Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease
1 EA 3596, Laboratoire ACTES, Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à-Pitre, Guadeloupe 2 UMR S 763 Inserm/Université des Antilles et de la Guyane, CHU Pointe-à-Pitre, Guadeloupe 3 Department of Physiology and Biophysics, University of South...
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| Published in | Haematologica (Roma) Vol. 94; no. 8; pp. 1060 - 1065 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Pavia
Ferrata Storti Foundation
01.08.2009
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0390-6078 1592-8721 1592-8721 |
| DOI | 10.3324/haematol.2008.005371 |
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| Abstract | 1 EA 3596, Laboratoire ACTES, Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à-Pitre, Guadeloupe
2 UMR S 763 Inserm/Université des Antilles et de la Guyane, CHU Pointe-à-Pitre, Guadeloupe
3 Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
4 Caribbean Sickle Cell Center, Pointe-à-Pitre, Guadeloupe
5 Department of Hematology/Immunology, Academic Hospital of Pointe-à-Pitre, Guadeloupe
Correspondence: Philippe Connes, PhD, Laboratoire ACTES (EA 3596), Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, 97159 Pointe-à-Pitre, Guadeloupe (French West Indies). E-mail: pconnes{at}yahoo.fr
Background: Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease.
Design and Methods: We compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA).
Results: Blood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates.
Conclusions: The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates.
Key words: sickle cell disease, red blood cell aggregation, viscosity, red blood cell deformability. |
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| AbstractList | Recent evidence suggests that red cell aggregation and the ratio of hematocrit to blood viscosity, an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. The findings of this study indicate that patients with sickle cell disease and those with sickle cell hemoglobin C disease have low ratios of hematocrit to blood viscosity as compared to normal controls. This may play a role in tissue hypoxia and clinical status of these patients. 1 EA 3596, Laboratoire ACTES, Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à-Pitre, Guadeloupe 2 UMR S 763 Inserm/Université des Antilles et de la Guyane, CHU Pointe-à-Pitre, Guadeloupe 3 Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA 4 Caribbean Sickle Cell Center, Pointe-à-Pitre, Guadeloupe 5 Department of Hematology/Immunology, Academic Hospital of Pointe-à-Pitre, Guadeloupe Correspondence: Philippe Connes, PhD, Laboratoire ACTES (EA 3596), Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, 97159 Pointe-à-Pitre, Guadeloupe (French West Indies). E-mail: pconnes{at}yahoo.fr Background: Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease. Design and Methods: We compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA). Results: Blood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates. Conclusions: The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates. Key words: sickle cell disease, red blood cell aggregation, viscosity, red blood cell deformability. Background Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease.Design and Methods We compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA).Results Blood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates.Conclusions The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates. Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease.BACKGROUNDRecent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease.We compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA).DESIGN AND METHODSWe compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA).Blood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates.RESULTSBlood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates.The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates.CONCLUSIONSThe low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates. Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease. We compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA). Blood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates. The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates. |
| Author | Mougenel, Daniele Hue, Olivier Meiselman, Herbert J Hardy-Dessources, Marie-Dominique Etienne-Julan, Maryse Chout, Roger Tripette, Julien Connes, Philippe Beltan, Eric Alexy, Tamas Chalabi, Tawfik |
