HYGIEIA: HYpothesizing the Genesis of Infectious Diseases and Epidemics through an Integrated Systems Biology Approach

More than two years on, the COVID-19 pandemic continues to wreak havoc around the world and has battle-tested the pandemic-situation responses of all major global governments. Two key areas of investigation that are still unclear are: the molecular mechanisms that lead to heterogenic patient outcome...

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Published inViruses Vol. 14; no. 7; p. 1373
Main Authors Ward, Bradley, Yombi, Jean Cyr, Balligand, Jean-Luc, Cani, Patrice D., Collet, Jean-François, de Greef, Julien, Dewulf, Joseph P., Gatto, Laurent, Haufroid, Vincent, Jodogne, Sébastien, Kabamba, Benoît, Pyr dit Ruys, Sébastien, Vertommen, Didier, Elens, Laure, Belkhir, Leïla
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.06.2022
MDPI
Subjects
Antibodies
Belgium
Biomarkers
Communicable Diseases - epidemiology
Communication
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 infection
COVID-19 vaccines
Diabetes
Disease transmission
Epidemics
Fatalities
Genomes
Genomics
Genotype & phenotype
Hospitalization
Humans
Infections
Infectious diseases
Kidneys
Long COVID
Longitudinal Studies
mass spectrometry
Medical research
medicine
Medicine, Experimental
metabolome
Metabolomics
Metabolomics - methods
metagenomics
Methods
microbiome
Microbiomes
Molecular modelling
Next-generation sequencing
Pandemics
Pathogenesis
patient care
Patients
post COVID condition
Post-Acute COVID-19 Syndrome
proteome
Proteomes
Proteomics
Risk factors
Severe acute respiratory syndrome coronavirus 2
Systems biology
Systems Biology - methods
transcriptome
Transcriptomes
viral genome
Virulence
Belgium
COVID-19
proteomics
metabolomics
metagenomics
network medicine
transcriptomics
genomics
post COVID condition
Online AccessGet full text
ISSN1999-4915
1999-4915
DOI10.3390/v14071373

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Abstract More than two years on, the COVID-19 pandemic continues to wreak havoc around the world and has battle-tested the pandemic-situation responses of all major global governments. Two key areas of investigation that are still unclear are: the molecular mechanisms that lead to heterogenic patient outcomes, and the causes of Post COVID condition (AKA Long-COVID). In this paper, we introduce the HYGIEIA project, designed to respond to the enormous challenges of the COVID-19 pandemic through a multi-omic approach supported by network medicine. It is hoped that in addition to investigating COVID-19, the logistics deployed within this project will be applicable to other infectious agents, pandemic-type situations, and also other complex, non-infectious diseases. Here, we first look at previous research into COVID-19 in the context of the proteome, metabolome, transcriptome, microbiome, host genome, and viral genome. We then discuss a proposed methodology for a large-scale multi-omic longitudinal study to investigate the aforementioned biological strata through high-throughput sequencing (HTS) and mass-spectrometry (MS) technologies. Lastly, we discuss how a network medicine approach can be used to analyze the data and make meaningful discoveries, with the final aim being the translation of these discoveries into the clinics to improve patient care.
AbstractList More than two years on, the COVID-19 pandemic continues to wreak havoc around the world and has battle-tested the pandemic-situation responses of all major global governments. Two key areas of investigation that are still unclear are: the molecular mechanisms that lead to heterogenic patient outcomes, and the causes of Post COVID condition (AKA Long-COVID). In this paper, we introduce the HYGIEIA project, designed to respond to the enormous challenges of the COVID-19 pandemic through a multi-omic approach supported by network medicine. It is hoped that in addition to investigating COVID-19, the logistics deployed within this project will be applicable to other infectious agents, pandemic-type situations, and also other complex, non-infectious diseases. Here, we first look at previous research into COVID-19 in the context of the proteome, metabolome, transcriptome, microbiome, host genome, and viral genome. We then discuss a proposed methodology for a large-scale multi-omic longitudinal study to investigate the aforementioned biological strata through high-throughput sequencing (HTS) and mass-spectrometry (MS) technologies. Lastly, we discuss how a network medicine approach can be used to analyze the data and make meaningful discoveries, with the final aim being the translation of these discoveries into the clinics to improve patient care.
More than two years on, the COVID-19 pandemic continues to wreak havoc around the world and has battle-tested the pandemic-situation responses of all major global governments. Two key areas of investigation that are still unclear are: the molecular mechanisms that lead to heterogenic patient outcomes, and the causes of Post COVID condition (AKA Long-COVID). In this paper, we introduce the HYGIEIA project, designed to respond to the enormous challenges of the COVID-19 pandemic through a multi-omic approach supported by network medicine. It is hoped that in addition to investigating COVID-19, the logistics deployed within this project will be applicable to other infectious agents, pandemic-type situations, and also other complex, non-infectious diseases. Here, we first look at previous research into COVID-19 in the context of the proteome, metabolome, transcriptome, microbiome, host genome, and viral genome. We then discuss a proposed methodology for a large-scale multi-omic longitudinal study to investigate the aforementioned biological strata through high-throughput sequencing (HTS) and mass-spectrometry (MS) technologies. Lastly, we discuss how a network medicine approach can be used to analyze the data and make meaningful discoveries, with the final aim being the translation of these discoveries into the clinics to improve patient care.More than two years on, the COVID-19 pandemic continues to wreak havoc around the world and has battle-tested the pandemic-situation responses of all major global governments. Two key areas of investigation that are still unclear are: the molecular mechanisms that lead to heterogenic patient outcomes, and the causes of Post COVID condition (AKA Long-COVID). In this paper, we introduce the HYGIEIA project, designed to respond to the enormous challenges of the COVID-19 pandemic through a multi-omic approach supported by network medicine. It is hoped that in addition to investigating COVID-19, the logistics deployed within this project will be applicable to other infectious agents, pandemic-type situations, and also other complex, non-infectious diseases. Here, we first look at previous research into COVID-19 in the context of the proteome, metabolome, transcriptome, microbiome, host genome, and viral genome. We then discuss a proposed methodology for a large-scale multi-omic longitudinal study to investigate the aforementioned biological strata through high-throughput sequencing (HTS) and mass-spectrometry (MS) technologies. Lastly, we discuss how a network medicine approach can be used to analyze the data and make meaningful discoveries, with the final aim being the translation of these discoveries into the clinics to improve patient care.
