Effects of smoking abstinence on impulsive behavior among smokers high and low in ADHD-like symptoms

• Published in: Psychopharmacology Vol. 219; no. 2; pp. 537 - 547
• Main Authors: Ashare, Rebecca L., Hawk, Larry W.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.01.2012; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Attention; Attention Deficit Disorder with Hyperactivity - complications; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - psychology; Attention deficit hyperactivity disorder; Behavior; Biomedical and Life Sciences; Biomedicine; Choice Behavior; Drug abuse; Drug self-administration; Female; Humans; impulsive behavior; Impulsive Behavior - complications; Impulsive Behavior - psychology; Individuality; Inhibition, Psychological; Male; Middle Aged; Neurosciences; Original Investigation; Personality; Personality traits; Pharmacology/Toxicology; Psychiatry; Psychopathology; Reflex, Startle; Reinforcement; Self Report; Smokers; Smoking; Smoking cessation; Smoking Cessation - psychology; Stop task; Impulsivity; Inhibitory control; Individual differences; Delay discounting; Attention-deficit/hyperactivity disorder; Abstinence; Smoking; Prepulse inhibition
• ISSN: 0033-3158; 1432-2072; 1432-2072
• DOI: 10.1007/s00213-011-2324-2

Rationale Impulsivity, a multifaceted construct that includes inhibitory control and heightened preference for immediate reward, is central to models of drug use and abuse. Within a self-medication framework, abstinence from smoking may lead to an increase in impulsive behavior and the likelihood of relapse, particularly among persons with disorders (e.g., attention-deficit/hyperactivity disorder, ADHD) and personality traits (e.g., impulsivity) linked to impulsive behavior. Objectives This study aimed to examine the effects of smoking abstinence on multiple measures of impulsivity among a non-clinical sample of adult smokers selected for high and low levels of ADHD symptoms. Methods In a within-subjects design, participants selected for high or low levels of self-reported ADHD symptoms ( N  = 56) completed sessions following overnight abstinence and when smoking as usual (order counterbalanced). Measures of impulsive behavior included response inhibition (i.e., stop signal task), interference control (i.e., attentional modification of prepulse inhibition (PPI) of startle), and impulsive choice (i.e., hypothetical delay discounting). Results As hypothesized, abstinence decreased response inhibition and PPI. Although ADHD symptoms moderated abstinence effects on impulsive choice and response inhibition, the pattern was opposite to our predictions: the low-ADHD group responded more impulsively when abstinent, whereas the high-ADHD group was relatively unaffected by abstinence. Conclusions These findings highlight the importance of utilizing multiple laboratory measures to examine a multifactorial construct such as impulsive behavior and raise questions about how best to assess symptoms of ADHD and impulsivity among non-abstinent smokers.