Undeclared exposure to St. John's Wort in hospitalized patients

Aim The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co‐administered drugs. Therefore, we evaluated the extent of systemic exposure to hyperforin and hypericin, two of the main constituents of SJW, in patients on admission and dur...

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Published inBritish journal of clinical pharmacology Vol. 58; no. 4; pp. 437 - 441
Main Authors Martin‐Facklam, Meret, Rieger, Karin, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Walter‐Sack, Ingeborg, Haefeli, Walter E.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Ltd 01.10.2004
Blackwell Science
Blackwell Science Inc
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ISSN0306-5251
1365-2125
1365-2125
DOI10.1111/j.1365-2125.2004.02169.x

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Abstract Aim The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co‐administered drugs. Therefore, we evaluated the extent of systemic exposure to hyperforin and hypericin, two of the main constituents of SJW, in patients on admission and during hospital stay, and compared the results with known use of SJW as documented in the drug chart and detected in additional interviews. Methods One hundred and fifty patients aged ≥ 18 years and admitted, between August 2000 and February 2002, to an internal medicine ward of a large German university hospital were included. Hyperforin and hypericin was determined in plasma by a sensitive liquid chromotography/mass spectometry (LC/MS/MS) method. To assess undeclared use of SJW the data were compared to information obtained from drug charts and from up to three interviews that had a particular focus on intake of herbal medicines and self‐medication during hospitalization. Results Hyperforin was detected in 12 patients (plasma concentration on the first day of hospitalization = 12–100 ng ml−1 in five patients and <3 ng ml−1 in seven), and hypericin in five patients (0.5–4.3 ng ml−1). Nine patients (6%) were taking/had taken SJW without the knowledge of the medical team and the pharmacist, who conducted the additional interviews, and 11 (7.3%) were taking/had taken SJW without the knowledge of the medical team alone. Seven of these patients were treated concurrently with drugs that can interact with SJW. Conclusions Unrecognized use of SJW is frequent and may have an important influence on the effectiveness and safety of drug therapy during hospital stay.
AbstractList Aim The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co‐administered drugs. Therefore, we evaluated the extent of systemic exposure to hyperforin and hypericin, two of the main constituents of SJW, in patients on admission and during hospital stay, and compared the results with known use of SJW as documented in the drug chart and detected in additional interviews. Methods One hundred and fifty patients aged ≥ 18 years and admitted, between August 2000 and February 2002, to an internal medicine ward of a large German university hospital were included. Hyperforin and hypericin was determined in plasma by a sensitive liquid chromotography/mass spectometry (LC/MS/MS) method. To assess undeclared use of SJW the data were compared to information obtained from drug charts and from up to three interviews that had a particular focus on intake of herbal medicines and self‐medication during hospitalization. Results Hyperforin was detected in 12 patients (plasma concentration on the first day of hospitalization = 12–100 ng ml−1 in five patients and <3 ng ml−1 in seven), and hypericin in five patients (0.5–4.3 ng ml−1). Nine patients (6%) were taking/had taken SJW without the knowledge of the medical team and the pharmacist, who conducted the additional interviews, and 11 (7.3%) were taking/had taken SJW without the knowledge of the medical team alone. Seven of these patients were treated concurrently with drugs that can interact with SJW. Conclusions Unrecognized use of SJW is frequent and may have an important influence on the effectiveness and safety of drug therapy during hospital stay.