Audience Academic
Author Kabamba, Benoît
Belkhir, Leïla
Ward, Bradley
Cani, Patrice D.
Vertommen, Didier
Elens, Laure
de Greef, Julien
Haufroid, Vincent
Balligand, Jean-Luc
Collet, Jean-François
Jodogne, Sébastien
Pyr dit Ruys, Sébastien
Yombi, Jean Cyr
Gatto, Laurent
Dewulf, Joseph P.
AuthorAffiliation 5 WELBIO (Walloon Excellence in Life Sciences and Biotechnology), Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium; patrice.cani@uclouvain.be
1 Integrated Pharmacometrics, Pharmacogenomics and Pharmacokinetics Group (PMGK), Louvain Drug Research Institute (LDRI), UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium; bradley.ward@uclouvain.be (B.W.); sebastien.pyrditruys@uclouvain.be (S.P.d.R.)
3 Department of Internal Medicine, Cliniques Universitaires Saint-Luc, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium; jean.yombi@uclouvain.be
8 Department of Biochemistry, de Duve Institute, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium
4 WELBIO (Walloon Excellence in Life Sciences and Biotechnology), Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Experimentale et Clinique (IREC), Cliniques Universitaires Saint-Luc, UCLouva
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– name: 9 Computational Biology and Bioinformatics Unit (CBIO), de Duve Institute, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium; laurent.gatto@uclouvain.be
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– name: 12 De Duve Institute, and MASSPROT Platform, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium; didier.vertommen@uclouvain.be
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– name: 2 Louvain Center for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium; julien.degreef@saintluc.uclouvain.be (J.d.G.); joseph.dewulf@saintluc.uclouvain.be (J.P.D.); vincent.haufroid@saintluc.uclouvain.be (V.H.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35891354$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.isci.2020.101947
10.1093/cid/ciaa902
10.1038/s41385-020-00361-8
10.15252/emmm.202012421
10.3389/fneur.2020.573095
10.1016/j.isci.2021.102823
10.1016/j.biocel.2016.06.016
10.1038/srep14582
10.1038/s41467-021-27797-1
10.1016/j.compbiomed.2020.104123
10.20944/preprints202004.0510.v1
10.1016/j.mayocp.2020.10.022
10.2807/1560-7917.ES.2022.27.10.2200181
10.1007/s00705-009-0472-z
10.1016/j.cell.2020.08.002
10.1093/bioinformatics/btt537
10.1096/fj.202001062R
10.1183/13993003.03448-2020
10.1101/2022.04.30.489997
10.1038/emm.2014.110
10.1055/s-0039-1687818
10.1016/j.cell.2020.05.032
10.1007/s00134-020-06219-8
10.1016/j.cell.2022.01.014
10.1152/ajplung.00440.2020
10.1038/s41591-021-01281-1
10.2217/fvl-2020-0188
10.1016/j.genrep.2021.101200
10.1038/s41586-020-2818-3
10.3390/genes11070760
10.1186/s12867-018-0115-6
10.1016/j.neuron.2020.11.002
10.1016/j.csbj.2021.07.002
10.1172/JCI152386
10.1074/jbc.M109.041871
10.1038/s41588-021-00996-8
10.1021/acschemneuro.0c00210
10.1039/D1RA04694B
10.1002/alr.22592
10.18632/oncotarget.26995
10.1128/JVI.01410-20
10.1101/2022.04.29.22274477
10.1016/j.ebiom.2021.103723
10.1073/pnas.2003138117
10.1111/jcmm.16444
10.3389/fpls.2016.00892
10.1016/S1473-3099(22)00141-4
10.1073/pnas.1822046116
10.1038/s41598-020-80120-8
10.1016/j.rmed.2021.106383
10.1126/science.abh2644
10.1056/NEJMc2013020
10.3389/fcimb.2021.765039
10.1186/s12870-016-0726-3
10.1038/s41401-020-0485-4
10.1128/JVI.00510-20
10.1007/s00405-020-05965-1
10.1007/s11684-020-0754-0
10.1016/j.gpb.2021.09.007
10.1101/2021.12.21.21268116
10.1056/NEJMoa1109400
10.1038/s41598-021-03245-4
10.3390/ncrna5010007
10.1161/CIRCULATIONAHA.117.032291
10.1016/j.bbadis.2021.166291
10.1136/gutjnl-2021-325989
10.1101/2021.12.27.21268278
10.1183/13993003.01763-2021
10.1126/science.abc6027
10.1038/s41586-020-2355-0
10.1093/bioinformatics/btz318
10.1093/bib/bbw114
10.1016/j.isci.2021.102151
10.1186/s12864-019-5749-3
10.1038/s41586-020-03065-y
10.1073/pnas.2026309118
10.1093/ofid/ofaa220
10.1007/s00408-021-00468-0
10.1038/s41586-021-03767-x
10.2807/1560-7917.ES.2021.26.16.2100348
10.2337/dbi20-0032
10.1016/j.virusres.2021.198631
10.1038/s41586-021-03402-9
10.1016/j.immuni.2020.10.008
10.1021/acs.jproteome.1c00475
10.1097/CCE.0000000000000189
10.1186/s13073-021-00904-z
10.1093/infdis/jiab490
10.1016/j.cbi.2021.109777
10.1038/s41598-020-77525-w
10.1101/2020.02.21.960062
10.3390/metabo10030097
10.1016/j.cell.2020.10.037
10.1016/j.cell.2021.07.023
10.1016/j.isci.2020.101896
10.1016/j.intimp.2021.107497
10.1093/brain/awaa240
10.1016/j.immuni.2020.11.017
10.1172/JCI89031
10.1021/acs.jproteome.0c00365
10.1002/pmic.202000202
10.1007/s00726-014-1889-6
10.1056/NEJMoa2015432
10.1371/journal.pone.0206511
10.1080/07853890.2020.1790643
10.1016/j.jcv.2020.104364
10.1016/j.jamda.2021.07.003
10.1073/pnas.1900083116
10.1038/s41540-018-0057-0
10.1101/2021.01.05.425420
10.1101/2021.12.30.21268560
10.1001/jama.2020.12603
10.3389/fonc.2020.01065
10.1016/j.mehy.2020.110415
10.1016/j.bbadis.2019.01.006
10.1016/j.biopha.2021.112176
10.1016/S0140-6736(21)01358-1
10.1056/NEJMoa2020283
10.3390/ijerph18105329
10.1016/j.cels.2020.10.003
10.1016/j.cell.2020.10.004
10.1038/nmeth.2810
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Issue 7
Keywords COVID-19
proteomics
metabolomics
metagenomics
network medicine
transcriptomics
genomics
post COVID condition
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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These authors contributed equally to this work.
