Cetylpyridinium Chloride-Containing Mouthwashes Show Virucidal Activity against Herpes Simplex Virus Type 1
The oral cavity is particularly susceptible to viral infections that are self-recovering in most cases. However, complications may appear in severe cases and/or immunocompromised subjects. Cetylpyridinium chloride (CPC)-containing mouthwashes are able to decrease the infectivity of the SARS-CoV-2 vi...
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| Published in | Viruses Vol. 15; no. 7; p. 1433 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
25.06.2023
MDPI |
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| Online Access | Get full text |
| ISSN | 1999-4915 1999-4915 |
| DOI | 10.3390/v15071433 |
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| Abstract | The oral cavity is particularly susceptible to viral infections that are self-recovering in most cases. However, complications may appear in severe cases and/or immunocompromised subjects. Cetylpyridinium chloride (CPC)-containing mouthwashes are able to decrease the infectivity of the SARS-CoV-2 virus by disrupting the integrity of the viral envelope. Here, we show that CPC, as the active ingredient contained in commercialized, exerts significant antiviral activity against enveloped viruses, such as HSV-1, but not against non-enveloped viruses, such as HPV. CPC-containing mouthwashes have been used as antiseptics for decades, and thus, they can represent a cost-effective measure to limit infection and spread of enveloped viruses infecting the oral cavity, aiding in reducing viral transmission. |
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| AbstractList | The oral cavity is particularly susceptible to viral infections that are self-recovering in most cases. However, complications may appear in severe cases and/or immunocompromised subjects. Cetylpyridinium chloride (CPC)-containing mouthwashes are able to decrease the infectivity of the SARS-CoV-2 virus by disrupting the integrity of the viral envelope. Here, we show that CPC, as the active ingredient contained in commercialized, exerts significant antiviral activity against enveloped viruses, such as HSV-1, but not against non-enveloped viruses, such as HPV. CPC-containing mouthwashes have been used as antiseptics for decades, and thus, they can represent a cost-effective measure to limit infection and spread of enveloped viruses infecting the oral cavity, aiding in reducing viral transmission. The oral cavity is particularly susceptible to viral infections that are self-recovering in most cases. However, complications may appear in severe cases and/or immunocompromised subjects. Cetylpyridinium chloride (CPC)-containing mouthwashes are able to decrease the infectivity of the SARS-CoV-2 virus by disrupting the integrity of the viral envelope. Here, we show that CPC, as the active ingredient contained in commercialized, exerts significant antiviral activity against enveloped viruses, such as HSV-1, but not against non-enveloped viruses, such as HPV. CPC-containing mouthwashes have been used as antiseptics for decades, and thus, they can represent a cost-effective measure to limit infection and spread of enveloped viruses infecting the oral cavity, aiding in reducing viral transmission.The oral cavity is particularly susceptible to viral infections that are self-recovering in most cases. However, complications may appear in severe cases and/or immunocompromised subjects. Cetylpyridinium chloride (CPC)-containing mouthwashes are able to decrease the infectivity of the SARS-CoV-2 virus by disrupting the integrity of the viral envelope. Here, we show that CPC, as the active ingredient contained in commercialized, exerts significant antiviral activity against enveloped viruses, such as HSV-1, but not against non-enveloped viruses, such as HPV. CPC-containing mouthwashes have been used as antiseptics for decades, and thus, they can represent a cost-effective measure to limit infection and spread of enveloped viruses infecting the oral cavity, aiding in reducing viral transmission. |
