Warning SINEs: Alu elements, evolution of the human brain, and the spectrum of neurological disease

Alu elements are a highly successful family of primate-specific retrotransposons that have fundamentally shaped primate evolution, including the evolution of our own species. Alu s play critical roles in the formation of neurological networks and the epigenetic regulation of biochemical processes th...

Full description

Saved in:
Bibliographic Details
Published inChromosome research Vol. 26; no. 1-2; pp. 93 - 111
Main Authors Larsen, Peter A., Hunnicutt, Kelsie E., Larsen, Roxanne J., Yoder, Anne D., Saunders, Ann M.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2018
Springer Nature B.V
Subjects
Alu elements
Alu Elements - physiology
Animal Genetics and Genomics
biochemical pathways
Biological Evolution
Biomedical and Life Sciences
brain
Brain - physiology
Cell Biology
Central nervous system
Chemical elements
Cognition
Disease
Epigenetics
Evolution
Genome, Human
Homeostasis
Human Genetics
Humans
Life Sciences
Mitochondria
Mitochondrial DNA
mitochondrial genes
Nervous System Diseases - genetics
Neurodegenerative diseases
Neurogenesis
Neurological diseases
Neurological disorders
neurons
Original
Original Article
Parkinson's disease
Plant Genetics and Genomics
Retroelements
retrotransposons
Spectrum analysis
Brain connectome
A-to-I editing
Mitochondria
Alzheimer’s disease
Epigenetics
Mosaic brain
Parkinson’s disease
Online AccessGet full text
ISSN0967-3849
1573-6849
1573-6849
DOI10.1007/s10577-018-9573-4

Cover

Abstract Alu elements are a highly successful family of primate-specific retrotransposons that have fundamentally shaped primate evolution, including the evolution of our own species. Alu s play critical roles in the formation of neurological networks and the epigenetic regulation of biochemical processes throughout the central nervous system (CNS), and thus are hypothesized to have contributed to the origin of human cognition. Despite the benefits that Alus provide, deleterious Alu activity is associated with a number of neurological and neurodegenerative disorders. In particular, neurological networks are potentially vulnerable to the epigenetic dysregulation of Alu elements operating across the suite of nuclear-encoded mitochondrial genes that are critical for both mitochondrial and CNS function. Here, we highlight the beneficial neurological aspects of Alu elements as well as their potential to cause disease by disrupting key cellular processes across the CNS. We identify at least 37 neurological and neurodegenerative disorders wherein deleterious Alu activity has been implicated as a contributing factor for the manifestation of disease, and for many of these disorders, this activity is operating on genes that are essential for proper mitochondrial function. We conclude that the epigenetic dysregulation of Alu elements can ultimately disrupt mitochondrial homeostasis within the CNS. This mechanism is a plausible source for the incipient neuronal stress that is consistently observed across a spectrum of sporadic neurological and neurodegenerative disorders.
AbstractList Alu elements are a highly successful family of primate-specific retrotransposons that have fundamentally shaped primate evolution, including the evolution of our own species. Alus play critical roles in the formation of neurological networks and the epigenetic regulation of biochemical processes throughout the central nervous system (CNS), and thus are hypothesized to have contributed to the origin of human cognition. Despite the benefits that Alus provide, deleterious Alu activity is associated with a number of neurological and neurodegenerative disorders. In particular, neurological networks are potentially vulnerable to the epigenetic dysregulation of Alu elements operating across the suite of nuclear-encoded mitochondrial genes that are critical for both mitochondrial and CNS function. Here, we highlight the beneficial neurological aspects of Alu elements as well as their potential to cause disease by disrupting key cellular processes across the CNS. We identify at least 37 neurological and neurodegenerative disorders wherein deleterious Alu activity has been implicated as a contributing factor for the manifestation of disease, and for many of these disorders, this activity is operating on genes that are essential for proper mitochondrial function. We conclude that the epigenetic dysregulation of Alu elements can ultimately disrupt mitochondrial homeostasis within the CNS. This mechanism is a plausible source for the incipient neuronal stress that is consistently observed across a spectrum of sporadic neurological and neurodegenerative disorders.Alu elements are a highly successful family of primate-specific retrotransposons that have fundamentally shaped primate evolution, including the evolution of our own species. Alus play critical roles in the formation of neurological networks and the epigenetic regulation of biochemical processes throughout the central nervous system (CNS), and thus are hypothesized to have contributed to the origin of human cognition. Despite the benefits that Alus provide, deleterious Alu activity is associated with a number of neurological and neurodegenerative disorders. In particular, neurological networks are potentially vulnerable to the epigenetic dysregulation of Alu elements operating across the suite of nuclear-encoded mitochondrial genes that are critical for both mitochondrial and CNS function. Here, we highlight the beneficial neurological aspects of Alu elements as well as their potential to cause disease by disrupting key cellular processes across the CNS. We identify at least 37 neurological and neurodegenerative disorders wherein deleterious Alu activity has been implicated as a contributing factor for the manifestation of disease, and for many of these disorders, this activity is operating on genes that are essential for proper mitochondrial function. We conclude that the epigenetic dysregulation of Alu elements can ultimately disrupt mitochondrial homeostasis within the CNS. This mechanism is a plausible source for the incipient neuronal stress that is consistently observed across a spectrum of sporadic neurological and neurodegenerative disorders.
Alu elements are a highly successful family of primate-specific retrotransposons that have fundamentally shaped primate evolution, including the evolution of our own species. Alu s play critical roles in the formation of neurological networks and the epigenetic regulation of biochemical processes throughout the central nervous system (CNS), and thus are hypothesized to have contributed to the origin of human cognition. Despite the benefits that Alus provide, deleterious Alu activity is associated with a number of neurological and neurodegenerative disorders. In particular, neurological networks are potentially vulnerable to the epigenetic dysregulation of Alu elements operating across the suite of nuclear-encoded mitochondrial genes that are critical for both mitochondrial and CNS function. Here, we highlight the beneficial neurological aspects of Alu elements as well as their potential to cause disease by disrupting key cellular processes across the CNS. We identify at least 37 neurological and neurodegenerative disorders wherein deleterious Alu activity has been implicated as a contributing factor for the manifestation of disease, and for many of these disorders, this activity is operating on genes that are essential for proper mitochondrial function. We conclude that the epigenetic dysregulation of Alu elements can ultimately disrupt mitochondrial homeostasis within the CNS. This mechanism is a plausible source for the incipient neuronal stress that is consistently observed across a spectrum of sporadic neurological and neurodegenerative disorders.
Alu elements are a highly successful family of primate-specific retrotransposons that have fundamentally shaped primate evolution, including the evolution of our own species. Alus play critical roles in the formation of neurological networks and the epigenetic regulation of biochemical processes throughout the central nervous system (CNS), and thus are hypothesized to have contributed to the origin of human cognition. Despite the benefits that Alus provide, deleterious Alu activity is associated with a number of neurological and neurodegenerative disorders. In particular, neurological networks are potentially vulnerable to the epigenetic dysregulation of Alu elements operating across the suite of nuclear-encoded mitochondrial genes that are critical for both mitochondrial and CNS function. Here, we highlight the beneficial neurological aspects of Alu elements as well as their potential to cause disease by disrupting key cellular processes across the CNS. We identify at least 37 neurological and neurodegenerative disorders wherein deleterious Alu activity has been implicated as a contributing factor for the manifestation of disease, and for many of these disorders, this activity is operating on genes that are essential for proper mitochondrial function. We conclude that the epigenetic dysregulation of Alu elements can ultimately disrupt mitochondrial homeostasis within the CNS. This mechanism is a plausible source for the incipient neuronal stress that is consistently observed across a spectrum of sporadic neurological and neurodegenerative disorders.
Author Yoder, Anne D.
Larsen, Roxanne J.
Saunders, Ann M.
Larsen, Peter A.
Hunnicutt, Kelsie E.
Author_xml – sequence: 1
  givenname: Peter A.
  surname: Larsen
  fullname: Larsen, Peter A.
  email: peter.larsen@duke.edu
  organization: Department of Biology, Duke University, Duke Lemur Center, Duke University, Department of Biology, Duke University
– sequence: 2
  givenname: Kelsie E.
  surname: Hunnicutt
  fullname: Hunnicutt, Kelsie E.
  organization: Department of Biology, Duke University
– sequence: 3
  givenname: Roxanne J.
  surname: Larsen
  fullname: Larsen, Roxanne J.
  organization: Duke University School of Medicine, Duke University
– sequence: 4
  givenname: Anne D.
  surname: Yoder
  fullname: Yoder, Anne D.
  organization: Department of Biology, Duke University, Duke Lemur Center, Duke University
– sequence: 5
  givenname: Ann M.
  surname: Saunders
  fullname: Saunders, Ann M.
  organization: Zinfandel Pharmaceuticals Inc
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29460123$$D View this record in MEDLINE/PubMed
BookMark eNqNkk1rFTEUhoNU7G31B7iRgBsXHc3HZJK4KJRStVB0oeIyZHLP3JuSSa7JTMF_b8bb-lFQXOWQPO_LOTnvETqIKQJCTyl5SQmRrwolQsqGUNVoIXnTPkAruhSdavUBWhHdyYbX-hAdlXJNCFG8pY_QIdNtRyjjK-S-2Bx93OCPl-8vymt8FmYMAUaIUznBcJPCPPkUcRrwtAW8nUcbcZ-tjyfYxvWPy7IDN-V5XKAIc04hbbyzAa99AVvgMXo42FDgye15jD6_ufh0_q65-vD28vzsqnGi01PTKqeJYm1HVde7ThLCFR1aMTghB9szqgemFeiuV0Qr2w4ge0rFIBWABMH5MTrd--7mfoS1qzNkG8wu-9HmbyZZb_58iX5rNunGCCUkk6oavLg1yOnrDGUyoy8OQrAR0lwMI4IrSfV_oURSKrnQFX1-D71Oc471JxaKMyEEFZV69nvzP7u-W1UF5B5wOZWSYTDOT3ZZTp3FB0OJWUJh9qEwNRRmCYVpq5LeU96Z_0vD9ppS2biB_Kvpv4u-A1Aex-M
CitedBy_id crossref_primary_10_1093_nargab_lqac009
crossref_primary_10_1038_s41467_022_30181_2
crossref_primary_10_3390_genes14040858
crossref_primary_10_1007_s12311_020_01192_w
crossref_primary_10_1093_molbev_msae123
crossref_primary_10_1042_BST20230757
crossref_primary_10_3233_JAD_191258
crossref_primary_10_1093_nar_gky1301
crossref_primary_10_1172_JCI143397
crossref_primary_10_1007_s11427_018_9447_8
crossref_primary_10_1242_dev_175786
crossref_primary_10_1007_s40610_020_00134_z
crossref_primary_10_1016_j_arr_2024_102539
crossref_primary_10_1093_nar_gkac1129
crossref_primary_10_3390_ijms23105847
crossref_primary_10_1266_ggs_23_00140
crossref_primary_10_3390_ijms24087518
crossref_primary_10_1016_j_neubiorev_2021_09_049
crossref_primary_10_3233_JAD_231184
crossref_primary_10_1007_s11033_021_06258_4
crossref_primary_10_1016_j_neubiorev_2021_03_019
crossref_primary_10_1093_brain_awaa015
crossref_primary_10_18632_aging_203020
crossref_primary_10_1093_nar_gkaa074
crossref_primary_10_1007_s11357_018_00050_2
crossref_primary_10_1371_journal_pone_0261170
crossref_primary_10_3389_fnins_2024_1445540
crossref_primary_10_3389_fpsyt_2021_637789
crossref_primary_10_1002_mds_29280
crossref_primary_10_1038_s42003_022_03011_w
crossref_primary_10_3389_fgene_2021_767341
crossref_primary_10_1016_j_biopsych_2022_04_021
crossref_primary_10_15252_embr_202052255
crossref_primary_10_15302_J_FASE_2019307
crossref_primary_10_3389_fbinf_2022_1062328
crossref_primary_10_1371_journal_pone_0234578
crossref_primary_10_1186_s13100_018_0138_z
crossref_primary_10_3233_JAD_220643
crossref_primary_10_3389_fnmol_2018_00163
crossref_primary_10_1093_bib_bbab259
crossref_primary_10_3390_life11050376
crossref_primary_10_17650_2222_8721_2020_10_3_27_34
crossref_primary_10_1186_s12864_024_10201_9
crossref_primary_10_1111_jnc_15445
crossref_primary_10_1080_20905068_2024_2368693
crossref_primary_10_3390_ijms23052469
crossref_primary_10_1002_1873_3468_14205
Cites_doi 10.1177/193229680800200619
10.1016/j.ymgme.2006.09.005
10.1016/S0027-5107(01)00065-3
10.3233/JAD-2006-10113
10.1186/1756-6606-2-13
10.1016/j.mce.2016.02.008
10.1038/ejhg.2012.29
10.1146/annurev.neuro.30.051606.094232
10.1186/s13148-017-0395-6
10.1038/gim.2015.124
10.1016/j.molcel.2009.06.027
10.1016/j.tig.2004.12.005
10.1038/ng.2414
10.1016/j.jalz.2011.03.005
10.1073/pnas.1704117114
10.3390/genes6030577
10.1073/pnas.1310914110
10.1038/ncomms9207
10.1038/tpj.2009.69
10.3233/JAD-2005-7107
10.1080/15476286.2017.1306173
10.1016/S0378-1119(03)00805-9
10.1016/j.bbagen.2011.08.008
10.1016/j.cell.2012.03.036
10.1371/journal.pone.0182448
10.1038/srep25589
10.1371/journal.pcbi.1000610
10.1002/hbm.22555
10.1097/00001756-200203040-00019
10.1038/nrneurol.2010.180
10.1038/1214
10.1152/physrev.00036.2006
10.1016/j.gde.2003.10.013
10.1186/1471-2164-8-23
10.1038/nature05292
10.1186/gb-2011-12-12-236
10.1038/nature24041
10.1038/srep41095
10.1016/j.jalz.2016.12.009
10.1371/journal.pgen.1005827
10.1101/cshperspect.a023622
10.1186/s12915-017-0409-z
10.1016/j.tig.2015.12.005
10.1261/rna.058271.116
10.1016/j.jalz.2016.03.015
10.1016/j.jalz.2016.06.006
10.1007/s11910-009-0032-7
10.1038/312171a0
10.1038/nature09544
10.1038/srep43421
10.1016/j.nbd.2017.04.020
10.1016/j.semcancer.2010.06.001
10.1016/j.neurobiolaging.2015.11.017
10.1007/s00439-017-1832-5
10.1212/WNL.0000000000001883
10.1002/humu.21474
10.1093/nar/gkv1003
10.1016/j.tins.2016.06.006
10.1016/j.coviro.2013.09.002
10.1007/s11064-008-9865-8
10.1186/gb-2014-15-2-r28
10.1038/nn.4337
10.1186/s13059-016-0876-5
10.1371/journal.pone.0070386
10.1038/nature03663
10.1016/S0896-6273(02)00660-8
10.1371/journal.pgen.1000225
10.1146/annurev.genom.1.1.507
10.1016/j.gene.2009.01.013
10.1261/rna.061317.117
10.1002/ajmg.a.38181
10.18097/pbmc20166206630
10.1016/j.jalz.2017.01.017
10.3389/fmicb.2017.02252
10.1038/nature10531
10.1007/s00439-017-1837-0
10.1186/1471-2164-12-617
10.1016/j.gene.2009.08.006
10.1186/s13073-016-0317-9
10.1007/s12035-016-0055-4
10.1038/emboj.2012.38
10.1093/hmg/ddp443
10.1016/j.ajhg.2014.06.014
10.1016/j.neures.2011.02.005
10.1126/science.aac7247
10.1126/science.1082588
10.1016/S0378-1119(01)00637-0
10.1073/pnas.90.5.1977
10.4161/cc.7.21.6927
10.1186/s13024-015-0064-1
10.1016/S0378-1119(97)00399-5
10.1038/nrn3730
10.1016/j.cmet.2014.01.010
10.1002/(SICI)1098-1004(200004)15:4<316::AID-HUMU3>3.0.CO;2-9
10.1126/science.1077209
10.1038/nrg798
10.1098/rstb.2013.0504
10.1080/15476286.2016.1269999
10.1038/nature18933
10.1101/gr.162537.113
10.1038/gim.2011.7
10.1038/srep44465
10.1001/archneurol.2010.88
10.1016/j.tcb.2017.01.002
10.1111/bph.13175
10.1083/jcb.141.4.1031
10.1093/hmg/ddq306
10.1016/j.ymgme.2007.06.018
10.1517/17425255.2016.1133586
10.1186/s13100-016-0070-z
10.1152/physiolgenomics.00146.2009
10.1016/j.schres.2017.05.003
10.1074/jbc.M115.642173
10.1093/hmg/ddt319
10.1016/j.brainres.2011.07.052
10.1073/pnas.1012834108
10.1093/hmg/ddx233
10.1073/pnas.1411260111
10.1038/nn.3539
10.4161/rna.3.1.2495
10.1016/S1474-4422(17)30299-5
10.1016/j.jalz.2010.01.011
10.1038/427801a
10.1016/j.euroneuro.2014.06.002
10.1006/exnr.1998.6977
10.1093/hmg/ddv146
10.1101/gr.2530404
10.1074/jbc.270.39.22777
10.1371/journal.pone.0117854
10.1002/humu.10072
10.1016/j.ymgme.2006.06.010
10.3233/JAD-2010-100339
10.4161/15476286.2014.992286
10.1038/nrg2640
10.1101/gr.164749.113
10.1074/jbc.M113.535112
10.1186/1756-6606-7-5
10.1096/fj.10-157032
10.1016/j.ymgme.2007.01.003
10.1186/s12863-016-0395-0
10.1016/j.coisb.2016.12.004
10.1038/nature09830
10.1093/nar/gkw767
10.1016/j.neuron.2013.10.053
10.1016/B978-0-12-385883-2.00005-9
10.1101/cshperspect.a011304
10.1016/S0002-9440(10)64463-X
10.1016/j.tins.2008.02.003
10.1038/nature11082
10.1038/nn.4017
10.1002/mgg3.89
10.1016/j.tics.2013.09.012
10.1038/nrn2967
10.3892/or.2015.3907
10.1523/JNEUROSCI.1469-06.2006
10.4161/epi.29676
10.1038/srep14941
10.3389/fnagi.2015.00094
10.1007/s00232-011-9372-8
10.1023/B:NERE.0000014820.99232.8a
10.1006/mgme.1999.2864
10.1038/nrm.2015.4
10.1038/tp.2016.121
10.1016/j.braindev.2006.05.012
10.1002/humu.22603
10.1074/jbc.M116.727248
10.2217/epi.15.107
10.1016/j.mad.2008.12.003
10.1126/science.aak9761
10.1007/s00439-013-1322-3
10.1007/s10048-014-0429-6
10.1212/NXG.0000000000000073
10.1016/j.cub.2017.09.015
10.1002/ajmg.a.38381
10.1261/rna.035667.112
10.1261/rna.054627.115
10.1186/1471-2164-7-133
10.1002/humu.20682
10.1038/nrn2212
10.1073/pnas.92.18.8229
10.1073/pnas.1403814111
10.1038/nsmb.3318
10.1371/journal.pbio.0020391
10.1523/JNEUROSCI.0884-11.2011
10.1261/rna.165106
10.1016/0140-6736(93)91709-U
10.1002/(SICI)1098-1004(1999)13:6<431::AID-HUMU2>3.0.CO;2-Y
10.1186/1759-8753-2-8
10.1111/j.1749-6632.2000.tb05554.x
10.1126/sciadv.1600584
10.1007/s00439-011-1083-9
10.1007/s00439-016-1736-9
10.1016/j.gde.2016.01.001
10.1002/ajmg.a.31441
10.1016/j.bcp.2013.12.012
10.1016/j.molcel.2007.12.013
10.1007/s10048-010-0272-3
10.1093/gbe/evu142
10.1016/j.neuron.2013.01.012
10.1007/s00109-004-0599-z
10.1016/j.molcel.2015.03.027
10.1126/science.aac6428
10.1046/j.1365-2559.2001.01082.x
10.1016/0092-8674(95)90274-0
10.1038/ncomms7569
10.3233/JAD-2011-110911
10.1242/dmm.021766
10.1038/nm1066
10.1093/molbev/msg153
10.1016/j.neurobiolaging.2014.01.006
10.1093/molbev/msx303
10.1016/j.gene.2015.05.067
10.1038/nature11128
10.1002/glia.23252
10.1126/stke.2002.133.pe26
10.1371/journal.pone.0105723
10.3233/JAD-170585
10.1385/1-59745-088-X:197
10.1093/brain/awx347
10.1016/j.neurobiolaging.2013.01.003
10.1080/15548627.2017.1363950
10.1126/science.1566067
10.1007/s12035-017-0421-x
10.1371/journal.pone.0004456
10.1186/s13100-016-0065-9
10.1007/s10577-018-9571-6
10.1074/jbc.M117.779868
10.1016/J.NEUROSCIENCE.2017.09.049
10.1371/journal.pgen.1002371
10.1016/S0021-9258(18)60477-6
10.3389/fnins.2012.00099
10.1038/npp.2017.273
10.3389/fnmol.2012.00034
10.1371/journal.pone.0044099
ContentType Journal Article
Copyright The Author(s) 2018
Chromosome Research is a copyright of Springer, (2018). All Rights Reserved.
