The Role of the Pre-B Cell Receptor in B Cell Development, Repertoire Selection, and Tolerance

Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of light chains. It was thus possible that these cells expressed another molecule(s), that assembled with μH chains. The en...

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Published inFrontiers in immunology Vol. 9; p. 2423
Main Authors Winkler, Thomas H., Mårtensson, Inga-Lill
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.11.2018
Subjects
1986
1991
allelic exclusion
ang h
antibody repertoire
B-cell development
cker dj
h-chain
immunoglobulin heavy
Immunologi inom det medicinska området
Immunology
Immunology in the Medical Area
journal of experimental medicine
journal of immunology
lambda-5
mouse bone-marrow
mu-heavy-chains
negative selection
p350
p425
pre-B cells
surface expression
surrogate light chain
targeted disruption
v146
v163
VpreB
λ-5
B-cell development
pre-B cells
allelic exclusion
surrogate light chain
VpreB
λ-5
Online AccessGet full text
ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2018.02423

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Abstract Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of light chains. It was thus possible that these cells expressed another molecule(s), that assembled with μH chains. The ensuing studies led to the discovery of the pre-B cell receptor (pre-BCR), which is assembled from Ig μH and surrogate light (SL) chains, together with the signaling molecules Igα and β. It is expressed on a fraction of pro-B (pre-BI) cells and most large pre-B(II) cells, and has been implicated in IgH chain allelic exclusion and down-regulation of the recombination machinery, assessment of the expressed μH chains and shaping the IgH repertoire, transition from the pro-B to pre-B stage, pre-B cell expansion, and cessation.
AbstractList Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of bona fide light chains. It was thus possible that these cells expressed another molecule(s), that assembled with μH chains. The ensuing studies led to the discovery of the pre-B cell receptor (pre-BCR), which is assembled from Ig μH and surrogate light (SL) chains, together with the signaling molecules Igα and β. It is expressed on a fraction of pro-B (pre-BI) cells and most large pre-B(II) cells, and has been implicated in IgH chain allelic exclusion and down-regulation of the recombination machinery, assessment of the expressed μH chains and shaping the IgH repertoire, transition from the pro-B to pre-B stage, pre-B cell expansion, and cessation.
Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of bona fide light chains. It was thus possible that these cells expressed another molecule(s), that assembled with μH chains. The ensuing studies led to the discovery of the pre-B cell receptor (pre-BCR), which is assembled from Ig μH and surrogate light (SL) chains, together with the signaling molecules Igα and β. It is expressed on a fraction of pro-B (pre-BI) cells and most large pre-B(II) cells, and has been implicated in IgH chain allelic exclusion and down-regulation of the recombination machinery, assessment of the expressed μH chains and shaping the IgH repertoire, transition from the pro-B to pre-B stage, pre-B cell expansion, and cessation.Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of bona fide light chains. It was thus possible that these cells expressed another molecule(s), that assembled with μH chains. The ensuing studies led to the discovery of the pre-B cell receptor (pre-BCR), which is assembled from Ig μH and surrogate light (SL) chains, together with the signaling molecules Igα and β. It is expressed on a fraction of pro-B (pre-BI) cells and most large pre-B(II) cells, and has been implicated in IgH chain allelic exclusion and down-regulation of the recombination machinery, assessment of the expressed μH chains and shaping the IgH repertoire, transition from the pro-B to pre-B stage, pre-B cell expansion, and cessation.
Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of light chains. It was thus possible that these cells expressed another molecule(s), that assembled with μH chains. The ensuing studies led to the discovery of the pre-B cell receptor (pre-BCR), which is assembled from Ig μH and surrogate light (SL) chains, together with the signaling molecules Igα and β. It is expressed on a fraction of pro-B (pre-BI) cells and most large pre-B(II) cells, and has been implicated in IgH chain allelic exclusion and down-regulation of the recombination machinery, assessment of the expressed μH chains and shaping the IgH repertoire, transition from the pro-B to pre-B stage, pre-B cell expansion, and cessation.
Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of bona fide light chains. It was thus possible that these cells expressed another molecule(s), that assembled with μH chains. The ensuing studies led to the discovery of the pre-B cell receptor (pre-BCR), which is assembled from Ig μH and surrogate light (SL) chains, together with the signaling molecules Igα and β. It is expressed on a fraction of pro-B (pre-BI) cells and most large pre-B(II) cells, and has been implicated in IgH chain allelic exclusion and down-regulation of the recombination machinery, assessment of the expressed μH chains and shaping the IgH repertoire, transition from the pro-B to pre-B stage, pre-B cell expansion, and cessation.
Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody mu heavy (mu H) chains in the apparent absence of bona fide light chains. It was thus possible that these cells expressed another molecule(s), that assembled with mu H chains. The ensuing studies led to the discovery of the pre-B cell receptor (pre-BCR), which is assembled from Ig mu H and surrogate light (SL) chains, together with the signaling molecules Ig a and beta. It is expressed on a fraction of pro-B (pre-BI) cells and most large pre-B(II) cells, and has been implicated in IgH chain allelic exclusion and down-regulation of the recombination machinery, assessment of the expressed mu H chains and shaping the IgH repertoire, transition from the pro-B to pre-B stage, pre-B cell expansion, and cessation.
Author Mårtensson, Inga-Lill
Winkler, Thomas H.
AuthorAffiliation 1 Chair of Genetics, Department of Biology, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nuremberg , Erlangen , Germany
2 Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden
AuthorAffiliation_xml – name: 1 Chair of Genetics, Department of Biology, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nuremberg , Erlangen , Germany
– name: 2 Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden
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  fullname: Mårtensson, Inga-Lill
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https://gup.ub.gu.se/publication/274340$$DView record from Swedish Publication Index
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Keywords B-cell development
pre-B cells
allelic exclusion
surrogate light chain
VpreB
λ-5
Language English
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Snippet Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the...
Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody mu heavy (mu H) chains in...
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StartPage 2423
SubjectTerms 1986
1991
allelic exclusion
ang h
antibody repertoire
B-cell development
cker dj
h-chain
immunoglobulin heavy
Immunologi inom det medicinska området
Immunology
Immunology in the Medical Area
journal of experimental medicine
journal of immunology
lambda-5
mouse bone-marrow
mu-heavy-chains
negative selection
p350
p425
pre-B cells
surface expression
surrogate light chain
targeted disruption
v146
v163
VpreB
λ-5
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Title The Role of the Pre-B Cell Receptor in B Cell Development, Repertoire Selection, and Tolerance
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