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References ref_14
Kousathanas (ref_122) 2022; 1
Song (ref_126) 2020; 34
Kunutsor (ref_12) 2020; 52
Paul (ref_64) 2022; 308
Liu (ref_22) 2022; 71
Huang (ref_5) 2020; 41
Banerjee (ref_61) 2020; 183
Park (ref_97) 2020; 10
Wang (ref_136) 2014; 11
Ziegler (ref_78) 2021; 184
Bathke (ref_92) 2019; 20
Mcardle (ref_96) 2021; 20
Wendt (ref_101) 2020; 20
Cardozo (ref_87) 2019; 116
ref_125
Wang (ref_128) 2021; 109
ref_127
Zhang (ref_27) 2022; 352
Huffman (ref_109) 2022; 54
Cervia (ref_21) 2022; 13
Bernardes (ref_30) 2020; 53
ref_123
Gunawardana (ref_95) 2013; 29
Khan (ref_13) 2021; 11
Schlotter (ref_131) 2018; 138
Zhong (ref_98) 2021; 74
Bernabei (ref_135) 2020; 324
Dong (ref_90) 2016; 7
Khan (ref_24) 2021; 143
Bai (ref_94) 2015; 5
Choi (ref_110) 2015; 47
ref_79
Fonager (ref_38) 2022; 27
Sepahi (ref_68) 2019; 116
Zeberg (ref_107) 2021; 118
Krishnamoorthy (ref_63) 2021; 128
Camargo (ref_114) 2015; 47
Thomas (ref_99) 2020; 19
Prasad (ref_66) 2019; 28
Fraser (ref_103) 2020; 2
Bassetti (ref_49) 2020; 46
Yan (ref_70) 2020; 10
Zhang (ref_48) 2020; 127
Cheng (ref_80) 2021; 25
ref_82
Parmentier (ref_119) 2009; 284
Shu (ref_105) 2020; 53
Mohammad (ref_47) 2021; 11
He (ref_83) 2019; 1
Hadjadj (ref_58) 2020; 369
Maggipinto (ref_116) 2020; 190
ref_85
Gasparello (ref_75) 2021; 146
Wang (ref_117) 2021; 13
Wyler (ref_77) 2021; 24
Clohisey (ref_111) 2021; 591
Zolotareva (ref_124) 2019; 35
Reynaert (ref_65) 2016; 81
Peluso (ref_23) 2021; 224
Kosmopoulos (ref_67) 2019; 1865
Liu (ref_100) 2020; 12
Chen (ref_7) 2021; 11
Chen (ref_15) 2022; 1
ref_55
Faria (ref_33) 2021; 372
Huang (ref_9) 2021; 96
Sharma (ref_132) 2018; 4
Sheikh (ref_32) 2021; 397
Manzoni (ref_91) 2018; 19
Chierici (ref_137) 2020; 10
Lechien (ref_69) 2020; 277
Froidure (ref_134) 2021; 181
Fu (ref_51) 2020; 7
Pinski (ref_46) 2021; 73
Lerum (ref_133) 2021; 57
Sakurai (ref_2) 2020; 383
Kohn (ref_16) 2021; 1
Hoque (ref_57) 2021; 11
Silvin (ref_74) 2020; 182
Liang (ref_89) 2016; 16
Ackermann (ref_10) 2020; 383
Wang (ref_86) 2021; 96
Su (ref_25) 2020; 183
Feldman (ref_19) 2020; 69
ref_115
Obitsu (ref_62) 2009; 154
ref_118
Shi (ref_26) 2021; 19
Nguyen (ref_120) 2020; 94
ref_36
Naeije (ref_17) 2021; 58
Lokugamage (ref_60) 2020; 94
Lehmann (ref_50) 2021; 72
ref_31
Talotta (ref_88) 2022; 1868
Rekdal (ref_54) 2019; 364
Zhang (ref_59) 2020; 583
ref_113
Tang (ref_56) 2013; 368
Hoque (ref_52) 2021; 23
Su (ref_20) 2022; 185
ref_39
ref_37
Bell (ref_73) 2021; 24
Mercatelli (ref_72) 2021; 19
Turjya (ref_81) 2020; 15
Salumets (ref_102) 2020; 10
Gupta (ref_84) 2021; 320
Shang (ref_121) 2020; 117
Clavreul (ref_93) 2018; 19
Shen (ref_104) 2020; 182
ref_106
Mirzakhani (ref_130) 2016; 126
Zou (ref_6) 2020; 14
Jeganathan (ref_4) 2021; 199
ref_45
ref_44
ref_43
Funk (ref_34) 2021; 26
ref_42
Maras (ref_28) 2021; 24
ref_41
ref_40
Zhou (ref_112) 2021; 27
ref_1
ref_3
Tosato (ref_18) 2021; 22
Sencio (ref_53) 2021; 14
Tegally (ref_35) 2021; 592
Zeberg (ref_108) 2020; 587
ref_8
Barupal (ref_129) 2019; 10
Paterson (ref_11) 2020; 143
Thair (ref_76) 2021; 24
Overmyer (ref_29) 2021; 12
Bilinska (ref_71) 2020; 11
References_xml – volume: 24
  start-page: 101947
  year: 2021
  ident: ref_76
  article-title: Transcriptomic Similarities and Differences in Host Response between SARS-CoV-2 and Other Viral Infections
  publication-title: iScience
  doi: 10.1016/j.isci.2020.101947
– volume: 1
  start-page: 1
  year: 2021
  ident: ref_16
  article-title: Long COVID : Pathophysiology—Epidemiology and Patient Needs
  publication-title: KCE Rep.
