The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies - Nitulescu, George Mihai; Stancov, Gheorghe; Seremet, Oana Cristina; Nitulescu, Georgiana; Mihai, Dragos Paul; Duta-Bratu, Cosmina Gabriela; Barbuceanu, Stefania Felicia; Olaru, Octavian Tudorel (Molecules (Basel, Switzerland), 2023)
Keywords: adenine-mimetic; Adenosine triphosphate; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; asciminib; ATP-competitive; avapritinib; Binding sites; Cancer; Care and treatment; Crizotinib; Drug approval; Drug Design; Drug development; encorafenib; Enzymes; Humans; Inhibitor drugs; Kinases; Mutation; Nitrogen; Pharmaceutical sciences; Phosphorylation; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - classification; Protein Kinase Inhibitors - pharmacology; Protein kinases; Proteins; Pyrazoles - chemistry; Pyrazoles - pharmacology; Pyrimidines; Review; Signal transduction; Structure-Activity Relationship; adenine-mimetic; ATP-competitive; crizotinib; pralsetinib; ruxolitinib; avapritinib; erdafitinib; pirtobrutinib; asciminib; encorafenib