Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands - Nishimoto, Koshiro; Tomlins, Scott A.; Kuick, Rork; Cani, Andi K.; Giordano, Thomas J.; Hovelson, Daniel H.; Liu, Chia-Jen; Sanjanwala, Aalok R.; Edwards, Michael A.; Gomez-Sanchez, Celso E.; Nanba, Kazutaka; Rainey, William E. (Proceedings of the National Academy of Sciences - PNAS, 2015)
Keywords: Adrenal Cortex - metabolism; Adrenal glands; Adrenal Glands - metabolism; Aldosterone - biosynthesis; Biological Sciences; Calcium channels; Cytochrome P-450 CYP11B2 - metabolism; DNA - chemistry; Gene expression; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Homeostasis; Humans; Hyperaldosteronism - etiology; Hypertension; Mutation; Oligonucleotide Array Sequence Analysis; PNAS Plus; Principal Component Analysis; Sequence Analysis, DNA; Sequence Analysis, RNA; Transcriptome; Zona Glomerulosa; somatic mutations; aldosterone-producing cell cluster; adrenal; aldosterone; primary aldosteronism