Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis - Huang, Miller; Tailor, Jignesh; Zhen, Qiqi; Gillmor, Aaron H.; Miller, Matthew L.; Weishaupt, Holger; Chen, Justin; Zheng, Tina; Nash, Emily K.; McHenry, Lauren K.; An, Zhenyi; Ye, Fubaiyang; et al. (Cell stem cell, 2019)
Keywords: Animals; Basal Cell Nevus Syndrome - genetics; Basal Cell Nevus Syndrome - metabolism; Basal Cell Nevus Syndrome - pathology; Brain Neoplasms - genetics; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Carcinogenesis - genetics; DEAD-box RNA Helicases - genetics; Disease Models, Animal; Genetic Engineering; Genetic Predisposition to Disease; human pluripotent stem cells; Humans; medulloblastoma; Medulloblastoma - genetics; Medulloblastoma - metabolism; Medulloblastoma - pathology; Mice; Mice, SCID; N-Myc Proto-Oncogene Protein - genetics; N-Myc Proto-Oncogene Protein - metabolism; Neoplasm Proteins - genetics; Neural Stem Cells - physiology; Neuroepithelial Cells - physiology; neuroepithelial stem cells; Patched-1 Receptor - genetics; Pluripotent Stem Cells - physiology; SHH; Stem Cell Transplantation; Transplantation, Heterologous; neuroepithelial stem cells; SHH; human pluripotent stem cells; medulloblastoma