Nucleated red blood cells explain most of the association between DNA methylation and gestational age

Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified...

Full description

Saved in:
Bibliographic Details
Published inCommunications biology Vol. 6; no. 1; pp. 224 - 11
Main Authors Haftorn, Kristine L., Denault, William R. P., Lee, Yunsung, Page, Christian M., Romanowska, Julia, Lyle, Robert, Næss, Øyvind E., Kristjansson, Dana, Magnus, Per M., Håberg, Siri E., Bohlin, Jon, Jugessur, Astanand
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 27.02.2023
Nature Publishing Group
Nature Portfolio
Subjects
45/61
631/136/232/1473
631/208/176/1988
Age
Algorithms
Biology
Biomedical and Life Sciences
Blood
CpG islands
DNA Methylation
Epigenetics
Epigenomics
Erythroblasts
Erythrocytes
Erythropoiesis
Gestational Age
Life Sciences
Neonates
Phenotypes
Online AccessGet full text
ISSN2399-3642
2399-3642
DOI10.1038/s42003-023-04584-w

Cover

Abstract Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (p Bonferroni <0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm–GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults. CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.
AbstractList Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (p <0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm-GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults.
CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.
Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (pBonferroni<0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm–GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults.
Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (pBonferroni<0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm-GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults.Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (pBonferroni<0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm-GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults.
Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (pBonferroni<0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm–GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults.CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.
Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (p Bonferroni <0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm–GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults. CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.
Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (p Bonferroni <0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm–GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults.
ArticleNumber 224
Author Romanowska, Julia
Lee, Yunsung
Næss, Øyvind E.
Jugessur, Astanand
Bohlin, Jon
Denault, William R. P.
Kristjansson, Dana
Page, Christian M.
Magnus, Per M.
Håberg, Siri E.
Haftorn, Kristine L.
Lyle, Robert
Author_xml – sequence: 1
  givenname: Kristine L.
  orcidid: 0000-0002-2152-1839
  surname: Haftorn
  fullname: Haftorn, Kristine L.
  email: KristineLokas.Haftorn@fhi.no
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health, Institute of Health and Society, University of Oslo
– sequence: 2
  givenname: William R. P.
  orcidid: 0000-0002-9690-3890
  surname: Denault
  fullname: Denault, William R. P.
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health, Department of Human Genetics, University of Chicago
– sequence: 3
  givenname: Yunsung
  orcidid: 0000-0002-2512-1082
  surname: Lee
  fullname: Lee, Yunsung
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health
– sequence: 4
  givenname: Christian M.
  surname: Page
  fullname: Page, Christian M.
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health, Department of Physical Health and Ageing, Division of Mental and Physical Health, Norwegian Institute of Public Health
– sequence: 5
  givenname: Julia
  orcidid: 0000-0001-6733-1953
  surname: Romanowska
  fullname: Romanowska, Julia
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health, Department of Global Public Health and Primary Care, , University of Bergen
– sequence: 6
  givenname: Robert
  orcidid: 0000-0001-6317-732X
  surname: Lyle
  fullname: Lyle, Robert
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health, Department of Medical Genetics, Oslo University Hospital and University of Oslo
– sequence: 7
  givenname: Øyvind E.
  surname: Næss
  fullname: Næss, Øyvind E.
  organization: Institute of Health and Society, University of Oslo, Division of Mental and Physical Health, Norwegian Institute of Public Health
– sequence: 8
  givenname: Dana
  surname: Kristjansson
  fullname: Kristjansson, Dana
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health, Department of Genetics and Bioinformatics, Norwegian Institute of Public Health
– sequence: 9
  givenname: Per M.
  surname: Magnus
  fullname: Magnus, Per M.
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health
– sequence: 10
  givenname: Siri E.
  surname: Håberg
  fullname: Håberg, Siri E.
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health
– sequence: 11
  givenname: Jon
  orcidid: 0000-0002-0992-1311
  surname: Bohlin
  fullname: Bohlin, Jon
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health, Division for Infection Control and Environmental Health, Department of Infectious Disease Epidemiology and Modelling, Norwegian Institute of Public Health
– sequence: 12
  givenname: Astanand
  surname: Jugessur
  fullname: Jugessur, Astanand
  organization: Centre for Fertility and Health, Norwegian Institute of Public Health, Department of Global Public Health and Primary Care, , University of Bergen
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36849614$$D View this record in MEDLINE/PubMed
BookMark eNqNUs1vFCEcnZgaW2v_AQ-GxIuXURi-LyZN_WrS1IueCcMwu2xYWIFx3f9eurOtbQ-NB2AG3nu_x-_xsjkKMdimeY3gewSx-JBJByFuYVcHoYK022fNSYelbDEj3dG97-PmLOcVhBBJKRkmL5pjzASRDJGTxl5Pxltd7ABSHb2PcQDGep-B_bPx2gWwjrmAOIKytEDnHI3TxcUAelu21gbw6focrG1Z7vy8r8MAFjaX_Z_2QC_sq-b5qH22Z4f1tPn55fOPi2_t1fevlxfnV62hjJaWYAyZZGZEHR_IaLSWnFILKRoNFRBRZnsCe8vqsaYjGyWTggrDRy6s6Sk-bS5n3SHqldokt9Zpp6J2ar8R00LpVFy9sWKCGs1HhhClxEgu-p5gg2Qv-SAG3FctPGtNYaN3W-39nSCC6iYDNWegagZqn4HaVtbHmbWZ-rUdjA0laf_AysOT4JZqEX8rKXnVhFUAzAImuVxcUCEmXcsJ2tWZMS4q5N2hRoq_ptpptXb5JjMdbJyy6riAnHUUoQp9-wi6ilOqqcyojknOeEW9uW_6zu3tM6mA7tZUzDnZ8f9aIR6RjJsfRb24809TD73PtU5Y2PTP9hOsv-pF8Ug
