The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome
Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and...
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| Published in | Psychological medicine Vol. 38; no. 7; pp. 941 - 951 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge, UK
Cambridge University Press
01.07.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0033-2917 1469-8978 |
| DOI | 10.1017/S0033291708003450 |
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| Abstract | Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and controls.
We compared the blood oxygen level dependent (BOLD) responses of 12 CFS patients and 11 healthy controls to a novel fatigue provocation procedure designed to mimic real-life situations. A non-fatiguing anxiety-provoking condition was also included to control for the non-specific effects of negative affect.
During the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. The reverse pattern of findings was observed during the anxiety-provoking scenarios.
The results may suggest that, in CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS. |
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| AbstractList | Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and controls. We compared the blood oxygen level dependent (BOLD) responses of 12 CFS patients and 11 healthy controls to a novel fatigue provocation procedure designed to mimic real-life situations. A non-fatiguing anxiety-provoking condition was also included to control for the non-specific effects of negative affect. During the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. The reverse pattern of findings was observed during the anxiety-provoking scenarios. The results may suggest that, in CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS. Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and controls. We compared the blood oxygen level dependent (BOLD) responses of 12 CFS patients and 11 healthy controls to a novel fatigue provocation procedure designed to mimic real-life situations. A non-fatiguing anxiety-provoking condition was also included to control for the non-specific effects of negative affect. During the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. The reverse pattern of findings was observed during the anxiety-provoking scenarios. The results may suggest that, in CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS. Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and controls.BACKGROUNDFatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and controls.We compared the blood oxygen level dependent (BOLD) responses of 12 CFS patients and 11 healthy controls to a novel fatigue provocation procedure designed to mimic real-life situations. A non-fatiguing anxiety-provoking condition was also included to control for the non-specific effects of negative affect.METHODWe compared the blood oxygen level dependent (BOLD) responses of 12 CFS patients and 11 healthy controls to a novel fatigue provocation procedure designed to mimic real-life situations. A non-fatiguing anxiety-provoking condition was also included to control for the non-specific effects of negative affect.During the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. The reverse pattern of findings was observed during the anxiety-provoking scenarios.RESULTSDuring the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. The reverse pattern of findings was observed during the anxiety-provoking scenarios.The results may suggest that, in CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS.CONCLUSIONSThe results may suggest that, in CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS. Background Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and controls. Method We compared the blood oxygen level dependent (BOLD) responses of 12 CFS patients and 11 healthy controls to a novel fatigue provocation procedure designed to mimic real-life situations. A non-fatiguing anxiety-provoking condition was also included to control for the non-specific effects of negative affect. Results During the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. The reverse pattern of findings was observed during the anxiety-provoking scenarios. Conclusions The results may suggest that, in CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS. Background. Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and controls. Method. We compared the blood oxygen level dependent (BOLD) responses of 12 CFS patients and 11 healthy controls to a novel fatigue provocation procedure designed to mimic real-life situations. A non-fatiguing anxiety-provoking condition was also included to control for the non-specific effects of negative affect. Results. During the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. The reverse pattern of findings was observed during the anxiety-provoking scenarios. Conclusions. The results may suggest that, in CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS. Adapted from the source document. |
| Author | Mataix-Cols, D. Caseras, X. Zelaya, F. Rimes, K. A. Brammer, M. Giampietro, V. Chalder, T. Godfrey, E. |
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| Cites_doi | 10.1162/089892902760807212 10.1002/(SICI)1097-0193(1999)7:13.0.CO;2-Q 10.1016/j.comppsych.2004.08.007 10.1016/j.neuroimage.2007.02.033 10.1212/WNL.43.1_Part_1.125 10.1016/j.biopsych.2004.10.030 10.1097/00005650-199206000-00002 10.7326/0003-4819-121-12-199412150-00009 10.1001/archpsyc.63.11.1258 10.1001/archpsyc.61.6.564 10.1002/1097-0193(200102)12:23.0.CO;2-W 10.1016/S0730-725X(97)00135-5 10.1016/j.neuron.2005.12.025 10.1016/0022-3999(93)90081-P 10.1042/CS20020354 10.1111/j.1600-0447.1997.tb09653.x 10.1016/S0022-3999(00)00197-5 10.1097/01.psy.0000242770.50979.5f 10.1007/BF00380989 10.1016/j.neuroimage.2005.02.011 10.1001/jama.286.11.1360 10.1016/S0022-3999(98)00021-X 10.1016/S0022-3999(01)00267-7 10.1016/S0022-3999(01)00298-7 10.1097/01.wnr.0000220132.32091.9f 10.1109/42.750253 10.1016/j.pain.2004.02.029 10.1001/archpsyc.63.11.1267 10.1016/S1053-8119(03)00077-6 10.1016/S0006-3223(03)00171-9 10.1016/j.neuroimage.2006.05.024 10.1192/bjp.180.5.461 10.1016/j.neuroimage.2005.04.034 10.1111/j.1600-0447.1983.tb09716.x 10.1016/j.neuroimage.2005.12.034 10.1006/nimg.2002.1087 10.1348/014466506X147420 10.2165/00007256-200333030-00001 10.1073/pnas.0401510101 |
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| Keywords | chronic fatigue syndrome fMRI fatigue Anxiety Human Affect affectivity Topography Fatigue Emotion emotionality Experimental study Nuclear magnetic resonance imaging Chronic fatigue syndrome Functional imaging |
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| References | S0033291708003450_ref030 S0033291708003450_ref032 S0033291708003450_ref010 S0033291708003450_ref031 S0033291708003450_ref034 S0033291708003450_ref012 S0033291708003450_ref011 S0033291708003450_ref036 S0033291708003450_ref014 S0033291708003450_ref035 S0033291708003450_ref013 S0033291708003450_ref038 S0033291708003450_ref015 S0033291708003450_ref018 S0033291708003450_ref039 S0033291708003450_ref017 S0033291708003450_ref008 S0033291708003450_ref041 S0033291708003450_ref040 S0033291708003450_ref021 S0033291708003450_ref042 Kent-Braun (S0033291708003450_ref022) 1993; 43 S0033291708003450_ref020 Talairach (S0033291708003450_ref037) 1988 S0033291708003450_ref001 S0033291708003450_ref023 S0033291708003450_ref003 S0033291708003450_ref025 S0033291708003450_ref002 S0033291708003450_ref024 S0033291708003450_ref005 S0033291708003450_ref027 S0033291708003450_ref004 S0033291708003450_ref026 Chalder (S0033291708003450_ref009) 2000 S0033291708003450_ref007 S0033291708003450_ref029 S0033291708003450_ref006 Sheehan (S0033291708003450_ref033) 1998; 59 S0033291708003450_ref028 Fukuda (S0033291708003450_ref016) 1994; 121 S0033291708003450_ref019 19091159 - Psychol Med. 2009 Mar;39(3):523-4 |
