Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size
The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or...
Saved in:
| Published in | Molecular psychiatry Vol. 25; no. 8; pp. 1822 - 1834 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.08.2020
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1359-4184 1476-5578 1476-5578 |
| DOI | 10.1038/s41380-018-0078-5 |
Cover
| Abstract | The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 ± 8.6; 46.9% female) and 315 typically developing, matched controls (age = 18.0 ± 9.2; 45.9% female). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen’s
d
= 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres:
d
= −1.01/−1.02). 22q11DS cases vs. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia. |
|---|---|
| AbstractList | The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 ± 8.6; 46.9% female) and 315 typically developing, matched controls (age = 18.0 ± 9.2; 45.9% female). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen’s d = 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres: d = −1.01/−1.02). 22q11DS cases vs. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia. The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 ± 8.6; 46.9% female) and 315 typically developing, matched controls (age = 18.0 ± 9.2; 45.9% female). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen's d = 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres: d = -1.01/-1.02). 22q11DS cases vs. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia. The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 ± 8.6; 46.9% female) and 315 typically developing, matched controls (age = 18.0 ± 9.2; 45.9% female). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen’s d = 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres: d = −1.01/−1.02). 22q11DS cases vs. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia. The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 [plus or minus] 8.6; 46.9% female) and 315 typically developing, matched controls (age = 18.0 [plus or minus] 9.2; 45.9% female). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen's d = 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres: d = -1.01/-1.02). 22q11DS cases vs. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia. The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 ± 8.6; 46.9% female) and 315 typically developing, matched controls (age = 18.0 ± 9.2; 45.9% female). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen's d = 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres: d = -1.01/-1.02). 22q11DS cases vs. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia.The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 ± 8.6; 46.9% female) and 315 typically developing, matched controls (age = 18.0 ± 9.2; 45.9% female). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen's d = 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres: d = -1.01/-1.02). 22q11DS cases vs. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia. |
| Audience | Academic |
| Author | Vila-Rodriguez, Fidel Vorstman, Jacob Koops, Sanne Sun, Daqiang Gudbrandsen, Maria Ruparel, Kosha Moss, Hayley Lin, Amy Bassett, Anne S. Murphy, Kieran C. Jalbrzikowski, Maria van den Bree, Marianne B.M. Hansen, Laura Fremont, Wanda Antshel, Kevin M. Murphy, Clodagh M. Turner, Jessica A. Murphy, Declan van Amelsvoort, Therese Goodrich-Hunsaker, Naomi J. Qu, Xiaoping Schmitt, J. Eric Cunningham, Adam Linden, David E. J. Ching, Christopher R. K. Durdle, Courtney A. Villalon-Reina, Julio E. Bearden, Carrie E. Craig, Michael Kushan, Leila Doherty, Joanne Roalf, David R. Forsyth, Jennifer K. Campbell, Linda E. Emanuel, Beverly Bakker, Geor van Erp, Theo G. M. Daly, Eileen Thompson, Paul M. Kates, Wendy R. Fiksinski, Ania Butcher, Nancy J. McCabe, Kathryn L. Vajdi, Ariana Jonas, Rachel K. Simon, Tony J. Gur, Raquel E. Chow, Eva W. C. Owen, Michael J. McDonald-McGinn, Donna M. |
| Author_xml | – sequence: 1 givenname: Daqiang surname: Sun fullname: Sun, Daqiang organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Department of Mental Health, Veterans Affairs Greater Los Angeles Healthcare System – sequence: 2 givenname: Christopher R. K. surname: Ching fullname: Ching, Christopher R. K. organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Interdepartmental Neuroscience Program, University of California, Los Angeles – sequence: 3 givenname: Amy surname: Lin fullname: Lin, Amy organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Interdepartmental Neuroscience Program, University of California, Los Angeles – sequence: 4 givenname: Jennifer K. surname: Forsyth fullname: Forsyth, Jennifer K. organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Department of Psychology, University of California, Los Angeles – sequence: 5 givenname: Leila surname: Kushan fullname: Kushan, Leila organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles – sequence: 6 givenname: Ariana surname: Vajdi fullname: Vajdi, Ariana organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles – sequence: 7 givenname: Maria surname: Jalbrzikowski fullname: Jalbrzikowski, Maria organization: Department of Psychiatry, University of Pittsburgh – sequence: 8 givenname: Laura surname: Hansen fullname: Hansen, Laura organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles – sequence: 9 givenname: Julio E. surname: Villalon-Reina fullname: Villalon-Reina, Julio E. organization: Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California – sequence: 10 givenname: Xiaoping surname: Qu fullname: Qu, Xiaoping organization: Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California – sequence: 11 givenname: Rachel K. surname: Jonas fullname: Jonas, Rachel K. organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Interdepartmental Neuroscience Program, University of California, Los Angeles – sequence: 12 givenname: Therese surname: van Amelsvoort fullname: van Amelsvoort, Therese organization: Department of Psychiatry & Neuropsychology, Maastricht University – sequence: 13 givenname: Geor surname: Bakker fullname: Bakker, Geor organization: Department of Psychiatry & Neuropsychology, Maastricht University – sequence: 14 givenname: Wendy R. surname: Kates fullname: Kates, Wendy R. organization: Department of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University – sequence: 15 givenname: Kevin M. surname: Antshel fullname: Antshel, Kevin M. organization: Department of Psychology, Syracuse University – sequence: 16 givenname: Wanda surname: Fremont fullname: Fremont, Wanda organization: Department of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University – sequence: 17 givenname: Linda E. surname: Campbell fullname: Campbell, Linda E. organization: PRC GrowUpWell, University of Newcastle, School of Psychology, University of Newcastle – sequence: 18 givenname: Kathryn L. surname: McCabe fullname: McCabe, Kathryn L. organization: School of Psychology, University of Newcastle, UC Davis MIND Institute and Department of Psychiatry and Behavioral Sciences – sequence: 19 givenname: Eileen surname: Daly fullname: Daly, Eileen organization: Sackler Institute for Translational Neurodevelopment and Department of Forensic and Neurodevelopmental Sciences, King’s College London, Institute of Psychiatry, Psychology & Neuroscience – sequence: 20 givenname: Maria surname: Gudbrandsen fullname: Gudbrandsen, Maria organization: Sackler Institute for Translational Neurodevelopment and Department of Forensic and Neurodevelopmental Sciences, King’s College London, Institute of Psychiatry, Psychology & Neuroscience – sequence: 21 givenname: Clodagh M. surname: Murphy fullname: Murphy, Clodagh M. organization: Sackler Institute for Translational Neurodevelopment and Department of Forensic and Neurodevelopmental Sciences, King’s College London, Institute of Psychiatry, Psychology & Neuroscience, Behavioural Genetics Clinic, Adult Autism Service, Behavioural and Developmental Psychiatry Clinical Academic Group, South London and Maudsley Foundation NHS Trust – sequence: 22 givenname: Declan surname: Murphy fullname: Murphy, Declan organization: Sackler Institute for Translational Neurodevelopment and Department of Forensic and Neurodevelopmental Sciences, King’s College London, Institute of Psychiatry, Psychology & Neuroscience, Behavioural Genetics Clinic, Adult Autism Service, Behavioural and Developmental Psychiatry Clinical Academic Group, South London and Maudsley Foundation NHS Trust – sequence: 23 givenname: Michael surname: Craig fullname: Craig, Michael organization: Sackler Institute for Translational Neurodevelopment and Department of Forensic and Neurodevelopmental Sciences, King’s College London, Institute of Psychiatry, Psychology & Neuroscience, National Autism Unit, Bethlem Royal Hospital, Behavioural and Developmental Psychiatry Clinical Academic Group, South London and Maudsley Foundation NHS Trust – sequence: 24 givenname: Jacob surname: Vorstman fullname: Vorstman, Jacob organization: Hospital for Sick Children, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Department of Psychiatry, University of Toronto – sequence: 25 givenname: Ania surname: Fiksinski fullname: Fiksinski, Ania organization: Hospital for Sick Children, Clinical Genetics Research Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, The Dalglish Family 22q Clinic, Department of Psychiatry, and Toronto General Research Institute, University Health Network, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health – sequence: 26 givenname: Sanne surname: Koops fullname: Koops, Sanne organization: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht – sequence: 27 givenname: Kosha surname: Ruparel fullname: Ruparel, Kosha organization: Department of Psychiatry, University of Pennsylvania, and the Lifespan Brain Institute, Penn Medicine and the Children’s Hospital of Philadelphia – sequence: 28 givenname: David R. surname: Roalf fullname: Roalf, David R. organization: Department of Psychiatry, University of Pennsylvania, and the Lifespan Brain Institute, Penn Medicine and the Children’s Hospital of Philadelphia – sequence: 29 givenname: Raquel E. surname: Gur fullname: Gur, Raquel E. organization: Department of Radiology, Division of Neuroradiology, Perelman School of Medicine, University of Pennsylvania, Department of Psychiatry, University of Pennsylvania, and the Lifespan Brain Institute, Penn Medicine and the Children’s Hospital of Philadelphia – sequence: 30 givenname: J. Eric surname: Schmitt fullname: Schmitt, J. Eric organization: Department of Radiology, Division of Neuroradiology, Perelman School of Medicine, University of Pennsylvania, Department of Psychiatry, University of Pennsylvania, and the Lifespan Brain Institute, Penn Medicine and the Children’s Hospital of Philadelphia – sequence: 31 givenname: Tony J. surname: Simon fullname: Simon, Tony J. organization: UC Davis MIND Institute and Department of Psychiatry and Behavioral Sciences – sequence: 32 givenname: Naomi J. surname: Goodrich-Hunsaker fullname: Goodrich-Hunsaker, Naomi J. organization: UC Davis MIND Institute and Department of Psychiatry and Behavioral Sciences, Department of Psychology, Brigham Young University – sequence: 33 givenname: Courtney A. surname: Durdle fullname: Durdle, Courtney A. organization: UC Davis MIND Institute and Department of Psychiatry and Behavioral Sciences – sequence: 34 givenname: Anne S. surname: Bassett fullname: Bassett, Anne S. organization: Clinical Genetics Research Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, The Dalglish Family 22q Clinic, Department of Psychiatry, and Toronto General Research Institute, University Health Network, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health – sequence: 35 givenname: Eva W. C. surname: Chow fullname: Chow, Eva W. C. organization: Clinical Genetics Research Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto – sequence: 36 givenname: Nancy J. surname: Butcher fullname: Butcher, Nancy J. organization: Hospital for Sick Children, Clinical Genetics Research Program, Centre for Addiction and Mental Health – sequence: 37 givenname: Fidel surname: Vila-Rodriguez fullname: Vila-Rodriguez, Fidel organization: Department of Psychiatry, University of British Columbia – sequence: 38 givenname: Joanne surname: Doherty fullname: Doherty, Joanne organization: MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University – sequence: 39 givenname: Adam orcidid: 0000-0002-9791-7813 surname: Cunningham fullname: Cunningham, Adam organization: MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University – sequence: 40 givenname: Marianne B.M. surname: van den Bree fullname: van den Bree, Marianne B.M. organization: MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University – sequence: 41 givenname: David E. J. surname: Linden fullname: Linden, David E. J. organization: MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University – sequence: 42 givenname: Hayley surname: Moss fullname: Moss, Hayley organization: MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University – sequence: 43 givenname: Michael J. orcidid: 0000-0003-4798-0862 surname: Owen fullname: Owen, Michael J. organization: MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University – sequence: 44 givenname: Kieran C. surname: Murphy fullname: Murphy, Kieran C. organization: Department of Psychiatry, Royal College of Surgeons in Ireland – sequence: 45 givenname: Donna M. surname: McDonald-McGinn fullname: McDonald-McGinn, Donna M. organization: Division of Human Genetics, The Children’s Hospital of Philadelphia, Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Division of Clinical Genetics, The Children’s Hospital of Philadelphia – sequence: 46 givenname: Beverly