Copyright_xml – notice: The Author(s) 2018
– notice: Chromosome Research is a copyright of Springer, (2018). All Rights Reserved.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7TM
7X7
7XB
88A
88E
88I
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
RC3
7X8
7S9
L.6
5PM
DOI 10.1007/s10577-018-9573-4
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Nucleic Acids Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest : Biological Science Collection journals [unlimited simultaneous users]
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Science Database
ProQuest Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE - Academic

ProQuest Central Student
AGRICOLA
MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: SpringerLink Open Access Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Biology
EISSN 1573-6849
EndPage 111
ExternalDocumentID PMC5857278
29460123
10_1007_s10577_018_9573_4
Genre Journal Article
Review
GrantInformation_xml – fundername: NIH HHS
  grantid: S10 OD018164
GroupedDBID ---
-4W
-56
-5G
-BR
-EM
-Y2
-~C
.86
.VR
06C
06D
0R~
0VY
1N0
1SB
2.D
203
28-
29B
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
3SX
3V.
4.4
406
408
409
40D
40E
53G
5GY
5QI
5VS
67N
67Z
6NX
7X7
88A
88E
88I
8AO
8FE
8FH
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
AAAVM
AABHQ
AACDK
AAHBH
AAHNG
AAIAL
AAJBT
AAJKR
AANXM
AANZL
AARHV
AARTL
AASML
AATNV
AATVU
AAUYE
AAWCG
AAYIU
AAYQN
AAYTO
AAYZH
ABAKF
ABBBX
ABBXA
ABDZT
ABECU
ABFTV
ABHLI
ABHQN
ABJNI
ABJOX
ABKCH
ABKTR
ABMNI
ABMQK
ABNWP
ABPLI
ABQBU
ABQSL
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABUWG
ABWNU
ABXPI
ACAOD
ACBXY
ACDTI
ACGFS
ACGOD
ACHSB
ACHXU
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPIV
ACPRK
ACZOJ
ADBBV
ADHHG
ADHIR
ADIMF
ADINQ
ADKNI
ADKPE
ADRFC
ADTPH
ADURQ
ADYFF
ADYPR
ADZKW
AEBTG
AEFIE
AEFQL
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AEMSY
AENEX
AEOHA
AEPYU
AESKC
AETLH
AEVLU
AEXYK
AFBBN
AFEXP
AFGCZ
AFKRA
AFLOW
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGDS
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHKAY
AHMBA
AHSBF
AHYZX
AIAKS
AIGIU
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
AKMHD
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
B-.
BA0
BBNVY
BBWZM
BDATZ
BENPR
BGNMA
BHPHI
BPHCQ
BSONS
BVXVI
C6C
CAG
CCPQU
COF
CS3
CSCUP
DDRTE
DL5
DNIVK
DPUIP
DU5
DWQXO
EBD
EBLON
EBS
EIOEI
EJD
EMOBN
EN4
EPAXT
ESBYG
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNUQQ
GNWQR
GQ6
GQ7
GQ8
GXS
H13
HCIFZ
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IHE
IJ-
IKXTQ
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KDC
KOV
KOW
KPH
LAK
LK8
LLZTM
M0L
M1P
M2P
M4Y
M7P
MA-
N2Q
NB0
NDZJH
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
OVD
P19
PF0
PQQKQ
PROAC
PSQYO
PT4
PT5
Q2X
QOK
QOR
QOS
R4E
R89
R9I
RHV
RNI
ROL
RPX
RRX
RSV
RZC
RZE
RZK
S16
S1Z
S26
S27
S28
S3A
S3B
SAP
SBL
SBY
SCLPG
SDH
SDM
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
T16
TEORI
TSG
TSK
TSV
TUC
U2A
U9L
UG4
UKHRP
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WJK
WK6
WK8
YLTOR
Z45
Z7U
Z82
Z8V
ZMTXR
ZOVNA
~A9
~EX
~KM
AAPKM
AAYXX
ABBRH
ABDBE
ABFSG
ACSTC
ADHKG
AEZWR
AFDZB
AFHIU
AFOHR
AGQPQ
AHPBZ
AHWEU
AIXLP
ATHPR
AYFIA
CITATION
PHGZM
PHGZT
ABRTQ
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7TM
7XB
8FD
8FK
FR3
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
Q9U
RC3
7X8
PUEGO
7S9
L.6
5PM
ID FETCH-LOGICAL-c569t-48c908246186bc6700381f45fc57fab219f298e96b8098a4fe7b115f78ee7e533
IEDL.DBID 7X7
ISSN 0967-3849
1573-6849
IngestDate Thu Aug 21 18:01:37 EDT 2025
Fri Sep 05 06:49:16 EDT 2025
Fri Sep 05 10:43:32 EDT 2025
Fri Jul 25 08:53:17 EDT 2025
Mon Jul 21 05:53:28 EDT 2025
Thu Apr 24 23:06:08 EDT 2025
Tue Jul 01 02:07:17 EDT 2025
Fri Feb 21 02:38:47 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1-2
Keywords Brain connectome
A-to-I editing
Mitochondria
Alzheimer’s disease
Epigenetics
Mosaic brain
Parkinson’s disease
Language English
License Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c569t-48c908246186bc6700381f45fc57fab219f298e96b8098a4fe7b115f78ee7e533
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
Responsible Editor: Beth Sullivan.
OpenAccessLink https://doi.org/10.1007/s10577-018-9573-4
PMID 29460123
PQID 2003255515
PQPubID 54106
PageCount 19
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5857278
proquest_miscellaneous_2053871978
proquest_miscellaneous_2007117359
proquest_journals_2003255515
pubmed_primary_29460123
crossref_citationtrail_10_1007_s10577_018_9573_4
crossref_primary_10_1007_s10577_018_9573_4
springer_journals_10_1007_s10577_018_9573_4
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2018-03-01
PublicationDateYYYYMMDD 2018-03-01
PublicationDate_xml – month: 03
  year: 2018
  text: 2018-03-01
  day: 01
PublicationDecade 2010
PublicationPlace Dordrecht
PublicationPlace_xml – name: Dordrecht
– name: Netherlands
PublicationSubtitle Chromatin, Chromosomes and Genomes
PublicationTitle Chromosome research
PublicationTitleAbbrev Chromosome Res
PublicationTitleAlternate Chromosome Res
PublicationYear 2018
Publisher Springer Netherlands
Springer Nature B.V
Publisher_xml – name: Springer Netherlands
– name: Springer Nature B.V
References Bhattacharjee, Yang, Duffy (CR13) 2016; 291
Lu (CR130) 2009; 9
Roses, Lutz, Amrine-Madsen (CR182) 2010; 10
Herrup (CR82) 2015; 18
Tarallo, Hirano, Gelfand (CR214) 2012; 149
Zhang, Dipple, Vilain (CR237) 2000; 15
Neven, Piola, Angelici (CR154) 2016; 17
Oliver, Greene (CR160) 2011; 2
CR163
Cordaux, Batzer (CR38) 2009; 10
Deininger (CR49) 2011; 12
Mager, Gessmann, Nussberger, Zeth (CR137) 2011; 242
CR158
Vassetzky, Ten, Kramerov (CR227) 2003; 319
Jiang, Wu, Shen (CR94) 2017; 7
Kim, Tarallo, Kerur (CR106) 2014; 111
Linker, Marchetto, Narvaiza (CR127) 2017; 15
Elbarbary, Lucas, Maquat (CR57) 2016; 351
D’Andrea, Nagele, Wang (CR40) 2001; 38
Jintaridth, Mutirangura (CR95) 2010; 41
Kaneko, Dridi, Tarallo (CR100) 2011; 471
Hoenicka, Arrasate, de Yebenes, Avila (CR83) 2002; 13
Kwak, Kawahara (CR112) 2005; 83
Knight Johnson, Schaefer, Lee (CR107) 2017; 173
Behm, Öhman (CR11) 2016; 32
CR168
Li, Schmid (CR121) 2001; 276
Picardi, Horner, Pesole (CR171) 2017; 23
Khanna, Kovalevich, Lee (CR103) 2016; 12
Hedges, Callinan, Cordaux (CR81) 2004; 14
Seeley (CR197) 2017; 9
Kawahara, Ito, Sun (CR102) 2004; 427
Rybak-Wolf, Stottmeister, Glazar (CR188) 2015; 58
Szpakowski, Sun, Lage (CR210) 2009; 448
Vandewalle, Bauters, Van Esch (CR223) 2013; 132
Chen, Yang (CR33) 2017; 27
Baillie, Barnett, Upton (CR6) 2011; 479
Johnson, Gonzalez, Zhang (CR98) 2017; 136
CR133
Rossi, Lombardo, Ciriolo, Rotilio (CR186) 2004; 29
Shiota, Imai, Qiu (CR200) 2015; 349
Mefford, Zemel, Geraghty (CR144) 2015; 85
Gu, Kodama, Watanabe (CR75) 2007; 29
Saunders, Schmader, Breitner (CR190) 1993; 342
Schollen, Keldermans, Foulquier (CR194) 2007; 90
CR139
Goodier (CR71) 2016; 7
Bedrosian, Linker, Gage (CR10) 2016; 8
Kaur, Pociot (CR101) 2015; 6
Harbauer, Zahedi, Sickmann (CR79) 2014; 19
Lerner, Boustany, Anderson (CR118) 1995; 82
Mariner, Walters, Espinoza (CR140) 2008; 29
Luco (CR131) 2016; 23
Belancio, Roy-Engel, Deininger (CR12) 2010; 20
Prendergast, Chambers, Semple (CR173) 2014; 6
CR146
Dannlowski, Kugel, Redlich (CR42) 2014; 35
Floris, Zhang, Follesa, Sun (CR63) 2017; 54
Gurevich, Tamir, Arango (CR77) 2002; 34
Castelnuovo, Massone, Tasso (CR28) 2010; 24
Boone, Yuan, Campbell (CR19) 2014; 95
Paquola, Erwin, Gage (CR164) 2016; 1
Mahley, Rall (CR138) 2000; 1
Picardi, Manzari, Mastropasqua (CR169) 2015; 5
Shen, Lin, Cai (CR199) 2011; 108
Brooks, Branda, Nicklas, O’Neill (CR23) 2001; 476
Laperriere, Wang, White, Mader (CR113) 2007; 8
Pal, Tyler (CR162) 2016; 2
Schmauss, Howe (CR192) 2002; 2002
Huda, Mariño-Ramírez, Landsman, Jordan (CR88) 2009; 436
Schanze, Neubauer, Cormier-Daire (CR191) 2014; 35
Sakurai, Ueda, Yano (CR189) 2014; 24
Mehler, Mattick (CR145) 2007; 87
CR235
CR233
Daniel, Silberberg, Behm, Öhman (CR41) 2014; 15
CR117
Dong, Ma, Chen, Yang (CR55) 2017; 14
Khermesh, D’Erchia, Barak (CR104) 2016; 22
Kubota-Sakashita, Iwamoto, Bundo, Kato (CR108) 2014; 7
Prudencio, Gonzales, Cook (CR174) 2017; 26
Le Guennec, Veugelen, Quenez (CR116) 2017; 104
Okubo, Horinishi, Saito (CR159) 2007; 92
(CR67) 2017; 16
Lin, Jiang, Park (CR126) 2016; 17
Takahashi, Milner, Li (CR211) 2002; 161
De La Monte, Tong (CR46) 2014; 88
Taşkesen, Collin, Evsikov (CR216) 2012; 131
Kutsche, Ressler, Katzera (CR111) 2002; 19
Evrony (CR59) 2016; 354
Kuszak, Jacobs, Gurnev (CR110) 2015; 290
CR122
Zempel, Mandelkow (CR236) 2015; 10
López, Casasnovas, Giménez (CR129) 2015; 16
Viader, Sasaki, Kim (CR229) 2013; 77
Huang, Ripps, Korman (CR87) 1989; 264
Polak, Domany (CR172) 2006; 7
Ferrick-Kiddie, Rosenthal, Ayers, Emeson (CR61) 2017; 7
CR14
Antonell, Gelpi, Sánchez-Valle (CR2) 2012; 28
CR215
Muotri, Chu, Marchetto (CR150) 2005; 435
Nozu, Iijima, Ohtsuka (CR157) 2014; 2
Gu, Yuan, Campbell (CR76) 2015; 24
Martin (CR141) 2012; 107
Burggren, Mahmood, Harrison (CR25) 2017; 13
Weissmann, van der Laan, Underwood (CR232) 2016; 6
Gallo, Vukic, Michalík (CR64) 2017; 136
CR226
Viader, Golden, Baloh (CR228) 2011; 31
Dobrovolny, Nazarenko, Kim (CR54) 2011; 32
Roses, Akkari, Chiba-Falek (CR184) 2016; 12
Borchert, Gilmore, Spengler (CR20) 2009; 18
Chen, Carmichael (CR30) 2008; 7
McKhann, Knopman, Chertkow (CR143) 2011; 7
Gal-Mark, Shallev, Sweetat (CR66) 2017; 7
Hood, Emeson (CR85) 2011
Arnoldi, Tonelli, Crippa (CR3) 2008; 29
Britten (CR22) 1997; 205
Lin, Beal (CR124) 2006; 443
Mittal, Mani, Katare (CR148) 2016; 6
Steen, Terry, Rivera (CR205) 2005; 7
De Felice, Lourenco (CR45) 2015; 7
Batzer, Deininger (CR8) 2002; 3
Conceição Pereira, Loureiro, Pinto-Basto (CR36) 2012; 14
CR37
Kaler (CR99) 2011; 7
Strittmatter, Saunders, Schmechel (CR206) 1993; 90
Bouchet, Vuillaumier-Barrot, Gonzales (CR21) 2007; 90
Bondurand, Fouquet, Baral (CR16) 2012; 20
De La Monte, Tong, Lester-Coll (CR48) 2006; 10
Jobic, Morin, Vincent-Delorme (CR97) 2017; 173
Athanasiadis, Rich, Maas (CR5) 2004; 2
Ittner, Götz (CR91) 2011; 12
Jeck, Sorrentino, Wang (CR93) 2013; 19
Nishikura (CR155) 2016; 17
Van Den Heuvel, Sporns (CR222) 2013; 17
Dawson, Kilkus, Siakotos (CR43) 1995; 29
Chen, Schuman (CR32) 2016; 39
CR201
Deininger, Moran, Batzer, Kazazian (CR51) 2003; 13
Hwang, Park, Leung (CR90) 2016; 19
Smalheiser (CR203) 2014; 369
Tan, Li, Shanmugam (CR213) 2017; 550
Rugarli, Langer (CR187) 2012; 31
CR208
Deininger, Batzer (CR50) 1999; 67
Eisenberg, Nemzer, Kinar (CR56) 2005; 21
Skovronsky, Doms, Lee (CR202) 1998; 141
Checler, Goiran, da Costa (CR29) 2017; 15
Choi, Kim, Park (CR34) 2011; 12
Wright, Vissel (CR234) 2012; 5
Maas, Kawahara, Tamburro, Nishikura (CR134) 2006; 3
Dixon, Selvaraj, Yue (CR53) 2012; 485
Lapp, Hunter (CR114) 2016; 8
Flippo, Strack (CR62) 2017; 187
Lin, Shen, Tye (CR125) 2008; 4
Coskun, Wyrembak, Schriner (CR39) 2012; 1820
Roses, Sundseth, Saunders (CR183) 2016; 12
Glasser, Coalson, Robinson (CR69) 2016; 536
Lev-Maor, Sorek, Shomron, Ast (CR119) 2003; 300
Selkoe (CR198) 2000; 924
Sun, Wu, Ordog (CR207) 2014; 9
Varizhuk, Sekridova, Tankevich (CR225) 2016; 62
Chen, Carmichael (CR31) 2009; 35
Hunter, Gagnidze, McEwen, Pfaff (CR89) 2015; 112
Udaka, Okamoto, Aramaki (CR220) 2007; 143
Thongsroy, Patchsung, Mutirangura (CR217) 2017; 9
Calvo, Clauser, Mootha (CR27) 2015; 44
De Andrade, Wang, Bonaldo (CR44) 2011; 12
Reynolds, Rhees, Maciejewski (CR177) 1999; 155
Roger, Muñoz-Gómez, Kamikawa (CR180) 2017; 27
Madsen, Gitlin (CR136) 2007; 30
Gallus, Cardaioli, Rufa (CR65) 2010; 10
Cai, Davis, Sheng (CR26) 2011; 70
Chong-Chong, Denton, Wang (CR35) 2016; 9
Soibam (CR204) 2017; 23
Ottesen, Seo, Singh, Singh (CR161) 2017; 8
Pehlivan, Beck, Okamoto (CR167) 2016; 18
Roses (CR181) 2010; 67
CR78
Jintaridth, Tungtrongchitr, Preutthipan, Mutirangura (CR96) 2013; 8
Lutz, Crenshaw, Saunders, Roses (CR132) 2010; 6