– volume: 72
  start-page: 1450
  year: 2021
  ident: ref_50
  article-title: Community-Acquired Coinfection in Coronavirus Disease 2019: A Retrospective Observational Experience
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciaa902
– volume: 14
  start-page: 296
  year: 2021
  ident: ref_53
  article-title: The Lung–Gut Axis during Viral Respiratory Infections: The Impact of Gut Dysbiosis on Secondary Disease Outcomes
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-020-00361-8
– volume: 12
  start-page: e12421
  year: 2020
  ident: ref_100
  article-title: The Role of Interleukin-6 in Monitoring Severe Case of Coronavirus Disease 2019
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.202012421
– volume: 11
  start-page: 1860
  year: 2021
  ident: ref_7
  article-title: The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2020.573095
– volume: 24
  start-page: 102823
  year: 2021
  ident: ref_28
  article-title: Multi-Omics Analysis of Respiratory Specimen Characterizes Baseline Molecular Determinants Associated with SARS-CoV-2 Outcome
  publication-title: iScience
  doi: 10.1016/j.isci.2021.102823
– ident: ref_39
– volume: 81
  start-page: 403
  year: 2016
  ident: ref_65
  article-title: Advanced Glycation End Products and Their Receptor in Age-Related, Non-Communicable Chronic Inflammatory Diseases; Overview of Clinical Evidence and Potential Contributions to Disease
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2016.06.016
– volume: 5
  start-page: 14582
  year: 2015
  ident: ref_94
  article-title: Integrative Analyses Reveal Transcriptome-Proteome Correlation in Biological Pathways and Secondary Metabolism Clusters in A. Flavus in Response to Temperature
  publication-title: Sci. Rep.
  doi: 10.1038/srep14582
– volume: 13
  start-page: 446
  year: 2022
  ident: ref_21
  article-title: Immunoglobulin Signature Predicts Risk of Post-Acute COVID-19 Syndrome
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27797-1
– volume: 128
  start-page: 104123
  year: 2021
  ident: ref_63
  article-title: Comparative Transcriptome Analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to Identify Potential Pathways for Drug Repurposing
  publication-title: Comput. Biol. Med.
  doi: 10.1016/j.compbiomed.2020.104123
– ident: ref_1
– ident: ref_123
– volume: 364
  start-page: 1
  year: 2019
  ident: ref_54
  article-title: Discovery and Inhibition of an Interspecies Gut Bacterial Pathway for Levodopa Metabolism
  publication-title: Science
– ident: ref_31
  doi: 10.20944/preprints202004.0510.v1
– volume: 96
  start-page: 183
  year: 2021
  ident: ref_9
  article-title: Clinical Characteristics, Treatment, and Outcomes of Critically Ill Patients with COVID-19: A Scoping Review
  publication-title: Mayo Clin. Proc.
  doi: 10.1016/j.mayocp.2020.10.022
– volume: 27
  start-page: 2200181
  year: 2022
  ident: ref_38
  article-title: Molecular Epidemiology of the SARS-CoV-2 Variant Omicron BA.2 Sub-Lineage in Denmark, 29 November 2021 to 2 January 2022
  publication-title: Eurosurveillance
  doi: 10.2807/1560-7917.ES.2022.27.10.2200181
– volume: 154
  start-page: 1457
  year: 2009
  ident: ref_62
  article-title: Potential Enhancement of Osteoclastogenesis by Severe Acute Respiratory Syndrome Coronavirus 3a/X1 Protein
  publication-title: Arch. Virol.
  doi: 10.1007/s00705-009-0472-z
– volume: 182
  start-page: 1401
  year: 2020
  ident: ref_74
  article-title: Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19
  publication-title: Cell
  doi: 10.1016/j.cell.2020.08.002
– volume: 29
  start-page: 3060
  year: 2013
  ident: ref_95
  article-title: Bridging the Gap between Transcriptome and Proteome Measurements Identifies Post-Translationally Regulated Genes
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt537
– volume: 34
  start-page: 11087
  year: 2020
  ident: ref_126
  article-title: Network Determinants of Cardiovascular Calcification and Repositioned Drug Treatments
  publication-title: FASEB J.
  doi: 10.1096/fj.202001062R
– volume: 57
  start-page: 1
  year: 2021
  ident: ref_133
  article-title: Dyspnoea, Lung Function and CT Findings 3 Months after Hospital Admission for COVID-19
  publication-title: Eur. Respir. J.
  doi: 10.1183/13993003.03448-2020
– ident: ref_45
  doi: 10.1101/2022.04.30.489997
– volume: 47
  start-page: e144
  year: 2015
  ident: ref_110
  article-title: Oligoadenylate Synthase-like (OASL) Proteins: Dual Functions and Associations with Diseases
  publication-title: Exp. Mol. Med.
  doi: 10.1038/emm.2014.110
– volume: 28
  start-page: 71
  year: 2019
  ident: ref_66
  article-title: AGE-RAGE Stress in the Pathophysiology of Pulmonary Hypertension and Its Treatment
  publication-title: Int. J. Angiol.
  doi: 10.1055/s-0039-1687818
– volume: 182
  start-page: 59
  year: 2020
  ident: ref_104
  article-title: Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
  publication-title: Cell
  doi: 10.1016/j.cell.2020.05.032
– volume: 46
  start-page: 2071
  year: 2020
  ident: ref_49
  article-title: Bacterial and Fungal Superinfections in Critically Ill Patients with COVID-19
  publication-title: Intensive Care Med.
