Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region

GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration...

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Published inActa neuropathologica Vol. 122; no. 5; pp. 615 - 626
Main Authors Wang, Alice Y., Lohmann, Kathryn M., Yang, C. Kevin, Zimmerman, Eric I., Pantazopoulos, Harry, Herring, Nicole, Berretta, Sabina, Heckers, Stephan, Konradi, Christine
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.11.2011
Springer Nature B.V
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Autopsy
Bipolar disorder
Bipolar Disorder - metabolism
Bipolar Disorder - pathology
Brain
Calbindins
Case-Control Studies
Cell Count
Circuits
Cortex (entorhinal)
Cortex (subicular)
Entorhinal Cortex - metabolism
Entorhinal Cortex - pathology
Female
gamma -Aminobutyric acid
Hippocampus
Hippocampus - metabolism
Hippocampus - pathology
Humans
Information processing
Integration
Interneurons
Interneurons - metabolism
Interneurons - pathology
Male
Medical records
Medicine
Medicine & Public Health
Mental disorders
Middle Aged
Nerve Net - metabolism
Nerve Net - pathology
Neurons
Neurosciences
Original Paper
Parahippocampal Gyrus - metabolism
Parahippocampal Gyrus - pathology
Parvalbumins - metabolism
Pathology
S100 Calcium Binding Protein G - metabolism
Schizophrenia
Schizophrenia - metabolism
Schizophrenia - pathology
Somatostatin - metabolism
Stains & staining
Synchronization
Young Adult
United States > US
Nashville Tennessee
Interneurons
Entorhinal cortex
Schizophrenia
Bipolar disorder
Subiculum
Somatostatin
Parahippocampal gyrus
Parvalbumin
Online AccessGet full text
ISSN0001-6322
1432-0533
1432-0533
DOI10.1007/s00401-011-0881-4

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Abstract GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.
AbstractList GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.
GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical inter-neurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Postmortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.
GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.
GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.[PUBLICATION ABSTRACT]
Author Herring, Nicole
Lohmann, Kathryn M.
Zimmerman, Eric I.
Pantazopoulos, Harry
Wang, Alice Y.
Heckers, Stephan
Konradi, Christine
Berretta, Sabina
Yang, C. Kevin
Author_xml – sequence: 1
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  fullname: Wang, Alice Y.
  organization: Neuroscience Program for Undergraduates, Vanderbilt University
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  surname: Lohmann
  fullname: Lohmann, Kathryn M.
  organization: Department of Psychiatry, Vanderbilt University
– sequence: 3
  givenname: C. Kevin
  surname: Yang
  fullname: Yang, C. Kevin
  organization: Department of Psychiatry, Vanderbilt University
– sequence: 4
  givenname: Eric I.
  surname: Zimmerman
  fullname: Zimmerman, Eric I.
  organization: Department of Psychiatry, Vanderbilt University
– sequence: 5
  givenname: Harry
  surname: Pantazopoulos
  fullname: Pantazopoulos, Harry
  organization: Translational Neuroscience Laboratory, McLean Hospital, Department of Psychiatry, Harvard Medical School
– sequence: 6
  givenname: Nicole
  surname: Herring
  fullname: Herring, Nicole
  organization: Department of Psychiatry, Vanderbilt University
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  surname: Berretta
  fullname: Berretta, Sabina
  organization: Translational Neuroscience Laboratory, McLean Hospital, Department of Psychiatry, Harvard Medical School
– sequence: 8
  givenname: Stephan
  surname: Heckers
  fullname: Heckers, Stephan
  organization: Department of Psychiatry, Vanderbilt University
– sequence: 9
  givenname: Christine
  surname: Konradi
  fullname: Konradi, Christine
  email: christine.konradi@vanderbilt.edu
  organization: Department of Psychiatry, Vanderbilt University, Department of Pharmacology, Vanderbilt University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21968533$$D View this record in MEDLINE/PubMed
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Thu Apr 24 22:54:26 EDT 2025
Fri Feb 21 02:35:55 EST 2025
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Issue 5
Keywords Interneurons
Entorhinal cortex
Schizophrenia
Bipolar disorder
Subiculum
Somatostatin
Parahippocampal gyrus
Parvalbumin
Language English
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SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Autopsy
Bipolar disorder
Bipolar Disorder - metabolism
Bipolar Disorder - pathology
Brain
Calbindins
Case-Control Studies
Cell Count
Circuits
Cortex (entorhinal)
Cortex (subicular)
Entorhinal Cortex - metabolism
Entorhinal Cortex - pathology
Female
gamma -Aminobutyric acid
Hippocampus
Hippocampus - metabolism
Hippocampus - pathology
Humans
Information processing
Integration
Interneurons
Interneurons - metabolism
Interneurons - pathology
Male
Medical records
Medicine
Medicine & Public Health
Mental disorders
Middle Aged
Nerve Net - metabolism
Nerve Net - pathology
Neurons
Neurosciences
Original Paper
Parahippocampal Gyrus - metabolism
Parahippocampal Gyrus - pathology
Parvalbumins - metabolism
Pathology
S100 Calcium Binding Protein G - metabolism
Schizophrenia
Schizophrenia - metabolism
Schizophrenia - pathology
Somatostatin - metabolism
Stains & staining
Synchronization
Young Adult
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Title Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region
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