Mita, Boeke (CR147) 2016; 37
Schwahn, Lenzner, Dong (CR195) 1998; 19
Muotri, Marchetto, Coufal (CR151) 2010; 468
CR74
CR72
CR70
Bondy-Chorney, Crawford Parks, Ravel-Chapuis (CR17) 2016; 12
Hofer, Campbell (CR84) 2016; 173
Ferrari, Scuvera, Tucci (CR60) 2017; 136
Töhönen, Katayama, Vesterlund (CR218) 2015; 6
Bajad, Jantsch, Keegan, O’Connell (CR7) 2017; 14
Devi, Prabhu, Galati (CR52) 2006; 26
Schwarz (CR196) 2013; 5
Hormozdiari, Konkel, Prado-Martinez (CR86) 2013; 110
Larsen, Lutz, Hunnicutt (CR115) 2017; 13
Payton, Sindrewicz, Pessoa (CR166) 2016; 39
Zhang, Fukao, Sakurai (CR238) 2006; 89
Bundo, Toyoshima, Okada (CR24) 2014; 81
Bollati, Schwartz, Wright (CR15) 2009; 130
CR80
Swerdlow, Burns, Khan (CR209) 2010; 20
Tan, Huang, Lam, Soong (CR212) 2009; 2
Vansant, Reynolds (CR224) 1995; 92
Ade, Roy-Engel, Deininger (CR1) 2013; 3
Erwin, Marchetto, Gage (CR58) 2014; 15
Kurnosov, Ustyugova, Nazarov (CR109) 2015; 10
Neeman, Levanon, Jantsch, Eisenberg (CR153) 2006; 12
Payer, Steranka, Yang (CR165) 2017; 114
CR185
Wang, Wang, Azadzoi (CR231) 2016; 426
Picardi, D’Erchia, Lo Giudice, Pesole (CR170) 2017; 45
Morais, Bastos-Ferreira, Sequeiros, Alonso (CR149) 2016; 2
CR175
CR92
Bonifati, Rizzu, van Baren (CR18) 2003; 299
Ullu, Tschudi (CR221) 1984; 312
Rice, Kasher, Forte (CR179) 2012; 44
Maden (CR135) 2007; 8
Mattick, Mehler (CR142) 2008; 31
Li, Church (CR120) 2013; 16
Tsirigos, Rigoutsos (CR219) 2009; 5
Greenbaum, Springer, Lutz (CR73) 2014; 24
Liscovitch, Bazak, Levanon, Chechik (CR128) 2014; 11
Norris, Fan, Aleman (CR156) 1995; 270
Kim, Moody, Edgerly (CR105) 2010; 19
Arpawong, Pendleton, Mekli (CR4) 2017; 12
Mustajoki, Ahola, Mustajoki, Kauppinen (CR152) 1999; 13
CR193
Li, Tian, Tian (CR123) 2015; 33
Wang, Li, Lin (CR230) 2013; 22
Reddy (CR176) 2011; 1415
Rezin, Amboni, Zugno (CR178) 2009; 34
Bazak, Haviv, Barak (CR9) 2014; 24
De La Monte, Wands (CR47) 2008; 2
Girotto, Cendron, Bisaglia (CR68) 2014; 289
AM Saunders (9573_CR190) 1993; 342
AR Muotri (9573_CR150) 2005; 435
RW Mahley (9573_CR138) 2000; 1
9573_CR158
JK Baillie (9573_CR6) 2011; 479
A Payton (9573_CR166) 2016; 39
B Soibam (9573_CR204) 2017; 23
MA Batzer (9573_CR8) 2002; 3
M Maden (9573_CR135) 2007; 8
PD Mariner (9573_CR140) 2008; 29
B Lu (9573_CR130) 2009; 9
J Vandewalle (9573_CR223) 2013; 132
9573_CR92
W Chen (9573_CR32) 2016; 39
C Ade (9573_CR1) 2013; 3
AA Kurnosov (9573_CR109) 2015; 10
N Bondurand (9573_CR16) 2012; 20
T Udaka (9573_CR220) 2007; 143
H Kaneko (9573_CR100) 2011; 471
E Picardi (9573_CR169) 2015; 5
MR D’Andrea (9573_CR40) 2001; 38
S Morais (9573_CR149) 2016; 2
9573_CR146
NS Vassetzky (9573_CR227) 2003; 319
X Chong-Chong (9573_CR35) 2016; 9
KR Oliver (9573_CR160) 2011; 2
G Dawson (9573_CR43) 1995; 29
JGD Prendergast (9573_CR173) 2014; 6
9573_CR139
A Wright (9573_CR234) 2012; 5
AM Varizhuk (9573_CR225) 2016; 62
W Wang (9573_CR231) 2016; 426
9573_CR80
S Kaur (9573_CR101) 2015; 6
RJ Britten (9573_CR22) 1997; 205
A Huda (9573_CR88) 2009; 436
D Pehlivan (9573_CR167) 2016; 18
HE Lapp (9573_CR114) 2016; 8
AJ Kuszak (9573_CR110) 2015; 290
L Lin (9573_CR126) 2016; 17
9573_CR175
H Zempel (9573_CR236) 2015; 10
P Polak (9573_CR172) 2006; 7
SM Monte De La (9573_CR47) 2008; 2
LJ Martin (9573_CR141) 2012; 107
U Dannlowski (9573_CR42) 2014; 35
J Jiang (9573_CR94) 2017; 7
E Picardi (9573_CR171) 2017; 23
MT Lin (9573_CR124) 2006; 443
I Gurevich (9573_CR77) 2002; 34
F Jobic (9573_CR97) 2017; 173
AR Muotri (9573_CR151) 2010; 468
K Nishikura (9573_CR155) 2016; 17
9573_CR168
M Kubota-Sakashita (9573_CR108) 2014; 7
Y Neeman (9573_CR153) 2006; 12
A Bhattacharjee (9573_CR13) 2016; 291
9573_CR163
L Ferrari (9573_CR60) 2017; 136
M Bundo (9573_CR24) 2014; 81
EA Ferrick-Kiddie (9573_CR61) 2017; 7
T Shiota (9573_CR200) 2015; 349
FG Felice De (9573_CR45) 2015; 7
F Hormozdiari (9573_CR86) 2013; 110
M Behm (9573_CR11) 2016; 32
K Nozu (9573_CR157) 2014; 2
K Herrup (9573_CR82) 2015; 18
S Pal (9573_CR162) 2016; 2
LM Ittner (9573_CR91) 2011; 12
RA Elbarbary (9573_CR57) 2016; 351
V Tarallo (9573_CR214) 2012; 149
B-O Choi (9573_CR34) 2011; 12
LM Payer (9573_CR165) 2017; 114
A Arnoldi (9573_CR3) 2008; 29
JS Mattick (9573_CR142) 2008; 31
9573_CR235
9573_CR233
C Daniel (9573_CR41) 2014; 15
PH Reddy (9573_CR176) 2011; 1415
WW Seeley (9573_CR197) 2017; 9
9573_CR226
E Bondy-Chorney (9573_CR17) 2016; 12
C Schmauss (9573_CR192) 2002; 2002
V Bonifati (9573_CR18) 2003; 299
RH Takahashi (9573_CR211) 2002; 161
P Deininger (9573_CR49) 2011; 12
SB Linker (9573_CR127) 2017; 15
M Prudencio (9573_CR174) 2017; 26
N Gal-Mark (9573_CR66) 2017; 7
PM Boone (9573_CR19) 2014; 95
SG Kaler (9573_CR99) 2011; 7
KH Flippo (9573_CR62) 2017; 187
AB Harbauer (9573_CR79) 2014; 19
9573_CR215
MH Tan (9573_CR213) 2017; 550
A Viader (9573_CR228) 2011; 31
GI Rice (9573_CR179) 2012; 44
P Coskun (9573_CR39) 2012; 1820
L Rossi (9573_CR186) 2004; 29
G Lev-Maor (9573_CR119) 2003; 300
9573_CR74
Y Kim (9573_CR106) 2014; 111
9573_CR72
SC Johnson (9573_CR98) 2017; 136
AD Roses (9573_CR182) 2010; 10
SM Monte De La (9573_CR46) 2014; 88
9573_CR78
E Schollen (9573_CR194) 2007; 90
9573_CR133
F Checler (9573_CR29) 2017; 15
WF Reynolds (9573_CR177) 1999; 155
PL Deininger (9573_CR50) 1999; 67
MW Lutz (9573_CR132) 2010; 6
P Jintaridth (9573_CR96) 2013; 8
9573_CR70
P Jintaridth (9573_CR95) 2010; 41
U Schwahn (9573_CR195) 1998; 19
V Bollati (9573_CR15) 2009; 130
PL Deininger (9573_CR51) 2003; 13
TH Li (9573_CR121) 2001; 276
9573_CR122
L-L Chen (9573_CR30) 2008; 7
K Guennec Le (9573_CR116) 2017; 104
TA Bedrosian (9573_CR10) 2016; 8
EM Brooks (9573_CR23) 2001; 476
A Andrade De (9573_CR44) 2011; 12
9573_CR117
E Picardi (9573_CR170) 2017; 45
M Castelnuovo (9573_CR28) 2010; 24
GD Evrony (9573_CR59) 2016; 354
L-L Chen (9573_CR33) 2017; 27
A Rybak-Wolf (9573_CR188) 2015; 58
NR Smalheiser (9573_CR203) 2014; 369
K Mittal (9573_CR148) 2016; 6
P Mita (9573_CR147) 2016; 37
GBD 2015 Neurological Disorders Collaborator Group 2015 NDC (9573_CR67) 2017; 16
9573_CR14
W Wang (9573_CR230) 2013; 22
A Athanasiadis (9573_CR5) 2004; 2
A Tsirigos (9573_CR219) 2009; 5
SE Calvo (9573_CR27) 2015; 44
ACM Paquola (9573_CR164) 2016; 1
EI Rugarli (9573_CR187) 2012; 31
L Lin (9573_CR125) 2008; 4
WJ Strittmatter (9573_CR206) 1993; 90
RH Swerdlow (9573_CR209) 2010; 20
Y Kawahara (9573_CR102) 2004; 427
J Kim (9573_CR105) 2010; 19
MP Heuvel Van Den (9573_CR222) 2013; 17
D Schanze (9573_CR191) 2014; 35
RF Luco (9573_CR131) 2016; 23
VP Belancio (9573_CR12) 2010; 20
M Conceição Pereira (9573_CR36) 2012; 14
E López (9573_CR129) 2015; 16
T Lerner (9573_CR118) 1995; 82
N Liscovitch (9573_CR128) 2014; 11
9573_CR37
C Bouchet (9573_CR21) 2007; 90
J Norris (9573_CR156) 1995; 270
Y-H Zhang (9573_CR237) 2000; 15
9573_CR208
Z Sun (9573_CR207) 2014; 9
AD Roses (9573_CR184) 2016; 12
S Girotto (9573_CR68) 2014; 289
G Vansant (9573_CR224) 1995; 92
A Antonell (9573_CR2) 2012; 28
GM Borchert (9573_CR20) 2009; 18
D Laperriere (9573_CR113) 2007; 8
MR Khanna (9573_CR103) 2016; 12
M Sakurai (9573_CR189) 2014; 24
E Madsen (9573_CR136) 2007; 30
S Mustajoki (9573_CR152) 1999; 13
K Kutsche (9573_CR111) 2002; 19
S Szpakowski (9573_CR210) 2009; 448
9573_CR201
A Knight Johnson (9573_CR107) 2017; 173
R Cordaux (9573_CR38) 2009; 10
MF Glasser (9573_CR69) 2016; 536
L Bazak (9573_CR9) 2014; 24
R Dobrovolny (9573_CR54) 2011; 32
TL Schwarz (9573_CR196) 2013; 5
G Zhang (9573_CR238) 2006; 89
L Greenbaum (9573_CR73) 2014; 24
DM Skovronsky (9573_CR202) 1998; 141
Q Cai (9573_CR26) 2011; 70
TE Arpawong (9573_CR4) 2017; 12
GT Rezin (9573_CR178) 2009; 34
9573_CR193
G Floris (9573_CR63) 2017; 54
AD Roses (9573_CR181) 2010; 67
S Shen (9573_CR199) 2011; 108
LS Huang (9573_CR87) 1989; 264
Y Gu (9573_CR75) 2007; 29
S Gu (9573_CR76) 2015; 24
M Taşkesen (9573_CR216) 2012; 131
AC Burggren (9573_CR25) 2017; 13
JR Dixon (9573_CR53) 2012; 485
M Okubo (9573_CR159) 2007; 92
JL Hood (9573_CR85) 2011
DJ Selkoe (9573_CR198) 2000; 924
EW Ottesen (9573_CR161) 2017; 8
DJ Hedges (9573_CR81) 2004; 14
JL Goodier (9573_CR71) 2016; 7
R Hunter (9573_CR89) 2015; 112
J Hoenicka (9573_CR83) 2002; 13
B Tan (9573_CR212) 2009; 2
9573_CR185
P Bajad (9573_CR7) 2017; 14
JB Li (9573_CR120) 2013; 16
S Maas (9573_CR134) 2006; 3
D Weissmann (9573_CR232) 2016; 6
JA Erwin (9573_CR58) 2014; 15
HC Mefford (9573_CR144) 2015; 85
Z Li (9573_CR123) 2015; 33
GM McKhann (9573_CR143) 2011; 7
A Gallo (9573_CR64) 2017; 136
K Khermesh (9573_CR104) 2016; 22
T Hwang (9573_CR90) 2016; 19
WR Jeck (9573_CR93) 2013; 19
KY Neven (9573_CR154) 2016; 17
E Eisenberg (9573_CR56) 2005; 21
E Steen (9573_CR205) 2005; 7
PA Larsen (9573_CR115) 2017; 13
AJ Roger (9573_CR180) 2017; 27
V Töhönen (9573_CR218) 2015; 6
MJ Hofer (9573_CR84) 2016; 173
F Mager (9573_CR137) 2011; 242
SM Monte De La (9573_CR48) 2006; 10
E Ullu (9573_CR221) 1984; 312
GN Gallus (9573_CR65) 2010; 10
S Kwak (9573_CR112) 2005; 83
L Devi (9573_CR52) 2006; 26
J Thongsroy (9573_CR217) 2017; 9
A Viader (9573_CR229) 2013; 77
MF Mehler (9573_CR145) 2007; 87
AD Roses (9573_CR183) 2016; 12
R Dong (9573_CR55) 2017; 14
L-L Chen (9573_CR31) 2009; 35
References_xml – volume: 2
  start-page: 1101
  year: 2008
  end-page: 1113
  ident: CR47
  article-title: Alzheimer’s disease is type 3 diabetes—evidence reviewed
  publication-title: J Diabetes Sci Technol
  doi: 10.1177/193229680800200619
– ident: CR74
– volume: 90
  start-page: 93
  year: 2007
  end-page: 96
  ident: CR21
  article-title: Detection of an Alu insertion in the POMT1 gene from three French Walker Warburg syndrome families
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2006.09.005
– volume: 476
  start-page: 43
  year: 2001
  end-page: 54
  ident: CR23
  article-title: Molecular description of three macro-deletions and an Alu-Alu recombination-mediated duplication in the HPRT gene in four patients with Lesch-Nyhan disease
  publication-title: Mutat Res
  doi: 10.1016/S0027-5107(01)00065-3
– volume: 10
  start-page: 89
  year: 2006
  end-page: 109
  ident: CR48
  article-title: Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2006-10113
– volume: 2
  start-page: 13
  year: 2009
  ident: CR212
  article-title: Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system
  publication-title: Mol Brain
  doi: 10.1186/1756-6606-2-13
– volume: 426
  start-page: 91
  year: 2016
  end-page: 100
  ident: CR231
  article-title: Alu RNA accumulation in hyperglycemia augments oxidative stress and impairs eNOS and SOD2 expression in endothelial cells
  publication-title: Mol Cell Endrocrinol
  doi: 10.1016/j.mce.2016.02.008
– volume: 20
  start-page: 990
  year: 2012
  end-page: 994
  ident: CR16
  article-title: Alu-mediated deletion of SOX10 regulatory elements in Waardenburg syndrome type 4
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2012.29
– volume: 30
  start-page: 317
  year: 2007
  end-page: 337
  ident: CR136
  article-title: Copper and iron disorders of the brain
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev.neuro.30.051606.094232
– ident: CR80
– ident: CR201
– volume: 9
  start-page: 93
  year: 2017
  ident: CR217
  article-title: The association between Alu hypomethylation and severity of type 2 diabetes mellitus
  publication-title: Clin Epigenetics
  doi: 10.1186/s13148-017-0395-6
– volume: 18
  start-page: 443
  year: 2016
  end-page: 451
  ident: CR167
  article-title: The role of combined SNV and CNV burden in patients with distal symmetric polyneuropathy
  publication-title: Genet Med
  doi: 10.1038/gim.2015.124
– volume: 35
  start-page: 467
  year: 2009
  end-page: 478
  ident: CR31
  article-title: Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA
  publication-title: Molecular Cell
  doi: 10.1016/j.molcel.2009.06.027
– volume: 21
  start-page: 77
  year: 2005
  end-page: 81
  ident: CR56
  article-title: Is abundant A-to-I RNA editing primate-specific?
