Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing

• Published in: Advanced science Vol. 10; no. 22; pp. e2300576 - n/a
• Main Authors: Li, Shengbo, Wang, Xuemei, Yan, Zhiyao, Wang, Tian, Chen, Zhenbing, Song, Heng, Zheng, Yongbin
• Format: Journal Article
• Language: English
• Published: Germany John Wiley and Sons Inc 01.08.2023; Wiley
• Subjects: antimicrobial; dopamine; immunity; infected wound healing; microneedle; microneedle; antimicrobial; immunity; infected wound healing; dopamine
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202300576

Treatment of infected wounds remains a challenge owing to antibiotic resistance; thus, developing smart biomaterials for the healing of infected wounds is urgently needed. In this study, a microneedle (MN) patch system with antimicrobial and immunomodulatory properties is developed to promote and accelerate infected wound healing. In the MN patch (termed PFG/M MNs), a nanoparticle with polydopamine (PDA)‐loaded iron oxide is grafted with glucose oxidase (GOx) and hyaluronic acid (HA) and then integrated into the tips, and amine‐modified mesoporous silica nanoparticles (AP‐MSNs) are incorporated into the bases. Results show that PFG/M MNs eradicate bacterial infections and modulate the immune microenvironment, combining the advantages of chemodynamic therapy, photothermal therapy, and M2 macrophage polarization from Fe/PDA@GOx@HA in the tips as well as anti‐inflammatory effect of AP‐MSNs from the MN bases. Thus, the PFG/M MN system is a promising clinical candidate for promoting infected wound healing. A novel microneedle system with excellent antimicrobial and immunomodulatory properties is designed and developed. The microneedle system penetrates the bacterial biofilm to efficiently deliver nanomaterials. Under NIR laser irradiation, this system can be integrated into multiple treatment methods (chemodynamic therapy, photothermal therapy, and immunomodulation).