| Audience | Academic |
| Author | León, Rubén Ballana, Ester Bañó-Polo, Manuel Blanc, Vanessa Clotet, Bonaventura Riveira-Muñoz, Eva Garcia-Vidal, Edurne |
| AuthorAffiliation | 2 Department of Microbiology, Dentaid Research Center, 08290 Cerdanyola del Vallès, Spain; manuel.bano@dentaid.es (M.B.-P.); leon@dentaid.es (R.L.); blanc@dentaid.es (V.B.) 1 IrsiCaixa AIDS Research Institute, Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, Spain; eriveira@irsicaixa.es (E.R.-M.); egvidal@irsicaixa.es (E.G.-V.); bclotet@irsicaixa.es (B.C.) |
| AuthorAffiliation_xml | – name: 2 Department of Microbiology, Dentaid Research Center, 08290 Cerdanyola del Vallès, Spain; manuel.bano@dentaid.es (M.B.-P.); leon@dentaid.es (R.L.); blanc@dentaid.es (V.B.) – name: 1 IrsiCaixa AIDS Research Institute, Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, Spain; eriveira@irsicaixa.es (E.R.-M.); egvidal@irsicaixa.es (E.G.-V.); bclotet@irsicaixa.es (B.C.) |
| Author_xml | – sequence: 1 givenname: Eva surname: Riveira-Muñoz fullname: Riveira-Muñoz, Eva – sequence: 2 givenname: Edurne surname: Garcia-Vidal fullname: Garcia-Vidal, Edurne – sequence: 3 givenname: Manuel orcidid: 0000-0002-4840-4480 surname: Bañó-Polo fullname: Bañó-Polo, Manuel – sequence: 4 givenname: Rubén surname: León fullname: León, Rubén – sequence: 5 givenname: Vanessa surname: Blanc fullname: Blanc, Vanessa – sequence: 6 givenname: Bonaventura surname: Clotet fullname: Clotet, Bonaventura – sequence: 7 givenname: Ester orcidid: 0000-0002-5215-7363 surname: Ballana fullname: Ballana, Ester |
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| CitedBy_id | crossref_primary_10_1371_journal_pone_0297291 crossref_primary_10_3390_molecules29163802 crossref_primary_10_7759_cureus_58301 crossref_primary_10_1111_fcp_12972 crossref_primary_10_3389_fphar_2024_1451083 crossref_primary_10_3390_microorganisms13040734 |
| Cites_doi | 10.3402/jom.v2i0.2127 10.1016/j.antiviral.2020.104818 10.1038/s41392-022-00974-4 10.4103/0975-7406.163577 10.1128/AEM.02633-14 10.1128/AAC.00576-20 10.1038/ijos.2016.18 10.1038/s41598-021-03461-y 10.20411/pai.v2i2.200 10.1099/jmm.0.001508 10.1016/j.cmi.2021.05.028 10.1067/moe.2001.115392 10.1128/AAC.43.2.314 10.1016/j.jdent.2021.103768 10.1089/vim.2005.18.170 10.1016/j.bjoms.2020.08.016 10.3389/fonc.2019.00355 10.1093/jac/dkv363 10.1177/00220345221102310 10.1016/S0168-1702(02)00055-2 10.1038/s41598-022-18367-6 10.1016/S1473-3099(02)00317-1 10.1002/jmv.28412 10.1016/0030-4220(85)90163-X 10.1111/jcpe.13746 10.1177/00220345211029269 |
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| Copyright | COPYRIGHT 2023 MDPI AG 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 by the authors. 2023 |
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| SubjectTerms | active ingredients Antiseptics Antiviral activity Antiviral drugs antiviral properties Brief Report Cetylpyridinium chloride Chlorides commercialization Control Coronaviruses cost effectiveness CPC Cytomegalovirus Dental plaque Dichloropropane enveloped viruses Flow cytometry Health aspects Herpes simplex Herpes simplex virus Herpes viruses HIV HPV HSV Human alphaherpesvirus 1 Human immunodeficiency virus Human papillomavirus Immune system Infections Infectivity Intensive care Medical research mouth Mouthwashes Oral cavity oral infection pathogenicity Pharmaceutical research Plasmids Severe acute respiratory syndrome coronavirus 2 Surfactants Viral infections virus transmission Viruses |
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| Title | Cetylpyridinium Chloride-Containing Mouthwashes Show Virucidal Activity against Herpes Simplex Virus Type 1 |
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