CitedBy_id crossref_primary_10_1186_s13148_023_01528_3
crossref_primary_10_1186_s13148_024_01741_8
crossref_primary_10_1038_s42003_023_05025_4
crossref_primary_10_1080_15592294_2024_2437275
crossref_primary_10_1186_s40246_023_00540_1
crossref_primary_10_1371_journal_ppat_1012063
Cites_doi 10.1038/s41467-019-10864-z
10.1186/s13073-020-0716-9
10.1038/s41467-019-11052-9
10.1186/s13059-018-1448-7
10.1038/nature13544
10.1186/1471-2105-13-86
10.1016/j.blre.2020.100740
10.1016/j.steroids.2009.09.002
10.1371/journal.pone.0067489
10.1371/journal.pone.0041361
10.1007/s10544-015-0021-3
10.1136/fn.84.3.F211
10.1182/blood.V94.2.550
10.1186/s13059-019-1664-9
10.1371/journal.pone.0181155
10.1093/bioinformatics/btz196
10.1016/S0268-960X(98)90022-4
10.1371/journal.pgen.1005526
10.4049/jimmunol.174.4.2250
10.1186/s13148-021-01055-z
10.1186/s12864-022-08451-6
10.1080/15592294.2020.1767277
10.1073/pnas.0909296106
10.1159/000101567
10.1038/nbt.1630
10.1186/s13148-019-0717-y
10.1182/blood-2008-03-077883
10.1016/j.exphem.2021.01.001
10.1073/pnas.1303976110
10.1016/j.exphem.2009.02.005
10.1016/j.exphem.2020.07.011
10.1016/j.biocel.2014.02.019
10.1093/bioinformatics/bts680
10.1038/s41467-020-18618-y
10.1210/en.2010-1443
10.1038/s41467-022-29540-w
10.1101/cshperspect.a011643
10.1186/s13148-017-0339-1
10.1186/s13059-020-02126-9
10.1186/s13059-016-1068-z
10.2217/epi-2016-0153
10.1038/jp.2014.241
10.1093/aje/kwt433
10.3389/fimmu.2019.03017
10.1186/s13148-018-0520-1
10.1038/s41592-018-0213-x
10.4161/epi.6.12.18296
10.1093/ije/dyr237
10.1186/1471-2164-14-293
10.1186/s13059-016-1063-4
10.1016/j.ydbio.2008.01.047
10.1093/hmg/ddv119
10.1182/blood-2010-01-262964
10.3324/haematol.2019.233056
10.1038/nature14326
10.1038/nrendo.2014.73
10.1038/s41598-021-96585-0
10.1101/gad.13.22.2996
10.2217/bmm-2017-0055
10.1093/ije/dyy029
10.1038/sj.onc.1209308
10.1073/pnas.1314814111
10.1182/blood-2010-07-295550
10.1016/j.celrep.2019.08.020
10.1016/j.pedneo.2020.07.009
10.1093/hmg/ddx275
10.1186/s13148-017-0349-z
10.1084/jem.193.2.247
10.1155/2014/496416
10.1016/j.ajog.2012.07.022
10.1371/journal.pgen.1005583
10.1093/ije/dyq070
10.1542/peds.2003-0838-L
10.1186/s13059-016-1066-1
10.4161/epi.6.6.16196
10.1016/j.gdata.2016.05.012
10.1186/s13148-021-01114-5
10.1074/jbc.M112.423756
10.3390/children7110197
10.1093/ije/dyw029
10.2217/epi-2016-0157
10.5324/nje.v24i1-2.1755
ContentType Journal Article
Copyright The Author(s) 2023
2023. The Author(s).
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
info:eu-repo/semantics/openAccess
Copyright_xml – notice: The Author(s) 2023
– notice: 2023. The Author(s).
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: info:eu-repo/semantics/openAccess
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7XB
88I
8FE
8FH
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M2P
M7P
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
3HK
5PM
ADTOC
UNPAY
DOA
DOI 10.1038/s42003-023-04584-w
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Central (purchase pre-March 2016)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Journals
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
NORA - Norwegian Open Research Archives
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
Biological Science Database
ProQuest SciTech Collection
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE


MEDLINE - Academic
Publicly Available Content Database

CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
– sequence: 6
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2399-3642
EndPage 11
ExternalDocumentID oai_doaj_org_article_685ca7f611554c978bb43c19b97d8d3b
10.1038/s42003-023-04584-w
PMC9971030
10852_106678
36849614
10_1038_s42003_023_04584_w
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: Norges Forskningsråd (Research Council of Norway)
  grantid: 262700
  funderid: https://doi.org/10.13039/501100005416
– fundername: U.S. Department of Health & Human Services | National Institutes of Health (NIH)
  grantid: R01 1HL134840-01
  funderid: https://doi.org/10.13039/100000002
– fundername: Norges Forskningsråd (Research Council of Norway)
  grantid: 262700
– fundername: ;
  grantid: R01 1HL134840-01
– fundername: ;
  grantid: 262700
GroupedDBID 0R~
53G
88I
AAJSJ
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
AFKRA
AJTQC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BBNVY
BCNDV
BENPR
BHPHI
C6C
CCPQU
DWQXO
EBLON
EBS
GNUQQ
GROUPED_DOAJ
HCIFZ
HYE
M2P
M7P
M~E
NAO
O9-
OK1
PGMZT
PIMPY
RNT
RPM
SNYQT
AASML
AAYXX
CITATION
PHGZM
PHGZT
PQGLB
PUEGO
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7XB
8FE
8FH
8FK
LK8
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
3HK
AAADF
AFGXO
EJD
5PM
ADTOC
H13
UNPAY
ID FETCH-LOGICAL-c565t-4330696cf127d4fcaa9755e051fc580156eb40be627da5f6f969858c7f78ecb53
IEDL.DBID DOA
ISSN 2399-3642
IngestDate Fri Oct 03 12:51:26 EDT 2025
Sun Oct 26 04:12:42 EDT 2025
Tue Sep 30 17:16:39 EDT 2025
Wed Jan 31 07:00:07 EST 2024
Thu Sep 04 19:34:24 EDT 2025
Fri Jul 25 11:42:55 EDT 2025
Mon Jul 21 06:00:21 EDT 2025
Thu Apr 24 22:55:42 EDT 2025
Wed Oct 01 03:42:29 EDT 2025
Fri Feb 21 02:38:36 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2023. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
cc-by
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c565t-4330696cf127d4fcaa9755e051fc580156eb40be627da5f6f969858c7f78ecb53
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
NFR/262700
ORCID 0000-0002-0992-1311
0000-0002-2512-1082
0000-0002-9690-3890
0000-0002-2152-1839
0000-0001-6733-1953
0000-0001-6317-732X
OpenAccessLink https://doaj.org/article/685ca7f611554c978bb43c19b97d8d3b
PMID 36849614
PQID 2780269767
PQPubID 4669726
PageCount 11
ParticipantIDs doaj_primary_oai_doaj_org_article_685ca7f611554c978bb43c19b97d8d3b
unpaywall_primary_10_1038_s42003_023_04584_w
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9971030
cristin_nora_10852_106678
proquest_miscellaneous_2780762511
proquest_journals_2780269767
pubmed_primary_36849614
crossref_primary_10_1038_s42003_023_04584_w
crossref_citationtrail_10_1038_s42003_023_04584_w
springer_journals_10_1038_s42003_023_04584_w
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-02-27
PublicationDateYYYYMMDD 2023-02-27
PublicationDate_xml – month: 02
  year: 2023
  text: 2023-02-27
  day: 27
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Communications biology
PublicationTitleAbbrev Commun Biol
PublicationTitleAlternate Commun Biol
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Yang, Bergvall, Cnattingius, Kramer (CR4) 2010; 39
Satyanarayana (CR66) 2010; 116
Heller, Bogomolov, Benjamini (CR31) 2014; 111
Flygare, Rayon Estrada, Shin, Gupta, Lodish (CR49) 2011; 117
Bauer (CR25) 2018; 47
Gervin (CR19) 2019; 11
CR78
CR75
Parets (CR60) 2013; 8
Akhabir (CR9) 2022; 23
McCartney (CR81) 2016; 9
Lu (CR34) 2021; 13
Müller (CR80) 2019; 20
Mathangasinghe, Fauvet, Jane, Goloubinoff, Nillegoda (CR43) 2021; 106
