Role of osteopontin, a multifunctional protein, in allergy and asthma

Summary Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecula...

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Published in	Clinical and experimental allergy Vol. 41; no. 10; pp. 1360 - 1366
Main Authors	Konno, S., Kurokawa, M., Uede, T., Nishimura, M., Huang, S.-K.
Format	Journal Article
Language	English
Published	Oxford, UK Blackwell Publishing Ltd 01.10.2011 Blackwell Wiley Subscription Services, Inc
Subjects	Allergies Angiogenesis Animals Asthma Asthma - immunology Asthma - physiopathology Biological and medical sciences Cell adhesion & migration Cell migration Chronic obstructive pulmonary disease, asthma Cytokines Cytokines - immunology Cytokines - metabolism Data processing Extracellular matrix Fibrosis Fundamental and applied biological sciences. Psychology Fundamental immunology Helper cells Humans Hypersensitivity Hypersensitivity - immunology Hypersensitivity - physiopathology Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - physiopathology Immune response Immunoglobulin E Immunoglobulin E - blood Immunomodulation Inflammation Lymphocytes T Medical research Medical sciences Mice Mucosa Osteopontin Osteopontin - immunology Osteopontin - metabolism Pneumology Respiratory tract Rodents Immunopathology Lung disease Allergy Immunology Respiratory disease Osteopontin Bronchus disease Obstructive pulmonary disease Protein Asthma
Online Access	Get full text
ISSN	0954-7894 1365-2222 1365-2222
DOI	10.1111/j.1365-2222.2011.03775.x