surname: Emanuel fullname: Emanuel, Beverly organization: Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Division of Clinical Genetics, The Children’s Hospital of Philadelphia – sequence: 47 givenname: Theo G. M. orcidid: 0000-0002-2465-2797 surname: van Erp fullname: van Erp, Theo G. M. organization: Department of Psychiatry and Human Behavior, University of California, Irvine – sequence: 48 givenname: Jessica A. orcidid: 0000-0003-0076-8434 surname: Turner fullname: Turner, Jessica A. organization: Imaging Genetics and Neuroinformatics Lab, Department of Psychology, Georgia State University, Mind Research Network – sequence: 49 givenname: Paul M. surname: Thompson fullname: Thompson, Paul M. organization: Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Departments of Neurology, Psychiatry, Radiology, Engineering, Pediatrics and Ophthalmology, University of Southern California – sequence: 50 givenname: Carrie E. surname: Bearden fullname: Bearden, Carrie E. email: CBearden@mednet.ucla.edu organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Department of Psychology, University of California, Los Angeles |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29895892$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1u3CAUha0qVfPTPkA3FVI33TgFbAx0USka9U8aqZvsEQOXGSIbHPAkmj5DH7q4k2aaqI28wLp851y4nNPqKMQAVfWa4HOCG_E-t6QRuMZE1BhzUbNn1QlpeVczxsVR-W-YrFsi2uPqNOcrjOdN9qI6plJIJiQ9qX4udVpDnY3uAQ16HH1Yo-iQiWnypYh0P0HSk48hIx8QpdeEnFNkoYe5iPIu2BQH-IAWMdxAMQsG0K2fNshbH0c9bbxBY96ZTcw-Ix0sAufATHnuc_DxP-Bl9dzpPsOru_Wsuvz86XLxtV5-__JtcbGsDevYVDdc6o5aghnFLQMQtHPCctlygVedILQFbB2RGksiulW57Epo0tiWE-Gcbc6qj3vbcbsawBoIU9K9GpMfdNqpqL16uBP8Rq3jjeqopLwVxeDdnUGK11vIkxp8NtD3OkDcZkUxa2VHO0wL-vYRehW3KZTbKVoegzeMNPhpinLWMM7FgVqXx1I-uFhOZ-bW6qJrsBBUEl6o839Q5bMweFMC5HypPxC8-Xsc93P4E5ICkD1gUsw5gbtHCFZzENU-iKoEUc1BVKxo-CON8dPvGJXT-P5JJd0rc-kS1pAOs_i_6BfQHPAw |
| CitedBy_id | crossref_primary_10_1016_j_bpsc_2019_08_002 crossref_primary_10_3390_brainsci14070733 crossref_primary_10_1016_j_neulet_2021_136003 crossref_primary_10_1038_s41380_020_0845_y crossref_primary_10_1038_s41467_022_32420_y crossref_primary_10_1038_s41386_024_01832_3 crossref_primary_10_3390_life13010221 crossref_primary_10_1002_hbm_25354 crossref_primary_10_1016_j_biopsych_2022_02_961 crossref_primary_10_1016_S2215_0366_19_30076_8 crossref_primary_10_7554_eLife_75482 crossref_primary_10_1111_ejn_16485 crossref_primary_10_3390_genes13112003 crossref_primary_10_1016_j_psychres_2024_115835 crossref_primary_10_1111_pcn_12839 crossref_primary_10_1001_jamapsychiatry_2021_0638 crossref_primary_10_1038_s41380_019_0638_3 crossref_primary_10_1126_sciadv_adk6063 crossref_primary_10_1002_mds_28078 crossref_primary_10_1007_s11682_021_00479_8 crossref_primary_10_1093_cercor_bhab008 crossref_primary_10_1080_15622975_2022_2093969 crossref_primary_10_1001_jamapsychiatry_2023_3850 crossref_primary_10_1016_j_biopsych_2020_09_026 crossref_primary_10_1038_s41562_023_01541_9 crossref_primary_10_1002_hbm_26553 crossref_primary_10_1038_s41467_020_18997_2 crossref_primary_10_1038_s41380_021_01209_8 crossref_primary_10_1016_j_bpsc_2021_11_008 crossref_primary_10_1016_j_biopsych_2022_08_024 crossref_primary_10_1016_j_pnpbp_2020_109907 crossref_primary_10_1038_s41380_022_01901_3 crossref_primary_10_1038_s41398_019_0473_y crossref_primary_10_1016_j_gde_2021_01_007 crossref_primary_10_1038_s41398_020_01090_z crossref_primary_10_1038_s41380_024_02495_8 crossref_primary_10_1016_j_biopsych_2022_03_018 crossref_primary_10_3390_genes15040440 crossref_primary_10_1016_j_ebiom_2020_103138 crossref_primary_10_1016_j_neuroimage_2021_118520 crossref_primary_10_1176_appi_ajp_20230736 crossref_primary_10_1515_revneuro_2024_0106 crossref_primary_10_1016_j_biopsych_2021_05_028 crossref_primary_10_1093_brain_awab055 crossref_primary_10_1016_j_bpsc_2020_08_015 crossref_primary_10_1016_j_psyneuen_2019_104540 crossref_primary_10_1093_sleep_zsad282 crossref_primary_10_1038_s41551_024_01242_2 crossref_primary_10_1016_j_biopsych_2024_08_010 crossref_primary_10_1002_hbm_25098 crossref_primary_10_1038_s41380_022_01783_5 crossref_primary_10_1093_brain_awab096 crossref_primary_10_1038_s41398_021_01456_x crossref_primary_10_7554_eLife_83843 crossref_primary_10_3390_genes13091672 crossref_primary_10_1016_j_jaac_2018_11_012 crossref_primary_10_1038_s41380_021_01302_y crossref_primary_10_1038_s41380_024_02797_x crossref_primary_10_3390_genes15050595 crossref_primary_10_1016_j_gde_2021_03_002 crossref_primary_10_1038_s41398_023_02358_w crossref_primary_10_1093_abbs_gmaa113 crossref_primary_10_1038_s41398_019_0440_7 crossref_primary_10_1038_s41386_023_01628_x crossref_primary_10_1038_s41598_020_75811_1 crossref_primary_10_1002_glia_24221 crossref_primary_10_1176_appi_ajp_20220304 crossref_primary_10_3389_fneur_2022_1045678 crossref_primary_10_1016_j_ejmg_2020_104093 crossref_primary_10_1038_s41593_022_01186_3 crossref_primary_10_3390_biom13050763 crossref_primary_10_1016_j_schres_2019_09_014 crossref_primary_10_1016_j_biopsych_2019_12_028 crossref_primary_10_1038_s41398_021_01213_0 crossref_primary_10_1186_s13229_020_00356_z crossref_primary_10_1038_s41380_021_01359_9 crossref_primary_10_1038_s41398_020_0705_1 crossref_primary_10_1016_j_biopsych_2023_03_021 crossref_primary_10_1016_j_cjca_2022_09_026 crossref_primary_10_1126_sciadv_adq2807 crossref_primary_10_1016_j_neubiorev_2019_09_004 crossref_primary_10_1038_s41398_020_00998_w crossref_primary_10_1371_journal_pbio_3002314 crossref_primary_10_1038_s41380_024_02426_7 crossref_primary_10_1080_20473869_2024_2437592 crossref_primary_10_1111_pcn_13337 crossref_primary_10_1016_j_neuroimage_2018_09_001 crossref_primary_10_1038_s41467_024_54837_3 crossref_primary_10_1016_j_biopsych_2018_10_003 crossref_primary_10_1038_s41380_019_0450_0 crossref_primary_10_1038_s41398_021_01490_9 crossref_primary_10_1089_brain_2020_0911 crossref_primary_10_1093_sleep_zsab120 crossref_primary_10_1109_JPROC_2019_2947272 crossref_primary_10_1080_09540261_2022_2123273 crossref_primary_10_1176_appi_ajp_20230555 |