Pidsley (CR84) 2013; 14
Teschendorff (CR82) 2013; 29
Byeon, Ki, Han (CR76) 2015; 17
Schulz (CR67) 2019; 28
Engel (CR79) 2014; 179
Li, Wu, Jin, Wu (CR21) 2019; 35
Paulson, Hariharan, Little (CR57) 2020; 89
CR2
Hermansen (CR37) 2001; 84
Luo, Yang, Wei (CR22) 2019; 10
Leonard, Godson, Brady, Taylor (CR56) 2005; 174
You (CR33) 2020; 11
Xu (CR63) 2013; 110
Haftorn (CR30) 2021; 13
Salas (CR85) 2018; 19
Pidsley (CR13) 2016; 17
CR87
CR86
Håberg (CR29) 2022; 13
Bauer (CR54) 1999; 13
Reinius (CR15) 2012; 7
Houseman (CR18) 2012; 13
Palis, Segel (CR36) 1998; 12
Schroeder (CR61) 2011; 6
Menon, Ghaffari (CR40) 2021; 95
McLean (CR32) 2010; 28
Bohlin (CR10) 2016; 17
Rahmani (CR23) 2019; 10
Stellacci (CR53) 2009; 37
Sankaran, Orkin (CR45) 2013; 3
Solano, Arck (CR46) 2019; 10
Zermati (CR65) 2001; 193
Morton, Brettin, Feldman, Leeman (CR74) 2020; 61
Merid (CR5) 2020; 12
Teschendorff, Zhu, Breeze, Beck (CR20) 2020; 21
Guo (CR6) 2014; 511
Simpkin (CR59) 2015; 24
Raby (CR3) 2004; 114
Yu (CR68) 2013; 288
Girchenko (CR70) 2017; 9
Lee (CR62) 2012; 41
York (CR12) 2020; 15
Titus, Gallimore, Salas, Christensen (CR17) 2017; 26
Porayette, Paulson (CR58) 2008; 317
Sen, Chen, Singbrant (CR38) 2021; 11
de Goede, Lavoie, Robinson (CR35) 2017; 9
Varricchio (CR64) 2014; 50
Sandoval (CR14) 2011; 6
Knight (CR11) 2016; 17
Mei, Liu, Ji (CR39) 2021; 46
Chasis, Mohandas (CR44) 2008; 112
Khouja (CR69) 2018; 10
Lim (CR7) 2017; 12
Pérez, Gurbindo, Resino, Aguarón, Muñoz-Fernández (CR27) 2007; 92
Gasparović, Ahmetasević, Colić (CR72) 2012; 36
CR28
von Lindern (CR50) 1999; 94
Slieker (CR8) 2015; 11
Tang, Seckl, Nyirenda (CR48) 2011; 152
Hebbar, Misha, Rai (CR73) 2014; 2014
Zheng, Breeze, Beck, Teschendorff (CR24) 2018; 15
Zhou, Laird, Shen (CR83) 2017; 45
Ghartey (CR1) 2012; 207
Nicolaides, Galata, Kino, Chrousos, Charmandari (CR52) 2010; 75
Liang (CR42) 2015; 11
Moisiadis, Matthews (CR47) 2014; 10
Davari-Tanha, Kaveh, Nemati, Javadian, Salmanian (CR71) 2014; 8
Glasser, Sutton, Schmeling, Machan (CR26) 2015; 35
Dolznig (CR55) 2006; 25
Singh (CR77) 2017; 11
Teschendorff, Zheng (CR16) 2017; 9
Chen (CR41) 2009; 106
Lee (CR51) 2015; 522
L Akhabir (4584_CR9) 2022; 23
V Menon (4584_CR40) 2021; 95
J Xu (4584_CR63) 2013; 110
4584_CR87
KL Haftorn (4584_CR30) 2021; 13
AJ Simpkin (4584_CR59) 2015; 24
J Sandoval (4584_CR14) 2011; 6
NC Nicolaides (4584_CR52) 2010; 75
LA Salas (4584_CR85) 2018; 19
L Varricchio (4584_CR64) 2014; 50
DL McCartney (4584_CR81) 2016; 9
BA Raby (4584_CR3) 2004; 114
Y Mathangasinghe (4584_CR43) 2021; 106
JW Schroeder (4584_CR61) 2011; 6
Y Yu (4584_CR68) 2013; 288
4584_CR86
SE Parets (4584_CR60) 2013; 8
AJ Titus (4584_CR17) 2017; 26
RC Slieker (4584_CR8) 2015; 11
W Zhou (4584_CR83) 2017; 45
VG Sankaran (4584_CR45) 2013; 3
P Porayette (4584_CR58) 2008; 317
HY Lee (4584_CR51) 2015; 522
E Rahmani (4584_CR23) 2019; 10
4584_CR78
AE Teschendorff (4584_CR20) 2020; 21
CY McLean (4584_CR32) 2010; 28
S Hebbar (4584_CR73) 2014; 2014
K Ghartey (4584_CR1) 2012; 207
J Palis (4584_CR36) 1998; 12
H Lee (4584_CR62) 2012; 41
Z Li (4584_CR21) 2019; 35
Y Byeon (4584_CR76) 2015; 17
J Flygare (4584_CR49) 2011; 117
A Bauer (4584_CR54) 1999; 13
4584_CR75
YC Lim (4584_CR7) 2017; 12
P Girchenko (4584_CR70) 2017; 9
R Liang (4584_CR42) 2015; 11
AE Teschendorff (4584_CR82) 2013; 29
TP York (4584_CR12) 2020; 15
R Pidsley (4584_CR84) 2013; 14
T Sen (4584_CR38) 2021; 11
E Stellacci (4584_CR53) 2009; 37
R Pidsley (4584_CR13) 2016; 17
Y Zermati (4584_CR65) 2001; 193
M Bauer (4584_CR25) 2018; 47
F Davari-Tanha (4584_CR71) 2014; 8
SC Zheng (4584_CR24) 2018; 15
4584_CR28
SU Morton (4584_CR74) 2020; 61
X Luo (4584_CR22) 2019; 10
M von Lindern (4584_CR50) 1999; 94
MC Hermansen (4584_CR37) 2001; 84
EA Houseman (4584_CR18) 2012; 13
R Heller (4584_CR31) 2014; 111
Y Mei (4584_CR39) 2021; 46
VG Moisiadis (4584_CR47) 2014; 10
MO Leonard (4584_CR56) 2005; 174
AE Teschendorff (4584_CR16) 2017; 9
C You (4584_CR33) 2020; 11
4584_CR2
A Pérez (4584_CR27) 2007; 92
VE Gasparović (4584_CR72) 2012; 36
SE Håberg (4584_CR29) 2022; 13
K Chen (4584_CR41) 2009; 106
ME Solano (4584_CR46) 2019; 10
A Satyanarayana (4584_CR66) 2010; 116
S Yang (4584_CR4) 2010; 39
H Guo (4584_CR6) 2014; 511
RF Paulson (4584_CR57) 2020; 89
VP Schulz (4584_CR67) 2019; 28
K Gervin (4584_CR19) 2019; 11
J Bohlin (4584_CR10) 2016; 17
JA Chasis (4584_CR44) 2008; 112
H Dolznig (4584_CR55) 2006; 25
T Lu (4584_CR34) 2021; 13
SK Merid (4584_CR5) 2020; 12
JN Khouja (4584_CR69) 2018; 10
AK Knight (4584_CR11) 2016; 17
F Müller (4584_CR80) 2019; 20
JI Tang (4584_CR48) 2011; 152
OM de Goede (4584_CR35) 2017; 9
R Singh (4584_CR77) 2017; 11
L Glasser (4584_CR26) 2015; 35
LE Reinius (4584_CR15) 2012; 7
SM Engel (4584_CR79) 2014; 179
References_xml – volume: 10
  year: 2019
  ident: CR22
  article-title: Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10864-z
– volume: 12
  year: 2020
  ident: CR5
  article-title: Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
  publication-title: Genome Med.
  doi: 10.1186/s13073-020-0716-9
– volume: 10
  year: 2019
  ident: CR23
  article-title: Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-11052-9
– ident: CR87
– volume: 19
  year: 2018
  ident: CR85
  article-title: An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray
  publication-title: Genome Biol.
  doi: 10.1186/s13059-018-1448-7
– volume: 511
  start-page: 606
  year: 2014
  end-page: 610
  ident: CR6
  article-title: The DNA methylation landscape of human early embryos
  publication-title: Nature
  doi: 10.1038/nature13544
– volume: 13
  year: 2012
  ident: CR18
  article-title: DNA methylation arrays as surrogate measures of cell mixture distribution
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-13-86
– volume: 46
  start-page: 100740
  year: 2021
  ident: CR39
  article-title: Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation
  publication-title: Blood Rev.
  doi: 10.1016/j.blre.2020.100740
– volume: 75
  start-page: 1
  year: 2010
  end-page: 12
  ident: CR52
  article-title: The human glucocorticoid receptor: molecular basis of biologic function
  publication-title: Steroids
  doi: 10.1016/j.steroids.2009.09.002
– volume: 8
  start-page: e67489
  year: 2013
  ident: CR60
  article-title: Fetal DNA methylation associates with early spontaneous preterm birth and gestational age
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0067489
– volume: 7
  start-page: e41361
  year: 2012
  ident: CR15
  article-title: Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0041361
– volume: 17
  year: 2015
  ident: CR76
  article-title: Isolation of nucleated red blood cells in maternal blood for Non-invasive prenatal diagnosis
  publication-title: Biomed. Microdevices
  doi: 10.1007/s10544-015-0021-3
– volume: 84
  start-page: F211
  year: 2001
  end-page: F215
  ident: CR37
  article-title: Nucleated red blood cells in the fetus and newborn
  publication-title: Arch. Dis. Child Fetal Neonatal Ed.
