Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine) dendron-bearing lipids
In an earlier study, we developed a new type of gene vector using poly(amidoamine) (PAMAM) dendron-bearing lipids and reported that their transfection activity was affected by their structures, such as dendron generation and alkyl chain length. In this study, for improvement of their performance as...
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| Published in | Journal of controlled release Vol. 160; no. 3; pp. 552 - 560 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier B.V
28.06.2012
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0168-3659 1873-4995 1873-4995 |
| DOI | 10.1016/j.jconrel.2012.04.002 |
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| Abstract | In an earlier study, we developed a new type of gene vector using poly(amidoamine) (PAMAM) dendron-bearing lipids and reported that their transfection activity was affected by their structures, such as dendron generation and alkyl chain length. In this study, for improvement of their performance as gene vectors, we examined the effect of unsaturated chains of the dendron-bearing lipids using DL-G1-2C18, which consists of PAMAM G1 dendron moiety and two octadecyl chains, and achieved the most efficient transfection activity among the dendron-bearing lipids having saturated alkyl chains, and DL-G1-2C18-U2, which consists of the same dendron-moiety and two octadecenyl chains. DL-G1-2C18-U2 showed a higher ability to form lipoplexes with plasmid DNA than DL-G1-2C18. The DL-G1-2C18-U2 lipoplexes exhibited much smaller particle sizes than the DL-G1-2C18. In addition, the DL-G1-2C18-U2 lipoplexes exhibited more efficient transfection of HeLa cells than DL-G1-2C18 did. Results demonstrate the importance of unsaturated chains for the production of the dendron-bearing lipids having excellent gene transfection performance. Without the help of additional fusogenic lipids such as dioleoylphosphatidylethanolamine, DL-G1-2C18-U2 lipoplexes achieved the highly efficient transfection of the cells without marked cellular toxicity, in the presence of serum. Therefore, DL-G1-2C18-U2 might be promising as a potent gene vector.
Dendron-based lipid having unsaturated bonds (DL-G1-U2) form the smaller complexes with pDNA and induce higher transgene expression than its counterpart lipid not having unsaturated bond (DL-G1). [Display omitted] |
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| AbstractList | In an earlier study, we developed a new type of gene vector using poly(amidoamine) (PAMAM) dendron-bearing lipids and reported that their transfection activity was affected by their structures, such as dendron generation and alkyl chain length. In this study, for improvement of their performance as gene vectors, we examined the effect of unsaturated chains of the dendron-bearing lipids using DL-G1-2C₁₈, which consists of PAMAM G1 dendron moiety and two octadecyl chains, and achieved the most efficient transfection activity among the dendron-bearing lipids having saturated alkyl chains, and DL-G1-2C₁₈-U2, which consists of the same dendron-moiety and two octadecenyl chains. DL-G1-2C₁₈-U2 showed a higher ability to form lipoplexes with plasmid DNA than DL-G1-2C₁₈. The DL-G1-2C₁₈-U2 lipoplexes exhibited much smaller particle sizes than the DL-G1-2C₁₈. In addition, the DL-G1-2C₁₈-U2 lipoplexes exhibited more efficient transfection of HeLa cells than DL-G1-2C₁₈ did. Results demonstrate the importance of unsaturated chains for the production of the dendron-bearing lipids having excellent gene transfection performance. Without the help of additional fusogenic lipids such as dioleoylphosphatidylethanolamine, DL-G1-2C₁₈-U2 lipoplexes achieved the highly efficient transfection of the cells without marked cellular toxicity, in the presence of serum. Therefore, DL-G1-2C₁₈-U2 might be promising as a potent gene vector. In an earlier study, we developed a new type of gene vector using poly(amidoamine) (PAMAM) dendron-bearing lipids and reported that their transfection activity was affected by their structures, such as dendron generation and alkyl chain length. In this