A Phase I, dose-escalation trial in adults of three recombinant attenuated Salmonella Typhi vaccine vectors producing Streptococcus pneumoniae surface protein antigen PspA - Frey, Sharon E.; Lottenbach, Kathleen R.; Hill, Heather; Blevins, Tamara P.; Yu, Yinyi; Zhang, Ying; Brenneman, Karen E.; Kelly-Aehle, Sandra M.; McDonald, Caitlin; Jansen, Angela; Curtiss, Roy (Vaccine, 2013)
Keywords: Administration, Oral; Adult; adults; Allergy and Immunology; Animals; Antibodies, Bacterial - blood; antigens; Applied microbiology; Bacterial Proteins - genetics; Bacterial Proteins - immunology; Bacteriology; Biological and medical sciences; blood; Drug Carriers; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; ELISA; ELISPOT; Enzyme-Linked Immunosorbent Assay; Enzyme-Linked Immunospot Assay; Female; Fundamental and applied biological sciences. Psychology; Humans; immune response; immunoglobulin A; Immunoglobulin A - blood; immunoglobulin G; Immunoglobulin G - blood; lipopolysaccharides; Male; Microbiology; Miscellaneous; outer membrane proteins; Pneumococcal surface protein A; Pneumococcal Vaccines - administration & dosage; Pneumococcal Vaccines - adverse effects; Pneumococcal Vaccines - genetics; Pneumococcal Vaccines - immunology; Salmonella enterica; Salmonella Typhi; Salmonella typhi - genetics; Salmonella Typhi vaccine vector; Salmonella typhimurium; Streptococcus pneumoniae; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - immunology; surface proteins; Typhoid-Paratyphoid Vaccines - administration & dosage; Typhoid-Paratyphoid Vaccines - adverse effects; Typhoid-Paratyphoid Vaccines - genetics; Typhoid-Paratyphoid Vaccines - immunology; vaccination; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - adverse effects; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Young Adult; Salmonella Typhi vaccine vector; Pneumococcal surface protein A; ELISPOT; Streptococcus pneumoniae; ELISA; Salmonella typhi; Vaccine; Protein; Antigen; Streptococcaceae; Phase I trial; Bacteria; Micrococcales; ELISPOT assay; ELISA assay; Vector; Enterobacteriaceae