  doi: 10.1136/fn.84.3.F211
– volume: 94
  start-page: 550
  year: 1999
  end-page: 559
  ident: CR50
  article-title: The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro
  publication-title: Blood
  doi: 10.1182/blood.V94.2.550
– volume: 20
  year: 2019
  ident: CR80
  article-title: RnBeads 2.0: comprehensive analysis of DNA methylation data
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1664-9
– volume: 12
  start-page: e0181155
  year: 2017
  ident: CR7
  article-title: A complex association between DNA methylation and gene expression in human placenta at first and third trimesters
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0181155
– volume: 35
  start-page: 3898
  year: 2019
  end-page: 3905
  ident: CR21
  article-title: Dissecting differential signals in high-throughput data from complex tissues
  publication-title: Bioinforma.
  doi: 10.1093/bioinformatics/btz196
– volume: 12
  start-page: 106
  year: 1998
  end-page: 114
  ident: CR36
  article-title: Developmental biology of erythropoiesis
  publication-title: Blood Rev.
  doi: 10.1016/S0268-960X(98)90022-4
– ident: CR75
– volume: 11
  start-page: e1005526
  year: 2015
  ident: CR42
  article-title: A systems approach identifies essential FOXO3 functions at key steps of terminal erythropoiesis
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1005526
– volume: 174
  start-page: 2250
  year: 2005
  end-page: 2257
  ident: CR56
  article-title: Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.4.2250
– volume: 13
  year: 2021
  ident: CR30
  article-title: An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-021-01055-z
– volume: 23
  year: 2022
  ident: CR9
  article-title: DNA methylation changes in cord blood and the developmental origins of health and disease - a systematic review and replication study
  publication-title: BMC Genomics
  doi: 10.1186/s12864-022-08451-6
– volume: 45
  start-page: e22
  year: 2017
  ident: CR83
  article-title: Comprehensive characterization, annotation and innovative use of infinium DNA methylation BeadChip probes
  publication-title: Nucleic Acids Res.
– volume: 15
  start-page: 1243
  year: 2020
  end-page: 1258
  ident: CR12
  article-title: Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth
  publication-title: Epigenetics
  doi: 10.1080/15592294.2020.1767277
– ident: CR78
– volume: 106
  start-page: 17413
  year: 2009
  end-page: 17418
  ident: CR41
  article-title: Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0909296106
– volume: 92
  start-page: 158
  year: 2007
  end-page: 163
  ident: CR27
  article-title: NK cell increase in neonates from the preterm to the full-term period of gestation
  publication-title: Neonatology
  doi: 10.1159/000101567
– volume: 28
  start-page: 495
  year: 2010
  end-page: 501
  ident: CR32
  article-title: GREAT improves functional interpretation of cis-regulatory regions
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
– volume: 11
  year: 2019
  ident: CR19
  article-title: Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-019-0717-y
– volume: 112
  start-page: 470
  year: 2008
  end-page: 478
  ident: CR44
  article-title: Erythroblastic islands: niches for erythropoiesis
  publication-title: Blood
  doi: 10.1182/blood-2008-03-077883
– volume: 95
  start-page: 13
  year: 2021
  end-page: 22
  ident: CR40
  article-title: Erythroid enucleation: a gateway into a “bloody” world
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2021.01.001
– volume: 110
  start-page: 6518
  year: 2013
  end-page: 6523
  ident: CR63
  article-title: Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1303976110
– volume: 37
  start-page: 559
  year: 2009
  end-page: 572
  ident: CR53
  article-title: Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2009.02.005
– volume: 89
  start-page: 43
  year: 2020
  end-page: 54.e42
  ident: CR57
  article-title: Stress erythropoiesis: definitions and models for its study
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2020.07.011
– volume: 50
  start-page: 112
  year: 2014
  end-page: 122
  ident: CR64
  article-title: Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells
  publication-title: Int J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2014.02.019
– volume: 29
  start-page: 189
  year: 2013
  end-page: 196
  ident: CR82
  article-title: A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts680
– ident: CR2
– volume: 11
  year: 2020
  ident: CR33
  article-title: A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-18618-y
– volume: 152
  start-page: 2716
  year: 2011
  end-page: 2721
  ident: CR48
  article-title: Prenatal glucocorticoid overexposure causes permanent increases in renal erythropoietin expression and red blood cell mass in the rat offspring
  publication-title: Endocrinology
  doi: 10.1210/en.2010-1443
– volume: 13
  year: 2022
  ident: CR29
  article-title: DNA methylation in newborns conceived by assisted reproductive technology
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-29540-w
– volume: 3
  start-page: a011643
  year: 2013
  ident: CR45
  article-title: The switch from fetal to adult hemoglobin
  publication-title: Cold Spring Harb. Perspect. Med.
  doi: 10.1101/cshperspect.a011643
– volume: 9
  year: 2017
  ident: CR35
  article-title: Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-017-0339-1
– volume: 21
  year: 2020
  ident: CR20
  article-title: EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data
  publication-title: Genome Biol.
  doi: 10.1186/s13059-020-02126-9
– volume: 17
  year: 2016
  ident: CR11
  article-title: An epigenetic clock for gestational age at birth based on blood methylation data
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1068-z
– ident: CR86
– volume: 9
  start-page: 757
  year: 2017
  end-page: 768
  ident: CR16
  article-title: Cell-type deconvolution in epigenome-wide association studies: a review and recommendations
  publication-title: Epigenomics
  doi: 10.2217/epi-2016-0153
– volume: 35
  start-page: 469
  year: 2015
  end-page: 475
  ident: CR26
  article-title: A comprehensive study of umbilical cord blood cell developmental changes and reference ranges by gestation, gender and mode of delivery
  publication-title: J. Perinatol.
  doi: 10.1038/jp.2014.241
– volume: 179
  start-page: 834
  year: 2014
  end-page: 842
  ident: CR79
  article-title: Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwt433
– volume: 10
  start-page: 3017
  year: 2019
  ident: CR46
  article-title: Steroids, pregnancy and fetal development
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.03017
– volume: 10
  year: 2018
  ident: CR69
  article-title: Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-018-0520-1
– volume: 15
  start-page: 1059
  year: 2018
  end-page: 1066
  ident: CR24
  article-title: Identification of differentially methylated cell types in epigenome-wide association studies
  publication-title: Nat. Methods
  doi: 10.1038/s41592-018-0213-x
– volume: 6
  start-page: 1498
  year: 2011
  end-page: 1504
  ident: CR61
  article-title: Neonatal DNA methylation patterns associate with gestational age
  publication-title: Epigenetics
  doi: 10.4161/epi.6.12.18296
– volume: 8
  start-page: 77
  year: 2014
  end-page: 81
  ident: CR71
  article-title: Nucleated red blood cells count in pregnancies with idiopathic intra-uterine growth restriction
  publication-title: J. Fam. Reprod. Health
– volume: 41
  start-page: 188
  year: 2012
  end-page: 199
  ident: CR62
  article-title: DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyr237
– volume: 14
  year: 2013
  ident: CR84
  article-title: A data-driven approach to preprocessing Illumina 450K methylation array data
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-293
– volume: 17
  year: 2016
  ident: CR10
  article-title: Prediction of gestational age based on genome-wide differentially methylated regions
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1063-4
– volume: 317
  start-page: 24
  year: 2008
  end-page: 35
  ident: CR58
  article-title: BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2008.01.047
– volume: 24
  start-page: 3752
  year: 2015
  end-page: 3763
  ident: CR59
  article-title: Longitudinal analysis of DNA methylation associated with birth weight and gestational age
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddv119
– volume: 116
  start-page: 2921
  year: 2010
  end-page: 2931
  ident: CR66
  article-title: RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis
  publication-title: Blood
  doi: 10.1182/blood-2010-01-262964
– volume: 106
  start-page: 1519
  year: 2021
  end-page: 1534
  ident: CR43
  article-title: The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance
  publication-title: Haematologica
  doi: 10.3324/haematol.2019.233056
– volume: 36
  start-page: 853
  year: 2012
  end-page: 857
  ident: CR72
  article-title: Nucleated red blood cells count as first prognostic marker for adverse neonatal outcome in severe preeclamptic pregnancies
  publication-title: Coll. Antropol.