| Cites_doi | 10.1093/cercor/bhn064 10.1176/appi.ajp.157.3.409 10.2353/jmoldx.2010.090099 10.1016/j.neuroimage.2013.11.010 10.1097/CHI.0b013e3181b76683 10.1016/j.biopsych.2010.10.027 10.1038/nrdp.2015.71 10.1038/mp.2013.179 10.1016/j.pneurobio.2015.03.004 10.1093/brain/awl066 10.1038/mp.2016.60 10.1093/schbul/sbm168 10.1016/j.biopsych.2012.04.020 10.1176/appi.ajp.2008.07101562 10.1007/s11920-008-0026-1 10.1016/S0006-3223(01)01246-X 10.1126/science.3291116 10.1093/cercor/bhu285 10.1038/mp.2017.161 10.1038/nature08855 10.1038/mp.2015.118 10.1186/s12888-015-0594-7 10.1016/S0006-3223(00)01002-7 10.1016/j.biopsych.2008.03.031 10.1016/j.neuroimage.2015.11.057 10.1016/j.neuroimage.2006.01.021 10.1016/j.tig.2009.10.004 10.1093/schbul/sbm166 10.1016/j.schres.2009.09.010 10.1016/j.neuropsychologia.2008.06.012 10.1016/j.neuron.2017.03.033 10.1176/appi.ajp.2013.13070864 10.18637/jss.v033.i01 10.1186/s11689-015-9113-x 10.1016/j.schres.2014.01.020 10.1038/mp.2013.112 10.1007/s11682-013-9269-5 10.1093/cercor/bhl097 10.1086/515508 10.1016/j.nicl.2013.09.013 10.1093/cercor/bhp026 10.1086/323043 10.1073/pnas.0901866106 10.1186/1471-2350-13-122 10.1097/00004583-199801000-00026 10.1523/JNEUROSCI.0391-14.2014 10.1001/archpsyc.61.11.1085 10.1037/0033-2909.112.1.155 10.1016/S0896-6273(02)00569-X 10.1016/j.neuroimage.2009.12.028 10.1523/JNEUROSCI.0054-11.2011 10.1176/appi.ajp.160.9.1580 10.1371/journal.pone.0159928 10.1016/j.schres.2009.09.016 10.1016/j.biopsych.2014.10.025 10.1038/3643 10.1007/s00702-016-1548-z 10.1038/mp.2017.73 10.1038/ng1017-1558d 10.1111/j.2517-6161.1995.tb02031.x 10.1176/appi.ajp.2010.10081230 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2018 COPYRIGHT 2020 Nature Publishing Group The Author(s) 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2018 – notice: COPYRIGHT 2020 Nature Publishing Group – notice: The Author(s) 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TK 7X7 7XB 88E 88G 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2M M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM |
| DOI | 10.1038/s41380-018-0078-5 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Neurosciences Abstracts Proquest Health and Medical Complete ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Psychology Database ProQuest Biological Science ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest One Psychology MEDLINE CrossRef MEDLINE - Academic ProQuest One Psychology |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1476-5578 |
| EndPage | 1834 |
| ExternalDocumentID | PMC6292748 A630882917 29895892 10_1038_s41380_018_0078_5 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NICHD NIH HHS grantid: U54 HD086984 – fundername: Wellcome Trust – fundername: NIMH NIH HHS grantid: RC2 MH089983 – fundername: NIMH NIH HHS grantid: R01 MH085953 – fundername: Medical Research Council grantid: MR/N026063/1 – fundername: NIBIB NIH HHS grantid: U54 EB020403 – fundername: Wellcome Trust grantid: 102003/Z/13/Z – fundername: NIMH NIH HHS grantid: U01 MH087626 – fundername: NICHD NIH HHS grantid: U54 HD087101 – fundername: NICHD NIH HHS grantid: P50 HD105354 |
| GroupedDBID | --- -Q- 0R~ 123 29M 2WC 36B 39C 3V. 4.4 406 53G 70F 7X7 88E 8AO 8FI 8FJ 8R4 8R5 AACDK AANZL AASML AATNV AAYZH AAZLF ABAKF ABAWZ ABDBF ABIVO ABJNI ABLJU ABUWG ABZZP ACAOD ACGFS ACKTT ACPRK ACRQY ACUHS ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AXYYD AZQEC B0M BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI C6C CAG CCPQU COF CS3 DIK DNIVK DPUIP DU5 DWQXO E3Z EAD EAP EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EMOBN EPL EPS ESX F5P FDQFY FEDTE FERAY FIGPU FIZPM FSGXE FYUFA GNUQQ HCIFZ HMCUK HVGLF HZ~ IAO IHR INH INR IPY ITC IWAJR JSO JZLTJ KQ8 M1P M2M M7P NAO NQJWS O9- OK1 OVD P2P PQQKQ PROAC PSQYO PSYQQ Q2X RNS RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TEORI TR2 TSG TUS UKHRP ~8M AAYXX ABBRH ABDBE ABFSG ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT ABRTQ CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB AEIIB PMFND 7TK 7XB 8FE 8FH 8FK K9. LK8 PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c565t-379a62d1052045ee826f8d794780b68124e0df19a09186b298b8a13d4718ffd3 |
| IEDL.DBID | 7X7 |
| ISSN | 1359-4184 1476-5578 |
| IngestDate | Thu Aug 21 18:17:08 EDT 2025 Thu Sep 04 21:42:16 EDT 2025 Fri Jul 25 08:55:57 EDT 2025 Sat Aug 23 13:34:00 EDT 2025 Tue Jun 17 21:31:45 EDT 2025 Tue Jun 10 20:29:15 EDT 2025 Mon Jul 21 06:03:17 EDT 2025 Tue Jul 01 00:21:49 EDT 2025 Thu Apr 24 23:10:56 EDT 2025 Fri Feb 21 02:39:34 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c565t-379a62d1052045ee826f8d794780b68124e0df19a09186b298b8a13d4718ffd3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0003-4798-0862 0000-0002-9791-7813 0000-0002-2465-2797 0000-0003-0076-8434 |
| OpenAccessLink | https://www.nature.com/articles/s41380-018-0078-5 |
| PMID | 29895892 |
| PQID | 2427535778 |
| PQPubID | 44096 |
| PageCount | 13 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6292748 proquest_miscellaneous_2054962602 proquest_journals_2476735130 proquest_journals_2427535778 gale_infotracmisc_A630882917 gale_infotracacademiconefile_A630882917 pubmed_primary_29895892 crossref_primary_10_1038_s41380_018_0078_5 crossref_citationtrail_10_1038_s41380_018_0078_5 springer_journals_10_1038_s41380_018_0078_5 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-08-01 |
| PublicationDateYYYYMMDD | 2020-08-01 |
| PublicationDate_xml | – month: 08 year: 2020 text: 2020-08-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England – name: New York |
| PublicationTitle | Molecular psychiatry |
| PublicationTitleAbbrev | Mol Psychiatry |
| PublicationTitleAlternate | Mol Psychiatry |
| PublicationYear | 2020 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Friedman, Hastie, Tibshirani (CR42) 2010; 33 Desikan, Segonne, Fischl, Quinn, Dickerson, Blacker (CR38) 2006; 31 Ellegood, Markx, Lerch, Steadman, Genc, Provenzano (CR49) 2014; 19 Wierenga, Langen, Oranje, Durston (CR57) 2014; 87 Rakic (CR59) 1998; 1 Arango, Kahn (CR21) 2008; 34 Schmock, Vangkilde, Larsen, Fischer, Birknow, Jepsen (CR7) 2015; 15 Panizzon, Fennema-Notestine, Eyler, Jernigan, Prom-Wormley, Neale (CR16) 2009; 19 Rakic (CR58) 1988; 241 Hulshoff Pol, Kahn (CR22) 2008; 34 Gur, Bassett, McDonald-McGinn, Bearden, Chow, Emanuel (CR44) 2017; 22 Winkler, Kochunov, Blangero, Almasy, Zilles, Fox (CR15) 2010; 53 Scariati, Padula, Schaer, Eliez (CR18) 2016; 123 CR36 Sorensen, Agergaard, Olesen, Andersen, Larsen, Ostergaard (CR46) 2010; 12 Storsve, Fjell, Tamnes, Westlye, Overbye, Aasland (CR56) 2014; 34 Kates, Burnette, Jabs, Rutberg, Murphy, Grados (CR10) 2001; 49 Shepherd, Matheson, Laurens, Carr, Green (CR23) 2012; 72 Kates, Antshel, Faraone, Fremont, Higgins, Shprintzen (CR29) 2011; 69 Bearden, Thompson (CR31) 2017; 94 Ellegood, Markx, Lerch, Steadman, Genc, Provenzano (CR48) 2014; 19 CR3 Meechan, Maynard, Tucker, Fernandez, Karpinski, Rothblat (CR63) 2015; 130 Bassett, Chow (CR4) 2008; 10 Schneider, Debbane, Bassett, Chow, Fung, van den Bree (CR6) 2014; 171 Sebat, Levy, McCarthy (CR1) 2009; 25 Rakic, Lombroso (CR60) 1998; 37 Tan, Arnone, McIntosh, Ebmeier (CR12) 2009; 115 CR47 CR45 Schmaal, Hibar, Samann, Hall, Baune, Jahanshad (CR35) 2017; 22 CR43 CR41 Schmitt, Vandekar, Yi, Calkins, Ruparel, Roalf (CR14) 2015; 78 CR40 Schaer, Debbane, Bach Cuadra, Ottet, Glaser, Thiran (CR55) 2009; 115 Jenne, Tinschert, Reimann, Lasinger, Thiel, Hameister (CR20) 2001; 69 Guna, Butcher, Bassett (CR62) 2015; 7 Green, Gothelf, Glaser, Debbane, Frisch, Kotler (CR5) 2009; 48 Cohen (CR39) 1992; 112 Paronett, Meechan, Karpinski, LaMantia, Maynard (CR64) 2015; 25 Sigurdsson, Stark, Karayiorgou, Gogos, Gordon (CR65) 2010; 464 Jalbrzikowski, Jonas, Senturk, Patel, Chow, Green (CR13) 2013; 3 Bassett, Chow, AbdelMalik, Gheorghiu, Husted, Weksberg (CR50) 2003; 160 Michaelovsky, Frisch, Carmel, Patya, Zarchi, Green (CR52) 2012; 13 CR19 Eliez, Schmitt, White, Reiss (CR9) 2000; 157 Joyner, J, Bloss, Bakken, Rimol, Melle (CR37) 2009; 106 Monks, Niarchou, Davies, Walters, Williams, Owen (CR51) 2014; 153 Raznahan, Shaw, Lalonde, Stockman, Wallace, Greenstein (CR61) 2011; 31 Fischl, Salat, Busa, Albert, Dieterich, Haselgrove (CR34) 2002; 33 Dufour, Schaer, Debbane, Farhoumand, Glaser, Eliez (CR30) 2008; 46 Chow, Zipursky, Mikulis, Bassett (CR53) 2002; 51 Glahn, Laird, Ellison-Wright, Thelen, Robinson, Lancaster (CR26) 2008; 64 Carlson, Sirotkin, Pandita, Goldberg, McKie, Wadey (CR54) 1997; 61 Campbell, Daly, Toal, Stevens, Azuma, Catani (CR11) 2006; 129 Bearden, van Erp, Dutton, Tran, Zimmermann, Sun (CR8) 2007; 17 Ellison-Wright, Glahn, Laird, Thelen, Bullmore (CR25) 2008; 165 van Amelsvoort, Daly, Henry, Robertson, Ng, Owen (CR28) 2004; 61 CR67 CR66 Thompson, Stein, Medland, Hibar, Vasquez, Renteria (CR33) 2014; 8 Thompson, Andreassen, Arias-Vasquez, Bearden, Boedhoe, Brouwer (CR32) 2017; 145 van Erp, Hibar, Rasmussen, Glahn, Pearlson, Andreassen (CR24) 2016; 21 McDonald-McGinn, Sullivan, Marino, Philip, Swillen, Vorstman (CR2) 2015; 1 Bearden, van Erp, Dutton, Lee, Simon, Cannon (CR17) 2009; 19 Bakker, Caan, Vingerhoets, da Silva-Alves, de Koning, Boot (CR27) 2016; 11 C Arango (78_CR21) 2008; 34 G Bakker (78_CR27) 2016; 11 T Sigurdsson (78_CR65) 2010; 464 WR Kates (78_CR29) 2011; 69 AS Bassett (78_CR4) 2008; 10 J Ellegood (78_CR49) 2014; 19 TG van Erp (78_CR24) 2016; 21 AH Joyner (78_CR37) 2009; 106 E Michaelovsky (78_CR52) 2012; 13 78_CR19 DE Jenne (78_CR20) 2001; 69 AM Shepherd (78_CR23) 2012; 72 T van Amelsvoort (78_CR28) 2004; 61 J Friedman (78_CR42) 2010; 33 PM Thompson (78_CR32) 2017; 145 AS Bassett (78_CR50) 2003; 160 I Ellison-Wright (78_CR25) 2008; 165 AM Winkler (78_CR15) 2010; 53 F Dufour (78_CR30) 2008; 46 78_CR40 J Ellegood (78_CR48) 2014; 19 78_CR41 J Sebat (78_CR1) 2009; 25 78_CR43 CE Bearden (78_CR17) 2009; 19 78_CR45 78_CR47 GM Tan (78_CR12) 2009; 115 C Carlson (78_CR54) 1997; 61 CE Bearden (78_CR31) 2017; 94 B Fischl (78_CR34) 2002; 33 L Schmaal (78_CR35) 2017; 22 DC Glahn (78_CR26) 2008; 64 M Jalbrzikowski (78_CR13) 2013; 3 M Schneider (78_CR6) 2014; 171 CE Bearden (78_CR8) 2007; 17 E Scariati (78_CR18) 2016; 123 RS Desikan (78_CR38) 2006; 31 LM Wierenga (78_CR57) 2014; 87 JE Schmitt (78_CR14) 2015; 78 HE Hulshoff Pol (78_CR22) 2008; 34 P Rakic (78_CR58) 1988; 241 PM Thompson (78_CR33) 2014; 8 78_CR36 S Eliez (78_CR9) 2000; 157 H Schmock (78_CR7) 2015; 15 KM Sorensen (78_CR46) 2010; 12 A Raznahan (78_CR61) 2011; 31 EM Paronett (78_CR64) 2015; 25 T Green (78_CR5) 2009; 48 78_CR3 S Monks (78_CR51) 2014; 153 LE Campbell (78_CR11) 2006; 129 MS Panizzon (78_CR16) 2009; 19 P Rakic (78_CR59) 1998; 1 P Rakic (78_CR60) 1998; 37 DW Meechan (78_CR63) 2015; 130 WR Kates (78_CR10) 2001; 49 EW Chow (78_CR53) 2002; 51 78_CR66 78_CR67 J Cohen (78_CR39) 1992; 112 A Guna (78_CR62) 2015; 7 RE Gur (78_CR44) 2017; 22 M Schaer (78_CR55) 2009; 115 DM McDonald-McGinn (78_CR2) 2015; 1 AB Storsve (78_CR56) 2014; 34 |
| References_xml | – ident: CR45 – volume: 19 start-page: 115 year: 2009 end-page: 26 ident: CR17 article-title: Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletions publication-title: Cereb Cortex doi: 10.1093/cercor/bhn064 – volume: 157 start-page: 409 year: 2000 end-page: 15 ident: CR9 article-title: Children and adolescents with velocardiofacial syndrome: a volumetric MRI study publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.157.3.409 – volume: 12 start-page: 147 year: 2010 end-page: 51 ident: CR46 article-title: Detecting 22q11.2 deletions by use of multiplex ligation-dependent probe amplification on DNA from neonatal dried blood spot samples publication-title: J Mol Diagn doi: 10.2353/jmoldx.2010.090099 – volume: 87 start-page: 120 year: 2014 end-page: 6 ident: CR57 article-title: Unique developmental trajectories of cortical thickness and surface area publication-title: Neuroimage doi: 10.1016/j.neuroimage.2013.11.010 – volume: 48 start-page: 1060 year: 2009 end-page: 8 ident: CR5 article-title: Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome publication-title: J Am Acad Child Adolesc Psychiatry doi: 10.1097/CHI.0b013e3181b76683 – volume: 69 start-page: 945 year: 2011 end-page: 52 ident: CR29 article-title: Neuroanatomic predictors to prodromal psychosis in velocardiofacial syndrome (22q11.2 deletion syndrome): a longitudinal study publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2010.10.027 – volume: 1 start-page: 15071 year: 2015 ident: CR2 article-title: 22q11.2 deletion syndrome publication-title: Nat Rev Dis Prim doi: 10.1038/nrdp.2015.71 – volume: 19 start-page: 6 year: 2014 ident: CR48 article-title: A highly specific pattern of volumetric brain changes due to 22q11.2 deletions in both mice and humans publication-title: Mol Psychiatry doi: 10.1038/mp.2013.179 – volume: 130 start-page: 1 year: 2015 end-page: 28 ident: CR63 article-title: Modeling a model: mouse genetics, 22q11.2 deletion syndrome, and disorders of cortical circuit development publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2015.03.004 – volume: 129 start-page: 1218 year: 2006 end-page: 28 ident: CR11 article-title: Brain and behaviour in children with 22q11.2 deletion syndrome: a volumetric and voxel-based morphometry MRI study publication-title: Brain doi: 10.1093/brain/awl066 – volume: 22 start-page: 900 year: 2017 end-page: 9 ident: CR35 article-title: Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group publication-title: Mol Psychiatry doi: 10.1038/mp.2016.60 – volume: 34 start-page: 354 year: 2008 end-page: 66 ident: CR22 article-title: What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia publication-title: Schizophr Bull doi: 10.1093/schbul/sbm168 – volume: 72 start-page: 775 year: 2012 end-page: 84 ident: CR23 article-title: Systematic meta-analysis of insula volume in schizophrenia publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2012.04.020 – volume: 165 start-page: 1015 year: 2008 end-page: 23 ident: CR25 article-title: The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2008.07101562 – volume: 10 start-page: 148 year: 2008 end-page: 57 ident: CR4 article-title: Schizophrenia and 22q11.2 deletion syndrome publication-title: Curr Psychiatry Rep doi: 10.1007/s11920-008-0026-1 – volume: 51 start-page: 208 year: 2002 end-page: 15 ident: CR53 article-title: Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(01)01246-X – ident: CR19 – volume: 241 start-page: 170 year: 1988 end-page: 6 ident: CR58 article-title: Specification of cerebral cortical areas publication-title: Science doi: 10.1126/science.3291116 – volume: 25 start-page: 3977 year: 2015 end-page: 93 ident: CR64 article-title: Ranbp1, deleted in DiGeorge/22q11.2 deletion syndrome, is a microcephaly gene that selectively disrupts