The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co-administered drugs. Therefore, we evaluated the extent of systemic exposure to hyperforin and hypericin, two of the main constituents of SJW, in patients on admission and during hospital stay, and compared the results with known use of SJW as documented in the drug chart and detected in additional interviews.AIMThe herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co-administered drugs. Therefore, we evaluated the extent of systemic exposure to hyperforin and hypericin, two of the main constituents of SJW, in patients on admission and during hospital stay, and compared the results with known use of SJW as documented in the drug chart and detected in additional interviews.One hundred and fifty patients aged > or = 18 years and admitted, between August 2000 and February 2002, to an internal medicine ward of a large German university hospital were included. Hyperforin and hypericin was determined in plasma by a sensitive liquid chromotography/mass spectometry (LC/MS/MS) method. To assess undeclared use of SJW the data were compared to information obtained from drug charts and from up to three interviews that had a particular focus on intake of herbal medicines and self-medication during hospitalization.METHODSOne hundred and fifty patients aged > or = 18 years and admitted, between August 2000 and February 2002, to an internal medicine ward of a large German university hospital were included. Hyperforin and hypericin was determined in plasma by a sensitive liquid chromotography/mass spectometry (LC/MS/MS) method. To assess undeclared use of SJW the data were compared to information obtained from drug charts and from up to three interviews that had a particular focus on intake of herbal medicines and self-medication during hospitalization.Hyperforin was detected in 12 patients (plasma concentration on the first day of hospitalization = 12-100 ng ml(-1) in five patients and < 3 ng ml(-1) in seven), and hypericin in five patients (0.5-4.3 ng ml(-1)). Nine patients (6%) were taking/had taken SJW without the knowledge of the medical team and the pharmacist, who conducted the additional interviews, and 11 (7.3%) were taking/had taken SJW without the knowledge of the medical team alone. Seven of these patients were treated concurrently with drugs that can interact with SJW.RESULTSHyperforin was detected in 12 patients (plasma concentration on the first day of hospitalization = 12-100 ng ml(-1) in five patients and < 3 ng ml(-1) in seven), and hypericin in five patients (0.5-4.3 ng ml(-1)). Nine patients (6%) were taking/had taken SJW without the knowledge of the medical team and the pharmacist, who conducted the additional interviews, and 11 (7.3%) were taking/had taken SJW without the knowledge of the medical team alone. Seven of these patients were treated concurrently with drugs that can interact with SJW.Unrecognized use of SJW is frequent and may have an important influence on the effectiveness and safety of drug therapy during hospital stay.CONCLUSIONSUnrecognized use of SJW is frequent and may have an important influence on the effectiveness and safety of drug therapy during hospital stay.
The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co-administered drugs. Therefore, we evaluated the extent of systemic exposure to hyperforin and hypericin, two of the main constituents of SJW, in patients on admission and during hospital stay, and compared the results with known use of SJW as documented in the drug chart and detected in additional interviews. One hundred and fifty patients aged > or = 18 years and admitted, between August 2000 and February 2002, to an internal medicine ward of a large German university hospital were included. Hyperforin and hypericin was determined in plasma by a sensitive liquid chromotography/mass spectometry (LC/MS/MS) method. To assess undeclared use of SJW the data were compared to information obtained from drug charts and from up to three interviews that had a particular focus on intake of herbal medicines and self-medication during hospitalization. Hyperforin was detected in 12 patients (plasma concentration on the first day of hospitalization = 12-100 ng ml(-1) in five patients and < 3 ng ml(-1) in seven), and hypericin in five patients (0.5-4.3 ng ml(-1)). Nine patients (6%) were taking/had taken SJW without the knowledge of the medical team and the pharmacist, who conducted the additional interviews, and 11 (7.3%) were taking/had taken SJW without the knowledge of the medical team alone. Seven of these patients were treated concurrently with drugs that can interact with SJW. Unrecognized use of SJW is frequent and may have an important influence on the effectiveness and safety of drug therapy during hospital stay.
Author Rieger, Karin
Walter‐Sack, Ingeborg
Martin‐Facklam, Meret
Burhenne, Jürgen
Riedel, Klaus‐Dieter
Haefeli, Walter E.