– volume: 522
  start-page: 474
  year: 2015
  end-page: 477
  ident: CR51
  article-title: PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal
  publication-title: Nature
  doi: 10.1038/nature14326
– volume: 10
  start-page: 391
  year: 2014
  end-page: 402
  ident: CR47
  article-title: Glucocorticoids and fetal programming part 1: outcomes
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2014.73
– volume: 11
  year: 2021
  ident: CR38
  article-title: Decreased PGC1β expression results in disrupted human erythroid differentiation, impaired hemoglobinization and cell cycle exit
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-96585-0
– volume: 13
  start-page: 2996
  year: 1999
  end-page: 3002
  ident: CR54
  article-title: The glucocorticoid receptor is required for stress erythropoiesis
  publication-title: Genes Dev.
  doi: 10.1101/gad.13.22.2996
– volume: 11
  start-page: 705
  year: 2017
  end-page: 710
  ident: CR77
  article-title: Fetal cells in maternal blood for prenatal diagnosis: a love story rekindled
  publication-title: Biomark. Med.
  doi: 10.2217/bmm-2017-0055
– volume: 47
  start-page: 917
  year: 2018
  end-page: 927
  ident: CR25
  article-title: Cell-type-specific disturbance of DNA methylation pattern: a chance to get more benefit from and to minimize cohorts for epigenome-wide association studies
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyy029
– volume: 25
  start-page: 2890
  year: 2006
  end-page: 2900
  ident: CR55
  article-title: Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209308
– volume: 111
  start-page: 16262
  year: 2014
  end-page: 16267
  ident: CR31
  article-title: Deciding whether follow-up studies have replicated findings in a preliminary large-scale omics study
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1314814111
– volume: 117
  start-page: 3435
  year: 2011
  end-page: 3444
  ident: CR49
  article-title: HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal
  publication-title: Blood
  doi: 10.1182/blood-2010-07-295550
– volume: 28
  start-page: 2996
  year: 2019
  end-page: 3009.e2997
  ident: CR67
  article-title: A unique epigenomic landscape defines human erythropoiesis
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.08.020
– volume: 61
  start-page: 592
  year: 2020
  end-page: 597
  ident: CR74
  article-title: Association of nucleated red blood cell count with mortality among neonatal intensive care unit patients
  publication-title: Pediatr. Neonatol.
  doi: 10.1016/j.pedneo.2020.07.009
– volume: 26
  start-page: R216
  year: 2017
  end-page: r224
  ident: CR17
  article-title: Cell-type deconvolution from DNA methylation: a review of recent applications
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddx275
– volume: 9
  year: 2017
  ident: CR70
  article-title: Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-017-0349-z
– volume: 193
  start-page: 247
  year: 2001
  end-page: 254
  ident: CR65
  article-title: Caspase activation is required for terminal erythroid differentiation
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.193.2.247
– volume: 2014
  start-page: 496416
  year: 2014
  ident: CR73
  article-title: Significance of maternal and cord blood nucleated red blood cell count in pregnancies complicated by preeclampsia
  publication-title: J. Pregnancy
  doi: 10.1155/2014/496416
– volume: 207
  start-page: 292.e291
  year: 2012
  end-page: 294
  ident: CR1
  article-title: Neonatal respiratory morbidity in the early term delivery
  publication-title: Am. J. Obstet. Gynecol.
  doi: 10.1016/j.ajog.2012.07.022
– volume: 11
  start-page: e1005583
  year: 2015
  ident: CR8
  article-title: DNA methylation landscapes of human fetal development
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1005583
– volume: 39
  start-page: 1240
  year: 2010
  end-page: 1249
  ident: CR4
  article-title: Gestational age differences in health and development among young Swedish men born at term
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyq070
– ident: CR28
– volume: 114
  start-page: e327
  year: 2004
  end-page: e332
  ident: CR3
  article-title: Low-normal gestational age as a predictor of asthma at 6 years of age
  publication-title: Pediatrics
  doi: 10.1542/peds.2003-0838-L
– volume: 17
  year: 2016
  ident: CR13
  article-title: Critical evaluation of the illumina methylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1066-1
– volume: 6
  start-page: 692
  year: 2011
  end-page: 702
  ident: CR14
  article-title: Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
  publication-title: Epigenetics
  doi: 10.4161/epi.6.6.16196
– volume: 9
  start-page: 22
  year: 2016
  end-page: 24
  ident: CR81
  article-title: Identification of polymorphic and off-target probe binding sites on the illumina infinium methylationEPIC beadChip
  publication-title: Genomics Data
  doi: 10.1016/j.gdata.2016.05.012
– volume: 13
  year: 2021
  ident: CR34
  article-title: Detecting cord blood cell type-specific epigenetic associations with gestational diabetes mellitus and early childhood growth
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-021-01114-5
– volume: 288
  start-page: 8805
  year: 2013
  end-page: 8814
  ident: CR68
  article-title: High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.423756
– volume: 10
  year: 2019
  ident: 4584_CR23
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-11052-9
– volume: 112
  start-page: 470
  year: 2008
  ident: 4584_CR44
  publication-title: Blood
  doi: 10.1182/blood-2008-03-077883
– volume: 47
  start-page: 917
  year: 2018
  ident: 4584_CR25
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyy029
– volume: 13
  start-page: 2996
  year: 1999
  ident: 4584_CR54
  publication-title: Genes Dev.
  doi: 10.1101/gad.13.22.2996
– volume: 13
  year: 2012
  ident: 4584_CR18
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-13-86
– ident: 4584_CR75
  doi: 10.3390/children7110197
– ident: 4584_CR28
  doi: 10.1093/ije/dyw029
– volume: 10
  start-page: 3017
  year: 2019
  ident: 4584_CR46
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.03017
– volume: 41
  start-page: 188
  year: 2012
  ident: 4584_CR62
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyr237
– volume: 39
  start-page: 1240
  year: 2010
  ident: 4584_CR4
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyq070
– volume: 75
  start-page: 1
  year: 2010
  ident: 4584_CR52
  publication-title: Steroids
  doi: 10.1016/j.steroids.2009.09.002
– volume: 179
  start-page: 834
  year: 2014
  ident: 4584_CR79
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwt433
– volume: 8
  start-page: e67489
  year: 2013
  ident: 4584_CR60
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0067489
– volume: 10
  start-page: 391
  year: 2014
  ident: 4584_CR47
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2014.73
– volume: 174
  start-page: 2250
  year: 2005
  ident: 4584_CR56
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.4.2250
– volume: 8
  start-page: 77
  year: 2014
  ident: 4584_CR71
  publication-title: J. Fam. Reprod. Health
– volume: 24
  start-page: 3752
  year: 2015
  ident: 4584_CR59
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddv119
– volume: 106
  start-page: 1519
  year: 2021
  ident: 4584_CR43
  publication-title: Haematologica
  doi: 10.3324/haematol.2019.233056
– volume: 46
  start-page: 100740
  year: 2021
  ident: 4584_CR39
  publication-title: Blood Rev.
  doi: 10.1016/j.blre.2020.100740
– ident: 4584_CR2
  doi: 10.2217/epi-2016-0157
– volume: 37
  start-page: 559
  year: 2009
  ident: 4584_CR53
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2009.02.005
– volume: 114
  start-page: e327
  year: 2004
  ident: 4584_CR3
  publication-title: Pediatrics
  doi: 10.1542/peds.2003-0838-L
– volume: 6
  start-page: 1498
  year: 2011
  ident: 4584_CR61
  publication-title: Epigenetics
  doi: 10.4161/epi.6.12.18296
– volume: 15
  start-page: 1243
  year: 2020
  ident: 4584_CR12
  publication-title: Epigenetics
  doi: 10.1080/15592294.2020.1767277
– volume: 36
  start-page: 853
  year: 2012
  ident: 4584_CR72
  publication-title: Coll. Antropol.
