Increased cerebrospinal fluid interleukin-8 in bipolar disorder patients associated with lithium and antipsychotic treatment
•Higher CSF IL-8 concentrations in bipolar disorder patients as compared to controls.•Higher IL-8 concentrations associated to lithium- and antipsychotic treatment.•Findings might reflect disease related immune aberrations or be due to medication.•Important to consider medication status while studyi...
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| Published in | Brain, behavior, and immunity Vol. 43; pp. 198 - 204 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.01.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0889-1591 1090-2139 1090-2139 |
| DOI | 10.1016/j.bbi.2014.10.001 |
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| Abstract | •Higher CSF IL-8 concentrations in bipolar disorder patients as compared to controls.•Higher IL-8 concentrations associated to lithium- and antipsychotic treatment.•Findings might reflect disease related immune aberrations or be due to medication.•Important to consider medication status while studying the immune activity in BD.
Inflammation has been linked to the pathophysiology of bipolar disorder based on studies of inflammation markers, such as cytokine concentrations, in plasma and serum samples from cases and controls. However, peripheral measurements of cytokines do not readily translate to immunological activity in the brain. The aim of the present study was to study brain immune and inflammatory activity. To this end, we analyzed cytokines in cerebrospinal fluid from 121 euthymic bipolar disorder patients and 71 age and sex matched control subjects. Concentrations of 11 different cytokines were determined using immunoassays. Cerebrospinal fluid IL-8 concentrations were significantly higher in patients as compared to controls. The other cytokines measured were only detectable in part of the sample. IL-8 concentrations were positively associated to lithium- and antipsychotic treatment. The findings might reflect immune aberrations in bipolar disorder, or be due to the effects of medication. |
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| AbstractList | Inflammation has been linked to the pathophysiology of bipolar disorder based on studies of inflammation markers, such as cytokine concentrations, in plasma and serum samples from cases and controls. However, peripheral measurements of cytokines do not readily translate to immunological activity in the brain. The aim of the present study was to study brain immune and inflammatory activity. To this end, we analyzed cytokines in cerebrospinal fluid from 121 euthymic bipolar disorder patients and 71 age and sex matched control subjects. Concentrations of 11 different cytokines were determined using immunoassays. Cerebrospinal fluid IL-8 concentrations were significantly higher in patients as compared to controls. The other cytokines measured were only detectable in part of the sample. IL-8 concentrations were positively associated to lithium- and antipsychotic treatment. The findings might reflect immune aberrations in bipolar disorder, or be due to the effects of medication. Inflammation has been linked to the pathophysiology of bipolar disorder based on studies of inflammation markers, such as cytokine concentrations, in plasma and serum samples from cases and controls. However, peripheral measurements of cytokines do not readily translate to immunological activity in the brain. The aim of the present study was to study brain immune and inflammatory activity. To this end, we analyzed cytokines in cerebrospinal fluid from 121 euthymic bipolar disorder patients and 71 age and sex matched control subjects. Concentrations of 11 different cytokines were determined using immunoassays. Cerebrospinal fluid IL-8 concentrations were significantly higher in patients as compared to controls. The other cytokines measured were only detectable in part of the sample. IL-8 concentrations were positively associated to lithium- and antipsychotic treatment. The findings might reflect immune aberrations in bipolar disorder, or be due to the effects of medication.Inflammation has been linked to the pathophysiology of bipolar disorder based on studies of inflammation markers, such as cytokine concentrations, in plasma and serum samples from cases and controls. However, peripheral measurements of cytokines do not readily translate to immunological activity in the brain. The aim of the present study was to study brain immune and inflammatory activity. To this end, we analyzed cytokines in cerebrospinal fluid from 121 euthymic bipolar disorder patients and 71 age and sex matched control subjects. Concentrations of 11 different cytokines were determined using immunoassays. Cerebrospinal fluid IL-8 concentrations were significantly higher in patients as compared to controls. The other cytokines measured were only detectable in part of the sample. IL-8 concentrations were positively associated to lithium- and antipsychotic treatment. The findings might reflect immune aberrations in bipolar disorder, or be due to the effects of medication. •Higher CSF IL-8 concentrations in bipolar disorder patients as compared to controls.