IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans - Müller, Nike; Schulte, Dominik M.; Türk, Kathrin; Freitag-Wolf, Sandra; Hampe, Jochen; Zeuner, Rainald; Schröder, Johann O.; Gouni-Berthold, Ioanna; Berthold, Heiner K.; Krone, Wilhelm; Rose-John, Stefan; Schreiber, Stefan; et al. (Journal of lipid research, 2015)
Keywords: acute phase response; Adalimumab - pharmacology; Antibodies, Monoclonal, Humanized - pharmacology; Antirheumatic Agents - pharmacology; Apoprotein(a) - blood; Apoprotein(a) - genetics; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - metabolism; Female; Hep G2 Cells; Humans; inflammation; interleukin; Interleukin-6 - antagonists & inhibitors; Interleukin-6 - blood; Interleukin-6 - genetics; lipoprotein metabolism; Liver - metabolism; Male; Middle Aged; Patient-Oriented and Epidemiological Research; Protein Biosynthesis - drug effects; Response Elements; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; therapy of elevated Lp(a); acute phase response; interleukin; inflammation; therapy of elevated Lp(a); lipoprotein metabolism