  doi: 10.1007/s00134-020-06219-8
– volume: 185
  start-page: 881
  year: 2022
  ident: ref_20
  article-title: Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae
  publication-title: Cell
  doi: 10.1016/j.cell.2022.01.014
– volume: 320
  start-page: L1147
  year: 2021
  ident: ref_84
  article-title: Balancing Precision versus Cohort Transcriptomic Analysis of Acute and Recovery Phase of Viral Bronchiolitis
  publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00440.2020
– volume: 27
  start-page: 659
  year: 2021
  ident: ref_112
  article-title: A Neanderthal OAS1 Isoform Protects Individuals of European Ancestry against COVID-19 Susceptibility and Severity
  publication-title: Nat. Med.
  doi: 10.1038/s41591-021-01281-1
– volume: 15
  start-page: 577
  year: 2020
  ident: ref_81
  article-title: Perversely Expressed Long Noncoding RNAs Can Alter Host Response and Viral Proliferation in SARS-CoV-2 Infection
  publication-title: Future Virol.
  doi: 10.2217/fvl-2020-0188
– volume: 23
  start-page: 101200
  year: 2021
  ident: ref_52
  article-title: Diversity and Genomic Determinants of the Microbiomes Associated with COVID-19 and Non-COVID Respiratory Diseases
  publication-title: Gene Rep.
  doi: 10.1016/j.genrep.2021.101200
– volume: 587
  start-page: 610
  year: 2020
  ident: ref_108
  article-title: The Major Genetic Risk Factor for Severe COVID-19 Is Inherited from Neanderthals
  publication-title: Nature
  doi: 10.1038/s41586-020-2818-3
– ident: ref_3
– ident: ref_79
  doi: 10.3390/genes11070760
– volume: 19
  start-page: 13
  year: 2018
  ident: ref_93
  article-title: Integration of Transcriptome and Proteome Profiles in Glioblastoma: Looking for the Missing Link
  publication-title: BMC Mol. Biol.
  doi: 10.1186/s12867-018-0115-6
– volume: 109
  start-page: 257
  year: 2021
  ident: ref_128
  article-title: Transformative Network Modeling of Multi-Omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
  publication-title: Neuron
  doi: 10.1016/j.neuron.2020.11.002
– volume: 19
  start-page: 4092
  year: 2021
  ident: ref_72
  article-title: Exploiting the Molecular Basis of Age and Gender Differences in Outcomes of SARS-CoV-2 Infections
  publication-title: Comput. Struct. Biotechnol. J.
  doi: 10.1016/j.csbj.2021.07.002
– ident: ref_113
  doi: 10.1172/JCI152386
– volume: 284
  start-page: 27211
  year: 2009
  ident: ref_119
  article-title: The Cytoplasmic Peptidase DPP9 Is Rate-Limiting for Degradation of Proline-Containing Peptides
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.041871
– volume: 54
  start-page: 125
  year: 2022
  ident: ref_109
  article-title: Multi-Ancestry Fine Mapping Implicates OAS1 Splicing in Risk of Severe COVID-19
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-021-00996-8
– volume: 11
  start-page: 1555
  year: 2020
  ident: ref_71
  article-title: Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age
  publication-title: ACS Chem. Neurosci.
  doi: 10.1021/acschemneuro.0c00210
– volume: 11
  start-page: 30132
  year: 2021
  ident: ref_13
  article-title: The SARS-CoV-2 B.1.618 Variant Slightly Alters the Spike RBD-ACE2 Binding Affinity and Is an Antibody Escaping Variant: A Computational Structural Perspective
  publication-title: RSC Adv.
  doi: 10.1039/D1RA04694B
– volume: 10
  start-page: 821
  year: 2020
  ident: ref_70
  article-title: Self-Reported Olfactory Loss Associates with Outpatient Clinical Course in COVID-19
  publication-title: Int. Forum Allergy Rhinol.
  doi: 10.1002/alr.22592
– volume: 10
  start-page: 3894
  year: 2019
  ident: ref_129
  article-title: Prioritization of Metabolic Genes as Novel Therapeutic Targets in Estrogen-Receptor Negative Breast Tumors Using Multi-Omics Data and Text Mining
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.26995
– volume: 94
  start-page: 1
  year: 2020
  ident: ref_60
  article-title: Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV
  publication-title: J. Virol.
  doi: 10.1128/JVI.01410-20
– volume: 1
  start-page: 3138
  year: 2019
  ident: ref_83
  article-title: The Opening of Pandora’s Box: An Emerging Role of Long Noncoding RNA in Viral Infections
  publication-title: Front. Immunol.
– ident: ref_44
  doi: 10.1101/2022.04.29.22274477
– volume: 190
  start-page: e93
  year: 2020
  ident: ref_116
  article-title: COVID-19 and ABO Blood Group: Another Viewpoint
  publication-title: Br. J. Haematol.
– volume: 74
  start-page: 103723
  year: 2021
  ident: ref_98
  article-title: Next Generation Plasma Proteome Profiling of COVID-19 Patients with Mild to Moderate Symptoms
  publication-title: eBioMedicine
  doi: 10.1016/j.ebiom.2021.103723
– volume: 117
  start-page: 11727
  year: 2020
  ident: ref_121
  article-title: Cell Entry Mechanisms of SARS-CoV-2
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2003138117
– volume: 25
  start-page: 4753
  year: 2021
  ident: ref_80
  article-title: Risk Stratification by Long Non-Coding RNAs Profiling in COVID-19 Patients
  publication-title: J. Cell. Mol. Med.
  doi: 10.1111/jcmm.16444
– volume: 7
  start-page: 892
  year: 2016
  ident: ref_90
  article-title: Quantitative Proteomic and Transcriptomic Study on Autotetraploid Paulownia and Its Diploid Parent Reveal Key Metabolic Processes Associated with Paulownia Autotetraploidization
  publication-title: Front. Plant Sci.
