18F-DOPA制备研究进展
6-[^18F]氟-L-多巴（^18F-DOPA）为神经系统疾病和脑部肿瘤的理想示踪剂,广泛用于神经内分泌瘤的显像。本文综述近几年亲电取代法和亲核取代法合成^18F-DOPA取得的新进展,重点介绍新型标记前体和手性相转移催化剂在亲核取代法制备^18F-DOPA中的应用。...
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| Published in | 同位素 Vol. 30; no. 1; pp. 71 - 77 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国科学院上海应用物理研究所放射化学与工程技术部,上海201800
2017
中国科学院核辐射与核能技术重点实验室,上海201800 中国科学院钍基熔盐堆核能系统卓越创新中心,上海201800 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-7512 |
| DOI | 10.7538/tws.2017.30.01.0071 |
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| Abstract | 6-[^18F]氟-L-多巴（^18F-DOPA）为神经系统疾病和脑部肿瘤的理想示踪剂,广泛用于神经内分泌瘤的显像。本文综述近几年亲电取代法和亲核取代法合成^18F-DOPA取得的新进展,重点介绍新型标记前体和手性相转移催化剂在亲核取代法制备^18F-DOPA中的应用。 |
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| AbstractList | TL92+3%R817.9; 6-[18F]氟-L-多巴(18F-DOPA)为神经系统疾病和脑部肿瘤的理想示踪剂,广泛用于神经内分泌瘤的显像.本文综述近几年亲电取代法和亲核取代法合成18 F-DOPA取得的新进展,重点介绍新型标记前体和手性相转移催化剂在亲核取代法制备18F-DOPA中的应用. 6-[^18F]氟-L-多巴（^18F-DOPA）为神经系统疾病和脑部肿瘤的理想示踪剂,广泛用于神经内分泌瘤的显像。本文综述近几年亲电取代法和亲核取代法合成^18F-DOPA取得的新进展,重点介绍新型标记前体和手性相转移催化剂在亲核取代法制备^18F-DOPA中的应用。 |
| Abstract_FL | [18F]6-fluoro-3,4-dihydroxy-L-phenylalanine (18 F-DOPA) has been known to be a useful radiotracer for neuropsychiatric diseases and brain malignancies,and it is also abundantly used for visualizing neuroendocrine tumors at present.However,its more widespread clinical use was hampered by the lack of a high specific activity,high yielding labeling method.This review mainly summarized new developments in the synthesis of 18 F-DOPA with electrophilic reactions and nucleophilic substitution reactions in recent years.Among these,considerable advances in nucleophilic synthesis had been achieved by developing novel precursors and utilizing chiral phase-transfer catalysts (cPTC) mediated fluorinations allowing for the production of 18F-DOPA in high specific activity and high radiochemical yield. |
| Author | 贾丽娜 张岚 |
| AuthorAffiliation | 中国科学院上海应用物理研究所放射化学与工程技术部,上海201800 中国科学院钍基熔盐堆核能系统卓越创新中心,上海201800 中国科学院核辐射与核能技术重点实验室,上海201800 |
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| ClassificationCodes | TL92+3%R817.9 |
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| DOI | 10.7538/tws.2017.30.01.0071 |
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| DocumentTitleAlternate | Research Progress in the Preparation of ^18F-DOPA |
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| EndPage | 77 |
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| Keywords | 亲核取代 新型标记前体 nucleophilic substitution 手性相转移催化剂 chiral phase transfer catalyst new precursor 18F-DOPA |
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| Notes | 11-2566/TL 18F-DOPA; nucleophilic substitution; new precursor; chiral phase transfer catalyst [^18F]6-fluoro-3,4-dihydroxy-L-phenylalanine（^18F-DOPA）has been known to be a useful radiotracer for neuropsychiatric diseases and brain malignancies,and it is also abundantly used for visualizing neuroendocrine tumors at present.However,its more widespread clinical use was hampered by the lack of a high specific activity,high yielding labeling method.This review mainly summarized new developments in the synthesis of ^18F-DOPA with electrophilic reactions and nucleophilic substitution reactions in recent years.Among these,considerable advances in nucleophilic synthesis had been achieved by developing novel precursors and utilizing chiral phase-transfer catalysts（cPTC）mediated fluorinations allowing for the production of ^18F-DOPA in high specific activity and high radiochemical yield. JIA Li-na1,2,3,ZHANG Lan1,2,3 （1.Department of Radiochemistry and Engineering, Shanghai Institute of Applied Physics, Chinese Academy of |
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| Publisher | 中国科学院上海应用物理研究所放射化学与工程技术部,上海201800 中国科学院核辐射与核能技术重点实验室,上海201800 中国科学院钍基熔盐堆核能系统卓越创新中心,上海201800 |
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| Snippet | 6-[^18F]氟-L-多巴（^18F-DOPA）为神经系统疾病和脑部肿瘤的理想示踪剂,广泛用于神经内分泌瘤的显像。本文综述近几年亲电取代法和亲核取代法合成^18F-DOPA取得的新进展,重... TL92+3%R817.9; 6-[18F]氟-L-多巴(18F-DOPA)为神经系统疾病和脑部肿瘤的理想示踪剂,广泛用于神经内分泌瘤的显像.本文综述近几年亲电取代法和亲核取代法合成18 F-DOPA取得... |
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| SubjectTerms | 18F-DOPA 亲核取代 手性相转移催化剂 新型标记前体 |
| Title | 18F-DOPA制备研究进展 |
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