Cinnamomum verum component 2-methoxycinnamaldehyde: a novel antiproliferative drug inducing cell death through targeting both topoisomerase I and II in human colorectal adenocarcinoma COLO 205 cells - Tsai, Kuen-daw; Cherng, Jonathan; Liu, Yi-Heng; Chen, Ta-Wei; Wong, Ho-Yiu; Yang, Shu-mei; Chou, Kuo-Shen; Cherng, Jaw-Ming (Food & nutrition research, 2016)
Keywords: 2-methoxycinnamaldehyde; Acridine orange; Adenocarcinoma; animal disease models; Annexin V; Anticancer properties; antiproliferative; Apoptosis; Bioassays; Biocompatibility; Biomarkers; Cancer; cancer therapy; carcinogenesis; Caspase; Caspase-3; Cell death; cell growth; Cell viability; Cinnamomum verum; Cinnamon; Colorimetry; Comet assay; cortex; Cytotoxicity; Damage detection; Deoxyribonucleic acid; DNA; DNA topoisomerase; DNA topoisomerase (ATP-hydrolysing); enzyme activity; enzyme inhibition; Flow cytometry; Hepatocellular carcinoma; hepatoma; Herbal medicine; herbal medicines; human diseases; humans; kinetoplast DNA; Liver cancer; Lung cancer; Lungs; lysosomal vacuolation; manufacturing; Membrane potential; Mitochondria; mitochondrial membrane; Molting; Morphology; Original; Physical characteristics; Squamous cell carcinoma; staining; topoisomerase I; topoisomerase II; Toxicity; Tumor cell lines; Tumorigenesis; xenograft; topoisomerase II; lysosomal vacuolation; xenograft; 2-methoxycinnamaldehyde; antiproliferative; cytotoxicity; topoisomerase I