  doi: 10.3389/fpls.2016.00892
– ident: ref_41
  doi: 10.1016/S1473-3099(22)00141-4
– ident: ref_36
– volume: 116
  start-page: 17121
  year: 2019
  ident: ref_87
  article-title: Long Noncoding RNAs Are Involved in Multiple Immunological Pathways in Response to Vaccination
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1822046116
– volume: 10
  start-page: 1
  year: 2020
  ident: ref_97
  article-title: In-Depth Blood Proteome Profiling Analysis Revealed Distinct Functional Characteristics of Plasma Proteins between Severe and Non-Severe COVID-19 Patients
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-80120-8
– volume: 181
  start-page: 106383
  year: 2021
  ident: ref_134
  article-title: Integrative Respiratory Follow-up of Severe COVID-19 Reveals Common Functional and Lung Imaging Sequelae
  publication-title: Respir. Med.
  doi: 10.1016/j.rmed.2021.106383
– volume: 372
  start-page: 815
  year: 2021
  ident: ref_33
  article-title: Genomics and Epidemiology of the P.1 SARS-CoV-2 Lineage in Manaus, Brazil
  publication-title: Science
  doi: 10.1126/science.abh2644
– volume: 383
  start-page: 885
  year: 2020
  ident: ref_2
  article-title: Natural History of Asymptomatic SARS-CoV-2 Infection
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2013020
– volume: 11
  start-page: 951
  year: 2021
  ident: ref_47
  article-title: Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics Approach
  publication-title: Front. Cell. Infect. Microbiol.
  doi: 10.3389/fcimb.2021.765039
– volume: 16
  start-page: 43
  year: 2016
  ident: ref_89
  article-title: Transcriptomic, Proteomic and Metabolic Changes in Arabidopsis Thaliana Leaves after the Onset of Illumination
  publication-title: BMC Plant Biol.
  doi: 10.1186/s12870-016-0726-3
– volume: 41
  start-page: 1141
  year: 2020
  ident: ref_5
  article-title: Structural and Functional Properties of SARS-CoV-2 Spike Protein: Potential Antivirus Drug Development for COVID-19
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/s41401-020-0485-4
– volume: 94
  start-page: e00510
  year: 2020
  ident: ref_120
  article-title: Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2
  publication-title: J. Virol.
  doi: 10.1128/JVI.00510-20
– volume: 1
  start-page: jiac136
  year: 2022
  ident: ref_15
  article-title: Global Prevalence of Post COVID-19 Condition or Long COVID: A Meta-Analysis and Systematic Review
  publication-title: J. Infect. Dis.
– volume: 277
  start-page: 2251
  year: 2020
  ident: ref_69
  article-title: Olfactory and Gustatory Dysfunctions as a Clinical Presentation of Mild-to-Moderate Forms of the Coronavirus Disease (COVID-19): A Multicenter European Study
  publication-title: Eur. Arch. Oto Rhino Laryngol.
  doi: 10.1007/s00405-020-05965-1
– volume: 14
  start-page: 185
  year: 2020
  ident: ref_6
  article-title: Single-Cell RNA-Seq Data Analysis on the Receptor ACE2 Expression Reveals the Potential Risk of Different Human Organs Vulnerable to 2019-NCoV Infection
  publication-title: Front. Med.
  doi: 10.1007/s11684-020-0754-0
– volume: 19
  start-page: 707
  year: 2021
  ident: ref_26
  article-title: Integrative Multi-Omics Landscape of Non-Structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses
  publication-title: Genom. Proteom. Bioinform.
  doi: 10.1016/j.gpb.2021.09.007
– ident: ref_37
  doi: 10.1101/2021.12.21.21268116
– volume: 368
  start-page: 1575
  year: 2013
  ident: ref_56
  article-title: Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1109400
– volume: 11
  start-page: 24042
  year: 2021
  ident: ref_57
  article-title: SARS-CoV-2 Infection Reduces Human Nasopharyngeal Commensal Microbiome with Inclusion of Pathobionts
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-03245-4
– ident: ref_82
  doi: 10.3390/ncrna5010007
– volume: 138
  start-page: 377
  year: 2018
  ident: ref_131
  article-title: Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.117.032291
– ident: ref_127
– volume: 1868
  start-page: 166291
  year: 2022
  ident: ref_88
  article-title: Sequence Complementarity between Human Noncoding RNAs and SARS-CoV-2 Genes: What Are the Implications for Human Health?
  publication-title: Biochim. Et Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2021.166291
– volume: 71
  start-page: 544
  year: 2022
  ident: ref_22
  article-title: Gut Microbiota Dynamics in a Prospective Cohort of Patients with Post-Acute COVID-19 Syndrome
  publication-title: Gut
  doi: 10.1136/gutjnl-2021-325989
– ident: ref_42
  doi: 10.1101/2021.12.27.21268278
– volume: 58
  start-page: 1
  year: 2021
  ident: ref_17
  article-title: Phenotyping Long COVID
  publication-title: Eur. Respir. J.
  doi: 10.1183/13993003.01763-2021
– volume: 369
  start-page: 718
  year: 2020
  ident: ref_58
  article-title: Impaired Type I Interferon Activity and Inflammatory Responses in Severe COVID-19 Patients
  publication-title: Science
  doi: 10.1126/science.abc6027
– volume: 583
  start-page: 437
  year: 2020
  ident: ref_59
  article-title: Viral and Host Factors Related to the Clinical Outcome of COVID-19
  publication-title: Nature
  doi: 10.1038/s41586-020-2355-0
– volume: 35
  start-page: i501
  year: 2019
  ident: ref_124
  article-title: MOLI: Multi-Omics Late Integration with Deep Neural Networks for Drug Response Prediction
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btz318
– ident: ref_118
– volume: 19
  start-page: 286
  year: 2018
  ident: ref_91
  article-title: Genome, Transcriptome and Proteome: The Rise of Omics Data and Their Integration in Biomedical Sciences
  publication-title: Brief. Bioinform.
  doi: 10.1093/bib/bbw114
– volume: 24
  start-page: 102151
  year: 2021
  ident: ref_77
  article-title: Transcriptomic Profiling of SARS-CoV-2 Infected Human Cell Lines Identifies HSP90 as Target for COVID-19 Therapy
  publication-title: iScience
  doi: 10.1016/j.isci.2021.102151
– volume: 20
  start-page: 358
  year: 2019
  ident: ref_92
  article-title: Comparative Analyses of the Variation of the Transcriptome and Proteome of Rhodobacter Sphaeroides throughout Growth
  publication-title: BMC Genom.