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Abstract	Summary Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecular and cellular studies and studies of OPN‐deficient mice provide evidence that OPN plays multiple roles in the regulation of allergic responses, including regulation of IgE response, inflammatory cell migration, and the development of airway fibrosis and angiogenesis. These results suggest that OPN is a pleiotropic cytokine that functions both systemically and locally in tissue mucosa. Notably, OPN is able to exert its effects through different functional domains, and the secreted and intracellular forms of OPN may have distinct functions. Future research to elucidate all aspects of OPN function is needed to ultimately establish its role in the regulation of immune responses and various disease processes, including those critically involved in the development of allergies and asthma. Cite this as: S. Konno, M. Kurokawa, T. Uede, M. Nishimura and S.‐K. Huang, Clinical & Experimental Allergy, 2011 (41) 1360–1366.
AbstractList	Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecular and cellular studies and studies of OPN-deficient mice provide evidence that OPN plays multiple roles in the regulation of allergic responses, including regulation of IgE response, inflammatory cell migration, and the development of airway fibrosis and angiogenesis. These results suggest that OPN is a pleiotropic cytokine that functions both systemically and locally in tissue mucosa. Notably, OPN is able to exert its effects through different functional domains, and the secreted and intracellular forms of OPN may have distinct functions. Future research to elucidate all aspects of OPN function is needed to ultimately establish its role in the regulation of immune responses and various disease processes, including those critically involved in the development of allergies and asthma. Summary Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecular and cellular studies and studies of OPN-deficient mice provide evidence that OPN plays multiple roles in the regulation of allergic responses, including regulation of IgE response, inflammatory cell migration, and the development of airway fibrosis and angiogenesis. These results suggest that OPN is a pleiotropic cytokine that functions both systemically and locally in tissue mucosa. Notably, OPN is able to exert its effects through different functional domains, and the secreted and intracellular forms of OPN may have distinct functions. Future research to elucidate all aspects of OPN function is needed to ultimately establish its role in the regulation of immune responses and various disease processes, including those critically involved in the development of allergies and asthma. Cite this as: S. Konno, M. Kurokawa, T. Uede, M. Nishimura and S.-K. Huang, Clinical & Experimental Allergy, 2011 (41) 1360-1366. [PUBLICATION ABSTRACT] Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecular and cellular studies and studies of OPN-deficient mice provide evidence that OPN plays multiple roles in the regulation of allergic responses, including regulation of IgE response, inflammatory cell migration, and the development of airway fibrosis and angiogenesis. These results suggest that OPN is a pleiotropic cytokine that functions both systemically and locally in tissue mucosa. Notably, OPN is able to exert its effects through different functional domains, and the secreted and intracellular forms of OPN may have distinct functions. Future research to elucidate all aspects of OPN function is needed to ultimately establish its role in the regulation of immune responses and various disease processes, including those critically involved in the development of allergies and asthma. Cite this as: S. Konno, M. Kurokawa, T. Uede, M. Nishimura and S.-K. Huang, Clinical & Experimental Allergy, 2011 (41) 1360-1366. Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecular and cellular studies and studies of OPN-deficient mice provide evidence that OPN plays multiple roles in the regulation of allergic responses, including regulation of IgE response, inflammatory cell migration, and the development of airway fibrosis and angiogenesis. These results suggest that OPN is a pleiotropic cytokine that functions both systemically and locally in tissue mucosa. Notably, OPN is able to exert its effects through different functional domains, and the secreted and intracellular forms of OPN may have distinct functions. Future research to elucidate all aspects of OPN function is needed to ultimately establish its role in the regulation of immune responses and various disease processes, including those critically involved in the development of allergies and asthma.Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecular and cellular studies and studies of OPN-deficient mice provide evidence that OPN plays multiple roles in the regulation of allergic responses, including regulation of IgE response, inflammatory cell migration, and the development of airway fibrosis and angiogenesis. These results suggest that OPN is a pleiotropic cytokine that functions both systemically and locally in tissue mucosa. Notably, OPN is able to exert its effects through different functional domains, and the secreted and intracellular forms of OPN may have distinct functions. Future research to elucidate all aspects of OPN function is needed to ultimately establish its role in the regulation of immune responses and various disease processes, including those critically involved in the development of allergies and asthma. Summary Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecular and cellular studies and studies of OPN‐deficient mice provide evidence that OPN plays multiple roles in the regulation of allergic responses, including regulation of IgE response, inflammatory cell migration, and the development of airway fibrosis and angiogenesis. These results suggest that OPN is a pleiotropic cytokine that functions both systemically and locally in tissue mucosa. Notably, OPN is able to exert its effects through different functional domains, and the secreted and intracellular forms of OPN may have distinct functions. Future research to elucidate all aspects of OPN function is needed to ultimately establish its role in the regulation of immune responses and various disease processes, including those critically involved in the development of allergies and asthma. Cite this as: S. Konno, M. Kurokawa, T. Uede, M. Nishimura and S.‐K. Huang, Clinical & Experimental Allergy, 2011 (41) 1360–1366. Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune responses, yet its potential involvement in allergic/asthmatic responses has been investigated only recently. Current data from molecular and cellular studies and studies of OPN‐deficient mice provide evidence that OPN plays multiple roles in the regulation of allergic responses, including regulation of IgE response, inflammatory cell migration, and the development of airway fibrosis and angiogenesis. These results suggest that OPN is a pleiotropic cytokine that functions both systemically and locally in tissue mucosa. Notably, OPN is able to exert its effects through different functional domains, and the secreted and intracellular forms of OPN may have distinct functions. Future research to elucidate all aspects of OPN function is needed to ultimately establish its role in the regulation of immune responses and various disease processes, including those critically involved in the development of allergies and asthma. Cite this as : S. Konno, M. Kurokawa, T. Uede, M. Nishimura and S.‐K. Huang, Clinical & Experimental Allergy , 2011 (41) 1360–1366.
Author	Konno, S. Huang, S.-K. Kurokawa, M. Nishimura, M. Uede, T.
Author_xml	– sequence: 1 givenname: S. surname: Konno fullname: Konno, S. organization: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan – sequence: 2 givenname: M. surname: Kurokawa fullname: Kurokawa, M. organization: Department of Internal Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Tokyo, Japan – sequence: 3 givenname: T. surname: Uede fullname: Uede, T. organization: Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan – sequence: 4 givenname: M. surname: Nishimura fullname: Nishimura, M. organization: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan – sequence: 5 givenname: S.-K. surname: Huang fullname: Huang, S.-K. organization: Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
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Keywords	Immunopathology Lung disease Allergy Immunology Respiratory disease Osteopontin Bronchus disease Obstructive pulmonary disease Protein Asthma
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Osteoponti 2004; 21 2010; 11 2004; 286 2009; 41 2002; 19 2008; 38 2004; 23 2006; 36 2002; 99 2006; 174 1999; 162 2003; 16 2009; 119 2003; 112 2003; 111 2007; 37 2010; 65 2007; 178 2001; 294 2004; 71 1997; 99 2006; 24 2002; 84 2005; 102 2008; 29 2005; 106 2006; 26 2007; 7 2000; 287 2006; 368 2003; 167 2009; 15 2004; 43 2007; 19 2006; 97 2001; 164 2009; 64 2005; 158 2005; 115 2007; 122 2008; 58 2006; 7 2003; 171 2008; 205 2009; 179 2011; 37 2003; 136 2004; 305 2001; 24 2007; 13 2010; 40 1996; 97 2010; 48 2007; 119 2009; 76 1997; 33 2002; 240 2000; 105 2005; 54 2002; 70 2005; 2 2008; 178 2004; 316 1994; 5 2008; 372 2009; 149 2003; 23 2009; 39 e_1_2_8_28_2 e_1_2_8_49_2 Howell JE (e_1_2_8_74_2) 2006; 7 e_1_2_8_24_2 e_1_2_8_45_2 e_1_2_8_26_2 e_1_2_8_47_2 e_1_2_8_9_2 Anderson GP. 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Snippet	Summary Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1... Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1 immune... Summary Osteopontin (OPN) is an extracellular matrix protein and immune modulator with a wide range of functions. OPN is recognized as a key cytokine in Th1...
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SubjectTerms	Allergies Angiogenesis Animals Asthma Asthma - immunology Asthma - physiopathology Biological and medical sciences Cell adhesion & migration Cell migration Chronic obstructive pulmonary disease, asthma Cytokines Cytokines - immunology Cytokines - metabolism Data processing Extracellular matrix Fibrosis Fundamental and applied biological sciences. Psychology Fundamental immunology Helper cells Humans Hypersensitivity Hypersensitivity - immunology Hypersensitivity - physiopathology Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - physiopathology Immune response Immunoglobulin E Immunoglobulin E - blood Immunomodulation Inflammation Lymphocytes T Medical research Medical sciences Mice Mucosa Osteopontin Osteopontin - immunology Osteopontin - metabolism Pneumology Respiratory tract Rodents
Title	Role of osteopontin, a multifunctional protein, in allergy and asthma
URI	https://api.istex.fr/ark:/67375/WNG-KCF91XHG-4/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2222.2011.03775.x https://www.ncbi.nlm.nih.gov/pubmed/21623969 https://www.proquest.com/docview/1545784905 https://www.proquest.com/docview/1328507925 https://www.proquest.com/docview/902811491
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