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2004.12.005
– ident: CR235
– volume: 44
  start-page: 1243
  year: 2012
  end-page: 1248
  ident: CR179
  article-title: Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
  publication-title: Nat Genet
  doi: 10.1038/ng.2414
– ident: CR92
– volume: 7
  start-page: 263
  year: 2011
  end-page: 269
  ident: CR143
  article-title: The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
  publication-title: Alzheimer’s Dement.
  doi: 10.1016/j.jalz.2011.03.005
– volume: 114
  start-page: E3984
  year: 2017
  end-page: E3992
  ident: CR165
  article-title: Structural variants caused by Alu insertions are associated with risks for many human diseases
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1704117114
– volume: 6
  start-page: 577
  year: 2015
  end-page: 591
  ident: CR101
  article-title: Alu elements as novel regulators of gene expression in type 1 diabetes susceptibility genes?
  publication-title: Genes (Basel)
  doi: 10.3390/genes6030577
– volume: 110
  start-page: 13457
  year: 2013
  end-page: 13462
  ident: CR86
  article-title: Rates and patterns of great ape retrotransposition
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1310914110
– volume: 6
  start-page: 8207
  year: 2015
  ident: CR218
  article-title: Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development
  publication-title: Nat Commun
  doi: 10.1038/ncomms9207
– ident: CR185
– volume: 10
  start-page: 375
  year: 2010
  end-page: 384
  ident: CR182
  article-title: A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer’s disease
  publication-title: Pharmacogenomics J
  doi: 10.1038/tpj.2009.69
– volume: 7
  start-page: 63
  year: 2005
  end-page: 80
  ident: CR205
  article-title: Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease—is this type 3 diabetes?
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2005-7107
– volume: 14
  start-page: 1223
  year: 2017
  end-page: 1231
  ident: CR7
  article-title: A to I editing in disease is not fake news
  publication-title: RNA Biol
  doi: 10.1080/15476286.2017.1306173
– volume: 319
  start-page: 149
  year: 2003
  end-page: 160
  ident: CR227
  article-title: B1 and related SINEs in mammalian genomes
  publication-title: Gene
  doi: 10.1016/S0378-1119(03)00805-9
– volume: 1820
  start-page: 553
  year: 2012
  end-page: 564
  ident: CR39
  article-title: A mitochondrial etiology of Alzheimer and Parkinson disease
  publication-title: Biochim Biophys Acta (BBA)-General Subj
  doi: 10.1016/j.bbagen.2011.08.008
– volume: 149
  start-page: 847
  year: 2012
  end-page: 859
  ident: CR214
  article-title: DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.036
– volume: 12
  start-page: e0182448
  year: 2017
  ident: CR4
  article-title: Genetic variants specific to aging-related verbal memory: insights from GWASs in a population-based cohort
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0182448
– volume: 6
  start-page: 25589
  year: 2016
  ident: CR148
  article-title: Type 3 diabetes: cross talk between differentially regulated proteins of type 2 diabetes mellitus and Alzheimer’s disease
  publication-title: Sci Rep
  doi: 10.1038/srep25589
– volume: 5
  start-page: e1000610
  year: 2009
  ident: CR219
  article-title: Alu and B1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes
  publication-title: PLOS Comput Biol
  doi: 10.1371/journal.pcbi.1000610
– volume: 35
  start-page: 5356
  year: 2014
  end-page: 5367
  ident: CR42
  article-title: Serotonin transporter gene methylation is associated with hippocampal gray matter volume
  publication-title: Hum Brain Mapp
  doi: 10.1002/hbm.22555
– volume: 13
  start-page: 343
  year: 2002
  end-page: 349
  ident: CR83
  article-title: A two-hybrid screening of human Tau protein: interactions with Alu-derived domain
  publication-title: Neuroreport
  doi: 10.1097/00001756-200203040-00019
– volume: 7
  start-page: 15
  year: 2011
  end-page: 29
  ident: CR99
  article-title: ATP7A-related copper transport diseases—emerging concepts and future trends
  publication-title: Nat Rev Neurol
  doi: 10.1038/nrneurol.2010.180
– volume: 19
  start-page: 327
  year: 1998
  end-page: 332
  ident: CR195
  article-title: Positional cloning of the gene for X-linked retinitis pigmentosa 2
  publication-title: Nat Genet
  doi: 10.1038/1214
– volume: 87
  start-page: 799
  year: 2007
  end-page: 823
  ident: CR145
  article-title: Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00036.2006
– volume: 13
  start-page: 651
  year: 2003
  end-page: 658
  ident: CR51
  article-title: Mobile elements and mammalian genome evolution
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2003.10.013
– volume: 10
  start-page: 178
  year: 2010
  end-page: 183
  ident: CR65
  article-title: Alu-element insertion in an OPA1 intron sequence associated with autosomal dominant optic atrophy
  publication-title: Mol Vis
– start-page: 61
  year: 2011
  end-page: 90
  ident: CR85
  publication-title: Editing of neurotransmitter receptor and ion channel RNAs in the nervous system
– volume: 8
  start-page: 23
  year: 2007
  ident: CR113
  article-title: Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-8-23
– volume: 9
  start-page: 39
  year: 2016
  end-page: 49
  ident: CR35
  article-title: Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy
  publication-title: Dis Model Mech
– volume: 443
  start-page: 787
  year: 2006
  end-page: 795
  ident: CR124
  article-title: Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
  publication-title: Nature
  doi: 10.1038/nature05292
– volume: 12
  start-page: 1
  year: 2011
  ident: CR49
  article-title: Alu elements: know the SINEs
  publication-title: Genome Biol
  doi: 10.1186/gb-2011-12-12-236
– volume: 550
  start-page: 249
  year: 2017
  end-page: 254
  ident: CR213
  article-title: Dynamic landscape and regulation of RNA editing in mammals
  publication-title: Nature
  doi: 10.1038/nature24041
– volume: 7
  start-page: 41095
  year: 2017
  ident: CR61
  article-title: Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing
  publication-title: Sci Rep
  doi: 10.1038/srep41095
– volume: 13
  start-page: 739
  year: 2017
  end-page: 748
  ident: CR25
  article-title: Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ε4 variant
  publication-title: Alzheimer’s Dement
  doi: 10.1016/j.jalz.2016.12.009
– volume: 12
  start-page: e1005827
  year: 2016
  ident: CR17
  article-title: Staufen1 regulates multiple alternative splicing events either positively or negatively in DM1 indicating its role as a disease modifier
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1005827
– volume: 9
  start-page: a023622
  year: 2017
  ident: CR197
  article-title: Mapping neurodegenerative disease onset and progression
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a023622
– volume: 15
  start-page: 68
  year: 2017
  ident: CR127
  article-title: Examining non-LTR retrotransposons in the context of the evolving primate brain
  publication-title: BMC Biol
  doi: 10.1186/s12915-017-0409-z
– ident: CR139
– volume: 32
  start-page: 165
  year: 2016
  end-page: 175
  ident: CR11
  article-title: RNA editing: a contributor to neuronal dynamics in the mammalian brain
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2015.12.005
– volume: 23
  start-page: 860
  year: 2017
  end-page: 865
  ident: CR171
  article-title: Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
  publication-title: RNA
  doi: 10.1261/rna.058271.116
– volume: 12
  start-page: 687
  year: 2016
  end-page: 694
  ident: CR183
  article-title: Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer’s disease
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2016.03.015
– volume: 12
  start-page: 1051
  year: 2016
  end-page: 1065
  ident: CR103
  article-title: Therapeutic strategies for the treatment of tauopathies: Hopes and challenges
  publication-title: Alzheimer’s Dement.
  doi: 10.1016/j.jalz.2016.06.006
– volume: 9
  start-page: 212
  year: 2009
  ident: CR130
  article-title: Mitochondrial dynamics and neurodegeneration
  publication-title: Curr Neurol Neurosci Rep
  doi: 10.1007/s11910-009-0032-7
– volume: 312
  start-page: 171
  year: 1984
  end-page: 172
  ident: CR221
  article-title: Alu sequences are processed 7SL RNA genes
  publication-title: Nature
  doi: 10.1038/312171a0
– volume: 468
  start-page: 443
  year: 2010
  end-page: 446
  ident: CR151
  article-title: L1 retrotransposition in neurons is modulated by MeCP2
  publication-title: Nature
  doi: 10.1038/nature09544
– volume: 7
  start-page: 43421
  year: 2017
  ident: CR66
  article-title: Abnormalities in A-to-I RNA editing patterns in CNS injuries correlate with dynamic changes in cell type composition
  publication-title: Sci Rep
  doi: 10.1038/srep43421
– volume: 104
  start-page: 97
  year: 2017
  end-page: 103
  ident: CR116
  article-title: Deletion of exons 9 and 10 of the presenilin 1 gene in a patient with early-onset Alzheimer disease generates longer amyloid seeds
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2017.04.020
– volume: 20
  start-page: 200
  year: 2010
  end-page: 210
  ident: CR12
  article-title: All y’all need to know ’bout retroelements in cancer
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2010.06.001
– ident: CR70
– volume: 2002
  start-page: pe26
  year: 2002
  ident: CR192
  article-title: RNA editing of neurotransmitter receptors in the mammalian brain
  publication-title: Sci STKE
– volume: 39
  start-page: 217
  year: 2016
  ident: CR166
  article-title: A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in non-pathological aging
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2015.11.017
– volume: 136
  start-page: 1329
  year: 2017
  end-page: 1339
  ident: CR60
  article-title: Identification of an atypical microdeletion generating the RNF135-SUZ12 chimeric gene and causing a position effect in an NF1 patient with overgrowth
  publication-title: Hum Genet
  doi: 10.1007/s00439-017-1832-5
– volume: 85
  start-page: 756
  year: 2015
  end-page: 762
  ident: CR144
  article-title: Intragenic deletions of ALDH7A1 in pyridoxine-dependent epilepsy caused by Alu-Alu recombination
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000001883
– volume: 32
  start-page: 688
  year: 2011
  end-page: 695
  ident: CR54
  article-title: Detection of large gene rearrangements in X-linked genes by dosage analysis: identification of novel α-galactosidase A (GLA) deletions causing Fabry disease
  publication-title: Hum Mutat
  doi: 10.1002/humu.21474
– volume: 44
  start-page: D1251
  year: 2015
  end-page: D1257
  ident: CR27
  article-title: MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkv1003
– volume: 39
  start-page: 597
  year: 2016
  end-page: 604
  ident: CR32
  article-title: Circular RNAs in brain and other tissues: a functional enigma
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2016.06.006
– volume: 3
  start-page: 639
  year: 2013
  end-page: 645
  ident: CR1
  article-title: Alu elements: an intrinsic source of human genome instability
  publication-title: Curr. Opin. Virol.
  doi: 10.1016/j.coviro.2013.09.002
– volume: 34
  start-page: 1021
  year: 2009
  end-page: 1029
  ident: CR178
  article-title: Mitochondrial dysfunction and psychiatric disorders
  publication-title: Neurochem Res
  doi: 10.1007/s11064-008-9865-8
– volume: 15
  start-page: R28
  year: 2014
  ident: CR41
  article-title: Alu elements shape the primate transcriptome by cis-regulation of RNA editing
  publication-title: Genome Biol
  doi: 10.1186/gb-2014-15-2-r28
– volume: 19
  start-page: 1093
  year: 2016
  end-page: 1099
  ident: CR90
  article-title: Dynamic regulation of RNA editing in human brain development and disease
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4337
– volume: 17
  start-page: 15
  year: 2016
  ident: CR126
  article-title: The contribution of Alu exons to the human proteome
  publication-title: Genome Biol
  doi: 10.1186/s13059-016-0876-5
– volume: 8
  start-page: e70386
  year: 2013
  ident: CR96
  article-title: Hypomethylation of Alu elements in post-menopausal women with osteoporosis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0070386
– volume: 435
  start-page: 903
  year: 2005
  end-page: 910
  ident: CR150
  article-title: Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
  publication-title: Nature
  doi: 10.1038/nature03663
– volume: 34
  start-page: 349
  year: 2002
  end-page: 356
  ident: CR77
  article-title: Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)00660-8
– ident: CR208
– volume: 4
  start-page: e1000225
  year: 2008
  ident: CR125
  article-title: Diverse splicing patterns of exonized Alu elements in human tissues
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1000225
– volume: 1
  start-page: 507
  year: 2000
  end-page: 537
  ident: CR138
  article-title: Apolipoprotein E: far more than a lipid transport protein
  publication-title: Annu Rev Genomics Hum Genet
  doi: 10.1146/annurev.genom.1.1.507
– volume: 436
  start-page: 12
  year: 2009
  end-page: 22
  ident: CR88
  article-title: Repetitive DNA elements, nucleosome binding and human gene expression
  publication-title: Gene
  doi: 10.1016/j.gene.2009.01.013
– volume: 23
  start-page: 1729
  year: 2017
  end-page: 1742
  ident: CR204
  article-title: Super-lncRNAs: identification of lncRNAs that target super-enhancers via RNA:DNA:DNA triplex formation
  publication-title: RNA
  doi: 10.1261/rna.061317.117
– volume: 173
  start-page: 1378
  year: 2017
  end-page: 1382
  ident: CR107
  article-title: Alu-mediated deletion of PIGL in a Patient with CHIME syndrome
  publication-title: Am J Med Genet Part A
  doi: 10.1002/ajmg.a.38181
– volume: 62
  start-page: 630
  year: 2016
  end-page: 637
  ident: CR225
  article-title: Conformational polymorphysm of G-rich fragments of DNA Alu-repeats. II. the putative role of G-quadruplex structures in genomic rearrangements
  publication-title: Biomeditsinskaya Khimiya
  doi: 10.18097/pbmc20166206630
– volume: 13
  start-page: 828
  year: 2017
  end-page: 838
  ident: CR115
  article-title: The Alu neurodegeneration hypothesis: a primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease
  publication-title: Alzheimer’s Dement.