  doi: 10.1186/s12864-019-5749-3
– volume: 591
  start-page: 92
  year: 2021
  ident: ref_111
  article-title: Genetic Mechanisms of Critical Illness in COVID-19
  publication-title: Nature
  doi: 10.1038/s41586-020-03065-y
– volume: 118
  start-page: e2026309118
  year: 2021
  ident: ref_107
  article-title: A Genomic Region Associated with Protection against Severe COVID-19 Is Inherited from Neandertals
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2026309118
– volume: 7
  start-page: ofaa220
  year: 2020
  ident: ref_51
  article-title: Secondary Bacterial Infections in Critical Ill Patients with Coronavirus Disease 2019
  publication-title: Open Forum Infect. Dis.
  doi: 10.1093/ofid/ofaa220
– volume: 199
  start-page: 559
  year: 2021
  ident: ref_4
  article-title: Comparison of Deaths from COVID-19 and Seasonal Influenza in the USA
  publication-title: Lung
  doi: 10.1007/s00408-021-00468-0
– ident: ref_115
  doi: 10.1038/s41586-021-03767-x
– volume: 26
  start-page: 2100348
  year: 2021
  ident: ref_34
  article-title: Characteristics of SARS-CoV-2 Variants of Concern B.1.1.7, B.1.351 or P.1: Data from Seven EU/EEA Countries, Weeks 38/2020 to 10/2021
  publication-title: Eurosurveillance
  doi: 10.2807/1560-7917.ES.2021.26.16.2100348
– volume: 69
  start-page: 2549
  year: 2020
  ident: ref_19
  article-title: Covid-19 and Diabetes: A Collision and Collusion of Two Diseases
  publication-title: Diabetes
  doi: 10.2337/dbi20-0032
– volume: 308
  start-page: 198631
  year: 2022
  ident: ref_64
  article-title: The Role of MicroRNAs in Solving COVID-19 Puzzle from Infection to Therapeutics: A Mini-Review
  publication-title: Virus Res.
  doi: 10.1016/j.virusres.2021.198631
– volume: 592
  start-page: 438
  year: 2021
  ident: ref_35
  article-title: Detection of a SARS-CoV-2 Variant of Concern in South Africa
  publication-title: Nature
  doi: 10.1038/s41586-021-03402-9
– volume: 53
  start-page: 1108
  year: 2020
  ident: ref_105
  article-title: Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.10.008
– volume: 20
  start-page: 4627
  year: 2021
  ident: ref_96
  article-title: Discovery Proteomics for COVID-19: Where We Are Now
  publication-title: J. Proteome Res.
  doi: 10.1021/acs.jproteome.1c00475
– volume: 2
  start-page: e0189
  year: 2020
  ident: ref_103
  article-title: Novel Outcome Biomarkers Identified with Targeted Proteomic Analyses of Plasma From Critically Ill Coronavirus Disease 2019 Patients
  publication-title: Crit. Care Explor.
  doi: 10.1097/CCE.0000000000000189
– volume: 13
  start-page: 1
  year: 2021
  ident: ref_117
  article-title: An Atlas Connecting Shared Genetic Architecture of Human Diseases and Molecular Phenotypes Provides Insight into COVID-19 Susceptibility
  publication-title: Genome Med.
  doi: 10.1186/s13073-021-00904-z
– volume: 224
  start-page: 1839
  year: 2021
  ident: ref_23
  article-title: Markers of Immune Activation and Inflammation in Individuals with Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jiab490
– volume: 352
  start-page: 109777
  year: 2022
  ident: ref_27
  article-title: Comparisons of the Immunological Landscape of COVID-19 Patients Based on Sex and Disease Severity by Multi-Omics Analysis
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/j.cbi.2021.109777
– volume: 10
  start-page: 20533
  year: 2020
  ident: ref_102
  article-title: Longitudinal Proteomic Profiling Reveals Increased Early Inflammation and Sustained Apoptosis Proteins in Severe COVID-19
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-77525-w
– ident: ref_125
  doi: 10.1101/2020.02.21.960062
– volume: 73
  start-page: 1
  year: 2021
  ident: ref_46
  article-title: Pathogenic and Transcriptomic Differences of Emerging SARS-CoV-2 Variants in the Syrian Golden Hamster Model
  publication-title: EBioMedicine
– ident: ref_55
  doi: 10.3390/metabo10030097
– volume: 183
  start-page: 1479
  year: 2020
  ident: ref_25
  article-title: Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19
  publication-title: Cell
  doi: 10.1016/j.cell.2020.10.037
– volume: 184
  start-page: 4713
  year: 2021
  ident: ref_78
  article-title: Impaired Local Intrinsic Immunity to SARS-CoV-2 Infection in Severe COVID-19
  publication-title: Cell
  doi: 10.1016/j.cell.2021.07.023
– volume: 24
  start-page: 101896
  year: 2021
  ident: ref_73
  article-title: Transcriptional Response Modules Characterize IL-1β and IL-6 Activity in COVID-19
  publication-title: iScience
  doi: 10.1016/j.isci.2020.101896
– volume: 96
  start-page: 107497
  year: 2021
  ident: ref_86
  article-title: NUTM2A-AS1 Silencing Alleviates LPS-Induced Apoptosis and Inflammation in Dental Pulp Cells through Targeting Let-7c-5p/HMGB1 Axis
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2021.107497
– volume: 143
  start-page: 3104
  year: 2020
  ident: ref_11
  article-title: The Emerging Spectrum of COVID-19 Neurology: Clinical, Radiological and Laboratory Findings
  publication-title: Brain
  doi: 10.1093/brain/awaa240
– volume: 53
  start-page: 1296
  year: 2020
  ident: ref_30
  article-title: Longitudinal Multi-Omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.11.017
– volume: 126
  start-page: 4702
  year: 2016
  ident: ref_130
  article-title: Early Pregnancy Vitamin D Status and Risk of Preeclampsia
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI89031
– volume: 19
  start-page: 4417
  year: 2020
  ident: ref_99
  article-title: Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level
  publication-title: J. Proteome Res.