study, for improvement of their performance as gene vectors, we examined the effect of unsaturated chains of the dendron-bearing lipids using DL-G1-2C(18), which consists of PAMAM G1 dendron moiety and two octadecyl chains, and achieved the most efficient transfection activity among the dendron-bearing lipids having saturated alkyl chains, and DL-G1-2C(18)-U2, which consists of the same dendron-moiety and two octadecenyl chains. DL-G1-2C(18)-U2 showed a higher ability to form lipoplexes with plasmid DNA than DL-G1-2C(18). The DL-G1-2C(18)-U2 lipoplexes exhibited much smaller particle sizes than the DL-G1-2C(18). In addition, the DL-G1-2C(18)-U2 lipoplexes exhibited more efficient transfection of HeLa cells than DL-G1-2C(18) did. Results demonstrate the importance of unsaturated chains for the production of the dendron-bearing lipids having excellent gene transfection performance. Without the help of additional fusogenic lipids such as dioleoylphosphatidylethanolamine, DL-G1-2C(18)-U2 lipoplexes achieved the highly efficient transfection of the cells without marked cellular toxicity, in the presence of serum. Therefore, DL-G1-2C(18)-U2 might be promising as a potent gene vector.In an earlier study, we developed a new type of gene vector using poly(amidoamine) (PAMAM) dendron-bearing lipids and reported that their transfection activity was affected by their structures, such as dendron generation and alkyl chain length. In this study, for improvement of their performance as gene vectors, we examined the effect of unsaturated chains of the dendron-bearing lipids using DL-G1-2C(18), which consists of PAMAM G1 dendron moiety and two octadecyl chains, and achieved the most efficient transfection activity among the dendron-bearing lipids having saturated alkyl chains, and DL-G1-2C(18)-U2, which consists of the same dendron-moiety and two octadecenyl chains. DL-G1-2C(18)-U2 showed a higher ability to form lipoplexes with plasmid DNA than DL-G1-2C(18). The DL-G1-2C(18)-U2 lipoplexes exhibited much smaller particle sizes than the DL-G1-2C(18). In addition, the DL-G1-2C(18)-U2 lipoplexes exhibited more efficient transfection of HeLa cells than DL-G1-2C(18) did. Results demonstrate the importance of unsaturated chains for the production of the dendron-bearing lipids having excellent gene transfection performance. Without the help of additional fusogenic lipids such as dioleoylphosphatidylethanolamine, DL-G1-2C(18)-U2 lipoplexes achieved the highly efficient transfection of the cells without marked cellular toxicity, in the presence of serum. Therefore, DL-G1-2C(18)-U2 might be promising as a potent gene vector. In an earlier study, we developed a new type of gene vector using poly(amidoamine) (PAMAM) dendron-bearing lipids and reported that their transfection activity was affected by their structures, such as dendron generation and alkyl chain length. In this study, for improvement of their performance as gene vectors, we examined the effect of unsaturated chains of the dendron-bearing lipids using DL-G1-2C18, which consists of PAMAM G1 dendron moiety and two octadecyl chains, and achieved the most efficient transfection activity among the dendron-bearing lipids having saturated alkyl chains, and DL-G1-2C18-U2, which consists of the same dendron-moiety and two octadecenyl chains. DL-G1-2C18-U2 showed a higher ability to form lipoplexes with plasmid DNA than DL-G1-2C18. The DL-G1-2C18-U2 lipoplexes exhibited much smaller particle sizes than the DL-G1-2C18. In addition, the DL-G1-2C18-U2 lipoplexes exhibited more efficient transfection of HeLa cells than DL-G1-2C18 did. Results demonstrate the importance of unsaturated chains for the production of the dendron-bearing lipids having excellent gene transfection performance. Without the help of additional fusogenic lipids such as dioleoylphosphatidylethanolamine, DL-G1-2C18-U2 lipoplexes achieved the highly efficient transfection of the cells without marked cellular toxicity, in the presence of serum. Therefore, DL-G1-2C18-U2 might be promising as a potent gene vector. Dendron-based lipid having unsaturated bonds (DL-G1-U2) form the smaller complexes with pDNA and induce higher