  doi: 10.1016/j.jalz.2017.01.017
– volume: 8
  start-page: 2252
  year: 2017
  ident: CR161
  article-title: A multilayered control of the human survival motor neuron gene expression by Alu elements
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2017.02252
– volume: 479
  start-page: 534
  year: 2011
  end-page: 537
  ident: CR6
  article-title: Somatic retrotransposition alters the genetic landscape of the human brain
  publication-title: Nature
  doi: 10.1038/nature10531
– volume: 136
  start-page: 1265
  year: 2017
  end-page: 1278
  ident: CR64
  article-title: ADAR RNA editing in human disease; more to it than meets the I
  publication-title: Hum Genet
  doi: 10.1007/s00439-017-1837-0
– volume: 12
  start-page: 617
  year: 2011
  ident: CR44
  article-title: Genetic and epigenetic variations contributed by Alu retrotransposition
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-12-617
– ident: CR122
– volume: 448
  start-page: 151
  year: 2009
  end-page: 167
  ident: CR210
  article-title: Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements
  publication-title: Gene
  doi: 10.1016/j.gene.2009.08.006
– ident: CR14
– ident: CR37
– ident: CR226
– volume: 8
  start-page: 58
  year: 2016
  ident: CR10
  article-title: Environment-driven somatic mosaicism in brain disorders
  publication-title: Genome Med
  doi: 10.1186/s13073-016-0317-9
– ident: CR133
– volume: 54
  start-page: 156
  year: 2017
  end-page: 5165
  ident: CR63
  article-title: Regulatory role of circular RNAs and neurological disorders
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-016-0055-4
– volume: 31
  start-page: 1336
  year: 2012
  end-page: 1349
  ident: CR187
  article-title: Mitochondrial quality control: a matter of life and death for neurons
  publication-title: EMBO J
  doi: 10.1038/emboj.2012.38
– volume: 18
  start-page: 4801
  year: 2009
  end-page: 4807
  ident: CR20
  article-title: Adenosine deamination in human transcripts generates novel microRNA binding sites
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddp443
– volume: 95
  start-page: 143
  year: 2014
  end-page: 161
  ident: CR19
  article-title: The Alu-rich genomic architecture of SPAST predisposes to diverse and functionally distinct disease-associated CNV alleles
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2014.06.014
– volume: 70
  start-page: 9
  year: 2011
  end-page: 15
  ident: CR26
  article-title: Regulation of axonal mitochondrial transport and its impact on synaptic transmission
  publication-title: Neurosci Res
  doi: 10.1016/j.neures.2011.02.005
– volume: 351
  start-page: aac7247
  year: 2016
  ident: CR57
  article-title: Retrotransposons as regulators of gene expression
  publication-title: Science
  doi: 10.1126/science.aac7247
– volume: 300
  start-page: 1288
  year: 2003
  end-page: 1291
  ident: CR119
  article-title: The birth of an alternatively spliced exon: 3’splice-site selection in Alu exons
  publication-title: Science
  doi: 10.1126/science.1082588
– volume: 276
  start-page: 135
  year: 2001
  end-page: 141
  ident: CR121
  article-title: Differential stress induction of individual Alu loci: implications for transcription and retrotransposition
  publication-title: Gene
  doi: 10.1016/S0378-1119(01)00637-0
– volume: 90
  start-page: 1977
  year: 1993
  end-page: 1981
  ident: CR206
  article-title: Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.90.5.1977
– volume: 7
  start-page: 3294
  year: 2008
  end-page: 3301
  ident: CR30
  article-title: Gene regulation by SINES and inosines: biological consequences of A-to-I editing of Alu element inverted repeats
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.21.6927
– volume: 10
  start-page: 68
  year: 2015
  ident: CR236
  article-title: Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer disease and hereditary spastic paraplegia
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-015-0064-1
– volume: 205
  start-page: 177
  year: 1997
  end-page: 182
  ident: CR22
  article-title: Mobile elements inserted in the distant past have taken on important functions
  publication-title: Gene
  doi: 10.1016/S0378-1119(97)00399-5
– volume: 15
  start-page: 497
  year: 2014
  end-page: 506
  ident: CR58
  article-title: Mobile DNA elements in the generation of diversity and complexity in the brain
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn3730
– volume: 19
  start-page: 357
  year: 2014
  end-page: 372
  ident: CR79
  article-title: The protein import machinery of mitochondria—a regulatory hub in metabolism, stress, and disease
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2014.01.010
– volume: 15
  start-page: 316
  year: 2000
  end-page: 323
  ident: CR237
  article-title: AluY insertion (IVS4-52ins316alu) in the glycerol kinase gene from an individual with benign glycerol kinase deficiency
  publication-title: Hum Mutat
  doi: 10.1002/(SICI)1098-1004(200004)15:4<316::AID-HUMU3>3.0.CO;2-9
– volume: 299
  start-page: 256
  year: 2003
  end-page: 259
  ident: CR18
  article-title: Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
  publication-title: Science
  doi: 10.1126/science.1077209
– volume: 3
  start-page: 370
  year: 2002
  end-page: 379
  ident: CR8
  article-title: Alu repeats and human genomic diversity
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg798
– volume: 369
  start-page: 20130504
  year: 2014
  end-page: 20130504
  ident: CR203
  article-title: The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity
  publication-title: Philos Trans R Soc B Biol Sci
  doi: 10.1098/rstb.2013.0504
– volume: 14
  start-page: 1064
  year: 2017
  end-page: 1074
  ident: CR55
  article-title: Increased complexity of circRNA expression during species evolution
  publication-title: RNA Biol
  doi: 10.1080/15476286.2016.1269999
– volume: 536
  start-page: 171
  year: 2016
  end-page: 178
  ident: CR69
  article-title: A multi-modal parcellation of human cerebral cortex
  publication-title: Nature
  doi: 10.1038/nature18933
– volume: 24
  start-page: 522
  year: 2014
  end-page: 534
  ident: CR189
  article-title: A biochemical landscape of A-to-I RNA editing in the human brain transcriptome
  publication-title: Genome Res
  doi: 10.1101/gr.162537.113
– ident: CR158
– volume: 14
  start-page: 143
  year: 2012
  end-page: 151
  ident: CR36
  article-title: Alu elements mediate large SPG11 gene rearrangements: further spatacsin mutations
  publication-title: Genet Med
  doi: 10.1038/gim.2011.7
– volume: 7
  start-page: 44465
  year: 2017
  ident: CR94
  article-title: Analysis of RP2 and RPGR mutations in five X-linked Chinese families with retinitis pigmentosa
  publication-title: Sci Rep
  doi: 10.1038/srep44465
– volume: 67
  start-page: 536
  year: 2010
  end-page: 541
  ident: CR181
  article-title: An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease
  publication-title: Arch Neurol
  doi: 10.1001/archneurol.2010.88
– volume: 27
  start-page: 480
  year: 2017
  end-page: 490
  ident: CR33
  article-title: ALUternative regulation for gene expression
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2017.01.002
– volume: 173
  start-page: 716
  year: 2016
  end-page: 728
  ident: CR84
  article-title: Immunoinflammatory diseases of the central nervous system—the tale of two cytokines
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13175
– ident: CR215
– volume: 141
  start-page: 1031
  year: 1998
  end-page: 1039
  ident: CR202
  article-title: Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture
  publication-title: J Cell Biol
  doi: 10.1083/jcb.141.4.1031
– volume: 19
  start-page: 3919
  year: 2010
  end-page: 3935
  ident: CR105
  article-title: Mitochondrial loss, dysfunction and altered dynamics in Huntington’s disease
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddq306
– volume: 92
  start-page: 229
  year: 2007
  end-page: 233
  ident: CR159
  article-title: A novel complex deletion–insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2007.06.018
– volume: 12
  start-page: 135
  year: 2016
  end-page: 147
  ident: CR184
  article-title: Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing
  publication-title: Expert Opin Drug Metab Toxicol
  doi: 10.1517/17425255.2016.1133586
– volume: 7
  start-page: 16
  year: 2016
  ident: CR71
  article-title: Restricting retrotransposons: a review
  publication-title: Mob DNA
  doi: 10.1186/s13100-016-0070-z
– volume: 41
  start-page: 194
  year: 2010
  end-page: 200
  ident: CR95
  article-title: Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences
  publication-title: Physiol Genomics
  doi: 10.1152/physiolgenomics.00146.2009
– volume: 187
  start-page: 26
  year: 2017
  end-page: 32
  ident: CR62
  article-title: An emerging role for mitochondrial dynamics in schizophrenia
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2017.05.003
– volume: 290
  start-page: 26204
  year: 2015
  end-page: 26217
  ident: CR110
  article-title: Evidence of distinct channel conformations and substrate binding affinities for the nitochondrial outer membrane protein translocase pore Tom40
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M115.642173
– volume: 22
  start-page: 4706
  year: 2013
  end-page: 4719
  ident: CR230
  article-title: The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddt319
– volume: 1415
  start-page: 136
  year: 2011
  end-page: 148
  ident: CR176
  article-title: Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer’s disease
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2011.07.052
– volume: 108
  start-page: 2837
  year: 2011
  end-page: 2842
  ident: CR199
  article-title: Widespread establishment and regulatory impact of Alu exons in human genes
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1012834108
– volume: 26
  start-page: 3421
  year: 2017
  end-page: 3431
  ident: CR174
  article-title: Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddx233
– volume: 112
  start-page: 6828
  year: 2015
  end-page: 6833
  ident: CR89
  article-title: Stress and the dynamic genome: steroids, epigenetics, and the transposome
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1411260111
– volume: 16
  start-page: 1518
  year: 2013
  end-page: 1522
  ident: CR120
  article-title: Deciphering the functions and regulation of brain-enriched A-to-I RNA editing
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3539
– volume: 3
  start-page: 1
  year: 2006
  end-page: 9
  ident: CR134
  article-title: A-to-I RNA editing and human disease
  publication-title: RNA Biol
  doi: 10.4161/rna.3.1.2495
– volume: 16
  start-page: 877
  year: 2017
  end-page: 897
  ident: CR67
  article-title: Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(17)30299-5
– volume: 6
  start-page: 125
  year: 2010
  end-page: 131
  ident: CR132
  article-title: Genetic variation at a single locus and age of onset for Alzheimer’s disease
  publication-title: Alzheimer’s Dement
  doi: 10.1016/j.jalz.2010.01.011
– volume: 427
  start-page: 801
  year: 2004
  ident: CR102
  article-title: Glutamate receptors: RNA editing and death of motor neurons
  publication-title: Nature
  doi: 10.1038/427801a
– volume: 24
  start-page: 1492
  year: 2014
  end-page: 1499
  ident: CR73
  article-title: The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2014.06.002
– volume: 155
  start-page: 31
  year: 1999
  end-page: 41
  ident: CR177
  article-title: Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer’s disease
  publication-title: Exp Neurol
  doi: 10.1006/exnr.1998.6977
– volume: 24
  start-page: 4061
  year: 2015
  end-page: 4077
  ident: CR76
  article-title: Alu-mediated diverse and complex pathogenic copy-number variants within human chromosome 17 at p13.3
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddv146
– volume: 14
  start-page: 1068
  year: 2004
  end-page: 1075
  ident: CR81
  article-title: Differential Alu mobilization and polymorphism among the human and chimpanzee lineages
  publication-title: Genome Res
  doi: 10.1101/gr.2530404
– volume: 270
  start-page: 22777
  year: 1995
  end-page: 22782
  ident: CR156
  article-title: Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.39.22777
– volume: 10
  start-page: e0117854
  year: 2015
  ident: CR109
  article-title: The evidence for increased L1 activity in the site of human adult brain neurogenesis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0117854
– ident: CR72
– volume: 19
  start-page: 526
  year: 2002
  end-page: 535
  ident: CR111
  article-title: Characterization of breakpoint sequences of five rearrangements in L1CAM and ABCD1 (ALD) genes
  publication-title: Hum Mutat
  doi: 10.1002/humu.10072
– volume: 89
  start-page: 222
  year: 2006
  end-page: 226
  ident: CR238
  article-title: Identification of Alu-mediated, large deletion-spanning exons 2-4 in a patient with mitochondrial acetoacetyl-CoA thiolase deficiency
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2006.06.010
– volume: 20
  start-page: 265
  year: 2010
  ident: CR209
  article-title: The Alzheimer’s disease mitochondrial cascade hypothesis
  publication-title: J Alzheimer’s Dis JAD
  doi: 10.3233/JAD-2010-100339
– volume: 11
  start-page: 1447
  year: 2014
  end-page: 1456
  ident: CR128
  article-title: Positive correlation between ADAR expression and its targets suggests a complex regulation mediated by RNA editing in the human brain
  publication-title: RNA Biol
  doi: 10.4161/15476286.2014.992286
– volume: 10
  start-page: 691
  year: 2009
  end-page: 703
  ident: CR38
  article-title: The impact of retrotransposons on human genome evolution
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2640
– volume: 24
  start-page: 365
  year: 2014
  end-page: 376
  ident: CR9
  article-title: A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes
  publication-title: Genome Res
  doi: 10.1101/gr.164749.113
– ident: CR117
– volume: 289
  start-page: 10887
  year: 2014
  end-page: 10899
  ident: CR68
  article-title: DJ-1 is a copper chaperone acting on SOD1 activation
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.535112
– volume: 7
  start-page: 5
  year: 2014
  ident: CR108
  article-title: A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia
  publication-title: Mol Brain
  doi: 10.1186/1756-6606-7-5
– volume: 24
  start-page: 4033
  year: 2010
  end-page: 4046
  ident: CR28
  article-title: An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells
  publication-title: FASEB J
  doi: 10.1096/fj.10-157032
– volume: 90
  start-page: 408
  year: 2007
  end-page: 413
  ident: CR194
  article-title: Characterization of two unusual truncating PMM2 mutations in two CDG-Ia patients
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2007.01.003
– volume: 5
  start-page: 34
  year: 2012
  ident: CR234
  article-title: The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain
  publication-title: Front Mol Neurosci
– volume: 17
  start-page: 84
  year: 2016
  ident: CR154
  article-title: Repetitive element hypermethylation in multiple sclerosis patients
  publication-title: BMC Genet
  doi: 10.1186/s12863-016-0395-0
– volume: 1
  start-page: 90
  year: 2016
  end-page: 94
  ident: CR164
  article-title: Insights into the role of somatic mosaicism in the brain
  publication-title: Curr Opin Syst Biol
  doi: 10.1016/j.coisb.2016.12.004
– volume: 471
  start-page: 325
  year: 2011
  end-page: 330
  ident: CR100
  article-title: DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
  publication-title: Nature
  doi: 10.1038/nature09830
– volume: 45
  start-page: D750
  year: 2017
  end-page: D757
  ident: CR170
  article-title: REDIportal: a comprehensive database of A-to-I RNA editing events in humans
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkw767
– ident: CR233
– volume: 81
  start-page: 306
  year: 2014
  end-page: 313
  ident: CR24
  article-title: Increased L1 retrotransposition in the neuronal genome in schizophrenia
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.10.053
– volume: 107
  start-page: 355
  year: 2012
  end-page: 415
  ident: CR141
  article-title: Biology of mitochondria in neurodegenerative diseases
  publication-title: Prog Mol Biol Transl Sci
  doi: 10.1016/B978-0-12-385883-2.00005-9
– volume: 5
  start-page: a011304
  year: 2013
  ident: CR196
  article-title: Mitochondrial trafficking in neurons
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a011304
– volume: 29
  start-page: 227
  year: 1995
  end-page: 235
  ident: CR43
  article-title: Mitochondrial abnormalities in CLN2 and CLN3 forms batten disease. Mol Chem
  publication-title: Neuro
– volume: 161
  start-page: 1869
  year: 2002
  end-page: 1879
  ident: CR211
  article-title: Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)64463-X
– volume: 31
  start-page: 227
  year: 2008
  end-page: 233
  ident: CR142
  article-title: RNA editing, DNA recoding and the evolution of human cognition
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2008.02.003
– volume: 485
  start-page: 376
  year: 2012
  end-page: 380
  ident: CR53
  article-title: Topological domains in mammalian genomes identified by analysis of chromatin interactions
  publication-title: Nature
  doi: 10.1038/nature11082
– volume: 18
  start-page: 794
  year: 2015
  end-page: 799
  ident: CR82
  article-title: The case for rejecting the amyloid cascade hypothesis
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4017
– volume: 2
  start-page: 451
  year: 2014
  end-page: 453
  ident: CR157
  article-title: Alport syndrome caused by a COL4A5 deletion and exonization of an adjacent AluY
  publication-title: Mol Genet genomic Med
  doi: 10.1002/mgg3.89
– ident: CR193
– volume: 264
  start-page: 11394
  year: 1989
  end-page: 11400
  ident: CR87
  article-title: Hypobetalipoproteinemia due to an apolipoprotein B gene exon 21 deletion derived by Alu-Alu recombination
  publication-title: J Biol Chem
– volume: 17
  start-page: 683
  year: 2013
  end-page: 696
  ident: CR222
  article-title: Network hubs in the human brain
  publication-title: Trends Cogn Sci
  doi: 10.1016/j.tics.2013.09.012
– volume: 12
  start-page: 65
  year: 2011
  end-page: 72
  ident: CR91
  article-title: Amyloid-β and tau—a toxic pas de deux in Alzheimer’s disease
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2967
– volume: 33
  start-page: 2845
  year: 2015
  end-page: 2852
  ident: CR123
  article-title: Aberrant alternative splicing pattern of ADAR2 downregulates adenosine-to-inosine editing in glioma
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.3907
– volume: 26
  start-page: 9057
  year: 2006
  end-page: 9068
  ident: CR52
  article-title: Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer’s disease brain is associated with mitochondrial dysfunction
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1469-06.2006
– volume: 9
  start-page: 1184
  year: 2014
  end-page: 1193
  ident: CR207
  article-title: Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E
  publication-title: Epigenetics
  doi: 10.4161/epi.29676
– volume: 5
  start-page: 14941
  year: 2015
  ident: CR169
  article-title: Profiling RNA editing in human tissues: towards the inosinome Atlas
  publication-title: Sci Rep
  doi: 10.1038/srep14941
– volume: 7
  start-page: 94
  year: 2015
  ident: CR45
  article-title: Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2015.00094
– volume: 242
  start-page: 11
  year: 2011
  end-page: 21
  ident: CR137
  article-title: Functional refolding and characterization of two Tom40 isoforms from human mitochondria
  publication-title: J Membr Biol
  doi: 10.1007/s00232-011-9372-8
– volume: 29
  start-page: 493
  year: 2004
  end-page: 504
  ident: CR186
  article-title: Mitochondrial dysfunction in neurodegenerative diseases associated with copper imbalance
  publication-title: Neurochem. Res.