– ident: 4584_CR78
  doi: 10.5324/nje.v24i1-2.1755
– volume: 50
  start-page: 112
  year: 2014
  ident: 4584_CR64
  publication-title: Int J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2014.02.019
– volume: 45
  start-page: e22
  year: 2017
  ident: 4584_CR83
  publication-title: Nucleic Acids Res.
– volume: 110
  start-page: 6518
  year: 2013
  ident: 4584_CR63
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1303976110
– volume: 9
  start-page: 22
  year: 2016
  ident: 4584_CR81
  publication-title: Genomics Data
  doi: 10.1016/j.gdata.2016.05.012
– volume: 13
  year: 2022
  ident: 4584_CR29
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-29540-w
– volume: 17
  year: 2016
  ident: 4584_CR10
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1063-4
– volume: 116
  start-page: 2921
  year: 2010
  ident: 4584_CR66
  publication-title: Blood
  doi: 10.1182/blood-2010-01-262964
– volume: 2014
  start-page: 496416
  year: 2014
  ident: 4584_CR73
  publication-title: J. Pregnancy
  doi: 10.1155/2014/496416
– volume: 511
  start-page: 606
  year: 2014
  ident: 4584_CR6
  publication-title: Nature
  doi: 10.1038/nature13544
– volume: 13
  year: 2021
  ident: 4584_CR30
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-021-01055-z
– volume: 11
  start-page: e1005526
  year: 2015
  ident: 4584_CR42
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1005526
– volume: 23
  year: 2022
  ident: 4584_CR9
  publication-title: BMC Genomics
  doi: 10.1186/s12864-022-08451-6
– volume: 193
  start-page: 247
  year: 2001
  ident: 4584_CR65
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.193.2.247
– volume: 26
  start-page: R216
  year: 2017
  ident: 4584_CR17
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddx275
– volume: 15
  start-page: 1059
  year: 2018
  ident: 4584_CR24
  publication-title: Nat. Methods
  doi: 10.1038/s41592-018-0213-x
– volume: 92
  start-page: 158
  year: 2007
  ident: 4584_CR27
  publication-title: Neonatology
  doi: 10.1159/000101567
– volume: 11
  year: 2020
  ident: 4584_CR33
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-18618-y
– volume: 11
  start-page: 705
  year: 2017
  ident: 4584_CR77
  publication-title: Biomark. Med.
  doi: 10.2217/bmm-2017-0055
– volume: 19
  year: 2018
  ident: 4584_CR85
  publication-title: Genome Biol.
  doi: 10.1186/s13059-018-1448-7
– volume: 89
  start-page: 43
  year: 2020
  ident: 4584_CR57
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2020.07.011
– volume: 288
  start-page: 8805
  year: 2013
  ident: 4584_CR68
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.423756
– volume: 11
  start-page: e1005583
  year: 2015
  ident: 4584_CR8
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1005583
– volume: 84
  start-page: F211
  year: 2001
  ident: 4584_CR37
  publication-title: Arch. Dis. Child Fetal Neonatal Ed.
  doi: 10.1136/fn.84.3.F211
– volume: 9
  year: 2017
  ident: 4584_CR70
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-017-0349-z
– volume: 17
  year: 2016
  ident: 4584_CR11
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1068-z
– volume: 12
  year: 2020
  ident: 4584_CR5
  publication-title: Genome Med.
  doi: 10.1186/s13073-020-0716-9
– volume: 25
  start-page: 2890
  year: 2006
  ident: 4584_CR55
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209308
– volume: 10
  year: 2018
  ident: 4584_CR69
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-018-0520-1
– volume: 111
  start-page: 16262
  year: 2014
  ident: 4584_CR31
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1314814111
– volume: 13
  year: 2021
  ident: 4584_CR34
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-021-01114-5
– volume: 6
  start-page: 692
  year: 2011
  ident: 4584_CR14
  publication-title: Epigenetics
  doi: 10.4161/epi.6.6.16196
– volume: 10
  year: 2019
  ident: 4584_CR22
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10864-z
– volume: 94
  start-page: 550
  year: 1999
  ident: 4584_CR50
  publication-title: Blood
  doi: 10.1182/blood.V94.2.550
– volume: 17
  year: 2015
  ident: 4584_CR76
  publication-title: Biomed. Microdevices
  doi: 10.1007/s10544-015-0021-3
– volume: 106
  start-page: 17413
  year: 2009
  ident: 4584_CR41
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0909296106
– volume: 21
  year: 2020
  ident: 4584_CR20
  publication-title: Genome Biol.
  doi: 10.1186/s13059-020-02126-9
– volume: 95
  start-page: 13
  year: 2021
  ident: 4584_CR40
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2021.01.001
– volume: 117
  start-page: 3435
  year: 2011
  ident: 4584_CR49
  publication-title: Blood
  doi: 10.1182/blood-2010-07-295550
– ident: 4584_CR87
– volume: 9
  year: 2017
  ident: 4584_CR35
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-017-0339-1
– volume: 12
  start-page: e0181155
  year: 2017
  ident: 4584_CR7
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0181155
– volume: 9
  start-page: 757
  year: 2017
  ident: 4584_CR16
  publication-title: Epigenomics
  doi: 10.2217/epi-2016-0153
– volume: 207
  start-page: 292.e291
  year: 2012
  ident: 4584_CR1
  publication-title: Am. J. Obstet. Gynecol.
  doi: 10.1016/j.ajog.2012.07.022
– volume: 12
  start-page: 106
  year: 1998
  ident: 4584_CR36
  publication-title: Blood Rev.
  doi: 10.1016/S0268-960X(98)90022-4
– volume: 317
  start-page: 24
  year: 2008
  ident: 4584_CR58
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2008.01.047
– volume: 20
  year: 2019
  ident: 4584_CR80
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1664-9
– volume: 11
  year: 2019
  ident: 4584_CR19
  publication-title: Clin. Epigenetics
  doi: 10.1186/s13148-019-0717-y
– volume: 29
  start-page: 189
  year: 2013
  ident: 4584_CR82
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts680
– volume: 35
  start-page: 469
  year: 2015
  ident: 4584_CR26
  publication-title: J. Perinatol.
  doi: 10.1038/jp.2014.241
– volume: 7
  start-page: e41361
  year: 2012
  ident: 4584_CR15
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0041361
– volume: 35
  start-page: 3898
  year: 2019
  ident: 4584_CR21
  publication-title: Bioinforma.
  doi: 10.1093/bioinformatics/btz196
– volume: 28
  start-page: 2996
  year: 2019
  ident: 4584_CR67
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.08.020
– volume: 3
  start-page: a011643
  year: 2013
  ident: 4584_CR45
  publication-title: Cold Spring Harb. Perspect. Med.
  doi: 10.1101/cshperspect.a011643
– ident: 4584_CR86
– volume: 17
  year: 2016
  ident: 4584_CR13
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1066-1
– volume: 152
  start-page: 2716
  year: 2011
  ident: 4584_CR48
  publication-title: Endocrinology
  doi: 10.1210/en.2010-1443
– volume: 11
  year: 2021
  ident: 4584_CR38
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-96585-0
– volume: 522
  start-page: 474
  year: 2015
  ident: 4584_CR51
  publication-title: Nature
  doi: 10.1038/nature14326
– volume: 28
  start-page: 495
  year: 2010
  ident: 4584_CR32
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
– volume: 61
  start-page: 592
  year: 2020
  ident: 4584_CR74
  publication-title: Pediatr. Neonatol.
  doi: 10.1016/j.pedneo.2020.07.009
– volume: 14
  year: 2013
  ident: 4584_CR84
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-293
SSID ssj0001999634
Score 2.268103
Snippet Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the...
CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as...