transgene expression than its counterpart lipid not having unsaturated bond (DL-G1). [Display omitted] In an earlier study, we developed a new type of gene vector using poly(amidoamine) (PAMAM) dendron-bearing lipids and reported that their transfection activity was affected by their structures, such as dendron generation and alkyl chain length. In this study, for improvement of their performance as gene vectors, we examined the effect of unsaturated chains of the dendron-bearing lipids using DL-G1-2C(18), which consists of PAMAM G1 dendron moiety and two octadecyl chains, and achieved the most efficient transfection activity among the dendron-bearing lipids having saturated alkyl chains, and DL-G1-2C(18)-U2, which consists of the same dendron-moiety and two octadecenyl chains. DL-G1-2C(18)-U2 showed a higher ability to form lipoplexes with plasmid DNA than DL-G1-2C(18). The DL-G1-2C(18)-U2 lipoplexes exhibited much smaller particle sizes than the DL-G1-2C(18). In addition, the DL-G1-2C(18)-U2 lipoplexes exhibited more efficient transfection of HeLa cells than DL-G1-2C(18) did. Results demonstrate the importance of unsaturated chains for the production of the dendron-bearing lipids having excellent gene transfection performance. Without the help of additional fusogenic lipids such as dioleoylphosphatidylethanolamine, DL-G1-2C(18)-U2 lipoplexes achieved the highly efficient transfection of the cells without marked cellular toxicity, in the presence of serum. Therefore, DL-G1-2C(18)-U2 might be promising as a potent gene vector. |
| Author | Yuba, Eiji Iwashita, Shinki Kojima, Chie Harada, Atsushi Kono, Kenji Nakajima, Yosuke Tsukamoto, Kota |
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| Cites_doi | 10.1016/S0169-409X(98)00004-0 10.1021/bc9600630 10.1016/S0168-3659(98)00180-1 10.1002/anie.201101007 10.1021/bc00023a012 10.1007/s11164-009-0083-z 10.1038/sj.gt.3300865 10.1016/j.farmac.2004.06.007 10.1016/0005-2736(95)80016-9 10.1002/(SICI)1097-0290(20000120)67:2<217::AID-BIT11>3.0.CO;2-Q 10.1016/0005-2736(95)00135-P 10.1016/S0005-2736(99)00023-1 10.1126/science.1164270 10.1016/S0014-5793(98)00837-0 10.1016/S0006-3495(97)78282-1 10.1073/pnas.94.26.14412 10.1016/0022-1759(83)90303-4 10.1021/bc060311k 10.1021/bc070014v 10.1016/S0959-440X(00)00230-X 10.1016/j.jconrel.2010.03.001 10.1016/0005-2736(95)80017-A 10.1016/j.cell.2007.11.019 10.1021/bi00570a021 10.1021/bc050012f 10.1021/bc025663f 10.2533/chimia.1997.34 10.1038/sj.gt.3301365 10.1021/bc9801070 10.1016/0014-5793(94)01315-2 10.1016/j.cell.2006.07.024 10.1016/j.ejps.2010.03.019 10.1073/pnas.92.16.7297 10.1073/pnas.76.12.6361 10.1016/j.stem.2009.08.001 10.1016/S0021-9258(19)45197-1 10.1016/S0006-3495(96)79309-8 10.1021/bc200368b |
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| Keywords | Unsaturated bond Gene delivery Poly(amidoamine) dendrimer Transfection Dendron-based lipid Dendrimer Pharmaceutical technology Branched polymer Lipids Genetic transfer Amidoamine polymer Alkyl Gene therapy Dendritic structure |
| Language | English |
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| References | Takahashi, Hirose, Kojima, Harada, Kono (bb0110) 2007; 18 Yuba, Harada, Sakanishi, Kono (bb0195) 2011; 149 Arpicco, Canevari, Ceruti, Galmozzi, Rocco, Cattel (bb0125) 2004; 59 Boussif, Lezoualc'h, Zanta, Mergny, Scherman, Demeneix, Behr (bb0065) 1995; 92 Takahashi, Harada, Emi, Kono (bb0100) 2005; 16 Takahashi, Kono, Itoh, Emi, Takagishi (bb0095) 2003; 14 Monkkonen, Urtti (bb0025) 1998; 34 Farhood, Serbina, Huang (bb0050) 1995; 1235 Kono, Henmi, Yamashita, Hayashi, Takagishi (bb0135) 1999; 59 Pack, Putnam, Langer (bb0070) 2000; 67 Haensler, Szoka (bb0080) 1993; 4 Behr (bb0060) 1997; 51 Jahnig (bb0155) 1979; 76 Kono, Torikoshi, Mitsutomi, Itoh, Emi, Yanagie, Takagishi (bb0055) 2001; 8 Noguchi, Furuno, Kawaura, Nakanishi (bb0035) 1998; 433 Yoshida, Takahashi, Okita, Ichisaka, Yamanaka (bb0020) 2009; 5 Midoux, Monsigny (bb0075) 1999; 10 Illinger, Duportail, Mely, Poirel-Morales, Gerard, Kuhry (bb0130) 1995; 1239 Mosmann (bb0190) 1983; 65 Wrobel, Collins (bb0030) 1995; 1235 Kono, Murakami, Hiranaka, Yuba, Kojima, Harada, Sakurai (bb0145) 2011; 50 