Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis

• Published in: Bioscience, biotechnology, and biochemistry Vol. 65; no. 2; pp. 431 - 434
• Main Authors: Kawamoto, S. (Hiroshima Univ. (Japan)), Kita, M, Hamada, M, Aki, T, Shigeta, S, Suzuki, O, Ono, K
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.02.2001; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Allergic diseases; alpha-Linolenic Acid - blood; Animals; arachidonic acid; Arachidonic Acid - blood; atopic dermatitis; ATOPY; Biological and medical sciences; biotechnology; Blood Cells - drug effects; Blood Cells - metabolism; Calcimycin - pharmacology; calcium ionophores; Dermatitis, Atopic - blood; Dermatitis, Atopic - genetics; Disease Models, Animal; fatty acid composition; fatty acid metabolism; FATTY ACIDS; Fatty Acids - blood; Fatty Acids - chemistry; Humans; Immunopathology; In Vitro Techniques; Ionophores - pharmacology; leucotriene B; Leukotriene B4 - blood; LIPID METABOLISM; Male; Medical sciences; MICE; Mice, Inbred BALB C; Mice, Mutant Strains; NC/Nga mice; polyunsaturated fatty acid; Skin allergic diseases. Stinging insect allergies; specific pathogen-free animals; Allergy; Immunopathology; Animal model; Skin disease; Pathophysiology; Arachidonic acid derivatives; Rodentia; Polyunsaturated fatty acid; Arachidonic acid; Atopy; Vertebrata; Blood cell; Mammalia; Leukotriene B4; Mouse; Atopic dermatitis
• ISSN: 0916-8451; 1347-6947; 1347-6947
• DOI: 10.1271/bbb.65.431

Although clinical evidence has suggested that dysregulated fatty acid metabolism is associated with atopic disorders, the molecular basis for such a correlation remains to be demonstrated. In the present study, we analyzed the fatty acid composition in peripheral blood cells of NC/Nga mice, a model for atopic dermatitis (AD). We found that arachidonic acid significantly accumulated in mice with the AD manifestation. In addition, the leucotriene B 4 -releasing ability upon calcium ionophore A23187 stimulation was potentiated in blood cells. An arachidonic acid accumulation was not apparent in the non-atopic BALB/c strain, but was still observed in healthy NC/Nga mice fed under specific pathogen-free conditions. These results indicate that a disturbed fatty acid metabolism in NC/Nga mice was not a trigger factor for their dermatitis development.