  doi: 10.1021/acs.jproteome.0c00365
– volume: 20
  start-page: 2000202
  year: 2020
  ident: ref_101
  article-title: Urinary Peptides Significantly Associate with COVID-19 Severity: Pilot Proof-of-Principle Data and Design of a Multicentric Diagnostic Study
  publication-title: Proteomics
  doi: 10.1002/pmic.202000202
– volume: 47
  start-page: 693
  year: 2015
  ident: ref_114
  article-title: Human Intestine Luminal ACE2 and Amino Acid Transporter Expression Increased by ACE-Inhibitors
  publication-title: Amino Acids
  doi: 10.1007/s00726-014-1889-6
– volume: 383
  start-page: 120
  year: 2020
  ident: ref_10
  article-title: Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2015432
– ident: ref_85
  doi: 10.1371/journal.pone.0206511
– volume: 52
  start-page: 345
  year: 2020
  ident: ref_12
  article-title: Renal Complications in COVID-19: A Systematic Review and Meta-Analysis
  publication-title: Ann. Med.
  doi: 10.1080/07853890.2020.1790643
– volume: 127
  start-page: 104364
  year: 2020
  ident: ref_48
  article-title: Clinical Features and Short-Term Outcomes of 221 Patients with COVID-19 in Wuhan, China
  publication-title: J. Clin. Virol.
  doi: 10.1016/j.jcv.2020.104364
– volume: 22
  start-page: 1840
  year: 2021
  ident: ref_18
  article-title: Prevalence and Predictors of Persistence of COVID-19 Symptoms in Older Adults: A Single-Center Study
  publication-title: J. Am. Med. Dir. Assoc.
  doi: 10.1016/j.jamda.2021.07.003
– volume: 116
  start-page: 12428
  year: 2019
  ident: ref_68
  article-title: Olfactory Sensory Neurons Mediate Ultrarapid Antiviral Immune Responses in a TrkA-Dependent Manner
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1900083116
– volume: 4
  start-page: 1
  year: 2018
  ident: ref_132
  article-title: Controllability in an Islet Specific Regulatory Network Identifies the Transcriptional Factor NFATC4, Which Regulates Type 2 Diabetes Associated Genes
  publication-title: NPJ Syst. Biol. Appl.
  doi: 10.1038/s41540-018-0057-0
– ident: ref_8
  doi: 10.1101/2021.01.05.425420
– ident: ref_40
  doi: 10.1101/2021.12.30.21268560
– volume: 324
  start-page: 603
  year: 2020
  ident: ref_135
  article-title: Persistent Symptoms in Patients after Acute COVID-19
  publication-title: JAMA J. Am. Med. Assoc.
  doi: 10.1001/jama.2020.12603
– volume: 10
  start-page: 1065
  year: 2020
  ident: ref_137
  article-title: Integrative Network Fusion: A Multi-Omics Approach in Molecular Profiling
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2020.01065
– volume: 146
  start-page: 110415
  year: 2021
  ident: ref_75
  article-title: Tackling the COVID-19 “Cytokine Storm” with MicroRNA Mimics Directly Targeting the 3’UTR of pro-Inflammatory MRNAs
  publication-title: Med. Hypotheses
  doi: 10.1016/j.mehy.2020.110415
– volume: 1865
  start-page: 611
  year: 2019
  ident: ref_67
  article-title: Impact of Advanced Glycation End Products (AGEs) Signaling in Coronary Artery Disease
  publication-title: Biochim. Et Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2019.01.006
– volume: 143
  start-page: 112176
  year: 2021
  ident: ref_24
  article-title: SARS-CoV-2 New Variants: Characteristic Features and Impact on the Efficacy of Different Vaccines
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2021.112176
– volume: 397
  start-page: 2461
  year: 2021
  ident: ref_32
  article-title: SARS-CoV-2 Delta VOC in Scotland: Demographics, Risk of Hospital Admission, and Vaccine Effectiveness
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)01358-1
– ident: ref_106
  doi: 10.1056/NEJMoa2020283
– volume: 1
  start-page: 1
  year: 2022
  ident: ref_122
  article-title: Whole Genome Sequencing Reveals Host Factors Underlying Critical COVID-19
  publication-title: Nature
– ident: ref_43
– ident: ref_14
  doi: 10.3390/ijerph18105329
– volume: 12
  start-page: 23
  year: 2021
  ident: ref_29
  article-title: Large-Scale Multi-Omic Analysis of COVID-19 Severity
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2020.10.003
– volume: 183
  start-page: 1325
  year: 2020
  ident: ref_61
  article-title: SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses
  publication-title: Cell
  doi: 10.1016/j.cell.2020.10.004
– volume: 11
  start-page: 333
  year: 2014
  ident: ref_136
  article-title: Similarity Network Fusion for Aggregating Data Types on a Genomic Scale
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2810
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Snippet More than two years on, the COVID-19 pandemic continues to wreak havoc around the world and has battle-tested the pandemic-situation responses of all major...
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SubjectTerms Antibodies
Belgium
Biomarkers
Communicable Diseases - epidemiology
Communication
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 infection
COVID-19 vaccines
Diabetes
Disease transmission
Epidemics
Fatalities
Genomes
Genomics
Genotype & phenotype
Hospitalization
Humans
Infections
Infectious diseases
Kidneys
Long COVID
Longitudinal Studies
mass spectrometry
Medical research
medicine
Medicine, Experimental
metabolome
Metabolomics
Metabolomics - methods
metagenomics
Methods
microbiome
Microbiomes
Molecular modelling
Next-generation sequencing
Pandemics
Pathogenesis
patient care
Patients
post COVID condition
Post-Acute COVID-19 Syndrome
proteome
Proteomes
Proteomics
Risk factors
Severe acute respiratory syndrome coronavirus 2
Systems biology
Systems Biology - methods
transcriptome
Transcriptomes
viral genome
Virulence
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Volume 14
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