Ilarduya, Sun, Duzgunes (bb0175) 2010; 40 Takahashi, Tanabe, Ohnuki, Narita, Ichisaka, Tomoda, Yamanaka (bb0010) 2007; 131 Kono, Ikeda, Tsukamoto, Yuba, Kojima, Harada (bb0120) 2012; 23 Takahashi, Yuba, Kojima, Harada, Kono (bb0115) 2009; 35 Lakowicz, Prendergast, Hogen (bb0150) 1979; 18 Pitard, Aguerre, Airiau, Lachages, Boukhnikachvili, Byk, Dubertret, Herviou, Scherman, Mayaux, Crouzet (bb0170) 1997; 94 Pires, Sioes, Nir, Gaspar, Duzgunes, Pedroso de Lima (bb0165) 1999; 1418 Takahashi, Kojima, Harada, Kono (bb0105) 2007; 18 Hui, Langner, Zhao, Ross, Hurley, Chan (bb0045) 1996; 71 Okita, Nakagawa, Hyenjong, Ichisaka, Yamanaka (bb0015) 2008; 322 Mok, Cullis (bb0040) 1997; 73 Safinya (bb0180) 2001; 11 Kubasiak, Tomalia (bb0090) 2004; 9 Hinz, Sturtevant (bb0140) 1972; 247 Li, Tseng, Stolz, Wu, Watkins, Huang (bb0185) 1999; 6 Sternberg, Sorgi, Huang (bb0160) 1994; 356 Tang, Redemann, Szoka (bb0085) 1996; 7 Takahashi, Yamanaka (bb0005) 2006; 126 Hui (10.1016/j.jconrel.2012.04.002_bb0045) 1996; 71 Midoux (10.1016/j.jconrel.2012.04.002_bb0075) 1999; 10 Li (10.1016/j.jconrel.2012.04.002_bb0185) 1999; 6 Behr (10.1016/j.jconrel.2012.04.002_bb0060) 1997; 51 Okita (10.1016/j.jconrel.2012.04.002_bb0015) 2008; 322 Lakowicz (10.1016/j.jconrel.2012.04.002_bb0150) 1979; 18 Illinger (10.1016/j.jconrel.2012.04.002_bb0130) 1995; 1239 Takahashi (10.1016/j.jconrel.2012.04.002_bb0005) 2006; 126 Wrobel (10.1016/j.jconrel.2012.04.002_bb0030) 1995; 1235 Jahnig (10.1016/j.jconrel.2012.04.002_bb0155) 1979; 76 Hinz (10.1016/j.jconrel.2012.04.002_bb0140) 1972; 247 Tang (10.1016/j.jconrel.2012.04.002_bb0085) 1996; 7 Monkkonen (10.1016/j.jconrel.2012.04.002_bb0025) 1998; 34 Pires (10.1016/j.jconrel.2012.04.002_bb0165) 1999; 1418 Noguchi (10.1016/j.jconrel.2012.04.002_bb0035) 1998; 433 Kubasiak (10.1016/j.jconrel.2012.04.002_bb0090) 2004; 9 Yuba (10.1016/j.jconrel.2012.04.002_bb0195) 2011; 149 Ilarduya (10.1016/j.jconrel.2012.04.002_bb0175) 2010; 40 Mok (10.1016/j.jconrel.2012.04.002_bb0040) 1997; 73 Boussif (10.1016/j.jconrel.2012.04.002_bb0065) 1995; 92 Pack (10.1016/j.jconrel.2012.04.002_bb0070) 2000; 67 Safinya (10.1016/j.jconrel.2012.04.002_bb0180) 2001; 11 Kono (10.1016/j.jconrel.2012.04.002_bb0120) 2012; 23 Kono (10.1016/j.jconrel.2012.04.002_bb0055) 2001; 8 Kono (10.1016/j.jconrel.2012.04.002_bb0135) 1999; 59 Arpicco (10.1016/j.jconrel.2012.04.002_bb0125) 2004; 59 Sternberg (10.1016/j.jconrel.2012.04.002_bb0160) 1994; 356 Mosmann (10.1016/j.jconrel.2012.04.002_bb0190) 1983; 65 Takahashi (10.1016/j.jconrel.2012.04.002_bb0115) 2009; 35 Takahashi (10.1016/j.jconrel.2012.04.002_bb0010) 2007; 131 Farhood (10.1016/j.jconrel.2012.04.002_bb0050) 1995; 1235 Takahashi (10.1016/j.jconrel.2012.04.002_bb0105) 2007; 18 Kono (10.1016/j.jconrel.2012.04.002_bb0145) 2011; 50 Haensler (10.1016/j.jconrel.2012.04.002_bb0080) 1993; 4 Takahashi (10.1016/j.jconrel.2012.04.002_bb0100) 2005; 16 Pitard (10.1016/j.jconrel.2012.04.002_bb0170) 1997; 94 Yoshida (10.1016/j.jconrel.2012.04.002_bb0020) 2009; 5 Takahashi (10.1016/j.jconrel.2012.04.002_bb0110) 2007; 18 Takahashi (10.1016/j.jconrel.2012.04.002_bb0095) 2003; 14 |
| References_xml | – volume: 67 start-page: 217 year: 2000 end-page: 223 ident: bb0070 article-title: Design of imidazole-containing endosomo-lytic biopolymers for gene delivery publication-title: Biotechnol. Bioeng. – volume: 322 start-page: 949 year: 2008 end-page: 953 ident: bb0015 article-title: Generation of mouse induced pluripotent stem cells without viral vectors publication-title: Science – volume: 71 start-page: 590 year: 1996 end-page: 599 ident: bb0045 article-title: The role of helper lipids in cationic liposome-mediated gene transfer publication-title: Biophys. J. – volume: 4 start-page: 372 year: 1993 end-page: 379 ident: bb0080 article-title: Polyamidoamine cascade polymers mediate efficient transfection of cells in culture publication-title: Bioconjug. Chem. – volume: 50 start-page: 6332 year: 2011 end-page: 6336 ident: bb0145 article-title: Thermosensitive molecular assemblies from PAMAM dendron-based lipids publication-title: Angew. Chem. Int. Ed. – volume: 18 start-page: 1349 year: 2007 end-page: 1354 ident: bb0105 