  doi: 10.1023/B:NERE.0000014820.99232.8a
– volume: 67
  start-page: 183
  year: 1999
  end-page: 193
  ident: CR50
  article-title: Alu repeats and human disease
  publication-title: Mol Genet Metab
  doi: 10.1006/mgme.1999.2864
– volume: 17
  start-page: 83
  year: 2016
  end-page: 96
  ident: CR155
  article-title: A-to-I editing of coding and non-coding RNAs by ADARs
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm.2015.4
– volume: 15
  start-page: 1
  year: 2017
  end-page: 2
  ident: CR29
  article-title: Presenilins at the crossroad of a functional interplay between PARK/PARKIN and PINK1 to control mitophagy: implications for neurodegenerative diseases
  publication-title: Autophagy
– volume: 6
  start-page: e878
  year: 2016
  ident: CR232
  article-title: Region-specific alterations of A-to-I RNA editing of serotonin 2c receptor in the cortex of suicides with major depression
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2016.121
– volume: 28
  start-page: 303
  year: 2012
  end-page: 3088
  ident: CR2
  article-title: Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer’s disease and severe cerebral amyloid angiopathy
  publication-title: J Alzheimers Dis
– volume: 29
  start-page: 105
  year: 2007
  end-page: 108
  ident: CR75
  article-title: The first reported case of Menkes disease caused by an Alu insertion mutation
  publication-title: Brain Dev
  doi: 10.1016/j.braindev.2006.05.012
– volume: 35
  start-page: 1092
  year: 2014
  end-page: 1100
  ident: CR191
  article-title: Deletions in the 3′ part of the gene including a recurrent Alu-mediated deletion of exon 6 and 7 account for previously unexplained cases of Marshall-Smith syndrome
  publication-title: Hum Mutat
  doi: 10.1002/humu.22603
– volume: 291
  start-page: 16644
  year: 2016
  end-page: 16658
  ident: CR13
  article-title: The activity of menkes disease protein ATP7A is essential for redox balance in mitochondria
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.727248
– volume: 8
  start-page: 237
  year: 2016
  end-page: 249
  ident: CR114
  article-title: The dynamic genome: transposons and environmental adaptation in the nervous system
  publication-title: Epigenomics
  doi: 10.2217/epi.15.107
– volume: 130
  start-page: 234
  year: 2009
  end-page: 239
  ident: CR15
  article-title: Decline in genomic DNA methylation through aging in a cohort of elderly subjects
  publication-title: Mech Ageing Dev
  doi: 10.1016/j.mad.2008.12.003
– volume: 354
  start-page: 557
  year: 2016
  end-page: 558
  ident: CR59
  article-title: One brain, many genomes
  publication-title: Science
  doi: 10.1126/science.aak9761
– ident: CR163
– volume: 132
  start-page: 1177
  year: 2013
  end-page: 1185
  ident: CR223
  article-title: The mitochondrial solute carrier SLC25A5 at Xq24 is a novel candidate gene for non-syndromic intellectual disabilty
  publication-title: Hum Genet
  doi: 10.1007/s00439-013-1322-3
– volume: 16
  start-page: 97
  year: 2015
  end-page: 105
  ident: CR129
  article-title: Characterization of Alu and recombination-associated motifs mediating a large homozygous SPG7 gene rearrangement causing hereditary spastic paraplegia
  publication-title: Neurogenetics
  doi: 10.1007/s10048-014-0429-6
– volume: 2
  start-page: e73
  year: 2016
  ident: CR149
  article-title: Genomic mechanisms underlying PARK2 large deletions identified in a cohort of patients with PD
  publication-title: Neurol Genet
  doi: 10.1212/NXG.0000000000000073
– volume: 27
  start-page: R1177
  year: 2017
  end-page: R1192
  ident: CR180
  article-title: The origin and diversification of mitochondria
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2017.09.015
– volume: 173
  start-page: 2782
  year: 2017
  end-page: 2788
  ident: CR97
  article-title: New intragenic rearrangements in non-Finnish mulibrey nanism
  publication-title: Am J Med Genet Part A
  doi: 10.1002/ajmg.a.38381
– volume: 19
  start-page: 141
  year: 2013
  end-page: 157
  ident: CR93
  article-title: Circular RNAs are abundant, conserved, and associated with ALU repeats
  publication-title: RNA
  doi: 10.1261/rna.035667.112
– volume: 22
  start-page: 290
  year: 2016
  end-page: 302
  ident: CR104
  article-title: Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer’s disease
  publication-title: RNA
  doi: 10.1261/rna.054627.115
– volume: 7
  start-page: 133
  year: 2006
  ident: CR172
  article-title: Alu elements contain many binding sites for transcription factors and may play a role in regulation of developmental processes
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-7-133
– ident: CR78
– volume: 29
  start-page: 522
  year: 2008
  end-page: 531
  ident: CR3
  article-title: A clinical, genetic, and biochemical characterization of SPG7 mutations in a large cohort of patients with hereditary spastic paraplegia
  publication-title: Hum Mutat
  doi: 10.1002/humu.20682
– volume: 8
  start-page: 755
  year: 2007
  end-page: 765
  ident: CR135
  article-title: Retinoic acid in the development, regeneration and maintenance of the nervous system
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2212
– ident: CR168
– volume: 92
  start-page: 8229
  year: 1995
  end-page: 8233
  ident: CR224
  article-title: The consensus sequence of a major Alu subfamily contains a functional retinoic acid response element
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.92.18.8229
– ident: CR175
– volume: 111
  start-page: 16082
  year: 2014
  end-page: 16087
  ident: CR106
  article-title: DICER1/Alu RNA dysmetabolism induces caspase-8-mediated cell death in age-related macular degeneration
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1403814111
– volume: 23
  start-page: 952
  year: 2016
  end-page: 954
  ident: CR131
  article-title: Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb.3318
– volume: 2
  start-page: e391
  year: 2004
  ident: CR5
  article-title: Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0020391
– volume: 31
  start-page: 10128
  year: 2011
  end-page: 10140
  ident: CR228
  article-title: Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0884-11.2011
– volume: 12
  start-page: 1802
  year: 2006
  end-page: 1809
  ident: CR153
  article-title: RNA editing level in the mouse is determined by the genomic repeat repertoire
  publication-title: RNA
  doi: 10.1261/rna.165106
– volume: 342
  start-page: 710
  year: 1993
  end-page: 711
  ident: CR190
  article-title: Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer’s disease and in other amyloid-forming diseases
  publication-title: Lancet (London, England)
  doi: 10.1016/0140-6736(93)91709-U
– volume: 13
  start-page: 431
  year: 1999
  end-page: 438
  ident: CR152
  article-title: Insertion of Alu element responsible for acute intermittent porphyria
  publication-title: Hum Mutat
  doi: 10.1002/(SICI)1098-1004(1999)13:6<431::AID-HUMU2>3.0.CO;2-Y
– volume: 2
  start-page: 8
  year: 2011
  ident: CR160
  article-title: Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates
  publication-title: Mob DNA
  doi: 10.1186/1759-8753-2-8
– volume: 924
  start-page: 17
  year: 2000
  end-page: 25
  ident: CR198
  article-title: Toward a comprehensive theory for Alzheimer’s disease. Hypothesis: Alzheimer’s disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2000.tb05554.x
– volume: 2
  start-page: e1600584
  year: 2016
  end-page: e1600584
  ident: CR162
  article-title: Epigenetics and aging
  publication-title: Sci Adv
  doi: 10.1126/sciadv.1600584
– volume: 131
  start-page: 407
  year: 2012
  end-page: 413
  ident: CR216
  article-title: Novel Alu retrotransposon insertion leading to Alström syndrome
  publication-title: Hum Genet
  doi: 10.1007/s00439-011-1083-9
– volume: 136
  start-page: 55
  year: 2017
  end-page: 65
  ident: CR98
  article-title: Network analysis of mitonuclear GWAS reveals functional networks and tissue expression profiles of disease-associated genes
  publication-title: Hum Genet
  doi: 10.1007/s00439-016-1736-9
– volume: 37
  start-page: 90
  year: 2016
  end-page: 100
  ident: CR147
  article-title: How retrotransposons shape genome regulation
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2016.01.001
– ident: CR146
– volume: 143
  start-page: 721
  year: 2007
  end-page: 726
  ident: CR220
  article-title: An Alu retrotransposition-mediated deletion of CHD7 in a patient with CHARGE syndrome
  publication-title: Am J Med Genet Part A
  doi: 10.1002/ajmg.a.31441
– volume: 88
  start-page: 548
  year: 2014
  end-page: 559
  ident: CR46
  article-title: Brain metabolic dysfunction at the core of Alzheimer’s disease
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2013.12.012
– volume: 29
  start-page: 499
  year: 2008
  end-page: 509
  ident: CR140
  article-title: Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2007.12.013
– volume: 12
  start-page: 51
  year: 2011
  end-page: 58
  ident: CR34
  article-title: Inheritance of Charcot–Marie–Tooth disease 1A with rare nonrecurrent genomic rearrangement
  publication-title: Neurogenetics
  doi: 10.1007/s10048-010-0272-3
– volume: 6
  start-page: 1758
  year: 2014
  end-page: 1771
  ident: CR173
  article-title: Sequence-level mechanisms of human epigenome evolution
  publication-title: Genome Biol Evol
  doi: 10.1093/gbe/evu142
– volume: 77
  start-page: 886
  year: 2013
  end-page: 898
  ident: CR229
  article-title: Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.01.012
– volume: 83
  start-page: 110
  year: 2005
  end-page: 120
  ident: CR112
  article-title: Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis
  publication-title: J Mol Med (Berl)
  doi: 10.1007/s00109-004-0599-z
– volume: 58
  start-page: 870
  year: 2015
  end-page: 885
  ident: CR188
  article-title: Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2015.03.027
– volume: 349
  start-page: 1544
  year: 2015
  end-page: 1548
  ident: CR200
  article-title: Molecular architecture of the active mitochondrial protein gate
  publication-title: Science
  doi: 10.1126/science.aac6428
– volume: 38
  start-page: 120
  year: 2001
  end-page: 134
  ident: CR40
  article-title: Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer’s disease
  publication-title: Histopathology
  doi: 10.1046/j.1365-2559.2001.01082.x
– volume: 82
  start-page: 949
  year: 1995
  end-page: 957
  ident: CR118
  article-title: Isolation of a novel gene underlying Batten disease, CLN3
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90274-0
– volume: 143
  start-page: 721
  year: 2007
  ident: 9573_CR220
  publication-title: Am J Med Genet Part A
  doi: 10.1002/ajmg.a.31441
– ident: 9573_CR226
  doi: 10.1038/ncomms7569
– volume: 15
  start-page: 497
  year: 2014
  ident: 9573_CR58
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn3730
– volume: 8
  start-page: 58
  year: 2016
  ident: 9573_CR10
  publication-title: Genome Med
  doi: 10.1186/s13073-016-0317-9
– volume: 110
  start-page: 13457
  year: 2013
  ident: 9573_CR86
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1310914110
– volume: 67
  start-page: 183
  year: 1999
  ident: 9573_CR50
  publication-title: Mol Genet Metab
  doi: 10.1006/mgme.1999.2864
– volume: 471
  start-page: 325
  year: 2011
  ident: 9573_CR100
  publication-title: Nature
  doi: 10.1038/nature09830
– volume: 173
  start-page: 2782
  year: 2017
  ident: 9573_CR97
  publication-title: Am J Med Genet Part A
  doi: 10.1002/ajmg.a.38381
– volume: 35
  start-page: 467
  year: 2009
  ident: 9573_CR31
  publication-title: Molecular Cell
  doi: 10.1016/j.molcel.2009.06.027
– volume: 319
  start-page: 149
  year: 2003
  ident: 9573_CR227
  publication-title: Gene
  doi: 10.1016/S0378-1119(03)00805-9
– volume: 354
  start-page: 557
  year: 2016
  ident: 9573_CR59
  publication-title: Science
  doi: 10.1126/science.aak9761
– volume: 28
  start-page: 303
  year: 2012
  ident: 9573_CR2
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2011-110911
– volume: 2
  start-page: 13
  year: 2009
  ident: 9573_CR212
  publication-title: Mol Brain
  doi: 10.1186/1756-6606-2-13
– volume: 5
  start-page: e1000610
  year: 2009
  ident: 9573_CR219
  publication-title: PLOS Comput Biol
  doi: 10.1371/journal.pcbi.1000610
– volume: 9
  start-page: 39
  year: 2016
  ident: 9573_CR35
  publication-title: Dis Model Mech
  doi: 10.1242/dmm.021766
– volume: 7
  start-page: 133
  year: 2006
  ident: 9573_CR172
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-7-133
– volume: 19
  start-page: 327
  year: 1998
  ident: 9573_CR195
  publication-title: Nat Genet
  doi: 10.1038/1214
– volume: 15
  start-page: 316
  year: 2000
  ident: 9573_CR237
  publication-title: Hum Mutat
  doi: 10.1002/(SICI)1098-1004(200004)15:4<316::AID-HUMU3>3.0.CO;2-9
– volume: 7
  start-page: 41095
  year: 2017
  ident: 9573_CR61
  publication-title: Sci Rep
  doi: 10.1038/srep41095
– ident: 9573_CR185
  doi: 10.1038/nm1066
– ident: 9573_CR74
  doi: 10.1093/molbev/msg153
– volume: 435
  start-page: 903
  year: 2005
  ident: 9573_CR150
  publication-title: Nature
  doi: 10.1038/nature03663
– volume: 90
  start-page: 408
  year: 2007
  ident: 9573_CR194
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2007.01.003
– volume: 95
  start-page: 143
  year: 2014
  ident: 9573_CR19
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2014.06.014
– volume: 90
  start-page: 93
  year: 2007
  ident: 9573_CR21
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2006.09.005
– volume: 17
  start-page: 84
  year: 2016
  ident: 9573_CR154
  publication-title: BMC Genet
  doi: 10.1186/s12863-016-0395-0
– volume: 6
  start-page: 125
  year: 2010
  ident: 9573_CR132
  publication-title: Alzheimer’s Dement
  doi: 10.1016/j.jalz.2010.01.011
– volume: 479
  start-page: 534
  year: 2011
  ident: 9573_CR6
  publication-title: Nature
  doi: 10.1038/nature10531
– volume: 88
  start-page: 548
  year: 2014
  ident: 9573_CR46
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2013.12.012
– volume: 351
  start-page: aac7247
  year: 2016
  ident: 9573_CR57
  publication-title: Science
  doi: 10.1126/science.aac7247
– volume: 300
  start-page: 1288
  year: 2003
  ident: 9573_CR119
  publication-title: Science
  doi: 10.1126/science.1082588
– volume: 161
  start-page: 1869
  year: 2002
  ident: 9573_CR211
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)64463-X
– volume: 19
  start-page: 1093
  year: 2016
  ident: 9573_CR90
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4337
– volume: 3
  start-page: 1
  year: 2006
  ident: 9573_CR134
  publication-title: RNA Biol
  doi: 10.4161/rna.3.1.2495
– ident: 9573_CR133
  doi: 10.1016/j.neurobiolaging.2014.01.006
– volume: 426
  start-page: 91
  year: 2016
  ident: 9573_CR231
  publication-title: Mol Cell Endrocrinol
  doi: 10.1016/j.mce.2016.02.008
– volume: 12
  start-page: e1005827
  year: 2016
  ident: 9573_CR17
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1005827
– volume: 77
  start-page: 886
  year: 2013
  ident: 9573_CR229
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.01.012
– volume: 6
  start-page: 8207
  year: 2015
  ident: 9573_CR218
  publication-title: Nat Commun
  doi: 10.1038/ncomms9207
– volume: 39
  start-page: 597
  year: 2016
  ident: 9573_CR32
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2016.06.006
– volume: 32
  start-page: 688
  year: 2011
  ident: 9573_CR54
  publication-title: Hum Mutat
  doi: 10.1002/humu.21474
– ident: 9573_CR14
  doi: 10.1093/molbev/msx303
– volume: 14
  start-page: 143
  year: 2012
  ident: 9573_CR36
  publication-title: Genet Med
  doi: 10.1038/gim.2011.7
– volume: 90
  start-page: 1977
  year: 1993
  ident: 9573_CR206
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.90.5.1977
– volume: 24
  start-page: 4061
  year: 2015
  ident: 9573_CR76
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddv146