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Cites_doi 10.1016/S0378-5173(00)00660-8
10.1016/S0140-6736(05)75600-2
10.1177/089198879400701s13
10.1046/j.1365-2125.2003.02005.x
10.1016/S1086-5802(16)31280-3
10.1592/phco.20.6.568.35152
10.1128/AAC.45.2.517-524.2001
10.1128/AAC.40.9.2087
10.1046/j.1365-2125.2003.01716.x
10.1038/87912
10.1016/S0944-7113(00)80029-X
10.1016/S0140-6736(99)05467-7
10.1211/0022357011775910
10.1093/ndt/15.9.1473
10.1038/sj.bjp.0704399
10.1046/j.1365-2125.2002.01683.x
10.1093/jaoac/85.6.1360
10.1046/j.1365-2125.2000.00204.x
10.1016/S0090-4295(01)01491-1
10.1055/s-2007-979344
10.1016/S0009-9236(01)64092-X
10.1067/mcp.2000.112240
10.1073/pnas.130155097
10.1046/j.0306-5251.2001.01516.x
10.1016/S0006-2952(97)00239-6
10.1016/0304-3959(93)90167-N
10.1002/jps.2600810324
10.1111/j.1365-2044.1997.197-az0332.x
10.1016/j.clpt.2003.08.009
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Issue 4
Keywords Human
Hypericum perforatum
Self prescription
Dicotyledones
Guttiferae
Hypericum
Angiospermae
self-medication
Spermatophyta
Hospitalization
hospitalisation
Language English
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Copyright 2004 Blackwell Publishing Ltd
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References 2001; 70
2002; 59
1992; 81
2000; 49
2000; 355
2002; 53
2000; 68
2002; 54
2000; 20
2000; 7
2001; 45
2003; 74
2001; 41
2003; 55
2003; 56
2001; 134
2001; 7
2002; 85
2000; 15
1997; 52
1993; 52
2000; 97
1996; 40
21 March 2004
1999; 353
2003; 41
1998; 31
2001; 213
1998; 55
2001; 53
1994; 7
Ang CY (e_1_2_6_31_2) 2002; 85
e_1_2_6_30_2
e_1_2_6_18_2
e_1_2_6_19_2
e_1_2_6_12_2
e_1_2_6_13_2
e_1_2_6_10_2
e_1_2_6_11_2
e_1_2_6_32_2
e_1_2_6_16_2
e_1_2_6_17_2
e_1_2_6_14_2
e_1_2_6_15_2
e_1_2_6_20_2
Kerb R (e_1_2_6_25_2) 1996; 40
Bauer S (e_1_2_6_22_2) 2003; 41
e_1_2_6_8_2
e_1_2_6_7_2
e_1_2_6_9_2
e_1_2_6_29_2
e_1_2_6_4_2
e_1_2_6_3_2
e_1_2_6_6_2
e_1_2_6_5_2
e_1_2_6_23_2
e_1_2_6_2_2
e_1_2_6_21_2
Staffeldt B (e_1_2_6_24_2) 1994; 7
e_1_2_6_28_2
e_1_2_6_27_2
e_1_2_6_26_2
References_xml – volume: 97
  start-page: 7500
  year: 2000
  end-page: 2
  article-title: St. John's Wort induces hepatic drug metabolism through activation of the pregnane X receptor
  publication-title: Proc Natl Acad Sci USA
– volume: 49
  start-page: 597
  year: 2000
  end-page: 603
  article-title: The completeness of medication histories in hospital medical records of patients admitted to general internal medicine wards
  publication-title: Br J Clin Pharmacol
– volume: 54
  start-page: 349
  year: 2002
  end-page: 56
  article-title: St John's Wort (Hypericum perforatum): drug interactions and clinical outcomes
  publication-title: Br J Clin Pharmacol
– volume: 20
  start-page: 568
  year: 2000
  end-page: 74
  article-title: Consumer use of St. John's Wort: a survey on effectiveness, safety, and tolerability
  publication-title: Pharmacotherapy
– year: 21 March 2004
– volume: 31
  start-page: 36
  issue: Suppl 1
  year: 1998
  end-page: 43
  article-title: Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers
  publication-title: Pharmacopsychiatry
– volume: 15
  start-page: 1473
  year: 2000
  end-page: 4
  article-title: Unexplained decrease of cyclosporin trough levels in a compliant renal transplant patient
  publication-title: Nephrol Dial Transplant
– volume: 134
  start-page: 1601
  year: 2001
  end-page: 8
  article-title: Saint John's Wort: an in vitro analysis of P‐glycoprotein induction due to extended exposure
  publication-title: Br J Pharmacol
– volume: 59
  start-page: 272
  year: 2002
  end-page: 6
  article-title: Rates of unconventional medical therapy use in patients with prostate cancer: standard history versus directed questions
  publication-title: Urology
– volume: 55
  start-page: 113
  year: 1998
  end-page: 22