article-title: Alkyl chain moieties of polyamidoamine dendron-bearing lipids influence their function as a nonviral gene vector publication-title: Bioconjug. Chem. – volume: 35 start-page: 1005 year: 2009 end-page: 1014 ident: bb0115 article-title: Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors publication-title: Res. Chem. Intermed. – volume: 1239 start-page: 58 year: 1995 end-page: 66 ident: bb0130 article-title: A comparison of the fluorescence properties of TMA-DPH as a probe for plasma membrane and for endocytic membrane publication-title: Biochim. Biophys. Acta – volume: 1235 start-page: 289 year: 1995 end-page: 295 ident: bb0050 article-title: The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer publication-title: Biochim. Biophys. Acta – volume: 34 start-page: 37 year: 1998 end-page: 49 ident: bb0025 article-title: Lipid fusion in oligonucleotide and gene delivery with cationic lipids publication-title: Adv. Drug Delivery Rev. – volume: 14 start-page: 764 year: 2003 end-page: 773 ident: bb0095 article-title: Synthesis of novel cationic lipids having polyamidoamine dendrons and their transfection activity publication-title: Bioconjug. Chem. – volume: 18 start-page: 508 year: 1979 end-page: 519 ident: bb0150 article-title: Differential polarized phase fluorometric investigations of diphenylhexatriene in lipid bilayers. Quantitation of hindered depolarizing rotations publication-title: Biochemistry – volume: 59 start-page: 63 year: 1999 end-page: 75 ident: bb0135 article-title: Improvement of temperature-sensitivity of poly(N-isopropylacrylamide)-modified liposomes publication-title: J. Control. Release – volume: 16 start-page: 1160 year: 2005 end-page: 1165 ident: bb0100 article-title: Preparation of efficient gene carriers using a polyamidoamine dendron-bearing lipid: improvement of serum resistance publication-title: Bioconjug. Chem. – volume: 7 start-page: 703 year: 1996 end-page: 714 ident: bb0085 article-title: In vitro gene delivery by degraded polyamidoamine dendrimers publication-title: Bioconjug. Chem. – volume: 1235 start-page: 296 year: 1995 end-page: 304 ident: bb0030 article-title: Fusion of cationic liposomes with mammalian cells occurs after endocytosis publication-title: Biochim. Biophys. Acta – volume: 76 start-page: 6361 year: 1979 end-page: 6365 ident: bb0155 article-title: Structural order of lipids and proteins in membranes: evaluation of fluorescence anisotropy data publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 1418 start-page: 71 year: 1999 end-page: 84 ident: bb0165 article-title: Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells publication-title: Biochim. Biophys. Acta – volume: 131 start-page: 861 year: 2007 end-page: 872 ident: bb0010 article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors publication-title: Cell – volume: 149 start-page: 72 year: 2011 end-page: 80 ident: bb0195 article-title: Carboxylated hyperbranched poly(glycidol)s for preparation of pH-sensitive liposomes publication-title: J. Control. Release – volume: 356 start-page: 361 year: 1994 end-page: 366 ident: bb0160 article-title: New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy publication-title: FEBS Lett. – volume: 5 start-page: 237 year: 2009 end-page: 241 ident: bb0020 article-title: Hypoxia enhances the generation of induced pluripotent stem cells publication-title: Cell Stem Cell – volume: 11 start-page: 440 year: 2001 end-page: 448 ident: bb0180 article-title: Structures of lipid-DNA complexes: supramolecular assembly and gene delivery publication-title: Curr. Opin. Struct. Biol. – volume: 51 start-page: 34 year: 1997 end-page: 36 ident: bb0060 article-title: The proton sponge: a trick to enter cells the viruses did not exploit publication-title: Chimica – volume: 59 start-page: 869 year: 2004 end-page: 878 ident: bb0125 article-title: Synthesis, characterization and transfection activity of new saturated and unsaturated cationic lipids publication-title: Farmaco – volume: 9 start-page: 133 year: 2004 end-page: 157 ident: bb0090 article-title: Cationic dendrimers as gene transfection vectors: dendri-poly(amidoamines) and dendri-poly(propyleneimines) publication-title: Polymeric Gene Delivery: Principles and Applications – volume: 18 start-page: 1163 year: 2007 end-page: 1169 ident: bb0110 article-title: Synthesis of poly(amidoamine) dendron-bearing lipids with poly(ethylene glycol) grafts and their use for stabilization of nonviral gene vectors publication-title: Bioconjug. Chem. – volume: 94 start-page: 14412 year: 1997 end-page: 14417 ident: bb0170 article-title: Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 433 start-page: 169 year: 1998 end-page: 173 ident: bb0035 article-title: Membrane fusion plays an important role in gene transfection mediated by cationic liposomes publication-title: FEBS Lett. – volume: 8 start-page: 5 year: 2001 end-page: 12 ident: bb0055 article-title: Novel gene delivery systems: complexes of fusogenic polymer-modified liposomes and lipoplexes publication-title: Gene Ther. – volume: 126 start-page: 663 year: 2006 end-page: 676 ident: bb0005 article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors publication-title: Cell – volume: 23 start-page: 871 year: 2012 end-page: 879 ident: bb0120 article-title: Polyamidoamine dendron-bearing lipids as a non-viral vector: influence of dendron generation publication-title: Bioconjug. Chem. – volume: 73 start-page: 2534 year: 1997 end-page: 2545 ident: bb0040 article-title: Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA publication-title: Biophys. J. – volume: 10 start-page: 406 year: 1999 end-page: 411 ident: bb0075 article-title: Efficient gene transfer by histidylated polylysine/pDNA complexes publication-title: Bioconjug. Chem. – volume: 247 start-page: 3697 year: 1972 end-page: 3700 ident: bb0140 article-title: Calorimetric investigation of the influence of cholesterol on the transition properties of bilayers formed from synthetic publication-title: J. Biol. Chem. – volume: 40 start-page: 159 year: 2010 end-page: 170 ident: bb0175 article-title: Gene delivery by lipoplexes and polyplexes publication-title: Eur. J. Pharm. Sci. – volume: 6 start-page: 585 year: 1999 end-page: 594 ident: bb0185 article-title: Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection publication-title: Gene Ther. – volume: 92 start-page: 7297 year: 1995 end-page: 7301 ident: bb0065 article-title: A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 65 start-page: 55 year: 1983 end-page: 63 ident: bb0190 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods – volume: 34 start-page: 37 year: 1998 ident: 10.1016/j.jconrel.2012.04.002_bb0025 article-title: Lipid fusion in oligonucleotide and gene delivery with cationic lipids publication-title: Adv. Drug Delivery Rev. doi: 10.1016/S0169-409X(98)00004-0 – volume: 7 start-page: 703 year: 1996 ident: 10.1016/j.jconrel.2012.04.002_bb0085 article-title: In vitro gene delivery by degraded polyamidoamine dendrimers publication-title: Bioconjug. Chem. doi: 10.1021/bc9600630 – volume: 59 start-page: 63 year: 1999 ident: 10.1016/j.jconrel.2012.04.002_bb0135 article-title: Improvement of temperature-sensitivity of poly(N-isopropylacrylamide)-modified liposomes publication-title: J. Control. Release doi: 10.1016/S0168-3659(98)00180-1 – volume: 50 start-page: 6332 year: 2011 ident: 10.1016/j.jconrel.2012.04.002_bb0145 article-title: Thermosensitive molecular assemblies from PAMAM dendron-based lipids publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201101007 – volume: 4 start-page: 372 year: 1993 ident: 10.1016/j.jconrel.2012.04.002_bb0080 article-title: Polyamidoamine cascade polymers mediate efficient transfection of cells in culture publication-title: Bioconjug. Chem. doi: 10.1021/bc00023a012 – volume: 35 start-page: 1005 year: 2009 ident: 10.1016/j.jconrel.2012.04.002_bb0115 article-title: Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors publication-title: Res. Chem. Intermed. doi: 10.1007/s11164-009-0083-z – volume: 6 start-page: 585 year: 1999 ident: 10.1016/j.jconrel.2012.04.002_bb0185 article-title: Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection publication-title: Gene Ther. doi: 10.1038/sj.gt.3300865 – volume: 59 start-page: 869 year: 2004 ident: 10.1016/j.jconrel.2012.04.002_bb0125 article-title: Synthesis, characterization and transfection activity of new saturated and unsaturated cationic lipids publication-title: Farmaco doi: 10.1016/j.farmac.2004.06.007 – volume: 1235 start-page: 289 year: 1995 ident: 10.1016/j.jconrel.2012.04.002_bb0050 article-title: The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(95)80016-9 – volume: 67 start-page: 217 year: 2000 ident: 10.1016/j.jconrel.2012.04.002_bb0070 article-title: Design of imidazole-containing endosomo-lytic biopolymers for gene delivery publication-title: Biotechnol. Bioeng. doi: 10.1002/(SICI)1097-0290(20000120)67:2<217::AID-BIT11>3.0.CO;2-Q – volume: 1239 start-page: 58 year: 1995 ident: 10.1016/j.jconrel.2012.04.002_bb0130 article-title: A comparison of the fluorescence properties of TMA-DPH as a probe for plasma membrane and for endocytic membrane publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(95)00135-P – volume: 1418 start-page: 71 year: 1999 ident: 10.1016/j.jconrel.2012.04.002_bb0165 article-title: Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells publication-title: Biochim. Biophys. Acta doi: 10.1016/S0005-2736(99)00023-1 – volume: 322 start-page: 949 year: 2008 ident: 10.1016/j.jconrel.2012.04.002_bb0015 article-title: Generation of mouse induced pluripotent stem cells without viral vectors publication-title: Science doi: 10.1126/science.1164270 – volume: 433 start-page: 169 year: 1998 ident: 10.1016/j.jconrel.2012.04.002_bb0035 article-title: Membrane fusion plays an important role in gene transfection mediated by cationic liposomes publication-title: FEBS Lett. doi: 10.1016/S0014-5793(98)00837-0 – volume: 73 start-page: 2534 year: 1997 ident: 10.1016/j.jconrel.2012.04.002_bb0040 article-title: Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA publication-title: Biophys. J. doi: 10.1016/S0006-3495(97)78282-1 – volume: 94 start-page: 14412 year: 1997 ident: 10.1016/j.jconrel.2012.04.002_bb0170 article-title: Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.94.26.14412 – volume: 65 start-page: 55 year: 1983 ident: 10.1016/j.jconrel.2012.04.002_bb0190 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods doi: 10.1016/0022-1759(83)90303-4 – volume: 18 start-page: 1349 year: 2007 ident: 10.1016/j.jconrel.2012.04.002_bb0105 article-title: Alkyl chain moieties of polyamidoamine dendron-bearing lipids influence their function as a nonviral gene vector publication-title: Bioconjug. Chem. doi: 10.1021/bc060311k – volume: 18 start-page: 1163 year: 2007 ident: 10.1016/j.jconrel.2012.04.002_bb0110 article-title: Synthesis of poly(amidoamine) dendron-bearing lipids with poly(ethylene glycol) grafts and their use for stabilization of nonviral gene vectors publication-title: Bioconjug. Chem. doi: 10.1021/bc070014v – volume: 11 start-page: 440 year: 2001 ident: 10.1016/j.jconrel.2012.04.002_bb0180 article-title: Structures of lipid-DNA complexes: supramolecular assembly and gene delivery publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/S0959-440X(00)00230-X – volume: 149 start-page: 72 year: 2011 ident: 10.1016/j.jconrel.2012.04.002_bb0195 article-title: Carboxylated hyperbranched poly(glycidol)s for preparation of pH-sensitive liposomes publication-title: J. Control. Release doi: 10.1016/j.jconrel.2010.03.001 – volume: 1235 start-page: 296 year: 1995 ident: 10.1016/j.jconrel.2012.04.002_bb0030 article-title: Fusion of cationic liposomes with mammalian cells occurs after endocytosis publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(95)80017-A – volume: 131 start-page: 861 year: 2007 ident: 10.1016/j.jconrel.2012.04.002_bb0010 article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors publication-title: Cell doi: 10.1016/j.cell.2007.11.019 – volume: 18 start-page: 508 year: 1979 ident: 10.1016/j.jconrel.2012.04.002_bb0150 article-title: Differential polarized phase fluorometric investigations of diphenylhexatriene in lipid bilayers. Quantitation of hindered depolarizing rotations publication-title: Biochemistry doi: 10.1021/bi00570a021 – volume: 16 start-page: 1160 year: 2005 ident: 10.1016/j.jconrel.2012.04.002_bb0100 article-title: Preparation of efficient gene carriers using a polyamidoamine