Altered brain network centrality in depressed Parkinson's disease patients
ABSTRACT Background Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. He...
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| Published in | Movement disorders Vol. 30; no. 13; pp. 1777 - 1784 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.11.2015
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0885-3185 1531-8257 |
| DOI | 10.1002/mds.26321 |
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| Abstract | ABSTRACT
Background
Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. Here, we aim to investigate whole‐brain functional connectivity patterns in depressed PD patients.
Methods
We recruited 17 PD patients diagnosed with major depressive disorder, 17 PD patients without depression, and 17 healthy control subjects. Resting‐state functional MRI and eigenvector centrality mapping were used to identify functional connectivity alterations among these groups.
Results
Results showed that depressed PD patients had decreased functional connectivity in the left dorsolateral prefrontal cortex and right superior temporal gyrus and increased functional connectivity in the right posterior cingulate cortex, compared to nondepressed patients. In addition, there was a significant negative correlation between functional connectivity and depression scores in the posterior cingulate cortex.
Conclusions
This study suggests that functional connectivity changes in certain nodes of brain networks might contribute to depression in patients with PD. © 2015 International Parkinson and Movement Disorder Society |
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| AbstractList | Background Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. Here, we aim to investigate whole-brain functional connectivity patterns in depressed PD patients. Methods We recruited 17 PD patients diagnosed with major depressive disorder, 17 PD patients without depression, and 17 healthy control subjects. Resting-state functional MRI and eigenvector centrality mapping were used to identify functional connectivity alterations among these groups. Results Results showed that depressed PD patients had decreased functional connectivity in the left dorsolateral prefrontal cortex and right superior temporal gyrus and increased functional connectivity in the right posterior cingulate cortex, compared to nondepressed patients. In addition, there was a significant negative correlation between functional connectivity and depression scores in the posterior cingulate cortex. Conclusions This study suggests that functional connectivity changes in certain nodes of brain networks might contribute to depression in patients with PD. © 2015 International Parkinson and Movement Disorder Society ABSTRACT Background Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. Here, we aim to investigate whole‐brain functional connectivity patterns in depressed PD patients. Methods We recruited 17 PD patients diagnosed with major depressive disorder, 17 PD patients without depression, and 17 healthy control subjects. Resting‐state functional MRI and eigenvector centrality mapping were used to identify functional connectivity alterations among these groups. Results Results showed that depressed PD patients had decreased functional connectivity in the left dorsolateral prefrontal cortex and right superior temporal gyrus and increased functional connectivity in the right posterior cingulate cortex, compared to nondepressed patients. In addition, there was a significant negative correlation between functional connectivity and depression scores in the posterior cingulate cortex. Conclusions This study suggests that functional connectivity changes in certain nodes of brain networks might contribute to depression in patients with PD. © 2015 International Parkinson and Movement Disorder Society Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. Here, we aim to investigate whole-brain functional connectivity patterns in depressed PD patients. We recruited 17 PD patients diagnosed with major depressive disorder, 17 PD patients without depression, and 17 healthy control subjects. Resting-state functional MRI and eigenvector centrality mapping were used to identify functional connectivity alterations among these groups. Results showed that depressed PD patients had decreased functional connectivity in the left dorsolateral prefrontal cortex and right superior temporal gyrus and increased functional connectivity in the right posterior cingulate cortex, compared to nondepressed patients. In addition, there was a significant negative correlation between functional connectivity and depression scores in the posterior cingulate cortex. This study suggests that functional connectivity changes in certain nodes of brain networks might contribute to depression in patients with PD. BACKGROUNDDepression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. Here, we aim to investigate whole-brain functional connectivity patterns in depressed PD patients.METHODSWe recruited 17 PD patients diagnosed with major depressive disorder, 17 PD patients without depression, and 17 healthy control subjects. Resting-state functional MRI and eigenvector centrality mapping were used to identify functional connectivity alterations among these groups.RESULTSResults showed that depressed PD patients had decreased functional connectivity in the left dorsolateral prefrontal cortex and right superior temporal gyrus and increased functional connectivity in the right posterior cingulate cortex, compared to nondepressed patients. In addition, there was a significant negative correlation between functional connectivity and depression scores in the posterior cingulate cortex.CONCLUSIONSThis study suggests that functional connectivity changes in certain nodes of brain networks might contribute to depression in patients with PD. Background Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. Here, we aim to investigate whole-brain functional connectivity patterns in depressed PD patients. Methods We recruited 17 PD patients diagnosed with major depressive disorder, 17 PD patients without depression, and 17 healthy control subjects. Resting-state functional MRI and eigenvector centrality mapping were used to identify functional connectivity alterations among these groups. Results Results showed that depressed PD patients had decreased functional connectivity in the left dorsolateral prefrontal cortex and right superior temporal gyrus and increased functional connectivity in the right posterior cingulate cortex, compared to nondepressed patients. In addition, there was a significant negative correlation between functional connectivity and depression scores in the posterior cingulate cortex. Conclusions This study suggests that functional connectivity changes in certain nodes of brain networks might contribute to depression in patients with PD. copyright 2015 International Parkinson and Movement Disorder Society |
| Author | Cen, Zhidong Li, Dan Gao, Jixiang Wang, Bo Lou, Yuting Yu, Hualiang Xuan, Min Luo, Wei Huang, Peiyu Zhang, Minming |
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| Notes | the National Science & Technology Pillar Program during the Twelfth Five-Year Plan Period - No. (2012BAI10B00) ArticleID:MDS26321 ark:/67375/WNG-JKLZ3DFP-S The Natural Science Foundation of Zhejiang Province - No. (LY12H09006) istex:3E3B97565695F8F5723391758B79E037AF4114AA Yuting Lou and Peiyu Huang contributed equally to this work and should be considered co‐first authors. Full financial disclosures and author roles may be found in the online version of this article. Nothing to report. This study was supported by the Natural Science Foundation of Zhejiang Province (LY12H09006), the National Science & Technology Pillar Program during the Twelfth Five‐Year Plan Period (2012BAI10B00), the National Natural Science Foundation of China (no. 81301190), and the Program for Zhejiang Leading Team of Science and Technology Innovation (2012R10049‐04). Relevant conflicts of interest/financial disclosures Funding agencies ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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Background
Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life.... Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances... Background Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although... BACKGROUNDDepression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although... |
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| Title | Altered brain network centrality in depressed Parkinson's disease patients |
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