  article-title: In vitro approaches to predicting drug interactions in vivo
  publication-title: Biochem Pharmacol
– volume: 41
  start-page: 557
  year: 2003
  article-title: Effect of hypericum extracts with different hyperforin content on the pharmacokinetics of cyclosporin A
  publication-title: Int J Clin Pharmacol Ther
– volume: 81
  start-page: 309
  year: 1992
  end-page: 12
  article-title: Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies
  publication-title: J Pharm Sci
– volume: 355
  start-page: 548
  year: 2000
  end-page: 9
  article-title: Acute heart transplant rejection due to Saint John's Wort
  publication-title: Lancet
– volume: 55
  start-page: 112
  year: 2003
  end-page: 3
  article-title: Unwanted pregnancy on self‐medication with St John's Wort despite hormonal contraception
  publication-title: Br J Clin Pharmacol
– volume: 41
  start-page: 560
  year: 2001
  end-page: 6
  article-title: Comparison of German St. John's Wort products according to hyperforin and total hypericin content
  publication-title: J Am Pharm Assoc
– volume: 53
  start-page: 75
  year: 2002
  end-page: 82
  article-title: St John's Wort increases expression of P‐glycoprotein: implications for drug interactions
  publication-title: Br J Clin Pharmacol
– volume: 213
  start-page: 199
  year: 2001
  end-page: 208
  article-title: Evaluation of chemical stability of St. John's Wort commercial extract and some preparations
  publication-title: Int J Pharm
– volume: 40
  start-page: 2087
  year: 1996
  end-page: 93
  article-title: Single‐dose and steady‐state pharmacokinetics of hypericin and pseudohypericin
  publication-title: Antimicrob Agents Chemother
– volume: 56
  start-page: 683
  year: 2003
  end-page: 90
  article-title: Interaction of St John's Wort with low‐dose oral contraceptive therapy: a randomized controlled trial
  publication-title: Br J Clin Pharmacol
– volume: 52
  start-page: 331
  year: 1993
  end-page: 9
  article-title: Polymedication and medication compliance in patients with chronic non‐malignant pain
  publication-title: Pain
– volume: 7
  start-page: S47
  issue: Suppl 1
  year: 1994
  end-page: 53
  article-title: Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers
  publication-title: J Geriatr Psychiatry Neurol
– volume: 45
  start-page: 517
  year: 2001
  end-page: 24
  article-title: Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's Wort plant, in patients with chronic hepatitis C virus infection
  publication-title: Antimicrob Agents Chemother
– volume: 7
  start-page: 455
  year: 2000
  end-page: 62
  article-title: Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology
  publication-title: Phytomedicine
– volume: 68
  start-page: 598
  year: 2000
  end-page: 604
  article-title: St John's Wort induces intestinal P‐glycoprotein/MDR1 and intestinal and hepatic CYP3A4
  publication-title: Clin Pharmacol Ther
– volume: 7
  start-page: 584
  year: 2001
  end-page: 90
  article-title: The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
  publication-title: Nat Med
– volume: 74
  start-page: 525
  year: 2003
  end-page: 35
  article-title: The interaction between St John's Wort and an oral contraceptive
  publication-title: Clin Pharmacol Ther
– volume: 53
  start-page: 583
  year: 2001
  end-page: 600
  article-title: St John's Wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties
  publication-title: J Pharm Pharmacol
– volume: 52
  start-page: 904
  year: 1997
  end-page: 5
  article-title: Taking a ‘drugs’ history
  publication-title: Anaesthesia
– volume: 70
  start-page: 518
  year: 2001
  end-page: 24
  article-title: Different effects of St John's Wort on the pharmacokinetics of simvastatin and pravastatin
  publication-title: Clin Pharmacol Ther
– volume: 353
  start-page: 2160
