Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis - Kverka, Miloslav; Rossmann, Pavel; Tlaskalova-Hogenova, Helena; Klimesova, Klara; Jharap, Bindia; de Boer, Nanne K; Vos, Rene M; van Bodegraven, Adriaan A; Lukas, Milan; Mulder, Chris J (BMC gastroenterology, 2011)
Keywords: Acute Disease; Alanine Transaminase - blood; Analysis of Variance; Animal models in research; Animals; Apoptosis; Azathioprine - therapeutic use; Azathioprine - toxicity; Chronic Disease; Colitis; Colitis - blood; Colitis - chemically induced; Colitis - drug therapy; Colitis - pathology; Colon - metabolism; Colon - pathology; Dextran Sulfate; Drug therapy; Female; Gastroenterology; Health aspects; Hepatology; Immunosuppressive agents; Interferon-gamma - metabolism; Interleukin-6 - metabolism; Internal Medicine; Liver - drug effects; Liver - pathology; Medicine; Medicine & Public Health; Mice; Mice, Inbred BALB C; Models, Animal; Research Article; T-Lymphocytes, Helper-Inducer; Thioguanine - therapeutic use; Thioguanine - toxicity; Transforming Growth Factor beta - metabolism; Weight Loss - drug effects; Czech Republic; Treated Mouse; Inflammatory Bowel Disease; Dextran Sulfate Sodium; Inflammatory Bowel Disease Patient; Thiopurine