layer 2/3 cortical projection neuron generation publication-title: Cereb Cortex doi: 10.1093/cercor/bhu285 – ident: CR67 – volume: 22 start-page: 1664 year: 2017 end-page: 72 ident: CR44 article-title: A neurogenetic model for the study of schizophrenia spectrum disorders: the International 22q11.2 Deletion Syndrome Brain Behavior Consortium publication-title: Mol Psychiatry doi: 10.1038/mp.2017.161 – volume: 464 start-page: 763 year: 2010 end-page: 7 ident: CR65 article-title: Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia publication-title: Nature doi: 10.1038/nature08855 – volume: 21 start-page: 585 year: 2016 ident: CR24 article-title: Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium publication-title: Mol Psychiatry doi: 10.1038/mp.2015.118 – volume: 15 year: 2015 ident: CR7 article-title: The Danish 22q11 research initiative publication-title: BMC Psychiatry doi: 10.1186/s12888-015-0594-7 – volume: 49 start-page: 677 year: 2001 end-page: 84 ident: CR10 article-title: Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(00)01002-7 – volume: 64 start-page: 774 year: 2008 end-page: 81 ident: CR26 article-title: Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2008.03.031 – ident: CR36 – volume: 145 start-page: 389 year: 2017 end-page: 408 ident: CR32 article-title: ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide publication-title: Neuroimage doi: 10.1016/j.neuroimage.2015.11.057 – volume: 31 start-page: 968 year: 2006 end-page: 80 ident: CR38 article-title: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest publication-title: Neuroimage doi: 10.1016/j.neuroimage.2006.01.021 – volume: 25 start-page: 528 year: 2009 end-page: 35 ident: CR1 article-title: Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders publication-title: Trends Genet doi: 10.1016/j.tig.2009.10.004 – volume: 34 start-page: 310 year: 2008 end-page: 1 ident: CR21 article-title: Progressive brain changes in schizophrenia publication-title: Schizophr Bull doi: 10.1093/schbul/sbm166 – volume: 115 start-page: 173 year: 2009 end-page: 81 ident: CR12 article-title: Meta-analysis of magnetic resonance imaging studies in chromosome 22q11.2 deletion syndrome (velocardiofacial syndrome) publication-title: Schizophr Res doi: 10.1016/j.schres.2009.09.010 – volume: 46 start-page: 2986 year: 2008 end-page: 92 ident: CR30 article-title: Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q 11.2 deletion syndrome publication-title: Neuropsychologia doi: 10.1016/j.neuropsychologia.2008.06.012 – volume: 94 start-page: 232 year: 2017 end-page: 6 ident: CR31 article-title: Emerging global initiatives in neurogenetics: The Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) Consortium publication-title: Neuron doi: 10.1016/j.neuron.2017.03.033 – volume: 171 start-page: 627 year: 2014 end-page: 39 ident: CR6 article-title: Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2013.13070864 – volume: 33 start-page: 1 year: 2010 end-page: 22 ident: CR42 article-title: Regularization paths for generalized linear models via coordinate descent publication-title: J Stat Softw doi: 10.18637/jss.v033.i01 – ident: CR43 – ident: CR66 – ident: CR47 – volume: 7 start-page: 18 year: 2015 ident: CR62 article-title: Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms publication-title: J Neurodev Disord doi: 10.1186/s11689-015-9113-x – volume: 153 start-page: 231 year: 2014 end-page: 6 ident: CR51 article-title: Further evidence for high rates of schizophrenia in 22q11.2 deletion syndrome publication-title: Schizophr Res doi: 10.1016/j.schres.2014.01.020 – volume: 19 start-page: 99 year: 2014 end-page: 107 ident: CR49 article-title: Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion publication-title: Mol Psychiatry doi: 10.1038/mp.2013.112 – volume: 8 start-page: 153 year: 2014 end-page: 82 ident: CR33 article-title: The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data publication-title: Brain Imaging Behav doi: 10.1007/s11682-013-9269-5 – volume: 17 start-page: 1889 year: 2007 end-page: 98 ident: CR8 article-title: Mapping cortical thickness in children with 22q11.2 deletions publication-title: Cereb Cortex doi: 10.1093/cercor/bhl097 – volume: 61 start-page: 620 year: 1997 end-page: 9 ident: CR54 article-title: Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients publication-title: Am J Hum Genet doi: 10.1086/515508 – volume: 3 start-page: 405 year: 2013 end-page: 15 ident: CR13 article-title: Structural abnormalities in cortical volume, thickness, and surface area in 22q11.2 microdeletion syndrome: Relationship with psychotic symptoms publication-title: Neuroimage Clin doi: 10.1016/j.nicl.2013.09.013 – volume: 19 start-page: 2728 year: 2009 end-page: 35 ident: CR16 article-title: Distinct genetic influences on cortical surface area and cortical thickness publication-title: Cereb Cortex doi: 10.1093/cercor/bhp026 – volume: 69 start-page: 516 year: 2001 end-page: 27 ident: CR20 article-title: Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions publication-title: Am J Hum Genet doi: 10.1086/323043 – ident: CR40 – volume: 106 start-page: 15483 year: 2009 end-page: 8 ident: CR37 article-title: A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0901866106 – volume: 13 year: 2012 ident: CR52 article-title: Genotype-phenotype correlation in 22q11.2 deletion syndrome publication-title: BMC Med Genet doi: 10.1186/1471-2350-13-122 – volume: 37 start-page: 116 year: 1998 end-page: 7 ident: CR60 article-title: Development of the cerebral cortex: I. forming the cortical structure publication-title: J Am Acad Child Adolesc Psychiatry doi: 10.1097/00004583-199801000-00026 – volume: 34 start-page: 8488 year: 2014 end-page: 98 ident: CR56 article-title: Differential longitudinal changes in cortical thickness, surface area and volume across the adult life span: regions of accelerating and decelerating change publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0391-14.2014 – volume: 61 start-page: 1085 year: 2004 end-page: 96 ident: CR28 article-title: Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging study publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.61.11.1085 – volume: 112 start-page: 155 year: 1992 end-page: 9 ident: CR39 article-title: A power primer publication-title: Psychol Bull doi: 10.1037/0033-2909.112.1.155 – ident: CR3 – volume: 33 start-page: 341 year: 2002 end-page: 55 ident: CR34 article-title: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain publication-title: Neuron doi: 10.1016/S0896-6273(02)00569-X – volume: 53 start-page: 1135 year: 2010 end-page: 46 ident: CR15 article-title: Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.12.028 – volume: 31 start-page: 7174 year: 2011 end-page: 7 ident: CR61 article-title: How does your cortex grow? publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0054-11.2011 – volume: 160 start-page: 1580 year: 2003 end-page: 6 ident: CR50 