  year: 1999
  article-title: Increased number of hip fractures
  publication-title: Lancet
– volume: 85
  start-page: 1360
  year: 2002
  end-page: 9
  article-title: Determination of St. John's Wort components in dietary supplements and functional foods by liquid chromatography
  publication-title: J AOAC Int
– ident: e_1_2_6_17_2
  doi: 10.1016/S0378-5173(00)00660-8
– ident: e_1_2_6_6_2
  doi: 10.1016/S0140-6736(05)75600-2
– volume: 7
  start-page: S47
  issue: 1
  year: 1994
  ident: e_1_2_6_24_2
  article-title: Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers
  publication-title: J Geriatr Psychiatry Neurol
  doi: 10.1177/089198879400701s13
– ident: e_1_2_6_14_2
  doi: 10.1046/j.1365-2125.2003.02005.x
– ident: e_1_2_6_29_2
  doi: 10.1016/S1086-5802(16)31280-3
– ident: e_1_2_6_5_2
  doi: 10.1592/phco.20.6.568.35152
– ident: e_1_2_6_26_2
  doi: 10.1128/AAC.45.2.517-524.2001
– volume: 40
  start-page: 2087
  year: 1996
  ident: e_1_2_6_25_2
  article-title: Single‐dose and steady‐state pharmacokinetics of hypericin and pseudohypericin
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.40.9.2087
– ident: e_1_2_6_12_2
  doi: 10.1046/j.1365-2125.2003.01716.x
– ident: e_1_2_6_21_2
  doi: 10.1038/87912
– ident: e_1_2_6_28_2
  doi: 10.1016/S0944-7113(00)80029-X
– ident: e_1_2_6_11_2
  doi: 10.1016/S0140-6736(99)05467-7
– ident: e_1_2_6_16_2
  doi: 10.1211/0022357011775910
– ident: e_1_2_6_15_2
  doi: 10.1093/ndt/15.9.1473
– ident: e_1_2_6_19_2
  doi: 10.1038/sj.bjp.0704399
– ident: e_1_2_6_8_2
  doi: 10.1046/j.1365-2125.2002.01683.x
– volume: 85
  start-page: 1360
  year: 2002
  ident: e_1_2_6_31_2
  article-title: Determination of St. John's Wort components in dietary supplements and functional foods by liquid chromatography
  publication-title: J AOAC Int
  doi: 10.1093/jaoac/85.6.1360
– ident: e_1_2_6_2_2
  doi: 10.1046/j.1365-2125.2000.00204.x
– ident: e_1_2_6_4_2
  doi: 10.1016/S0090-4295(01)01491-1
– ident: e_1_2_6_27_2
  doi: 10.1055/s-2007-979344
– ident: e_1_2_6_32_2
  doi: 10.1016/S0009-9236(01)64092-X
– ident: e_1_2_6_9_2
  doi: 10.1067/mcp.2000.112240
– ident: e_1_2_6_20_2
  doi: 10.1073/pnas.130155097
– volume: 41
  start-page: 557
  year: 2003
  ident: e_1_2_6_22_2
  article-title: Effect of hypericum extracts with different hyperforin content on the pharmacokinetics of cyclosporin A
  publication-title: Int J Clin Pharmacol Ther
– ident: e_1_2_6_10_2
  doi: 10.1046/j.0306-5251.2001.01516.x
– ident: e_1_2_6_23_2
  doi: 10.1016/S0006-2952(97)00239-6
– ident: e_1_2_6_7_2
  doi: 10.1016/0304-3959(93)90167-N
– ident: e_1_2_6_18_2
  doi: 10.1002/jps.2600810324
– ident: e_1_2_6_30_2
– ident: e_1_2_6_3_2
  doi: 10.1111/j.1365-2044.1997.197-az0332.x
– ident: e_1_2_6_13_2
  doi: 10.1016/j.clpt.2003.08.009
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Snippet Aim The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co‐administered drugs. Therefore, we...
The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co-administered drugs. Therefore, we...
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StartPage 437
SubjectTerms Adult
Aged
Aged, 80 and over
Anthracenes
Biological and medical sciences
Bridged Bicyclo Compounds - blood
Drug Interactions
hospitalisation
Hospitalization
Humans
Hypericum
Hypericum - metabolism
Medical sciences
Middle Aged
Perylene - analogs & derivatives
Perylene - blood
Pharmacology. Drug treatments
Phloroglucinol - analogs & derivatives
Phloroglucinol - blood
Self Medication
Short Reports
Substance Abuse Detection
Terpenes - blood
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Title Undeclared exposure to St. John's Wort in hospitalized patients
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2125.2004.02169.x
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