Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients
Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. In this study, using pools of overlapping linear B-cell...
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| Published in | Nature communications Vol. 11; no. 1; pp. 2806 - 7 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.06.2020
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2041-1723 2041-1723 |
| DOI | 10.1038/s41467-020-16638-2 |
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| Abstract | Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. In this study, using pools of overlapping linear B-cell peptides, we report two IgG immunodominant regions on SARS-CoV-2 spike glycoprotein that are recognised by sera from COVID-19 convalescent patients. Notably, one is specific to SARS-CoV-2, which is located in close proximity to the receptor binding domain. The other region, which is localised at the fusion peptide, could potentially function as a pan-SARS target. Functionally, antibody depletion assays demonstrate that antibodies targeting these immunodominant regions significantly alter virus neutralisation capacities. Taken together, identification and validation of these neutralising B-cell epitopes will provide insights towards the design of diagnostics and vaccine candidates against this high priority coronavirus.
Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development. |
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| AbstractList | Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. In this study, using pools of overlapping linear B-cell peptides, we report two IgG immunodominant regions on SARS-CoV-2 spike glycoprotein that are recognised by sera from COVID-19 convalescent patients. Notably, one is specific to SARS-CoV-2, which is located in close proximity to the receptor binding domain. The other region, which is localised at the fusion peptide, could potentially function as a pan-SARS target. Functionally, antibody depletion assays demonstrate that antibodies targeting these immunodominant regions significantly alter virus neutralisation capacities. Taken together, identification and validation of these neutralising B-cell epitopes will provide insights towards the design of diagnostics and vaccine candidates against this high priority coronavirus. Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development. Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. In this study, using pools of overlapping linear B-cell peptides, we report two IgG immunodominant regions on SARS-CoV-2 spike glycoprotein that are recognised by sera from COVID-19 convalescent patients. Notably, one is specific to SARS-CoV-2, which is located in close proximity to the receptor binding domain. The other region, which is localised at the fusion peptide, could potentially function as a pan-SARS target. Functionally, antibody depletion assays demonstrate that antibodies targeting these immunodominant regions significantly alter virus neutralisation capacities. Taken together, identification and validation of these neutralising B-cell epitopes will provide insights towards the design of diagnostics and vaccine candidates against this high priority coronavirus.Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. In this study, using pools of overlapping linear B-cell peptides, we report two IgG immunodominant regions on SARS-CoV-2 spike glycoprotein that are recognised by sera from COVID-19 convalescent patients. Notably, one is specific to SARS-CoV-2, which is located in close proximity to the receptor binding domain. The other region, which is localised at the fusion peptide, could potentially function as a pan-SARS target. Functionally, antibody depletion assays demonstrate that antibodies targeting these immunodominant regions significantly alter virus neutralisation capacities. Taken together, identification and validation of these neutralising B-cell epitopes will provide insights towards the design of diagnostics and vaccine candidates against this high priority coronavirus. Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. In this study, using pools of overlapping linear B-cell peptides, we report two IgG immunodominant regions on SARS-CoV-2 spike glycoprotein that are recognised by sera from COVID-19 convalescent patients. Notably, one is specific to SARS-CoV-2, which is located in close proximity to the receptor binding domain. The other region, which is localised at the fusion peptide, could potentially function as a pan-SARS target. Functionally, antibody depletion assays demonstrate that antibodies targeting these immunodominant regions significantly alter virus neutralisation capacities. Taken together, identification and validation of these neutralising B-cell epitopes will provide insights towards the design of diagnostics and vaccine candidates against this high priority coronavirus. Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development. Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. In this study, using pools of overlapping linear B-cell peptides, we report two IgG immunodominant regions on SARS-CoV-2 spike glycoprotein that are recognised by sera from COVID-19 convalescent patients. Notably, one is specific to SARS-CoV-2, which is located in close proximity to the receptor binding domain. The other region, which is localised at the fusion peptide, could potentially function as a pan-SARS target. Functionally, antibody depletion assays demonstrate that antibodies targeting these immunodominant regions significantly alter virus neutralisation capacities. Taken together, identification and validation of these neutralising B-cell epitopes will provide insights towards the design of diagnostics and vaccine candidates against this high priority coronavirus. Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. In this study, using pools of overlapping linear B-cell peptides, we report two IgG immunodominant regions on SARS-CoV-2 spike glycoprotein that are recognised by sera from COVID-19 convalescent patients. Notably, one is specific to SARS-CoV-2, which is located in close proximity to the receptor binding domain. The other region, which is localised at the fusion peptide, could potentially function as a pan-SARS target. Functionally, antibody depletion assays demonstrate that antibodies targeting these immunodominant regions significantly alter virus neutralisation capacities. Taken together, identification and validation of these neutralising B-cell epitopes will provide insights towards the design of diagnostics and vaccine candidates against this high priority coronavirus.Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development. Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development. |
| ArticleNumber | 2806 |
| Author | Lye, David C. Chen, Mark I-Cheng Amrun, Siti Naqiah Torres-Ruesta, Anthony Tan, Seow-Yen Kheng, Shirley Seah Gek Kalimuddin, Shirin Lee, Wen-Hsin Thien, Siew-Yee Young, Barnaby Edward Wang, Bei Renia, Laurent Yeo, Nicholas Kim-Wah Hanson, Brendon John Wang, Cheng-I Poh, Chek Meng Fong, Siew-Wai Chai, Louis Yi Ann Ng, Lisa F. P. Carissimo, Guillaume Leo, Yee-Sin Lee, Cheryl Yi-Pin Chee, Rhonda Sin-Ling |
| Author_xml | – sequence: 1 givenname: Chek Meng surname: Poh fullname: Poh, Chek Meng organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 2 givenname: Guillaume orcidid: 0000-0002-9703-9096 surname: Carissimo fullname: Carissimo, Guillaume organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 3 givenname: Bei surname: Wang fullname: Wang, Bei organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 4 givenname: Siti Naqiah surname: Amrun fullname: Amrun, Siti Naqiah organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 5 givenname: Cheryl Yi-Pin surname: Lee fullname: Lee, Cheryl Yi-Pin organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 6 givenname: Rhonda Sin-Ling surname: Chee fullname: Chee, Rhonda Sin-Ling organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 7 givenname: Siew-Wai surname: Fong fullname: Fong, Siew-Wai organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis, Department of Biological Science, National University of Singapore – sequence: 8 givenname: Nicholas Kim-Wah surname: Yeo fullname: Yeo, Nicholas Kim-Wah organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 9 givenname: Wen-Hsin surname: Lee fullname: Lee, Wen-Hsin organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 10 givenname: Anthony orcidid: 0000-0003-0447-3131 surname: Torres-Ruesta fullname: Torres-Ruesta, Anthony organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore – sequence: 11 givenname: Yee-Sin surname: Leo fullname: Leo, Yee-Sin organization: National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Lee Kong Chian School of Medicine, Nanyang Technological University, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System – sequence: 12 givenname: Mark I-Cheng surname: Chen fullname: Chen, Mark I-Cheng organization: National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Saw Swee Hock School of Public Health, National University of Singapore and National University Health System – sequence: 13 givenname: Seow-Yen surname: Tan fullname: Tan, Seow-Yen organization: Department of Infectious Diseases, Changi General Hospital – sequence: 14 givenname: Louis Yi Ann surname: Chai fullname: Chai, Louis Yi Ann organization: Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Department of Medicine, National University Hospital – sequence: 15 givenname: Shirin surname: Kalimuddin fullname: Kalimuddin, Shirin organization: Department of Infectious Diseases, Singapore General Hospital, Emerging Infectious Disease Program, Duke-NUS Medical School – sequence: 16 givenname: Shirley Seah Gek surname: Kheng fullname: Kheng, Shirley Seah Gek organization: Biological Defence Program, DSO National Laboratories – sequence: 17 givenname: Siew-Yee surname: Thien fullname: Thien, Siew-Yee organization: Department of Infectious Diseases, Singapore General Hospital – sequence: 18 givenname: Barnaby Edward surname: Young fullname: Young, Barnaby Edward organization: National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Lee Kong Chian School of Medicine, Nanyang Technological University – sequence: 19 givenname: David C. surname: Lye fullname: Lye, David C. organization: National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Lee Kong Chian School of Medicine, Nanyang Technological University, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System – sequence: 20 givenname: Brendon John surname: Hanson fullname: Hanson, Brendon John organization: Biological Defence Program, DSO National Laboratories – sequence: 21 givenname: Cheng-I surname: Wang fullname: Wang, Cheng-I organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 22 givenname: Laurent orcidid: 0000-0003-0349-1557 surname: Renia fullname: Renia, Laurent organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis – sequence: 23 givenname: Lisa F. P. orcidid: 0000-0003-4071-5222 surname: Ng fullname: Ng, Lisa F. P. email: lisa_ng@immunol.a-star.edu.sg organization: Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32483236$$D View this record in MEDLINE/PubMed |
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| Snippet | Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards... Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear... |
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| Title | Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients |
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