| References_xml | – start-page: 160 volume-title: The Management of Stress and Anxiety in Medical Disorders year: 2000 ident: S0033291708003450_ref009 – ident: S0033291708003450_ref028 doi: 10.1162/089892902760807212 – ident: S0033291708003450_ref004 doi: 10.1002/(SICI)1097-0193(1999)7:13.0.CO;2-Q – ident: S0033291708003450_ref024 doi: 10.1016/j.comppsych.2004.08.007 – ident: S0033291708003450_ref010 doi: 10.1016/j.neuroimage.2007.02.033 – volume: 43 start-page: 125 year: 1993 ident: S0033291708003450_ref022 publication-title: Neurology doi: 10.1212/WNL.43.1_Part_1.125 – ident: S0033291708003450_ref029 doi: 10.1016/j.biopsych.2004.10.030 – ident: S0033291708003450_ref039 doi: 10.1097/00005650-199206000-00002 – volume: 121 start-page: 953 year: 1994 ident: S0033291708003450_ref016 publication-title: Annals of Internal Medicine doi: 10.7326/0003-4819-121-12-199412150-00009 – ident: S0033291708003450_ref020 doi: 10.1001/archpsyc.63.11.1258 – ident: S0033291708003450_ref025 doi: 10.1001/archpsyc.61.6.564 – ident: S0033291708003450_ref005 doi: 10.1002/1097-0193(200102)12:23.0.CO;2-W – ident: S0033291708003450_ref003 doi: 10.1016/S0730-725X(97)00135-5 – ident: S0033291708003450_ref035 doi: 10.1016/j.neuron.2005.12.025 – ident: S0033291708003450_ref008 doi: 10.1016/0022-3999(93)90081-P – ident: S0033291708003450_ref018 doi: 10.1042/CS20020354 – volume-title: Co-planar Stereotactic Atlas of the Human Brain year: 1988 ident: S0033291708003450_ref037 – ident: S0033291708003450_ref014 doi: 10.1111/j.1600-0447.1997.tb09653.x – ident: S0033291708003450_ref038 doi: 10.1016/S0022-3999(00)00197-5 – ident: S0033291708003450_ref007 doi: 10.1097/01.psy.0000242770.50979.5f – ident: S0033291708003450_ref001 doi: 10.1007/BF00380989 – ident: S0033291708003450_ref023 doi: 10.1016/j.neuroimage.2005.02.011 – ident: S0033291708003450_ref041 doi: 10.1001/jama.286.11.1360 – ident: S0033291708003450_ref013 doi: 10.1016/S0022-3999(98)00021-X – ident: S0033291708003450_ref011 doi: 10.1016/S0022-3999(01)00267-7 – ident: S0033291708003450_ref034 doi: 10.1016/S0022-3999(01)00298-7 – ident: S0033291708003450_ref002 doi: 10.1097/01.wnr.0000220132.32091.9f – ident: S0033291708003450_ref006 doi: 10.1109/42.750253 – ident: S0033291708003450_ref040 doi: 10.1016/j.pain.2004.02.029 – ident: S0033291708003450_ref021 doi: 10.1001/archpsyc.63.11.1267 – ident: S0033291708003450_ref015 doi: 10.1016/S1053-8119(03)00077-6 – ident: S0033291708003450_ref031 doi: 10.1016/S0006-3223(03)00171-9 – ident: S0033291708003450_ref017 doi: 10.1016/j.neuroimage.2006.05.024 – ident: S0033291708003450_ref026 doi: 10.1192/bjp.180.5.461 – volume: 59 start-page: 22 year: 1998 ident: S0033291708003450_ref033 publication-title: Journal of Clinical Psychiatry – ident: S0033291708003450_ref027 doi: 10.1016/j.neuroimage.2005.04.034 – ident: S0033291708003450_ref042 doi: 10.1111/j.1600-0447.1983.tb09716.x – ident: S0033291708003450_ref032 doi: 10.1016/j.neuroimage.2005.12.034 – ident: S0033291708003450_ref030 doi: 10.1006/nimg.2002.1087 – ident: S0033291708003450_ref019 doi: 10.1348/014466506X147420 – ident: S0033291708003450_ref036 doi: 10.2165/00007256-200333030-00001 – ident: S0033291708003450_ref012 doi: 10.1073/pnas.0401510101 – reference: 19091159 - Psychol Med. 2009 Mar;39(3):523-4 |
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| Snippet | Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore... Background Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was... Background. Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study... |
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| SubjectTerms | Adult Adult and adolescent clinical studies Anxiety Biological and medical sciences Brain Case-Control Studies Cerebellum - physiopathology Chronic fatigue syndrome Cognition Cognitive Therapy Cognitive-behavioral factors Cortex Emotional responses Fatigue Fatigue - physiopathology Fatigue Syndrome, Chronic - physiopathology Fatigue Syndrome, Chronic - psychology Female fMRI Functional magnetic resonance imaging Humans Magnetic Resonance Imaging - methods Medical sciences Middle Aged Negative emotions Organic mental disorders. Neuropsychology Oxygen Parietal cortex Pilot Projects Provocation Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - physiology Psychopathology. Psychiatry Reaction Time Studies Visual Perception - physiology |
| Title | The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome |
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