STAT6 gain-of-function variant exacerbates multiple allergic symptoms - Takeuchi, Ichiro; Yanagi, Kumiko; Takada, Shuji; Uchiyama, Toru; Igarashi, Arisa; Motomura, Kenichiro; Hayashi, Yuka; Nagano, Naoko; Matsuoka, Ryo; Sugiyama, Hiroki; Yoshioka, Takako; Saito, Hirohisa; et al. (Journal of allergy and clinical immunology, 2023)
Keywords: Animals; atopic dermatitis; Dermatitis, Atopic - genetics; eosinophilic gastrointestinal disorder; Gain of Function Mutation; HEK293 Cells; Humans; hyper-IgE syndrome; hypereosinophilia; Hypersensitivity - genetics; Immunoglobulin E; Interleukin-4 - genetics; Mice; primary atopic disorders; Signal Transduction; STAT6; STAT6 Transcription Factor - genetics; STAT6 Transcription Factor - metabolism; Th2 Cells; primary atopic disorders; PAD; LCL; hypereosinophilia; atopic dermatitis; STAT6; eosinophilic gastrointestinal disorder; EoG; hyper-IgE syndrome; EGID; WT; GOF