SourceID doaj
unpaywall
pubmedcentral
cristin
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 224
SubjectTerms 45/61
631/136/232/1473
631/208/176/1988
Age
Algorithms
Biology
Biomedical and Life Sciences
Blood
CpG islands
DNA Methylation
Epigenetics
Epigenomics
Erythroblasts
Erythrocytes
Erythropoiesis
Gestational Age
Life Sciences
Neonates
Phenotypes
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwED-NTgh4QHwvMJCReGPR2iT-yANCG2yakKgQYtLeLMcfMKkkXT9U-t9zdpyUClTx0DzUjuT47nw_-86_A3iDKEIblbFU8UqlhXI0VdRUaTayJnOFE1lI-f88ZheXxacrerUH4-4ujE-r7NbEsFCbRvsz8uOMC9wuoPPk76c3qa8a5aOrXQkNFUsrmHeBYuwW7GeeGWsA-6dn4y9fN6cuHt_nRbw9M8zF8bwI6VnoutIQM0xXiIR1MLB6y1cFSv9_4dC_0yn7mOo9uLOsp2q9UpPJH27r_AHcj3iTnLQK8hD2bP0IbrcVKNePwY49nzHiTUNm-Atp7MQf5s-J_TWdqOua_GzmC9I4gkiRqI0wSczwIh_HJ8TXoV63WXVE1Yb4oFU8ZSS4YD2By_Ozbx8u0lh5IdUI8Bb-GtWQlUy7UcZN4bRSJafUogE7TYW_fW2rYlhZhs2KOuZKVgoqNHdcWF3R_CkM6qa2B0AoIjYfmxvy0rP_UZUVilqB-87c4lbSJJDE2ZY1Kr0nLKUZPhl60QRG3fxLHSnLfeWMiQyh81zIVnoSpSeD9OQqgbf9O9OWsGNn71Mv1r6nJ9sOfzSz7zLarmSCasUdG3nspXHbXVVFrkdlVXIjTF4lcNgphYwrwFxu9DWB130z2q6Xoapts2z7oDNCzJvAs1aH-pHkTBQlYqcE-JZ2bQ11u6W-_hH4wcuS--JxCRx1ergZ1q6pOOp19T9m7vnuj34Bd7NgU_7y1yEMFrOlfYnwbVG9ijb5G0LNP7c
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LbxMxEB6VVAg4IN4sFGQkbmRF9uHXMTyqKhK5QKXeLNtri0qpEzWJQv49Y-9mQ1RUwSF7iO2V5ZnZ-cbzAniPKMI2umS55kbntfY017QxeVm4pvS1F2UK-f82ZWfn9eSCXhzBcJcLc-C_T6W7l3WKn0LdkienXr65A8cCGVMM4Hg8nnyf7O9UInqv6i43Bpd_vLkYca5N4hMONFEq2P83lHkzWLL3mD6Ae-uw0NuNns3-UEqnj-BhhybJuCX_Yzhy4QncbftLbp-Cm8ZqxYgmG3KNvxSkTuJV_ZK4X4uZvgzkar5ckbkniAOJ3pOKdPFb5Mt0TGKX6W0bM0d0aEh0SXV3iAQ_R8_g_PTrj89neddXIbcI31YxSWrEJLO-KHlTe6u15JQ6FE9vqYi51c7UI-MYDmvqmZdMCios91w4a2j1HAZhHtxLIBTxWPS8jbiMtf2oLmtNnUCrsnJoKDYZZN1pq4AsHcuR0hKfDHVkBsXu_JXtCpLHvhgzlRzjlVAt9RRSTyXqqU0GH_o1i7Ycx62zP0Wy9jNjKe30B3KY6iRTMUGt5p4VEVlZNKqNqStbSCN5I5rKZHCyYwrVyfdSlVyg8YpQjmfwrh9GyYw01MHN1-0cVDWIaDN40fJQv5OKiVoiMsqAH3DXwVYPR8Llz1T9W0oeW8NlMNzx4X5btx3FsOfVfzi5V__39tdwv0wyFlO9TmCwul67NwjWVuZtJ6O_AeaHNDg
  priority: 102
  providerName: Springer Nature
– databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LbxMxEB6VVAg48H4sFGQkbnRDsrt-HcOjqpCIOBBRTpbttaEibKI8FMKvZ-x9lEBV0UNyiGcl73jG_pyZ-QbgBaIIW-qMpZobnRba01TT0qTZ0JWZL7zIYsr_hzE7nhTvT-jJHrC2FiYm7UdKy7hNt9lhr5ZFzKLCEyaNob1005-X_grsM4oYvAf7k_HH0ZfYSU7KNEdU3VTIDHJxzsOIdm10omrnPIq0_edhzX9TJru46Q24tq7mervR0-kfR9PRLfjcvlSdkfK9v16Zvv31F9_j5d_6Ntxs0CoZ1ZJ3YM9Vd-Fq3b9yew_cOLAhI1otyQI_MQmehFDAkrif86k-rciP2XJFZp4gziT6zBRIkx9G3o5HJHSx3tY5eURXJQkhr-Y_SoLb3X2YHL379OY4bfo2pBbh4SoUYQ2YZNYPM14W3motOaUO3d9bKkLttjPFwDiGw5p65iWTggrLPRfOGpo_gF41q9wjIBTxXojsDbgM3IFUZ4WmTuCtNXd4ES0TSJp1VBW6TKA7pRl-MzyDExi2K6tsQ3ge-m5MVQy850LV6lWoXhXVqzYJvOyemdd0HxdKvw4G00kGqu74w2zxVTWLqJigVnPPhgG5Wby0G1PkdiiN5KUoc5PAQWtuqtk_lirjAi_HCBV5As-7YfT8sIa6crN1LYNHGSLmBB7W1tnNJGeikIi8EuA7drsz1d2R6vRbZBeXkofWcwkcthZ-Nq2LVHHYecF_aO7x5cSfwPUsOkEoJTuA3mqxdk8RDK7Ms8bzfwMa6lcA
  priority: 102
  providerName: Unpaywall
Title Nucleated red blood cells explain most of the association between DNA methylation and gestational age
URI https://link.springer.com/article/10.1038/s42003-023-04584-w
https://www.ncbi.nlm.nih.gov/pubmed/36849614
https://www.proquest.com/docview/2780269767
https://www.proquest.com/docview/2780762511
http://hdl.handle.net/10852/106678
https://pubmed.ncbi.nlm.nih.gov/PMC9971030
https://www.nature.com/articles/s42003-023-04584-w.pdf
https://doaj.org/article/685ca7f611554c978bb43c19b97d8d3b
UnpaywallVersion publishedVersion
Volume 6
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2399-3642
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001999634
  issn: 2399-3642
  databaseCode: DOA
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVEBS
  databaseName: EBSCOhost Academic Search Ultimate
  customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn
  eissn: 2399-3642
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001999634
  issn: 2399-3642
  databaseCode: ABDBF
  dateStart: 20180419
  isFulltext: true
  titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn
  providerName: EBSCOhost
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2399-3642
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001999634
  issn: 2399-3642
  databaseCode: M~E
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2399-3642
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001999634
  issn: 2399-3642
  databaseCode: RPM
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVAQT
  databaseName: Springer Nature - nature.com Journals - Fully Open Access
  customDbUrl:
  eissn: 2399-3642
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001999634
  issn: 2399-3642
  databaseCode: NAO
  dateStart: 20181201
  isFulltext: true
  titleUrlDefault: https://www.nature.com/siteindex/index.html
  providerName: Nature Publishing
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 2399-3642
