In vitro and in vivo evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity
Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solu...
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| Published in | Drug delivery Vol. 27; no. 1; pp. 54 - 65 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Taylor & Francis
01.01.2020
Taylor & Francis Ltd Taylor & Francis Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1071-7544 1521-0464 1521-0464 |
| DOI | 10.1080/10717544.2019.1704941 |
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| Abstract | Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solubility and resultant low bioavailability limit its potentials as an adjuvant phytochemical drug for chemotherapy. Thus, this study prepared the inclusion complex of didymin with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin to improve its bioavailability and then evaluate their chemosensitization effects. The didymin inclusion complexes formulation was prepared and their host-guest structure was characterized by FT-IR, PXRD, DSC, and SEM techniques. In vitro/in vivo results demonstrated that didymin inclusion complex enhanced its water solubility and orally bioavailability. Furthermore, didymin inclusion complex exerted considerable chemosensitivity potency, and improve the anti-tumor effects of chemotherapeutics in vivo. Therefore, didymin inclusion complex could provide a safe, effective, economical, and adjuvant drug for future treatment of chemoresistant cancers. |
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| AbstractList | Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solubility and resultant low bioavailability limit its potentials as an adjuvant phytochemical drug for chemotherapy. Thus, this study prepared the inclusion complex of didymin with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin to improve its bioavailability and then evaluate their chemosensitization effects. The didymin inclusion complexes formulation was prepared and their host-guest structure was characterized by FT-IR, PXRD, DSC, and SEM techniques. In vitro/in vivo results demonstrated that didymin inclusion complex enhanced its water solubility and orally bioavailability. Furthermore, didymin inclusion complex exerted considerable chemosensitivity potency, and improve the anti-tumor effects of chemotherapeutics in vivo. Therefore, didymin inclusion complex could provide a safe, effective, economical, and adjuvant drug for future treatment of chemoresistant cancers.Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solubility and resultant low bioavailability limit its potentials as an adjuvant phytochemical drug for chemotherapy. Thus, this study prepared the inclusion complex of didymin with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin to improve its bioavailability and then evaluate their chemosensitization effects. The didymin inclusion complexes formulation was prepared and their host-guest structure was characterized by FT-IR, PXRD, DSC, and SEM techniques. In vitro/in vivo results demonstrated that didymin inclusion complex enhanced its water solubility and orally bioavailability. Furthermore, didymin inclusion complex exerted considerable chemosensitivity potency, and improve the anti-tumor effects of chemotherapeutics in vivo. Therefore, didymin inclusion complex could provide a safe, effective, economical, and adjuvant drug for future treatment of chemoresistant cancers. Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solubility and resultant low bioavailability limit its potentials as an adjuvant phytochemical drug for chemotherapy. Thus, this study prepared the inclusion complex of didymin with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin to improve its bioavailability and then evaluate their chemosensitization effects. The didymin inclusion complexes formulation was prepared and their host-guest structure was characterized by FT-IR, PXRD, DSC, and SEM techniques. / results demonstrated that didymin inclusion complex enhanced its water solubility and orally bioavailability. Furthermore, didymin inclusion complex exerted considerable chemosensitivity potency, and improve the anti-tumor effects of chemotherapeutics . Therefore, didymin inclusion complex could provide a safe, effective, economical, and adjuvant drug for future treatment of chemoresistant cancers. Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solubility and resultant low bioavailability limit its potentials as an adjuvant phytochemical drug for chemotherapy. Thus, this study prepared the inclusion complex of didymin with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin to improve its bioavailability and then evaluate their chemosensitization effects. The didymin inclusion complexes formulation was prepared and their host-guest structure was characterized by FT-IR, PXRD, DSC, and SEM techniques. In vitro/in vivo results demonstrated that didymin inclusion complex enhanced its water solubility and orally bioavailability. Furthermore, didymin inclusion complex exerted considerable chemosensitivity potency, and improve the anti-tumor effects of chemotherapeutics in vivo. Therefore, didymin inclusion complex could provide a safe, effective, economical, and adjuvant drug for future treatment of chemoresistant cancers. Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solubility and resultant low bioavailability limit its potentials as an adjuvant phytochemical drug for chemotherapy. Thus, this study prepared the inclusion complex of didymin with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin to improve its bioavailability and then evaluate their chemosensitization effects. The didymin inclusion complexes formulation was prepared and their host-guest structure was characterized by FT-IR, PXRD, DSC, and SEM techniques. In vitro / in vivo results demonstrated that didymin inclusion complex enhanced its water solubility and orally bioavailability. Furthermore, didymin inclusion complex exerted considerable chemosensitivity potency, and improve the anti-tumor effects of chemotherapeutics in vivo . Therefore, didymin inclusion complex could provide a safe, effective, economical, and adjuvant drug for future treatment of chemoresistant cancers. Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solubility and resultant low bioavailability limit its potentials as an adjuvant phytochemical drug for chemotherapy. Thus, this study prepared the inclusion complex of didymin with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin to improve its bioavailability and then evaluate their chemosensitization effects. The didymin inclusion complexes formulation was prepared and their host-guest structure was characterized by FT-IR, PXRD, DSC, and SEM techniques. In vitro/in vivo results demonstrated that didymin inclusion complex enhanced its water solubility and orally bioavailability. Furthermore, didymin inclusion complex exerted considerable chemosensitivity potency, and improve the anti-tumor effects of chemotherapeutics in vivo. Therefore, didymin inclusion complex could provide a safe, effective, economical, and adjuvant drug for future treatment of chemoresistant cancers. |
| Author | Xu, He-Lin Yao, Qing Lin, Meng-Ting Jiang, Xue Zhao, Ying-Zheng Kou, Longfa Zhu, Yin-Di Huang, Zhi-Wei Zheng, Ya-Wen Lan, Qing-Hua |
| Author_xml | – sequence: 1 givenname: Qing surname: Yao fullname: Yao, Qing organization: School of Pharmaceutical Sciences, Wenzhou Medical University – sequence: 2 givenname: Meng-Ting surname: Lin fullname: Lin, Meng-Ting organization: School of Pharmaceutical Sciences, Wenzhou Medical University – sequence: 3 givenname: Qing-Hua surname: Lan fullname: Lan, Qing-Hua organization: School of Pharmaceutical Sciences, Wenzhou Medical University – sequence: 4 givenname: Zhi-Wei surname: Huang fullname: Huang, Zhi-Wei organization: School of Pharmaceutical Sciences, Wenzhou Medical University – sequence: 5 givenname: Ya-Wen surname: Zheng fullname: Zheng, Ya-Wen organization: School of Pharmaceutical Sciences, Wenzhou Medical University – sequence: 6 givenname: Xue surname: Jiang fullname: Jiang, Xue organization: School of Pharmaceutical Sciences, Wenzhou Medical University – sequence: 7 givenname: Yin-Di surname: Zhu fullname: Zhu, Yin-Di organization: School of Pharmaceutical Sciences, Wenzhou Medical University – sequence: 8 givenname: Longfa surname: Kou fullname: Kou, Longfa organization: Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University – sequence: 9 givenname: He-Lin surname: Xu fullname: Xu, He-Lin organization: School of Pharmaceutical Sciences, Wenzhou Medical University – sequence: 10 givenname: Ying-Zheng surname: Zhao fullname: Zhao, Ying-Zheng organization: School of Pharmaceutical Sciences, Wenzhou Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31858849$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.ijpharm.2016.08.007 10.1158/1940-6207.CAPR-11-0318 10.1021/acs.molpharmaceut.7b00278 10.1021/acsami.6b03064 10.1016/j.nano.2019.03.012 10.3390/molecules23102547 10.1016/j.yrtph.2016.10.013 10.1016/j.fct.2019.01.038 10.1016/j.intimp.2016.11.028 10.1016/j.ijpharm.2017.09.060 10.1016/j.molliq.2019.02.127 10.1124/dmd.113.056176 10.1021/jp409579m 10.1016/j.foodchem.2018.04.008 10.1016/j.lungcan.2009.08.013 10.1007/s10847-014-0410-x 10.1038/cddis.2015.195 10.1080/17425247.2018.1517749 10.1016/j.jff.2017.06.052 10.1016/j.biomaterials.2016.08.026 10.1016/j.foodchem.2018.02.007 10.1016/j.carbpol.2013.09.035 10.1016/j.ijpharm.2017.04.050 10.1016/j.carbpol.2016.09.072 |
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| Copyright | 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019 The Author(s) |
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| Keywords | 2-hydroxypropyl-β-cyclodextrin inclusion complex multidrug resistance chemosensitization Didymin |
| Language | English |
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| SubjectTerms | 2-Hydroxypropyl-beta-cyclodextrin - chemistry 2-hydroxypropyl-β-cyclodextrin Animals Aqueous solutions beta-Cyclodextrins - chemistry Bioavailability Calorimetry, Differential Scanning Cancer therapies chemosensitization Chemotherapy Didymin Drug resistance Flavonoids Flavonoids - administration & dosage Flavonoids - pharmacokinetics Flavonoids - pharmacology Fruits Glycosides - administration & dosage Glycosides - pharmacokinetics Glycosides - pharmacology Human Umbilical Vein Endothelial Cells Humans inclusion complex Male MCF-7 Cells multidrug resistance Multidrug resistant organisms PC12 Cells Pharmaceutical sciences Phytochemicals Rats Solubility Spectroscopy, Fourier Transform Infrared Technology, Pharmaceutical - methods X-Ray Diffraction |
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| Title | In vitro and in vivo evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity |
| URI | https://www.tandfonline.com/doi/abs/10.1080/10717544.2019.1704941 https://www.ncbi.nlm.nih.gov/pubmed/31858849 https://www.proquest.com/docview/2477991140 https://www.proquest.com/docview/2329738326 https://pubmed.ncbi.nlm.nih.gov/PMC6968488 https://doaj.org/article/6971cfe62daf45ed9c5ee59ac95f93c9 |
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