; Linear Models; Male; Medical sciences; Middle Aged; Mixed Function Oxygenases - genetics; Pharmacology. Drug treatments; Polymorphism, Genetic; Retrospective analysis; Retrospective Studies; Serum Albumin - genetics; Vitamin K Epoxide Reductases; VKORC1; Warfarin; Warfarin - administration & dosage; Warfarin - therapeutic use; VKORC1; FDA; Warfarin; Retrospective analysis; PCR-RFLP; Genetic polymorphisms; Dosing algorithm; CYP2C9; ANCOVA; SNP; GGCX; ANOVA; V max; MD; K m; PT-INR; single nucleotide polymorphism; maintenance dose; analysis of variance; Cytochrome P450 2C9; polymerase chain reaction-restriction fragment length polymorphism; Food and Drug Administration; γ-glutamylcarboxylase; prothrombin time normalized as an international normalized ratio; Michaelis constant; maximum velocity; Vitamin K epoxide reductase complex subunit 1; analysis of covariance; Human; Coumarine derivatives; Body weight; Albumin; Cardiovascular disease; Anticoagulant; Japanese; Antivitamin K; Polymorphism