article-title: The schizophrenia phenotype in 22q11 deletion syndrome publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.160.9.1580 – volume: 11 start-page: e0159928 year: 2016 ident: CR27 article-title: Cortical morphology differences in subjects at increased vulnerability for developing a psychotic disorder: a comparison between subjects with ultra-high risk and 22q11.2 deletion syndrome publication-title: PLoS One doi: 10.1371/journal.pone.0159928 – ident: CR41 – volume: 115 start-page: 182 year: 2009 end-page: 90 ident: CR55 article-title: Deviant trajectories of cortical maturation in 22q11.2 deletion syndrome (22q11DS): a cross-sectional and longitudinal study publication-title: Schizophr Res doi: 10.1016/j.schres.2009.09.016 – volume: 78 start-page: 135 year: 2015 end-page: 43 ident: CR14 article-title: Aberrant cortical morphometry in the 22q11.2 deletion syndrome publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2014.10.025 – volume: 1 start-page: 645 year: 1998 end-page: 7 ident: CR59 article-title: Young neurons for old brains? publication-title: Nat Neurosci doi: 10.1038/3643 – volume: 123 start-page: 823 year: 2016 end-page: 39 ident: CR18 article-title: Long-range dysconnectivity in frontal and midline structures is associated to psychosis in 22q11.2 deletion syndrome publication-title: J Neural Transm (Vienna) doi: 10.1007/s00702-016-1548-z – volume: 21 start-page: 585 year: 2016 ident: 78_CR24 publication-title: Mol Psychiatry doi: 10.1038/mp.2015.118 – volume: 31 start-page: 968 year: 2006 ident: 78_CR38 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2006.01.021 – volume: 19 start-page: 115 year: 2009 ident: 78_CR17 publication-title: Cereb Cortex doi: 10.1093/cercor/bhn064 – volume: 165 start-page: 1015 year: 2008 ident: 78_CR25 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2008.07101562 – volume: 13 year: 2012 ident: 78_CR52 publication-title: BMC Med Genet doi: 10.1186/1471-2350-13-122 – volume: 33 start-page: 1 year: 2010 ident: 78_CR42 publication-title: J Stat Softw doi: 10.18637/jss.v033.i01 – volume: 34 start-page: 310 year: 2008 ident: 78_CR21 publication-title: Schizophr Bull doi: 10.1093/schbul/sbm166 – volume: 19 start-page: 99 year: 2014 ident: 78_CR49 publication-title: Mol Psychiatry doi: 10.1038/mp.2013.112 – volume: 1 start-page: 645 year: 1998 ident: 78_CR59 publication-title: Nat Neurosci doi: 10.1038/3643 – volume: 10 start-page: 148 year: 2008 ident: 78_CR4 publication-title: Curr Psychiatry Rep doi: 10.1007/s11920-008-0026-1 – volume: 22 start-page: 900 year: 2017 ident: 78_CR35 publication-title: Mol Psychiatry doi: 10.1038/mp.2016.60 – volume: 464 start-page: 763 year: 2010 ident: 78_CR65 publication-title: Nature doi: 10.1038/nature08855 – volume: 31 start-page: 7174 year: 2011 ident: 78_CR61 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0054-11.2011 – volume: 8 start-page: 153 year: 2014 ident: 78_CR33 publication-title: Brain Imaging Behav doi: 10.1007/s11682-013-9269-5 – volume: 106 start-page: 15483 year: 2009 ident: 78_CR37 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0901866106 – volume: 61 start-page: 620 year: 1997 ident: 78_CR54 publication-title: Am J Hum Genet doi: 10.1086/515508 – volume: 130 start-page: 1 year: 2015 ident: 78_CR63 publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2015.03.004 – volume: 94 start-page: 232 year: 2017 ident: 78_CR31 publication-title: Neuron doi: 10.1016/j.neuron.2017.03.033 – ident: 78_CR36 doi: 10.1038/mp.2017.73 – volume: 25 start-page: 3977 year: 2015 ident: 78_CR64 publication-title: Cereb Cortex doi: 10.1093/cercor/bhu285 – volume: 115 start-page: 182 year: 2009 ident: 78_CR55 publication-title: Schizophr Res doi: 10.1016/j.schres.2009.09.016 – volume: 69 start-page: 516 year: 2001 ident: 78_CR20 publication-title: Am J Hum Genet doi: 10.1086/323043 – volume: 34 start-page: 8488 year: 2014 ident: 78_CR56 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0391-14.2014 – volume: 78 start-page: 135 year: 2015 ident: 78_CR14 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2014.10.025 – volume: 49 start-page: 677 year: 2001 ident: 78_CR10 publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(00)01002-7 – ident: 78_CR3 doi: 10.1038/ng1017-1558d – volume: 15 year: 2015 ident: 78_CR7 publication-title: BMC Psychiatry doi: 10.1186/s12888-015-0594-7 – volume: 61 start-page: 1085 year: 2004 ident: 78_CR28 publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.61.11.1085 – volume: 17 start-page: 1889 year: 2007 ident: 78_CR8 publication-title: Cereb Cortex doi: 10.1093/cercor/bhl097 – volume: 19 start-page: 2728 year: 2009 ident: 78_CR16 publication-title: Cereb Cortex doi: 10.1093/cercor/bhp026 – ident: 78_CR41 – volume: 112 start-page: 155 year: 1992 ident: 78_CR39 publication-title: Psychol Bull doi: 10.1037/0033-2909.112.1.155 – volume: 171 start-page: 627 year: 2014 ident: 78_CR6 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2013.13070864 – ident: 78_CR45 – volume: 145 start-page: 389 year: 2017 ident: 78_CR32 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2015.11.057 – volume: 64 start-page: 774 year: 2008 ident: 78_CR26 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2008.03.031 – volume: 19 start-page: 6 year: 2014 ident: 78_CR48 publication-title: Mol Psychiatry doi: 10.1038/mp.2013.179 – ident: 78_CR40 doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 48 start-page: 1060 year: 2009 ident: 78_CR5 publication-title: J Am Acad Child Adolesc Psychiatry doi: 10.1097/CHI.0b013e3181b76683 – volume: 115 start-page: 173 year: 2009 ident: 78_CR12 publication-title: Schizophr Res doi: 10.1016/j.schres.2009.09.010 – volume: 160 start-page: 1580 year: 2003 ident: 78_CR50 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.160.9.1580 – volume: 129 start-page: 1218 year: 2006 ident: 78_CR11 publication-title: Brain doi: 10.1093/brain/awl066 – ident: 78_CR19 doi: 10.1176/appi.ajp.2010.10081230 – volume: 3 start-page: 405 year: 2013 ident: 78_CR13 publication-title: Neuroimage Clin doi: 10.1016/j.nicl.2013.09.013 – volume: 37 start-page: 116 year: 1998 ident: 78_CR60 publication-title: J Am Acad Child Adolesc Psychiatry doi: 10.1097/00004583-199801000-00026 – volume: 7 start-page: 18 year: 2015 ident: 78_CR62 publication-title: J Neurodev Disord doi: 10.1186/s11689-015-9113-x – ident: 78_CR67 – volume: 22 start-page: 1664 year: 2017 ident: 78_CR44 publication-title: Mol Psychiatry doi: 10.1038/mp.2017.161 – volume: 87 start-page: 120 year: 2014 ident: 78_CR57 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2013.11.010 – volume: 33 start-page: 341 year: 2002 ident: 78_CR34 publication-title: Neuron doi: 10.1016/S0896-6273(02)00569-X – volume: 12 start-page: 147 year: 2010 ident: 78_CR46 publication-title: J Mol Diagn doi: 10.2353/jmoldx.2010.090099 – volume: 157 start-page: 409 year: 2000 ident: 78_CR9 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.157.3.409 – volume: 46 start-page: 2986 year: 2008 ident: 78_CR30 publication-title: Neuropsychologia doi: 10.1016/j.neuropsychologia.2008.06.012 – volume: 11 start-page: e0159928 year: 2016 ident: 78_CR27 publication-title: PLoS One doi: 10.1371/journal.pone.0159928 – volume: 51 start-page: 208 year: 2002 ident: 78_CR53 publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(01)01246-X – volume: 34 start-page: 354 year: 2008 ident: 78_CR22 publication-title: Schizophr Bull doi: 10.1093/schbul/sbm168 – volume: 25 start-page: 528 year: 2009 ident: 78_CR1 publication-title: Trends Genet doi: 10.1016/j.tig.2009.10.004 – ident: 78_CR43 – volume: 241 start-page: 170 year: 1988 ident: 78_CR58 publication-title: Science doi: 10.1126/science.3291116 – volume: 72 start-page: 775 year: 2012 ident: 78_CR23 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2012.04.020 – volume: 153 start-page: 231 year: 2014 ident: 78_CR51 publication-title: Schizophr Res doi: 10.1016/j.schres.2014.01.020 – volume: 53 start-page: 1135 year: 2010 ident: 78_CR15 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.12.028 – volume: 123 start-page: 823 year: 2016 ident: 78_CR18 publication-title: J Neural Transm (Vienna) doi: 10.1007/s00702-016-1548-z – volume: 69 start-page: 945 year: 2011 ident: 78_CR29 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2010.10.027 – ident: 78_CR66 doi: 10.1038/mp.2017.161 – ident: 78_CR47 – volume: 1 start-page: 15071 year: 2015 ident: 78_CR2 publication-title: Nat Rev Dis Prim doi: 10.1038/nrdp.2015.71 |
| SSID | ssj0014765 |
| Score | 2.615946 |
| Snippet | The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical... |
| SourceID | pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1822 |
| SubjectTerms | 59 59/57 631/378 692/699/476/1799 Adolescent Adult Anatomy Behavioral Sciences Biological Psychology Brain Brain architecture Cerebral Cortex - pathology Chromosome Deletion Convergence Cortex (cingulate) Cortex (temporal) DiGeorge Syndrome - genetics DiGeorge Syndrome - pathology Etiology Female Gene mapping Gray Matter - pathology Humans Magnetic Resonance Imaging Male Medical research Medicine Medicine & Public Health Medicine, Experimental Mental disorders Neuroimaging Neurosciences Pharmacotherapy Psychiatry Psychosis Psychotic Disorders - genetics Risk factors Schizophrenia Substantia grisea Systematic review Working groups Young Adult |
| SummonAdditionalLinks | – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9QwDLfGJtBeEBsfOxhTkJCQQBXXNF_lbToxTRPjaUh7i9ImhUrQY-vtYfsb-KOx04_RQ0PitXZz6dmJ7dj5GeB1GdJcBhUoyPGJcKpIjA8-qQolQ6aLtIjA86ef1fEXcXIuzzcgHe7CxKL9CGkZt-mhOux9i5utoRIqk5BVS-Q92DI6k6TUC7UYEwdCx-6RaSYpwWnEkMjMzN9DTEzR-ob8h0Var5ZcS5lGS3T0CB72LiQ77Ca9Axuh2YX7XVPJ6114cNqnyx_Dr09U5520KIfAfjiCYvjKlhXDiDMeYbOYK-_O7FjdMM4vUoxmGTXHoYdswDP4wBZUnR4vagZGZ7es9vUytjMuWXeTq61b5hrP-goR-p3bceqb8ATOjj6eLY6Tvv1CUqKXt8KtJ3eK-5QqZYQMAQORynhcv9rMC4ItE2HuqzR36HIYVfDcFMalmSdzV1U-ewqbzbIJe8AMd3npjahU8MKji6RLh8_m5EzhDiJnMB8EYcsempw6ZHy3MUWeGdvJzqLsLMnO4itvx1d-drgc_2J-Q9K1tGZx3NL1Vw9wdoR-ZQ9VRpEGRq4z2J9w4lorp-RBP2y_1luLTg7GfFJrcwdZK1RU9BVm8Gok08BU3taE5RXyoOOcU2jJZ_Cs07bxqwgiX5ocKXqihyMDAYRPKU39LQKFK55zLXBa7waNvZ3WnX_W8__ifgHbnE4gYknkPmyuLq_CS3TTVsVBXJi_AVFbNHE priority: 102 providerName: Springer Nature |
| Title | Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size |
| URI | https://link.springer.com/article/10.1038/s41380-018-0078-5 https://www.ncbi.nlm.nih.gov/pubmed/29895892 https://www.proquest.com/docview/2427535778 https://www.proquest.com/docview/2476735130 https://www.proquest.com/docview/2054962602 https://pubmed.ncbi.nlm.nih.gov/PMC6292748 |
| Volume | 25 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR3batRAdNAWwRfx7tpaRhAEJXQzmVv6IrtLlyK6iFTYtyHJTGpAk9ZsH-w3-NE9ZzJJzUL7FJhbJjmXObc5h5B3hYtT4aRDJcdGPJN5pK2zUZlL4RKVx7lPPP91JU9-8M9rsQ4GtzaEVfY80TNq2xRoIz9kXEmVCGC5n84vIqwahd7VUELjPtmNQRLB0g1qPShcMUwRXuES6O3UvPdqJvqwBeatMSRLR3hKRmJ0Lm1z5_-Op-3QyS3_qT-Wlo_JoyBP0lmHAE_IPVc_JQ-6CpN_n5F_XzDSO2oBEo7-zjAZwxltSgo6pzdiU-8t76x2tKopYxcx6LMUy-NgI-0zGhzRBcan-6uajqL1lla2anxB44J2d7naqqVZbWmIEcH33KxTXbnn5HR5fLo4iUIBhqgAOW8DzCfNJLMxxspw4RyoIqW2QMFKT3NMXMbd1JZxmoHQoWXOUp3rLE4sHnhlaZMXZKduaveKUM2ytLCal9JZbkFIUkUGbVMUp4CHiAmZ9n_fFCE5OdbI-GW8kzzRpgOYAYAZBJiBKR-GKeddZo67Br9HkBqkWli3yMLlA9gd5r8yM5mgrgG664Tsj0YCtRXj7h4pTKD21oCYA1qfUErf0t2j7oS8HbpxYQxwq11zCWNAdE5RuWQT8rJDseGrMEm-0Cn0qBHyDQMwRfi4p65--lThkqVMcdjWxx5Nb7Z16896ffdH7JGHDI0OPgpyn-xs_ly6NyCZbfIDT34HZHe2nM9X8Jwfr759h9aFXFwDjqQ3wQ |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3batRAdKgVsS9Sb-1q1REUQQndTOaWQpFSLVu77dMK-zYkmYkGNGnNFqnf4K_4jz1ncqlZaN_6mplMZnLulzmHkDeZC2PhpEMjxwY8kWmgrbNBnkrhIpWGqS88f3wiJ1_5l7mYr5B_3V0YTKvseKJn1LbK0Ee-zbiSKhLAcj-engXYNQqjq10LjQYtjtzFbzDZ6t3DTwDft4wdfJ7tT4K2q0CQgfKyAIqKE8lsiAkgXDgH-nWuLaCl0uMUq3FxN7Z5GCcgSbVMWaxTnYSRRS6e5zaCZe-QuxwjjEA-at7bdyHsUHj7TmBwVfMuiBrp7RpkhcYMMB2gUA7EQAwuC4P_pOFypuZSuNZLwYN18qBVX-leg28PyYorH5F7TUPLi8fk7xQTy4MaAO_ozwRrP3yjVU7BxPU-c-qD842TkBYlZewsBPOZYjcefEi7Ago7dB_T4f3NUEfRWUwLW1S-f3JGm6tjdVHTpLS0TUnB71ytU_xxT8jsNiDzlKyWVek2CdUsiTOreS6d5RZ0MpUl8GyM2huwLDEi4-7vm6ythY4tOX4YH5OPtGkAZgBgBgFm4JX3_SunTSGQmya_Q5AaZBKwbpa0dx1gd1huy-zJCE0bMJVHZGswE4g7Gw53SGFa5lIb0KrAyBRK6WuGO0oZkdf9MC6M-XSlq85hDmjqMdqybEQ2GhTrT4U1-YWOYUQNkK-fgBXJhyNl8d1XJpcsZorDtj50aHq1rWt_1rObD_GK3J_Mjqdmenhy9JysMfR3-ATMLbK6-HXuXoBSuEhfelKkxNwy6V8CBTlt_w |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3batRAdKgVxRfx7mrVERRBCbuZzC2CSGldWluLDxX2bZhkJhrQpDVbpH6DP-Tfec7kUrPQvvU1M5nM5Nwvcw4hL3Ifp8JLj0aOi7iVWaSdd1GRSeETlcVZKDz_6UDufOEfF2KxRv72d2EwrbLniYFRuzpHH_mUcSVVIoDlTosuLeLz9vz90XGEHaQw0tq302hRZM-f_gLzrXm3uw2wfsnY_MPh1k7UdRiIclBklkBdqZXMxZgMwoX3oGsX2gGKKj3LsDIX9zNXxKkFqaplxlKdaRsnDjl6UbgElr1CrqqEc-waoRaDrRfDbkWw9QQGWjXvA6qJnjYgNzRmg-kIBXQkRiJxVTD8JxlXszZXQrdBIs5vkZudKks3W9y7TdZ8dYdca5tbnt4lf_YxyTxqAAk8_WGxDsRXWhcUzN3gP6chUN86DGlZUcaOYzClKXbmwYe0L6bwlm5hany4JeopOo5p6co69FLOaXuNrCkbaitHu_QU_M7ZOuVvf48cXgZk7pP1qq78Q0I1s2nuNC-kd9yBfqZyC89mqMkB-xITMuv_vsm7uujYnuO7CfH5RJsWYAYAZhBgBl55Pbxy1BYFuWjyKwSpQYYB6-a2u_cAu8PSW2ZTJmjmgNk8IRujmUDo-Xi4RwrTMZrGgIYFBqdQSp8z3FPNhDwfhnFhzK2rfH0Cc0BrT9GuZRPyoEWx4VRYn1_oFEbUCPmGCVidfDxSld9ClXLJUqY4bOtNj6Zn2zr3Zz26-BDPyHUgerO_e7D3mNxg6PoIuZgbZH3588Q_Af1wmT0NlEiJuWTK_wdtQXIy |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Large-scale+mapping+of+cortical+alterations+in+22q11.2+deletion+syndrome%3A+Convergence+with+idiopathic+psychosis+and+effects+of+deletion+size&rft.jtitle=Molecular+psychiatry&rft.au=Sun+Daqiang&rft.au=Ching+Christopher+R+K&rft.au=Lin%2C+Amy&rft.au=syth%2C+Jennifer+K&rft.date=2020-08-01&rft.pub=Nature+Publishing+Group&rft.issn=1359-4184&rft.eissn=1476-5578&rft.volume=25&rft.issue=8&rft.spage=1822&rft.epage=1834&rft_id=info:doi/10.1038%2Fs41380-018-0078-5&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1359-4184&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1359-4184&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1359-4184&client=summon |