Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis - Lenoir, Olivia; Jasiek, Magali; Hénique, Carole; Guyonnet, Léa; Hartleben, Björn; Bork, Tillmann; Chipont, Anna; Flosseau, Kathleen; Bensaada, Imane; Schmitt, Alain; Massé, Jean-Marc; Souyri, Michèle; et al. (Autophagy, 2015)
Keywords: Animals; Apoptosis - drug effects; autophagy; Autophagy - drug effects; Autophagy-Related Protein 5; Cells, Cultured; Development Biology; Diabetic Nephropathies - pathology; Diabetic Nephropathies - physiopathology; Diabetic Nephropathies - prevention & control; diabetic nephropathy; endothelial cells; Endothelial Cells - drug effects; Endothelial Cells - pathology; Endothelial Cells - ultrastructure; Gene Deletion; Glomerular Filtration Rate - drug effects; Glucose - pharmacology; Integrases - metabolism; Life Sciences; Mesangial Cells - drug effects; Mesangial Cells - pathology; Mesangial Cells - ultrastructure; Mice, Inbred C57BL; Microtubule-Associated Proteins - deficiency; Microtubule-Associated Proteins - metabolism; Phenotype; podocytes; Podocytes - drug effects; Podocytes - pathology; Podocytes - ultrastructure; proteinuria; sclerosis; Translational Research Paper; CASP3, caspase 3, apoptosis-related cysteine peptidase; MTOR, mechanistic target of rapamycin; endothelial cells; autophagy; DM, diabetes mellitus; GEC, glomerular endothelial cells; proteinuria; STZ, streptozotocin; TEM, transmission electron microscopy; Nphs2, nephrosis 2, podocin; sclerosis; SQSTM1, sequestosome 1; Cdh5, cadherin 5; podocytes; MAP1LC3A/B/LC3A/B), microtubule-associated protein 1 light chain 3 α/β; GFB, glomerular filtration barrier; GBM, glomerular basement membrane; ESRD, end-stage renal disease; α, WT1, Wilms tumor 1; TUBA, tubulin; BUN, blood urea nitrogen; DN, diabetic nephropathy; diabetic nephropathy; ESRD; apoptosis-related cysteine peptidase; GFB; B; sequestosome 1; LC3A; DM; diabetes mellitus; DN; mechanistic target of rapamycin; blood urea nitrogen; caspase 3; microtubule-associated protein 1 light chain 3; Cdh5; GBM; MAP1LC3A; CASP3; STZ; Nphs2; BUN; glomerular endothelial cells; transmission electron microscopy; nephrosis 2; glomerular filtration barrier; GEC; podocin; TUBA; tubulin; cadherin 5; end-stage renal disease; MTOR; streptozotocin; WT1; Wilms tumor 1; glomerular basement membrane; SQSTM1; TEM