– volume: 1415
  start-page: 136
  year: 2011
  ident: 9573_CR176
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2011.07.052
– volume: 8
  start-page: 23
  year: 2007
  ident: 9573_CR113
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-8-23
– volume: 342
  start-page: 710
  year: 1993
  ident: 9573_CR190
  publication-title: Lancet (London, England)
  doi: 10.1016/0140-6736(93)91709-U
– volume: 7
  start-page: 63
  year: 2005
  ident: 9573_CR205
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2005-7107
– volume: 468
  start-page: 443
  year: 2010
  ident: 9573_CR151
  publication-title: Nature
  doi: 10.1038/nature09544
– volume: 14
  start-page: 1064
  year: 2017
  ident: 9573_CR55
  publication-title: RNA Biol
  doi: 10.1080/15476286.2016.1269999
– volume: 18
  start-page: 443
  year: 2016
  ident: 9573_CR167
  publication-title: Genet Med
  doi: 10.1038/gim.2015.124
– volume: 9
  start-page: a023622
  year: 2017
  ident: 9573_CR197
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a023622
– volume: 13
  start-page: 343
  year: 2002
  ident: 9573_CR83
  publication-title: Neuroreport
  doi: 10.1097/00001756-200203040-00019
– volume: 22
  start-page: 4706
  year: 2013
  ident: 9573_CR230
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddt319
– ident: 9573_CR139
  doi: 10.1016/j.gene.2015.05.067
– volume: 34
  start-page: 349
  year: 2002
  ident: 9573_CR77
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)00660-8
– volume: 12
  start-page: 51
  year: 2011
  ident: 9573_CR34
  publication-title: Neurogenetics
  doi: 10.1007/s10048-010-0272-3
– volume: 7
  start-page: 16
  year: 2016
  ident: 9573_CR71
  publication-title: Mob DNA
  doi: 10.1186/s13100-016-0070-z
– volume: 20
  start-page: 990
  year: 2012
  ident: 9573_CR16
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2012.29
– volume: 924
  start-page: 17
  year: 2000
  ident: 9573_CR198
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2000.tb05554.x
– volume: 7
  start-page: 94
  year: 2015
  ident: 9573_CR45
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2015.00094
– volume: 448
  start-page: 151
  year: 2009
  ident: 9573_CR210
  publication-title: Gene
  doi: 10.1016/j.gene.2009.08.006
– ident: 9573_CR175
  doi: 10.1038/nature11128
– volume: 15
  start-page: R28
  year: 2014
  ident: 9573_CR41
  publication-title: Genome Biol
  doi: 10.1186/gb-2014-15-2-r28
– volume: 104
  start-page: 97
  year: 2017
  ident: 9573_CR116
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2017.04.020
– volume: 10
  start-page: 691
  year: 2009
  ident: 9573_CR38
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2640
– volume: 26
  start-page: 3421
  year: 2017
  ident: 9573_CR174
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddx233
– volume: 29
  start-page: 499
  year: 2008
  ident: 9573_CR140
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2007.12.013
– volume: 114
  start-page: E3984
  year: 2017
  ident: 9573_CR165
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1704117114
– volume: 14
  start-page: 1223
  year: 2017
  ident: 9573_CR7
  publication-title: RNA Biol
  doi: 10.1080/15476286.2017.1306173
– volume: 92
  start-page: 229
  year: 2007
  ident: 9573_CR159
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2007.06.018
– ident: 9573_CR92
  doi: 10.1002/glia.23252
– volume: 2002
  start-page: pe26
  year: 2002
  ident: 9573_CR192
  publication-title: Sci STKE
  doi: 10.1126/stke.2002.133.pe26
– volume: 2
  start-page: 1101
  year: 2008
  ident: 9573_CR47
  publication-title: J Diabetes Sci Technol
  doi: 10.1177/193229680800200619
– ident: 9573_CR146
  doi: 10.1371/journal.pone.0105723
– volume: 11
  start-page: 1447
  year: 2014
  ident: 9573_CR128
  publication-title: RNA Biol
  doi: 10.4161/15476286.2014.992286
– volume: 13
  start-page: 431
  year: 1999
  ident: 9573_CR152
  publication-title: Hum Mutat
  doi: 10.1002/(SICI)1098-1004(1999)13:6<431::AID-HUMU2>3.0.CO;2-Y
– volume: 70
  start-page: 9
  year: 2011
  ident: 9573_CR26
  publication-title: Neurosci Res
  doi: 10.1016/j.neures.2011.02.005
– volume: 13
  start-page: 651
  year: 2003
  ident: 9573_CR51
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2003.10.013
– volume: 436
  start-page: 12
  year: 2009
  ident: 9573_CR88
  publication-title: Gene
  doi: 10.1016/j.gene.2009.01.013
– volume: 141
  start-page: 1031
  year: 1998
  ident: 9573_CR202
  publication-title: J Cell Biol
  doi: 10.1083/jcb.141.4.1031
– volume: 20
  start-page: 200
  year: 2010
  ident: 9573_CR12
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2010.06.001
– volume: 19
  start-page: 141
  year: 2013
  ident: 9573_CR93
  publication-title: RNA
  doi: 10.1261/rna.035667.112
– volume: 1
  start-page: 507
  year: 2000
  ident: 9573_CR138
  publication-title: Annu Rev Genomics Hum Genet
  doi: 10.1146/annurev.genom.1.1.507
– volume: 24
  start-page: 365
  year: 2014
  ident: 9573_CR9
  publication-title: Genome Res
  doi: 10.1101/gr.164749.113
– volume: 10
  start-page: 68
  year: 2015
  ident: 9573_CR236
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-015-0064-1
– volume: 23
  start-page: 952
  year: 2016
  ident: 9573_CR131
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb.3318
– volume: 3
  start-page: 370
  year: 2002
  ident: 9573_CR8
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg798
– volume: 33
  start-page: 2845
  year: 2015
  ident: 9573_CR123
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.3907
– volume: 2
  start-page: 451
  year: 2014
  ident: 9573_CR157
  publication-title: Mol Genet genomic Med
  doi: 10.1002/mgg3.89
– volume: 22
  start-page: 290
  year: 2016
  ident: 9573_CR104
  publication-title: RNA
  doi: 10.1261/rna.054627.115
– volume: 289
  start-page: 10887
  year: 2014
  ident: 9573_CR68
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.535112
– ident: 9573_CR208
  doi: 10.3233/JAD-170585
– volume: 349
  start-page: 1544
  year: 2015
  ident: 9573_CR200
  publication-title: Science
  doi: 10.1126/science.aac6428
– volume: 291
  start-page: 16644
  year: 2016
  ident: 9573_CR13
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.727248
– volume: 21
  start-page: 77
  year: 2005
  ident: 9573_CR56
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2004.12.005
– volume: 131
  start-page: 407
  year: 2012
  ident: 9573_CR216
  publication-title: Hum Genet
  doi: 10.1007/s00439-011-1083-9
– volume: 83
  start-page: 110
  year: 2005
  ident: 9573_CR112
  publication-title: J Mol Med (Berl)
  doi: 10.1007/s00109-004-0599-z
– volume: 16
  start-page: 97
  year: 2015
  ident: 9573_CR129
  publication-title: Neurogenetics
  doi: 10.1007/s10048-014-0429-6
– volume: 6
  start-page: 1758
  year: 2014
  ident: 9573_CR173
  publication-title: Genome Biol Evol
  doi: 10.1093/gbe/evu142
– volume: 92
  start-page: 8229
  year: 1995
  ident: 9573_CR224
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.92.18.8229
– ident: 9573_CR163
  doi: 10.1385/1-59745-088-X:197
– volume: 37
  start-page: 90
  year: 2016
  ident: 9573_CR147
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2016.01.001
– volume: 14
  start-page: 1068
  year: 2004
  ident: 9573_CR81
  publication-title: Genome Res
  doi: 10.1101/gr.2530404
– volume: 270
  start-page: 22777
  year: 1995
  ident: 9573_CR156
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.39.22777
– volume: 7
  start-page: 3294
  year: 2008
  ident: 9573_CR30
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.21.6927
– ident: 9573_CR37
  doi: 10.1093/brain/awx347
– volume: 6
  start-page: 577
  year: 2015
  ident: 9573_CR101
  publication-title: Genes (Basel)
  doi: 10.3390/genes6030577
– volume: 6
  start-page: 25589
  year: 2016
  ident: 9573_CR148
  publication-title: Sci Rep
  doi: 10.1038/srep25589
– volume: 1
  start-page: 90
  year: 2016
  ident: 9573_CR164
  publication-title: Curr Opin Syst Biol
  doi: 10.1016/j.coisb.2016.12.004
– volume: 23
  start-page: 1729
  year: 2017
  ident: 9573_CR204
  publication-title: RNA
  doi: 10.1261/rna.061317.117
– volume: 13
  start-page: 739
  year: 2017
  ident: 9573_CR25
  publication-title: Alzheimer’s Dement
  doi: 10.1016/j.jalz.2016.12.009
– volume: 7
  start-page: 43421
  year: 2017
  ident: 9573_CR66
  publication-title: Sci Rep
  doi: 10.1038/srep43421
– ident: 9573_CR72
– volume: 2
  start-page: e1600584
  year: 2016
  ident: 9573_CR162
  publication-title: Sci Adv
  doi: 10.1126/sciadv.1600584
– volume: 62
  start-page: 630
  year: 2016
  ident: 9573_CR225
  publication-title: Biomeditsinskaya Khimiya
  doi: 10.18097/pbmc20166206630
– volume: 111
  start-page: 16082
  year: 2014
  ident: 9573_CR106
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1403814111
– volume: 107
  start-page: 355
  year: 2012
  ident: 9573_CR141
  publication-title: Prog Mol Biol Transl Sci
  doi: 10.1016/B978-0-12-385883-2.00005-9
– volume: 39
  start-page: 217
  year: 2016
  ident: 9573_CR166
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2015.11.017
– volume: 9
  start-page: 93
  year: 2017
  ident: 9573_CR217
  publication-title: Clin Epigenetics
  doi: 10.1186/s13148-017-0395-6
– volume: 8
  start-page: 755
  year: 2007
  ident: 9573_CR135
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2212
– ident: 9573_CR235
  doi: 10.1016/j.neurobiolaging.2013.01.003
– volume: 19
  start-page: 3919
  year: 2010
  ident: 9573_CR105
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddq306
– volume: 112
  start-page: 6828
  year: 2015
  ident: 9573_CR89
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1411260111
– volume: 369
  start-page: 20130504
  year: 2014
  ident: 9573_CR203
  publication-title: Philos Trans R Soc B Biol Sci
  doi: 10.1098/rstb.2013.0504
– volume: 13
  start-page: 828
  year: 2017
  ident: 9573_CR115
  publication-title: Alzheimer’s Dement.
  doi: 10.1016/j.jalz.2017.01.017
– volume: 7
  start-page: 263
  year: 2011
  ident: 9573_CR143
  publication-title: Alzheimer’s Dement.
  doi: 10.1016/j.jalz.2011.03.005
– volume: 536
  start-page: 171
  year: 2016
  ident: 9573_CR69
  publication-title: Nature
  doi: 10.1038/nature18933
– volume: 108
  start-page: 2837
  year: 2011
  ident: 9573_CR199
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1012834108
– volume: 20
  start-page: 265
  year: 2010
  ident: 9573_CR209
  publication-title: J Alzheimer’s Dis JAD
  doi: 10.3233/JAD-2010-100339
– volume: 15
  start-page: 1
  year: 2017
  ident: 9573_CR29
  publication-title: Autophagy
  doi: 10.1080/15548627.2017.1363950
– ident: 9573_CR80
  doi: 10.1126/science.1566067
– volume: 550
  start-page: 249
  year: 2017
  ident: 9573_CR213
  publication-title: Nature
  doi: 10.1038/nature24041
– volume: 312
  start-page: 171
  year: 1984
  ident: 9573_CR221
  publication-title: Nature
  doi: 10.1038/312171a0
– volume: 44
  start-page: D1251
  year: 2015
  ident: 9573_CR27
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkv1003
– volume: 24
  start-page: 1492
  year: 2014
  ident: 9573_CR73
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2014.06.002
– volume: 31
  start-page: 227
  year: 2008
  ident: 9573_CR142
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2008.02.003
– volume: 6
  start-page: e878
  year: 2016
  ident: 9573_CR232
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2016.121
– volume: 29
  start-page: 227
  year: 1995
  ident: 9573_CR43
  publication-title: Neuro
– volume: 299
  start-page: 256
  year: 2003
  ident: 9573_CR18
  publication-title: Science
  doi: 10.1126/science.1077209
– volume: 58
  start-page: 870
  year: 2015
  ident: 9573_CR188
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2015.03.027
– volume: 2
  start-page: e391
  year: 2004
  ident: 9573_CR5
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0020391
– volume: 10
  start-page: 375
  year: 2010
  ident: 9573_CR182
  publication-title: Pharmacogenomics J
  doi: 10.1038/tpj.2009.69
– volume: 136
  start-page: 1265
  year: 2017
  ident: 9573_CR64
  publication-title: Hum Genet
  doi: 10.1007/s00439-017-1837-0
– volume: 173
  start-page: 1378
  year: 2017
  ident: 9573_CR107
  publication-title: Am J Med Genet Part A
  doi: 10.1002/ajmg.a.38181
– ident: 9573_CR201
  doi: 10.1007/s12035-017-0421-x
– volume: 7
  start-page: 5
  year: 2014
  ident: 9573_CR108
  publication-title: Mol Brain
  doi: 10.1186/1756-6606-7-5
– ident: 9573_CR117
  doi: 10.1371/journal.pone.0004456
– volume: 3
  start-page: 639
  year: 2013
  ident: 9573_CR1
  publication-title: Curr. Opin. Virol.
  doi: 10.1016/j.coviro.2013.09.002
– volume: 89
  start-page: 222
  year: 2006
  ident: 9573_CR238
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2006.06.010
– ident: 9573_CR78
  doi: 10.1186/s13100-016-0065-9
– volume: 155
  start-page: 31
  year: 1999
  ident: 9573_CR177
  publication-title: Exp Neurol
  doi: 10.1006/exnr.1998.6977
– volume: 19
  start-page: 526
  year: 2002
  ident: 9573_CR111
  publication-title: Hum Mutat
  doi: 10.1002/humu.10072
– volume: 16
  start-page: 877
  year: 2017
  ident: 9573_CR67
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(17)30299-5
– volume: 130
  start-page: 234
  year: 2009
  ident: 9573_CR15
  publication-title: Mech Ageing Dev
  doi: 10.1016/j.mad.2008.12.003
– ident: 9573_CR70
  doi: 10.1007/s10577-018-9571-6
– volume: 45
  start-page: D750
  year: 2017
  ident: 9573_CR170
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkw767
– volume: 242
  start-page: 11
  year: 2011
  ident: 9573_CR137
  publication-title: J Membr Biol
  doi: 10.1007/s00232-011-9372-8
– volume: 5
  start-page: 14941
  year: 2015
  ident: 9573_CR169
  publication-title: Sci Rep
  doi: 10.1038/srep14941
– volume: 9
  start-page: 212
  year: 2009
  ident: 9573_CR130
  publication-title: Curr Neurol Neurosci Rep
  doi: 10.1007/s11910-009-0032-7
– volume: 443
  start-page: 787
  year: 2006
  ident: 9573_CR124
  publication-title: Nature
  doi: 10.1038/nature05292
– volume: 32
  start-page: 165
  year: 2016
  ident: 9573_CR11
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2015.12.005
– volume: 35
  start-page: 5356
  year: 2014
  ident: 9573_CR42
  publication-title: Hum Brain Mapp
  doi: 10.1002/hbm.22555
– volume: 485
  start-page: 376
  year: 2012
  ident: 9573_CR53
  publication-title: Nature
  doi: 10.1038/nature11082
– volume: 8
  start-page: 237
  year: 2016
  ident: 9573_CR114
  publication-title: Epigenomics
  doi: 10.2217/epi.15.107
– volume: 18
  start-page: 794
  year: 2015
  ident: 9573_CR82
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4017
– ident: 9573_CR158
  doi: 10.1074/jbc.M117.779868
– volume: 2
  start-page: 8
  year: 2011
  ident: 9573_CR160
  publication-title: Mob DNA
  doi: 10.1186/1759-8753-2-8
– volume: 17
  start-page: 83
  year: 2016
  ident: 9573_CR155
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm.2015.4
– volume: 10
  start-page: e0117854
  year: 2015
  ident: 9573_CR109
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0117854
– volume: 24
  start-page: 4033
  year: 2010
  ident: 9573_CR28
  publication-title: FASEB J
  doi: 10.1096/fj.10-157032
– volume: 7
  start-page: 44465
  year: 2017
  ident: 9573_CR94
  publication-title: Sci Rep
  doi: 10.1038/srep44465
– volume: 26
  start-page: 9057
  year: 2006
  ident: 9573_CR52
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1469-06.2006
– volume: 87
  start-page: 799
  year: 2007
  ident: 9573_CR145
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00036.2006
– volume: 27
  start-page: 480
  year: 2017
  ident: 9573_CR33
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2017.01.002
– volume: 34
  start-page: 1021
  year: 2009
  ident: 9573_CR178
  publication-title: Neurochem Res
  doi: 10.1007/s11064-008-9865-8
– volume: 29
  start-page: 493
  year: 2004
  ident: 9573_CR186
  publication-title: Neurochem. Res.