| AuthorAffiliation | 3 Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA 5 Department of Hematology/Immunology, Academic Hospital of Pointe-à-Pitre, Guadeloupe 1 EA 3596, Laboratoire ACTES, Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à-Pitre, Guadeloupe 2 UMR S 763 Inserm/Université des Antilles et de la Guyane, CHU Pointe-à-Pitre, Guadeloupe 4 Caribbean Sickle Cell Center, Pointe-à-Pitre, Guadeloupe |
| AuthorAffiliation_xml | – name: 5 Department of Hematology/Immunology, Academic Hospital of Pointe-à-Pitre, Guadeloupe – name: 4 Caribbean Sickle Cell Center, Pointe-à-Pitre, Guadeloupe – name: 2 UMR S 763 Inserm/Université des Antilles et de la Guyane, CHU Pointe-à-Pitre, Guadeloupe – name: 1 EA 3596, Laboratoire ACTES, Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à-Pitre, Guadeloupe – name: 3 Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA |
| Author_xml | – sequence: 1 fullname: Tripette, Julien – sequence: 2 fullname: Alexy, Tamas – sequence: 3 fullname: Hardy-Dessources, Marie-Dominique – sequence: 4 fullname: Mougenel, Daniele – sequence: 5 fullname: Beltan, Eric – sequence: 6 fullname: Chalabi, Tawfik – sequence: 7 fullname: Chout, Roger – sequence: 8 fullname: Etienne-Julan, Maryse – sequence: 9 fullname: Hue, Olivier – sequence: 10 fullname: Meiselman, Herbert J – sequence: 11 fullname: Connes, Philippe |
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| References_xml | – reference: 16269018 - Eur J Clin Invest. 2005 Nov;35(11):687-90 – reference: 16734807 - Transfusion. 2006 Jun;46(6):912-8 – reference: 5443167 - J Clin Invest. 1970 Apr;49(4):623-34 – reference: 2348499 - J Trop Med Hyg. 1990 Jun;93(3):210-4 – reference: 10607725 - Blood. 2000 Jan 1;95(1):360-2 – reference: 18608991 - Microcirculation. 2008 Oct;15(7):585-90 – reference: 6712910 - Br J Ophthalmol. 1984 May;68(5):325-8 – reference: 11299197 - Am J Physiol Heart Circ Physiol. 2001 May;280(5):H1982-8 – reference: 14194270 - Blood. 1964 Jul;24:25-48 – reference: 61453 - Lancet. 1976 Oct 9;2(7989):784-6 – reference: 2424491 - Br J Ophthalmol. 1986 Jul;70(7):522-5 – reference: 11790865 - Clin Hemorheol Microcirc. 2001;25(1):1-11 – reference: 3209393 - Hemoglobin. 1988;12(5-6):509-17 – reference: 17993789 - Clin J Sport Med. 2007 Nov;17(6):465-70 – reference: 19065010 - Biorheology. 2008;45(6):629-38 – reference: 3590284 - Transfusion. 1987 May-Jun;27(3):228-33 – reference: 18499764 - Br J Sports Med. 2010 Mar;44(4):232-7 – reference: 18937523 - Sports Med. 2008;38(11):931-46 – reference: 6294138 - J Clin Invest. 1982 Dec;70(6):1253-9 – reference: 16015123 - Med Sci Sports Exerc. 2005 Jul;37(7):1086-92 – reference: 15474138 - Lancet. 2004 Oct 9-15;364(9442):1343-60 – reference: 7174796 - J Clin Invest. 1982 Dec;70(6):1315-9 – reference: 6690472 - J Clin Invest. 1984 Jan;73(1):116-23 – reference: 16899945 - Clin Hemorheol Microcirc. 2006;35(1-2):291-5 – reference: 2947642 - Blood. 1987 Jan;69(1):124-30 – reference: 9436619 - Free Radic Biol Med. 1998 Jan 1;24(1):102-10 – reference: 3401593 - Blood. 1988 Aug;72(2):539-45 |
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| Snippet | 1 EA 3596, Laboratoire ACTES, Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à-Pitre, Guadeloupe
2 UMR S 763... Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of... Recent evidence suggests that red cell aggregation and the ratio of hematocrit to blood viscosity, an index of the oxygen transport potential of blood, might... Background Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport... |
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| SubjectTerms | Anemia, Sickle Cell - blood Anemia, Sickle Cell - genetics Anemias. Hemoglobinopathies Biological and medical sciences Biological Transport Blood Viscosity Diseases of red blood cells Erythrocyte Aggregation Erythrocyte Deformability Erythrocytes - metabolism Fibrinogen - metabolism Hematocrit Hematologic and hematopoietic diseases Hemoglobin C - metabolism Hemoglobin C Disease - blood Hemoglobin C Disease - genetics Hemoglobin, Sickle - metabolism Hemorheology Homozygote Humans Life Sciences Medical sciences Original Oxygen - metabolism |
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| Title | Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease |
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