dendron-bearing lipid: improvement of serum resistance publication-title: Bioconjug. Chem. doi: 10.1021/bc050012f – volume: 14 start-page: 764 year: 2003 ident: 10.1016/j.jconrel.2012.04.002_bb0095 article-title: Synthesis of novel cationic lipids having polyamidoamine dendrons and their transfection activity publication-title: Bioconjug. Chem. doi: 10.1021/bc025663f – volume: 51 start-page: 34 year: 1997 ident: 10.1016/j.jconrel.2012.04.002_bb0060 article-title: The proton sponge: a trick to enter cells the viruses did not exploit publication-title: Chimica doi: 10.2533/chimia.1997.34 – volume: 8 start-page: 5 year: 2001 ident: 10.1016/j.jconrel.2012.04.002_bb0055 article-title: Novel gene delivery systems: complexes of fusogenic polymer-modified liposomes and lipoplexes publication-title: Gene Ther. doi: 10.1038/sj.gt.3301365 – volume: 10 start-page: 406 year: 1999 ident: 10.1016/j.jconrel.2012.04.002_bb0075 article-title: Efficient gene transfer by histidylated polylysine/pDNA complexes publication-title: Bioconjug. Chem. doi: 10.1021/bc9801070 – volume: 9 start-page: 133 year: 2004 ident: 10.1016/j.jconrel.2012.04.002_bb0090 article-title: Cationic dendrimers as gene transfection vectors: dendri-poly(amidoamines) and dendri-poly(propyleneimines) – volume: 356 start-page: 361 year: 1994 ident: 10.1016/j.jconrel.2012.04.002_bb0160 article-title: New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy publication-title: FEBS Lett. doi: 10.1016/0014-5793(94)01315-2 – volume: 126 start-page: 663 year: 2006 ident: 10.1016/j.jconrel.2012.04.002_bb0005 article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors publication-title: Cell doi: 10.1016/j.cell.2006.07.024 – volume: 40 start-page: 159 year: 2010 ident: 10.1016/j.jconrel.2012.04.002_bb0175 article-title: Gene delivery by lipoplexes and polyplexes publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2010.03.019 – volume: 92 start-page: 7297 year: 1995 ident: 10.1016/j.jconrel.2012.04.002_bb0065 article-title: A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.92.16.7297 – volume: 76 start-page: 6361 year: 1979 ident: 10.1016/j.jconrel.2012.04.002_bb0155 article-title: Structural order of lipids and proteins in membranes: evaluation of fluorescence anisotropy data publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.76.12.6361 – volume: 5 start-page: 237 year: 2009 ident: 10.1016/j.jconrel.2012.04.002_bb0020 article-title: Hypoxia enhances the generation of induced pluripotent stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.08.001 – volume: 247 start-page: 3697 year: 1972 ident: 10.1016/j.jconrel.2012.04.002_bb0140 article-title: Calorimetric investigation of the influence of cholesterol on the transition properties of bilayers formed from synthetic l-α-lecithins in aqueous suspension publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)45197-1 – volume: 71 start-page: 590 year: 1996 ident: 10.1016/j.jconrel.2012.04.002_bb0045 article-title: The role of helper lipids in cationic liposome-mediated gene transfer publication-title: Biophys. J. doi: 10.1016/S0006-3495(96)79309-8 – volume: 23 start-page: 871 year: 2012 ident: 10.1016/j.jconrel.2012.04.002_bb0120 article-title: Polyamidoamine dendron-bearing lipids as a non-viral vector: influence of dendron generation publication-title: Bioconjug. Chem. doi: 10.1021/bc200368b |
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| SubjectTerms | Biological and medical sciences blood serum Dendrimers - administration & dosage Dendrimers - chemistry Dendron-based lipid DNA - administration & dosage DNA - genetics Gene delivery General pharmacology genes Green Fluorescent Proteins - genetics HeLa Cells Humans lipids Liposomes Luciferases - genetics Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphatidylethanolamines - administration & dosage Phosphatidylethanolamines - chemistry Plasmids Poly(amidoamine) dendrimer Rhodamines - administration & dosage Rhodamines - chemistry toxicity Transfection Transfection - methods Unsaturated bond |
| Title | Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine) dendron-bearing lipids |
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