Small bowel injury induced by selective cyclooxygenase-2 inhibitors : a prospective, double-blind, randomized clinical trial comparing celecoxib and meloxicam

Background Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a...

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Published inJournal of gastroenterology Vol. 47; no. 4; pp. 387 - 393
Main Authors Maehata, Yuji, Esaki, Motohiro, Morishita, Toshibumi, Kochi, Shuji, Endo, Shingo, Shikata, Kentaro, Kobayashi, Hiroyuki, Matsumoto, Takayuki
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 01.04.2012
Springer
Springer Nature B.V
Subjects
Abdominal Surgery
Adult
Capsule Endoscopes
Capsule endoscopy
Celecoxib
Clinical trials
Colorectal Surgery
Comparative analysis
COX-2 inhibitors
Cyclooxygenase 2 Inhibitors - adverse effects
Cyclooxygenase 2 Inhibitors - therapeutic use
Double-Blind Method
Duodenal Ulcer - chemically induced
Endoscopy
Female
Gastroenterology
Hepatology
Humans
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Intestine, Small - drug effects
Intestine, Small - pathology
Male
Medicine
Medicine & Public Health
Meloxicam
Middle Aged
Original Article—Alimentary Tract
Prospective Studies
Pyrazoles - adverse effects
Pyrazoles - therapeutic use
Selective cyclooxygenase-2 inhibitor
Small bowel mucosal injury
Sulfonamides - adverse effects
Sulfonamides - therapeutic use
Surgical Oncology
Thiazines - adverse effects
Thiazines - therapeutic use
Thiazoles - adverse effects
Thiazoles - therapeutic use
Young Adult
Small bowel mucosal injury
Capsule endoscopy
Selective cyclooxygenase-2 inhibitor
Online AccessGet full text
ISSN0944-1174
1435-5922
1435-5922
DOI10.1007/s00535-011-0501-z

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Abstract Background Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE). Methods Twenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups. Results The overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P  = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group ( P  = 0.02), while such a trend was not found with regard to erosions ( P  = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups. Conclusions Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam.
AbstractList Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE). Twenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups. The overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group (P = 0.02), while such a trend was not found with regard to erosions (P = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups. Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam.
Background Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE). Methods Twenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups. Results The overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P  = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group ( P  = 0.02), while such a trend was not found with regard to erosions ( P  = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups. Conclusions Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam.
Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE). Twenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups. The overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group (P = 0.02), while such a trend was not found with regard to erosions (P = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups. Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam.[PUBLICATION ABSTRACT]
Background Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE). Methods Twenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups. Results The overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group (P = 0.02), while such a trend was not found with regard to erosions (P = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups. Conclusions Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam.
Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE).BACKGROUNDSelective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE).Twenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups.METHODSTwenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups.The overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group (P = 0.02), while such a trend was not found with regard to erosions (P = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups.RESULTSThe overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group (P = 0.02), while such a trend was not found with regard to erosions (P = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups.Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam.CONCLUSIONSSelective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam.
Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the severity of small bowel mucosal injury in healthy volunteers induced by two selective COX-2 inhibitors, celecoxib and meloxicam, in a randomized, double-blind trial, using capsule endoscopy (CE). Twenty-nine healthy subjects were randomized to take either celecoxib (200 mg twice daily) or meloxicam (10 mg once daily) for 2 weeks. The incidence and the number of small bowel mucosal injuries (bleeding, ulcers, and erosions) observed by CE were compared between the two groups. The overall incidence of small bowel mucosal injury was not different between the celecoxib group (6 of 14 subjects, 42.9%) and the meloxicam group (4 of 15 subjects, 26.7%, P = 0.45). In subjects with positive CE findings, the number of ulcers was greater in the meloxicam group than in the celecoxib group (P = 0.02), while such a trend was not found with regard to erosions (P = 0.52). The distribution of mucosal lesions within the small bowel was similar in the two groups. Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam.
Audience Academic
Author ESAKI Motohiro
MORISHITA Toshibumi
KOCHI Shuji
MATSUMOTO Takayuki
SHIKATA Kentaro
KOBAYASHI Hiroyuki
ENDO Shingo
MAEHATA Yuji
Author_xml – sequence: 1
  givenname: Yuji
  surname: Maehata
  fullname: Maehata, Yuji
  email: ymaehata@intmed2.med.kyushu-u.ac.jp
  organization: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
– sequence: 2
  givenname: Motohiro
  surname: Esaki
  fullname: Esaki, Motohiro
  organization: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
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  givenname: Toshibumi
  surname: Morishita
  fullname: Morishita, Toshibumi
  organization: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
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  givenname: Shuji
  surname: Kochi
  fullname: Kochi, Shuji
  organization: Division of Gastroenterology, International University of Health and Welfare Fukuoka Sanno Hospital
– sequence: 5
  givenname: Shingo
  surname: Endo
  fullname: Endo, Shingo
  organization: Division of Gastroenterology, International University of Health and Welfare Fukuoka Sanno Hospital
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  givenname: Kentaro
  surname: Shikata
  fullname: Shikata, Kentaro
  organization: Division of Gastroenterology, International University of Health and Welfare Fukuoka Sanno Hospital
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  givenname: Hiroyuki
  surname: Kobayashi
  fullname: Kobayashi, Hiroyuki
  organization: Division of Gastroenterology, International University of Health and Welfare Fukuoka Sanno Hospital
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  givenname: Takayuki
  surname: Matsumoto
  fullname: Matsumoto, Takayuki
  organization: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
BackLink https://cir.nii.ac.jp/crid/1573668925562240640$$DView record in CiNii
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Snippet Background Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to...
Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to compare the...
Background Selective cyclooxygenase (COX)-2 inhibitors are less harmful to the small bowel mucosa than non-selective anti-inflammatory drugs. We aimed to...
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SubjectTerms Abdominal Surgery
Adult
Capsule Endoscopes
Capsule endoscopy
Celecoxib
Clinical trials
Colorectal Surgery
Comparative analysis
COX-2 inhibitors
Cyclooxygenase 2 Inhibitors - adverse effects
Cyclooxygenase 2 Inhibitors - therapeutic use
Double-Blind Method
Duodenal Ulcer - chemically induced
Endoscopy
Female
Gastroenterology
Hepatology
Humans
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Intestine, Small - drug effects
Intestine, Small - pathology
Male
Medicine
Medicine & Public Health
Meloxicam
Middle Aged
Original Article—Alimentary Tract
Prospective Studies
Pyrazoles - adverse effects
Pyrazoles - therapeutic use
Selective cyclooxygenase-2 inhibitor
Small bowel mucosal injury
Sulfonamides - adverse effects
Sulfonamides - therapeutic use
Surgical Oncology
Thiazines - adverse effects
Thiazines - therapeutic use
Thiazoles - adverse effects
Thiazoles - therapeutic use
Young Adult
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Title Small bowel injury induced by selective cyclooxygenase-2 inhibitors : a prospective, double-blind, randomized clinical trial comparing celecoxib and meloxicam
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