Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1 - Pejchal, Robert; Walker, Laura M.; Stanfield, Robyn L.; Phogat, Sanjay K.; Koff, Wayne C.; Poignard, Pascal; Burton, Dennis R.; Wilson, Ian A.; Baker, David (Proceedings of the National Academy of Sciences - PNAS, 2010)
Keywords: Amino Acid Sequence; ANTIBODIES; Antibodies, Monoclonal - chemistry; Antibodies, Neutralizing - chemistry; Antibody response; ANTIGENS; Antigens - chemistry; Binding sites; Biological Sciences; CHAINS; CRYSTAL STRUCTURE; Crystallography, X-Ray - methods; Dimerization; ELECTRON DENSITY; engineering; Envelopes; Epitopes; Fab; GLYCOPROTEINS; HIV; HIV 1; HIV Envelope Protein gp120 - chemistry; HIV-1 - genetics; HIV-1 - metabolism; Homology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Light chains; light intensity; MATERIALS SCIENCE; MODIFICATIONS; Molecular Conformation; Molecular Sequence Data; MONOCLONAL ANTIBODIES; N-linked glycans; Neutralization; Neutralizing antibodies; Protein Structure, Tertiary; RESOLUTION; Sequence Homology, Amino Acid; SIMULATION; SPECIFICITY; Spectral analysis; Structure-function relationships; SULFATION; TARGETS; Trimers; TYROSINE; Tyrosine - analogs & derivatives; Tyrosine - chemistry; Vaccination; VACCINES