  doi: 10.1023/B:NERE.0000014820.99232.8a
– volume: 476
  start-page: 43
  year: 2001
  ident: 9573_CR23
  publication-title: Mutat Res
  doi: 10.1016/S0027-5107(01)00065-3
– volume: 12
  start-page: 1051
  year: 2016
  ident: 9573_CR103
  publication-title: Alzheimer’s Dement.
  doi: 10.1016/j.jalz.2016.06.006
– ident: 9573_CR168
  doi: 10.1016/J.NEUROSCIENCE.2017.09.049
– volume: 82
  start-page: 949
  year: 1995
  ident: 9573_CR118
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90274-0
– volume: 136
  start-page: 55
  year: 2017
  ident: 9573_CR98
  publication-title: Hum Genet
  doi: 10.1007/s00439-016-1736-9
– volume: 427
  start-page: 801
  year: 2004
  ident: 9573_CR102
  publication-title: Nature
  doi: 10.1038/427801a
– volume: 35
  start-page: 1092
  year: 2014
  ident: 9573_CR191
  publication-title: Hum Mutat
  doi: 10.1002/humu.22603
– volume: 38
  start-page: 120
  year: 2001
  ident: 9573_CR40
  publication-title: Histopathology
  doi: 10.1046/j.1365-2559.2001.01082.x
– volume: 9
  start-page: 1184
  year: 2014
  ident: 9573_CR207
  publication-title: Epigenetics
  doi: 10.4161/epi.29676
– ident: 9573_CR233
  doi: 10.1371/journal.pgen.1002371
– volume: 149
  start-page: 847
  year: 2012
  ident: 9573_CR214
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.036
– volume: 18
  start-page: 4801
  year: 2009
  ident: 9573_CR20
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddp443
– volume: 1820
  start-page: 553
  year: 2012
  ident: 9573_CR39
  publication-title: Biochim Biophys Acta (BBA)-General Subj
  doi: 10.1016/j.bbagen.2011.08.008
– volume: 29
  start-page: 105
  year: 2007
  ident: 9573_CR75
  publication-title: Brain Dev
  doi: 10.1016/j.braindev.2006.05.012
– volume: 44
  start-page: 1243
  year: 2012
  ident: 9573_CR179
  publication-title: Nat Genet
  doi: 10.1038/ng.2414
– volume: 31
  start-page: 1336
  year: 2012
  ident: 9573_CR187
  publication-title: EMBO J
  doi: 10.1038/emboj.2012.38
– volume: 81
  start-page: 306
  year: 2014
  ident: 9573_CR24
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.10.053
– volume: 12
  start-page: 617
  year: 2011
  ident: 9573_CR44
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-12-617
– volume: 10
  start-page: 89
  year: 2006
  ident: 9573_CR48
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2006-10113
– volume: 24
  start-page: 522
  year: 2014
  ident: 9573_CR189
  publication-title: Genome Res
  doi: 10.1101/gr.162537.113
– volume: 264
  start-page: 11394
  year: 1989
  ident: 9573_CR87
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)60477-6
– start-page: 61
  volume-title: Editing of neurotransmitter receptor and ion channel RNAs in the nervous system
  year: 2011
  ident: 9573_CR85
– volume: 12
  start-page: 687
  year: 2016
  ident: 9573_CR183
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2016.03.015
– volume: 67
  start-page: 536
  year: 2010
  ident: 9573_CR181
  publication-title: Arch Neurol
  doi: 10.1001/archneurol.2010.88
– volume: 8
  start-page: e70386
  year: 2013
  ident: 9573_CR96
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0070386
– volume: 16
  start-page: 1518
  year: 2013
  ident: 9573_CR120
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3539
– volume: 12
  start-page: 1802
  year: 2006
  ident: 9573_CR153
  publication-title: RNA
  doi: 10.1261/rna.165106
– volume: 136
  start-page: 1329
  year: 2017
  ident: 9573_CR60
  publication-title: Hum Genet
  doi: 10.1007/s00439-017-1832-5
– volume: 10
  start-page: 178
  year: 2010
  ident: 9573_CR65
  publication-title: Mol Vis
– volume: 27
  start-page: R1177
  year: 2017
  ident: 9573_CR180
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2017.09.015
– volume: 8
  start-page: 2252
  year: 2017
  ident: 9573_CR161
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2017.02252
– volume: 132
  start-page: 1177
  year: 2013
  ident: 9573_CR223
  publication-title: Hum Genet
  doi: 10.1007/s00439-013-1322-3
– volume: 29
  start-page: 522
  year: 2008
  ident: 9573_CR3
  publication-title: Hum Mutat
  doi: 10.1002/humu.20682
– volume: 7
  start-page: 15
  year: 2011
  ident: 9573_CR99
  publication-title: Nat Rev Neurol
  doi: 10.1038/nrneurol.2010.180
– volume: 12
  start-page: 135
  year: 2016
  ident: 9573_CR184
  publication-title: Expert Opin Drug Metab Toxicol
  doi: 10.1517/17425255.2016.1133586
– volume: 12
  start-page: 65
  year: 2011
  ident: 9573_CR91
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2967
– volume: 19
  start-page: 357
  year: 2014
  ident: 9573_CR79
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2014.01.010
– ident: 9573_CR215
  doi: 10.3389/fnins.2012.00099
– volume: 290
  start-page: 26204
  year: 2015
  ident: 9573_CR110
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M115.642173
– volume: 187
  start-page: 26
  year: 2017
  ident: 9573_CR62
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2017.05.003
– volume: 205
  start-page: 177
  year: 1997
  ident: 9573_CR22
  publication-title: Gene
  doi: 10.1016/S0378-1119(97)00399-5
– volume: 5
  start-page: a011304
  year: 2013
  ident: 9573_CR196
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a011304
– ident: 9573_CR193
  doi: 10.1038/npp.2017.273
– volume: 173
  start-page: 716
  year: 2016
  ident: 9573_CR84
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13175
– volume: 41
  start-page: 194
  year: 2010
  ident: 9573_CR95
  publication-title: Physiol Genomics
  doi: 10.1152/physiolgenomics.00146.2009
– volume: 15
  start-page: 68
  year: 2017
  ident: 9573_CR127
  publication-title: BMC Biol
  doi: 10.1186/s12915-017-0409-z
– volume: 2
  start-page: e73
  year: 2016
  ident: 9573_CR149
  publication-title: Neurol Genet
  doi: 10.1212/NXG.0000000000000073
– volume: 5
  start-page: 34
  year: 2012
  ident: 9573_CR234
  publication-title: Front Mol Neurosci
  doi: 10.3389/fnmol.2012.00034
– ident: 9573_CR122
  doi: 10.1371/journal.pone.0044099
– volume: 30
  start-page: 317
  year: 2007
  ident: 9573_CR136
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev.neuro.30.051606.094232
– volume: 31
  start-page: 10128
  year: 2011
  ident: 9573_CR228
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0884-11.2011
– volume: 85
  start-page: 756
  year: 2015
  ident: 9573_CR144
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000001883
– volume: 4
  start-page: e1000225
  year: 2008
  ident: 9573_CR125
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1000225
– volume: 17
  start-page: 15
  year: 2016
  ident: 9573_CR126
  publication-title: Genome Biol
  doi: 10.1186/s13059-016-0876-5
– volume: 276
  start-page: 135
  year: 2001
  ident: 9573_CR121
  publication-title: Gene
  doi: 10.1016/S0378-1119(01)00637-0
– volume: 54
  start-page: 156
  year: 2017
  ident: 9573_CR63
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-016-0055-4
– volume: 17
  start-page: 683
  year: 2013
  ident: 9573_CR222
  publication-title: Trends Cogn Sci
  doi: 10.1016/j.tics.2013.09.012
– volume: 12
  start-page: e0182448
  year: 2017
  ident: 9573_CR4
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0182448
– volume: 12
  start-page: 1
  year: 2011
  ident: 9573_CR49
  publication-title: Genome Biol
  doi: 10.1186/gb-2011-12-12-236
– volume: 23
  start-page: 860
  year: 2017
  ident: 9573_CR171
  publication-title: RNA
  doi: 10.1261/rna.058271.116
SSID ssj0008341
Score 2.4175801
SecondaryResourceType review_article
Snippet Alu elements are a highly successful family of primate-specific retrotransposons that have fundamentally shaped primate evolution, including the evolution of...
Alu elements are a highly successful family of primate-specific retrotransposons that have fundamentally shaped primate evolution, including the evolution of...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 93
SubjectTerms Alu elements
Alu Elements - physiology
Animal Genetics and Genomics
biochemical pathways
Biological Evolution
Biomedical and Life Sciences
brain
Brain - physiology
Cell Biology
Central nervous system
Chemical elements
Cognition
Disease
Epigenetics
Evolution
Genome, Human
Homeostasis
Human Genetics
Humans
Life Sciences
Mitochondria
Mitochondrial DNA
mitochondrial genes
Nervous System Diseases - genetics
Neurodegenerative diseases
Neurogenesis
Neurological diseases
Neurological disorders
neurons
Original
Original Article
Parkinson's disease
Plant Genetics and Genomics
Retroelements
retrotransposons
Spectrum analysis
SummonAdditionalLinks – databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bSx0xEB6sUuxLUVvttioRfLIu7CW37ZscFBHsU0XfliSb0ILuEY9H8N93JnuRo1Xo62Y27GYmky-ZzHwA-43OuZXGpU3R2JR7L1ObmSZ1WmRBCmeMo3PI85_y9IKfXYmrvlg05cI8i99TiptQdDkSp6VQZcrfwYpAv0vGPJGT0enqMpJUIiDHOaN5NQQw_9XF4hL0Ale-vB75LEYal56TNfjYY0Z21Cl5HZZ8uwHvOxbJxw1YnQykbZ_AXXYnHYzYNGY_2NH1nPnuhvjskPmH3tDYNDBEfiwy9DFLNBGHzLRNfBiTL-_mNyQUy1327pH1wZzPcHFy_GtymvY8CqkTsrpPuXZEbM6pNL51lJeDy3TgIjihgrHos0JRaV9Jq7NKGx68sggUg9LeK494cBOW22nrvwDLrOGFLWXucRvnjKqMEg1iLKuLYMrcJJANQ1u7vsg4cV1c10_lkUkbNWqjJm3UPIGD8ZXbrsLGW8Lbg77qfrLNiEmzxJ0RIrME9sZmHHiKfZjWT-dRRuW5KkX1lgx6f5XjvjqBrc4Exi8qKi4JfiagFoxjFKAy3Yst7Z_fsVw3bsgQJGKf3wczevr0V3_0639Jf4MPBdl3vBu3DctoJH4HwdK93Y3T5C9UTAqZ
  priority: 102
  providerName: Springer Nature
Title Warning SINEs: Alu elements, evolution of the human brain, and the spectrum of neurological disease
URI https://link.springer.com/article/10.1007/s10577-018-9573-4
https://www.ncbi.nlm.nih.gov/pubmed/29460123
https://www.proquest.com/docview/2003255515
https://www.proquest.com/docview/2007117359
https://www.proquest.com/docview/2053871978
https://pubmed.ncbi.nlm.nih.gov/PMC5857278
Volume 26
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwED7BJgQvaIwfC2yTkXiCWSSpHSe8oLZqmUBUCFFRniLbccSkkQ66IvHfc-c4qcpEXxIpvkRJ7uz77DvfB_CiyhNhMm15lVaGC-cybmJdcZvLuM6k1drSOuTHWXY-F-8XchEW3FYhrbIbE_1AXS0trZG_piQqhL_oft9e_eTEGkXR1UChcRv2E0QiRN2gFv2EC9GFZ65ElI4dKRdFF9Vst85JRUmX2N2lGnCx7ZdugM2bOZP_BE69P5oewP0AJNmw1fwDuOWaQ7jTUkv-OYS7447J7SHYr-3yByOKjdUbNrxcM9emja_OmPsdrI8ta4ZwkHnaPmaIO-KM6abyF_2OzF_rHyTka2CGMZOFCM8jmE8nX8bnPJArcCuz4pqL3BLbuaB6-cbSZh303bWQtZWq1gYHsjotcldkJo-LXIvaKYPosVa5c8ohSHwMe82ycUfAYqNFagZZ4nBuZ7UqtJIVAi-Tp7UeJDqCuPu1pQ2Vx4kA47Lc1EwmbZSojZK0UYoIXva3XLVlN3YJH3f6KkMPXJUbe4nged-MP54CIrpxy7WXUUmiBrLYJYMuQSU42Y7gSWsC_RulhcgIk0agtoyjF6Da3dstzcV3X8MbZ2mIHPGZrzoz2rz6fz_06e4PfQb3UjJonyF3DHtoFe4EIdO1OfX94hT2h9PRaEbnd98-TPA8msw-fcbWcTbG4zwd_gWL9hhq
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9RAEJ-QIwZfjOJXEXVN9EVp6MdutzUhBhFyCFyMgchb3d1uIwn20OM0_HP-bc5st72cxHvjtZ027c7sfOx8_ABeVnnMdaZMWCWVDrm1WagjVYUmF1GdCaOUoXPIo1E2POEfT8XpEvzpemGorLLTiU5RV2NDZ-SbVESF7i-a33cXP0JCjaLsagehoTy0QrXlRoz5xo4De_UbQ7jJ1v4H5PerJNnbPd4Zhh5lIDQiKy5DnhuC_eY0OF4b6lpBI1ZzURsha6VxR9dJkdsi03lU5IrXVmp0o2qZWyutoANRNAHLnA5QBrD8fnf06XNvC_LUYWdinIBbOedFl1dtm_eEpLJPVDhCpiGft4zX3N3rVZv_pG6dRdy7C3e8K8u2W9m7B0u2WYVbLbjl1Sqs7HRYcvfBfGkPYBiBfEzesu3zKbNt4fpkg9lfXv7ZuGbokDIHHMg0oVdsMNVU7qLrCf05_U5Ebgqn19rM55gewMmNLPxDGDTjxj4GFmnFE51mscXo0ihZKCkqdP10ntQqjVUAUbe0pfGzzwmC47ycTW0mbpTIjZK4UfIAXvePXLSDPxYRr3f8Kr0OmJQziQ3gRX8bF55SMqqx46mjkXEsU1EsokGjJGMM9wN41IpA_0VJwTPyigOQc8LRE9D08Pk7zdk3N0Uc40T0XfGdbzoxmn36f390bfGPPoeV4fHRYXm4Pzp4ArcTEm5Xr7cOA5QQ-xQduEv9zO8SBl9vemP-BSfgVBw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB5VRTwuCMorUMBIcIFazcOOEySEqpZVS6HiQMXeUtuxRaU2W9guqH-NX8eM81gtFXvrNZlEieftGc8H8LIuEmFybXmd1oYL53JuYl1zW8jY59JqbWkf8vNBvnsoPo7leAX-9GdhqK2yt4nBUNcTS3vkm9REheEvut9N37VFfNkZvT_7wQlBiiqtPZxGKyL77uI3pm_Td3s7yOtXaTr68HV7l3cIA9zKvDznorAE-S1oaLyxdGIFHZgX0lupvDaozT4tC1fmpojLQgvvlMEQyqvCOeUkbYai-b-mMiEINkKNh2QPI5uAmokZAipxIcq-otoe25OKGj7R1EiVcbHoEy8Fupf7Nf8p2gZfOLoDt7sglm21UncXVlyzBtdbWMuLNbi53aPI3QP7rd16YQTvMX3Ltk5mzLUt69MN5n51ks8mnmEoygJkIDOEW7HBdFOHi-E06M_ZKRGF-ZudvWZddek-HF7Jsj-A1WbSuEfAYqNFarI8cZhXWq1KrWSNQZ8pUq-zREcQ90tb2W7qOYFvnFTzec3EjQq5URE3KhHB6-GRs3bkxzLi9Z5fVaf902ouqxG8GG7jwlMxRjduMgs0KklUJstlNOiOVIKJfgQPWxEYvigtRU7xcARqQTgGApobvninOf4e5odjhohRK77zTS9G80__748-Xv6jz-EGqmP1ae9g_wncSkm2Q6PeOqyigLinGLmdm2dBRRgcXbVO_gXHmVG4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Warning+SINEs%3A+Alu+elements%2C+evolution+of+the+human+brain%2C+and+the+spectrum+of+neurological+disease&rft.jtitle=Chromosome+research&rft.au=Larsen%2C+Peter+A&rft.au=Hunnicutt%2C+Kelsie+E&rft.au=Larsen%2C+Roxanne+J&rft.au=Yoder%2C+Anne+D&rft.date=2018-03-01&rft.issn=1573-6849&rft.eissn=1573-6849&rft.volume=26&rft.issue=1-2&rft.spage=93&rft_id=info:doi/10.1007%2Fs10577-018-9573-4&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0967-3849&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0967-3849&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0967-3849&client=summon