Minimization of hepatitis B infection by a 25-year universal vaccination program
Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20years after the launch of the vaccination program...
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| Published in | Journal of hepatology Vol. 57; no. 4; pp. 730 - 735 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier B.V
01.10.2012
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0168-8278 1600-0641 1600-0641 |
| DOI | 10.1016/j.jhep.2012.05.021 |
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| Abstract | Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20years after the launch of the vaccination program.
We enrolled 3332 subjects younger than 30years of age, with approximately 100 of them in each age cohort. Subjects were recruited voluntarily from schools and other institutions in Taipei, as in previous surveys. HBV seromarkers included hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc). HBV DNA levels were measured in anti-HBc positive/HBsAg negative subjects (anti-HBc only).
The HBsAg, anti-HBs, and anti-HBc seropositive rates were very different between subjects born after the program in 2009 and the baseline group in 1984 (0.9% vs. 10%, 55.9% vs. 24.5%, and 7.0% vs. 28%, respectively). In this 6th survey, we showed that HBsAg prevalence further decreased in the vaccinated cohorts. A positive maternal HBsAg status was found in 86% of vaccine failures. Serum HBV DNA was detected in 4.2% (6/142) of anti-HBc positive/HBsAg negative subjects, with a low level of HBV DNA. All of these six subjects’ HBV were genotype C.
The universal infant HBV immunization program in Taiwan has completed its 25-year follow-up and its efficacy in young adults is clear. The continued decrease in HBsAg prevalence suggests that the elimination of HBV infection is becoming a reality. |
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| AbstractList | Background & Aims Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program. Methods We enrolled 3332 subjects younger than 30 years of age, with approximately 100 of them in each age cohort. Subjects were recruited voluntarily from schools and other institutions in Taipei, as in previous surveys. HBV seromarkers included hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc). HBV DNA levels were measured in anti-HBc positive/HBsAg negative subjects (anti-HBc only). Results The HBsAg, anti-HBs, and anti-HBc seropositive rates were very different between subjects born after the program in 2009 and the baseline group in 1984 (0.9% vs. 10%, 55.9% vs. 24.5%, and 7.0% vs. 28%, respectively). In this 6th survey, we showed that HBsAg prevalence further decreased in the vaccinated cohorts. A positive maternal HBsAg status was found in 86% of vaccine failures. Serum HBV DNA was detected in 4.2% (6/142) of anti-HBc positive/HBsAg negative subjects, with a low level of HBV DNA. All of these six subjects’ HBV were genotype C. Conclusions The universal infant HBV immunization program in Taiwan has completed its 25-year follow-up and its efficacy in young adults is clear. The continued decrease in HBsAg prevalence suggests that the elimination of HBV infection is becoming a reality. Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20years after the launch of the vaccination program. We enrolled 3332 subjects younger than 30years of age, with approximately 100 of them in each age cohort. Subjects were recruited voluntarily from schools and other institutions in Taipei, as in previous surveys. HBV seromarkers included hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc). HBV DNA levels were measured in anti-HBc positive/HBsAg negative subjects (anti-HBc only). The HBsAg, anti-HBs, and anti-HBc seropositive rates were very different between subjects born after the program in 2009 and the baseline group in 1984 (0.9% vs. 10%, 55.9% vs. 24.5%, and 7.0% vs. 28%, respectively). In this 6th survey, we showed that HBsAg prevalence further decreased in the vaccinated cohorts. A positive maternal HBsAg status was found in 86% of vaccine failures. Serum HBV DNA was detected in 4.2% (6/142) of anti-HBc positive/HBsAg negative subjects, with a low level of HBV DNA. All of these six subjects’ HBV were genotype C. The universal infant HBV immunization program in Taiwan has completed its 25-year follow-up and its efficacy in young adults is clear. The continued decrease in HBsAg prevalence suggests that the elimination of HBV infection is becoming a reality. Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program. We enrolled 3332 subjects younger than 30 years of age, with approximately 100 of them in each age cohort. Subjects were recruited voluntarily from schools and other institutions in Taipei, as in previous surveys. HBV seromarkers included hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc). HBV DNA levels were measured in anti-HBc positive/HBsAg negative subjects (anti-HBc only). The HBsAg, anti-HBs, and anti-HBc seropositive rates were very different between subjects born after the program in 2009 and the baseline group in 1984 (0.9% vs. 10%, 55.9% vs. 24.5%, and 7.0% vs. 28%, respectively). In this 6th survey, we showed that HBsAg prevalence further decreased in the vaccinated cohorts. A positive maternal HBsAg status was found in 86% of vaccine failures. Serum HBV DNA was detected in 4.2% (6/142) of anti-HBc positive/HBsAg negative subjects, with a low level of HBV DNA. All of these six subjects' HBV were genotype C. The universal infant HBV immunization program in Taiwan has completed its 25-year follow-up and its efficacy in young adults is clear. The continued decrease in HBsAg prevalence suggests that the elimination of HBV infection is becoming a reality. Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program.BACKGROUND & AIMSHepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program.We enrolled 3332 subjects younger than 30 years of age, with approximately 100 of them in each age cohort. Subjects were recruited voluntarily from schools and other institutions in Taipei, as in previous surveys. HBV seromarkers included hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc). HBV DNA levels were measured in anti-HBc positive/HBsAg negative subjects (anti-HBc only).METHODSWe enrolled 3332 subjects younger than 30 years of age, with approximately 100 of them in each age cohort. Subjects were recruited voluntarily from schools and other institutions in Taipei, as in previous surveys. HBV seromarkers included hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc). HBV DNA levels were measured in anti-HBc positive/HBsAg negative subjects (anti-HBc only).The HBsAg, anti-HBs, and anti-HBc seropositive rates were very different between subjects born after the program in 2009 and the baseline group in 1984 (0.9% vs. 10%, 55.9% vs. 24.5%, and 7.0% vs. 28%, respectively). In this 6th survey, we showed that HBsAg prevalence further decreased in the vaccinated cohorts. A positive maternal HBsAg status was found in 86% of vaccine failures. Serum HBV DNA was detected in 4.2% (6/142) of anti-HBc positive/HBsAg negative subjects, with a low level of HBV DNA. All of these six subjects' HBV were genotype C.RESULTSThe HBsAg, anti-HBs, and anti-HBc seropositive rates were very different between subjects born after the program in 2009 and the baseline group in 1984 (0.9% vs. 10%, 55.9% vs. 24.5%, and 7.0% vs. 28%, respectively). In this 6th survey, we showed that HBsAg prevalence further decreased in the vaccinated cohorts. A positive maternal HBsAg status was found in 86% of vaccine failures. Serum HBV DNA was detected in 4.2% (6/142) of anti-HBc positive/HBsAg negative subjects, with a low level of HBV DNA. All of these six subjects' HBV were genotype C.The universal infant HBV immunization program in Taiwan has completed its 25-year follow-up and its efficacy in young adults is clear. The continued decrease in HBsAg prevalence suggests that the elimination of HBV infection is becoming a reality.CONCLUSIONSThe universal infant HBV immunization program in Taiwan has completed its 25-year follow-up and its efficacy in young adults is clear. The continued decrease in HBsAg prevalence suggests that the elimination of HBV infection is becoming a reality. |
| Author | Chen, Huey-Ling Hsu, Hong-Yuan Chen, Ding-Shinn Chang, Mei-Hwei Wu, Jia-Feng Ni, Yen-Hsuan |
| Author_xml | – sequence: 1 givenname: Yen-Hsuan surname: Ni fullname: Ni, Yen-Hsuan email: yhni@ntu.edu.tw organization: Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan – sequence: 2 givenname: Mei-Hwei surname: Chang fullname: Chang, Mei-Hwei organization: Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan – sequence: 3 givenname: Jia-Feng surname: Wu fullname: Wu, Jia-Feng organization: Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan – sequence: 4 givenname: Hong-Yuan surname: Hsu fullname: Hsu, Hong-Yuan organization: Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan – sequence: 5 givenname: Huey-Ling surname: Chen fullname: Chen, Huey-Ling organization: Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan – sequence: 6 givenname: Ding-Shinn surname: Chen fullname: Chen, Ding-Shinn organization: Hepatitis Research Center, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26340771$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22668640$$D View this record in MEDLINE/PubMed |
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| Copyright | 2012 European Association for the Study of the Liver European Association for the Study of the Liver 2015 INIST-CNRS Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
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| Keywords | anti-HBs anti-HBc Vaccination HBeAg Occult infection HBsAg HCC Genotype HBV Hepatitis B hepatitis B surface antigen hepatitis B virus antibodies to HBsAg hepatitis B e antigen hepatocellular carcinoma antibodies to hepatitis B core antigen Typing Hepatic disease Infection Prevention Viral hepatitis B Immunoprophylaxis Microbiological investigation Viral disease Gastroenterology Digestive diseases |
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| Snippet | Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was... Background & Aims Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization... |
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| SubjectTerms | Adolescent Adult Antibodies, Viral - blood Biological and medical sciences Child Child, Preschool DNA, Viral - blood Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Genotype Hepatitis B Hepatitis B - epidemiology Hepatitis B - prevention & control Hepatitis B - transmission Hepatitis B Core Antigens - immunology Hepatitis B Surface Antigens - immunology Hepatitis B virus - genetics Hepatitis B virus - immunology Human viral diseases Humans Infant Infectious Disease Transmission, Vertical Infectious diseases Male Mass Vaccination Medical sciences Occult infection Prevalence Seroepidemiologic Studies Taiwan - epidemiology Vaccination Viral diseases Viral hepatitis Young Adult |
| Title | Minimization of hepatitis B infection by a 25-year universal vaccination program |
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