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001999634
  issn: 2399-3642
  databaseCode: BENPR
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: Springer Nature HAS Fully OA
  customDbUrl:
  eissn: 2399-3642
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001999634
  issn: 2399-3642
  databaseCode: AAJSJ
  dateStart: 20181201
  isFulltext: true
  titleUrlDefault: https://www.springernature.com
  providerName: Springer Nature
– providerCode: PRVAVX
  databaseName: Springer Nature OA Free Journals
  customDbUrl:
  eissn: 2399-3642
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001999634
  issn: 2399-3642
  databaseCode: C6C
  dateStart: 20181201
  isFulltext: true
  titleUrlDefault: http://www.springeropen.com/
  providerName: Springer Nature
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9swED-2jrHtYey73rqgwd5W08S2vh7drKUEZsq2QPckZFmihcwJTUKa_34n2XETNro97CEOWDLI9-H7ne50B_ARUYSpdMJizUsdZ9rRWNOqjJOBrRKXOZGElP8vBTsbZ6MLerHV6svnhDXlgRvCHTFBjeaODbzhM-jzlGWWmoEsJa9ElZb-69sXcsuZCrsrHsenWXtKpp-Ko3kW0rDQRMUhNhivEPGaoEj1jk0Kpfv_hDd_T5vsYqdP4NGynun1Sk8mW-bp9Bk8bXElyZv3eQ73bP0CHjadJtcvwRa-bjHiyopc4y-kqxO_aT8n9mY20Vc1-TmdL8jUEUSERN8yjbSZXORzkRPfb3rdZM8RXVfEB6fa3USCH6ZXMD49-T48i9sOC7FBILfwx6X6TDLjBgmvMme0lpxSi4rqDBX-lLUts35pGQ5r6piTTAoqDHdcWFPS9DXs1dPa7gOhiMx8DK7Ppa_yR3WSaWoF-pepRZexiiBqqa1qFG5fmJQmeGVoLSMYbOivTFua3HfImKgQIk-FarinkHsqcE-tIvjUPTNrCnPcOfvYs7Wb6YtqhxsoaqoVNfU3UYvgYCMUqtX0uUq4QDcWQR2P4EM3jDrqeahrO102c9DoILaN4E0jQ91KUiYyiRgpAr4jXTtL3R2pry5DHXApuW8SF8HhRg5vl3UXKQ47Wf0Hyr39H5R7B4-ToHn-KNgB7C2ul_Y9grlF2YMHeT76NsL_45Pi_GsP7g_ZsBe0Ge-Ni_P8xy-1Ckct
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED9Nm9DYA-KbwAAjwROL1iZ27DxMaGObOrZVCG3S3ozjOGxSSUo_VPrP8bdxdpyUClTxsofmoXYkx3e--53vC-AtogidqygJFc9USFXBQsXyLIy6Jo8KWojIhfyf95PeJf10xa7W4FeTC2PDKhuZ6AR1Xml7R74bcYHmAipP_mH4I7Rdo6x3tWmhoXxrhXzPlRjziR2nZj5DE268d3KI9H4XRcdHFx97oe8yEGoEMxObMtRJ0kQX3YjntNBKpZwxg8xaaCZsprHJaCczCQ4rViRFmqSCCc0LLozObNcIVAEbNKYpGn8bB0f9z18WtzzWnoipz9bpxGJ3TF04GKrK0Pkowxkib-0OdLmkG10LgX_h3r_DN1sf7hZsTsuhms_UYPCHmjy-D_c8viX7NUM-gDVTPoQ7dcfL-SMwfVs_GfFtTkb4c2HzxDoPxsT8HA7UTUm-V-MJqQqCyJSoBfMQH1FGDvv7xPa9ntdRfESVObFOMn-rSVBAPobLW6HBE1gvq9I8A8IQIVpfYIenttogUxFVzAi0c2ODpmseQOB3W5Z4yGyBVBbhM0GtHUC32X-pfYl026ljIJ2rPhaypp5E6klHPTkL4H37zrAuELJy9oElazvTFvd2f1Sjb9LLCpkIphUvkq7FehrN_Cyjse6mWcpzkcdZANsNU0gvccZycT4CeNMOo6ywNFSlqab1HFR-iLEDeFrzULuSOBE0RawWAF_irqWlLo-UN9euHnmactusLoCdhg8Xy1q1FTstr_7Hzj1f_dGvYbN3cX4mz076py_gbuTOl00824b1yWhqXiJ0nGSv_Pkk8PW2RcJvqsF8Ww
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Zj9MwEB4tu-J6QNwEFjASb2ygOXzksbBUS4EKCVbaN8vxASuVpOqh0n_P2DlKxWoFD8lD7ESOZ8bz2XMBvEQUoY1KWax4qeJcORoraso4TaxJXe5EGlz-P0_YyWk-PqNne8C6WJjgtB9SWoZluvMOe7PIgxcVapg4mPbi9euZcVfgQPCMITcfDIfjr-Pt6YrH8VneRskMMnHBBxDx6iBI1Y5OCqn7L8Kbf7tN9rbTm3B9Vc3UZq2m0z_U0-g23GpxJRk2f3IH9mx1F642lSY398BOfN5ixJWGzPEK7urEH9oviP01m6rzivysF0tSO4KIkKgt0UjryUWOJ0Pi601vGu85oipDvHGqPU0kuDDdh9PR-2_vTuK2wkKsEcgtfbjUgBVMuyTlJndaqYJTalFQnabCR1nbMh-UlmGzoo65ghWCCs0dF1aXNHsA-1Vd2UdAKCIzb4Mb8MJn-aMqzRW1AveXmcUto4kgamdbVsjcPjEpTfHOUFtGkHTzL3WbmtxXyJjKYCLPhGyoJ5F6MlBPriN41b8zaxJzXNr7rSdr39Mn1Q4P6vl32TKZZIJqxR1LPMbSuL0uyzzTSVEW3AiTlREcdkwhW0lfyJQL3MYiqOMRvOibUUY9DVVl61XTB5UOYtsIHjY81I8kYyIvECNFwHe4a2eouy3V-Y-QB7wouC8SF8FRx4fbYV02FUc9r_7DzD3-v68_h2tfjkfy04fJxydwIw3i5uO_DmF_OV_Zp4jgluWzVlx_A7mxPKo
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LbxMxEB6VVAg48H4sFGQkbnRDsrt-HcOjqpCIOBBRTpbttaEibKI8FMKvZ-x9lEBV0UNyiGcl73jG_pyZ-QbgBaIIW-qMpZobnRba01TT0qTZ0JWZL7zIYsr_hzE7nhTvT-jJHrC2FiYm7UdKy7hNt9lhr5ZFzKLCEyaNob1005-X_grsM4oYvAf7k_HH0ZfYSU7KNEdU3VTIDHJxzsOIdm10omrnPIq0_edhzX9TJru46Q24tq7mervR0-kfR9PRLfjcvlSdkfK9v16Zvv31F9_j5d_6Ntxs0CoZ1ZJ3YM9Vd-Fq3b9yew_cOLAhI1otyQI_MQmehFDAkrif86k-rciP2XJFZp4gziT6zBRIkx9G3o5HJHSx3tY5eURXJQkhr-Y_SoLb3X2YHL379OY4bfo2pBbh4SoUYQ2YZNYPM14W3motOaUO3d9bKkLttjPFwDiGw5p65iWTggrLPRfOGpo_gF41q9wjIBTxXojsDbgM3IFUZ4WmTuCtNXd4ES0TSJp1VBW6TKA7pRl-MzyDExi2K6tsQ3ge-m5MVQy850LV6lWoXhXVqzYJvOyemdd0HxdKvw4G00kGqu74w2zxVTWLqJigVnPPhgG5Wby0G1PkdiiN5KUoc5PAQWtuqtk_lirjAi_HCBV5As-7YfT8sIa6crN1LYNHGSLmBB7W1tnNJGeikIi8EuA7drsz1d2R6vRbZBeXkofWcwkcthZ-Nq2LVHHYecF_aO7x5cSfwPUsOkEoJTuA3mqxdk8RDK7Ms8bzfwMa6lcA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nucleated+red+blood+cells+explain+most+of+the+association+between+DNA+methylation+and+gestational+age&rft.jtitle=Communications+biology&rft.au=Haftorn%2C+Kristine+L&rft.au=Denault%2C+William+R+P&rft.au=Lee%2C+Yunsung&rft.au=Page%2C+Christian+M&rft.date=2023-02-27&rft.issn=2399-3642&rft.eissn=2399-3642&rft.volume=6&rft.issue=1&rft.spage=224&rft_id=info:doi/10.1038%2Fs42003-023-04584-w&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2399-3642&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2399-3642&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2399-3642&client=summon