•Higher IL-8 concentrations associated to lithium- and antipsychotic treatment.•Findings might reflect disease related immune aberrations or be due to medication.•Important to consider medication status while studying the immune activity in BD. Inflammation has been linked to the pathophysiology of bipolar disorder based on studies of inflammation markers, such as cytokine concentrations, in plasma and serum samples from cases and controls. However, peripheral measurements of cytokines do not readily translate to immunological activity in the brain. The aim of the present study was to study brain immune and inflammatory activity. To this end, we analyzed cytokines in cerebrospinal fluid from 121 euthymic bipolar disorder patients and 71 age and sex matched control subjects. Concentrations of 11 different cytokines were determined using immunoassays. Cerebrospinal fluid IL-8 concentrations were significantly higher in patients as compared to controls. The other cytokines measured were only detectable in part of the sample. IL-8 concentrations were positively associated to lithium- and antipsychotic treatment. The findings might reflect immune aberrations in bipolar disorder, or be due to the effects of medication. Highlights • Higher CSF IL-8 concentrations in bipolar disorder patients as compared to controls. • Higher IL-8 concentrations associated to lithium- and antipsychotic treatment. • Findings might reflect disease related immune aberrations or be due to medication. • Important to consider medication status while studying the immune activity in BD. |
| Author | Ekman, Carl Johan Jakobsson, Joel Pålsson, Erik Johansson, Anette G.M. Blennow, Kaj Zetterberg, Henrik Isgren, Anniella Sellgren, Carl Landén, Mikael |
| Author_xml | – sequence: 1 givenname: Anniella surname: Isgren fullname: Isgren, Anniella email: anniella.isgren@vgregion.se organization: Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden – sequence: 2 givenname: Joel surname: Jakobsson fullname: Jakobsson, Joel organization: Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden – sequence: 3 givenname: Erik surname: Pålsson fullname: Pålsson, Erik organization: Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden – sequence: 4 givenname: Carl Johan surname: Ekman fullname: Ekman, Carl Johan organization: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden – sequence: 5 givenname: Anette G.M. surname: Johansson fullname: Johansson, Anette G.M. organization: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden – sequence: 6 givenname: Carl surname: Sellgren fullname: Sellgren, Carl organization: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden – sequence: 7 givenname: Kaj surname: Blennow fullname: Blennow, Kaj organization: Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden – sequence: 8 givenname: Henrik surname: Zetterberg fullname: Zetterberg, Henrik organization: Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden – sequence: 9 givenname: Mikael surname: Landén fullname: Landén, Mikael organization: Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25451615$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/207384$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:131952768$$DView record from Swedish Publication Index |
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| Keywords | Antipsychotic drugs Cytokines Biomarkers Bipolar disorder Lithium Cerebrospinal fluid Interleukin-8 |
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| Snippet | •Higher CSF IL-8 concentrations in bipolar disorder patients as compared to controls.•Higher IL-8 concentrations associated to lithium- and antipsychotic... Highlights • Higher CSF IL-8 concentrations in bipolar disorder patients as compared to controls. • Higher IL-8 concentrations associated to lithium- and... Inflammation has been linked to the pathophysiology of bipolar disorder based on studies of inflammation markers, such as cytokine concentrations, in plasma... |
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| SubjectTerms | Adult Allergy and Immunology Antimanic Agents - therapeutic use Antipsychotic Agents - therapeutic use Antipsychotic drugs Biomarkers Bipolar disorder Bipolar Disorder - cerebrospinal fluid Bipolar Disorder - drug therapy Cerebrospinal fluid Cytokines Female Humans Interleukin-8 Interleukin-8 - cerebrospinal fluid Lithium Lithium - therapeutic use Male Middle Aged Neurosciences Neurovetenskaper Psychiatry |
| Title | Increased cerebrospinal fluid interleukin-8 in bipolar disorder patients associated with lithium and antipsychotic treatment |
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