Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates

To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity. Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sourc...

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Published inEuropean psychiatry Vol. 29; no. 3; pp. 117 - 124
Main Authors Di Florio, A., Craddock, N., van den Bree, M.
Format Journal Article
LanguageEnglish
Published Paris Elsevier Masson SAS 01.03.2014
Elsevier
Subjects
Addictive behaviors
Adult and adolescent clinical studies
Alcohol use disorders
Alcoholism
Alcoholism - epidemiology
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - epidemiology
Bipolar disorders
Co-occurrence
Comorbidity
Humans
Internal Medicine
Medical sciences
Miscellaneous
Mood disorders
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Toxicology
Bipolar disorder
Comorbidity
Co-occurrence
Alcohol use disorders
Mood disorder
Alcoholic beverage
Concomitant disease
Alcoholism
Substance abuse
Review
Metaanalysis
Online AccessGet full text
ISSN0924-9338
1778-3585
1778-3585
DOI10.1016/j.eurpsy.2013.07.004

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Abstract To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity. Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias. In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men. AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.
AbstractList To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity.AIMSTo assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity.Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias.METHODSStudies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias.In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men.RESULTSIn clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men.AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.CONCLUSIONAUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.
To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity. Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias. In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men. AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.
Abstract Aims To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity. Methods Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias. Results In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men. Conclusion AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.
Author Di Florio, A.
van den Bree, M.
Craddock, N.
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  surname: van den Bree
  fullname: van den Bree, M.
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Keywords Bipolar disorder
Comorbidity
Co-occurrence
Alcohol use disorders
Mood disorder
Alcoholic beverage
Concomitant disease
Alcoholism
Substance abuse
Review
Metaanalysis
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Snippet To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity. Studies were...
Abstract Aims To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity....
To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity.AIMSTo assess the...
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SubjectTerms Addictive behaviors
Adult and adolescent clinical studies
Alcohol use disorders
Alcoholism
Alcoholism - epidemiology
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - epidemiology
Bipolar disorders
Co-occurrence
Comorbidity
Humans
Internal Medicine
Medical sciences
Miscellaneous
Mood disorders
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Toxicology
Title Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates
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https://dx.doi.org/10.1016/j.eurpsy.2013.07.004
https://www.ncbi.nlm.nih.gov/pubmed/24075633
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