Rb and Prohibitin Target Distinct Regions of E2F1 for Repression and Respond to Different Upstream Signals

Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:

Bibliographic Details
Published in	Molecular and Cellular Biology Vol. 19; no. 11; pp. 7447 - 7460
Main Authors	Wang, Sheng, Nath, Niharika, Fusaro, Gina, Chellappan, Srikumar
Format	Journal Article
Language	English
Published	United States American Society for Microbiology 01.11.1999 Taylor & Francis
Subjects	Binding Sites Carrier Proteins Cell Cycle Proteins Cell Growth and Development Colony-Forming Units Assay Cyclin-Dependent Kinases - metabolism DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor Gene Expression Regulation Protein Binding Proteins - metabolism Proto-Oncogene Proteins c-raf - metabolism Receptor Cross-Talk Receptors, Fc - metabolism Recombinant Fusion Proteins - metabolism Repressor Proteins Retinoblastoma Protein - metabolism Retinoblastoma-Binding Protein 1 Signal Transduction Transcription Factors - metabolism Transcription, Genetic
Online Access	Get full text
ISSN	0270-7306 1098-5549 1067-8824 1098-5549
DOI	10.1128/MCB.19.11.7447

Cover

Abstract	Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology. For an alternate route to MCB .asm.org, visit: MCB
AbstractList	E2F transcription factor is subject to stringent regulation by a variety of molecules. We recently observed that prohibitin, a potential tumor suppressor protein, binds to the retinoblastoma (Rb) protein and represses E2F transcriptional activity. Here we demonstrate that prohibitin requires the marked box region of E2F for repression; further, prohibitin can effectively inhibit colony formation induced by overexpression of E2F1 in T47D cells. Prohibitin was also found to interact with the signaling kinase c-Raf-1, and Raf-1 could effectively reverse prohibitin-mediated repression of E2F activity. Agents such as E1A, p38 kinase, and cyclins D and E had no effect on prohibitin-mediated repression of E2F1, but all of these molecules could reverse Rb function. Similarly, stimulation of the immunoglobulin M signaling pathway in Ramos cells could inactivate prohibitin, but this had no effect on Rb function. Serum stimulation of quiescent Ramos cells inactivated Rb and prohibitin with different kinetics; further, while the serum-dependent inactivation of Rb was dependent on cyclin-dependent kinase activity, the inactivation of prohibitin was not. We believe that prohibitin is a novel regulator of E2F function which channels specific signaling cascades to the cell cycle regulatory machinery. E2F transcription factor is subject to stringent regulation by a variety of molecules. We recently observed that prohibitin, a potential tumor suppressor protein, binds to the retinoblastoma (Rb) protein and represses E2F transcriptional activity. Here we demonstrate that prohibitin requires the marked box region of E2F for repression; further, prohibitin can effectively inhibit colony formation induced by overexpression of E2F1 in T47D cells. Prohibitin was also found to interact with the signaling kinase c-Raf-1, and Raf-1 could effectively reverse prohibitin-mediated repression of E2F activity. Agents such as E1A, p38 kinase, and cyclins D and E had no effect on prohibitin-mediated repression of E2F1, but all of these molecules could reverse Rb function. Similarly, stimulation of the immunoglobulin M signaling pathway in Ramos cells could inactivate prohibitin, but this had no effect on Rb function. Serum stimulation of quiescent Ramos cells inactivated Rb and prohibitin with different kinetics; further, while the serum-dependent inactivation of Rb was dependent on cyclin-dependent kinase activity, the inactivation of prohibitin was not. We believe that prohibitin is a novel regulator of E2F function which channels specific signaling cascades to the cell cycle regulatory machinery.E2F transcription factor is subject to stringent regulation by a variety of molecules. We recently observed that prohibitin, a potential tumor suppressor protein, binds to the retinoblastoma (Rb) protein and represses E2F transcriptional activity. Here we demonstrate that prohibitin requires the marked box region of E2F for repression; further, prohibitin can effectively inhibit colony formation induced by overexpression of E2F1 in T47D cells. Prohibitin was also found to interact with the signaling kinase c-Raf-1, and Raf-1 could effectively reverse prohibitin-mediated repression of E2F activity. Agents such as E1A, p38 kinase, and cyclins D and E had no effect on prohibitin-mediated repression of E2F1, but all of these molecules could reverse Rb function. Similarly, stimulation of the immunoglobulin M signaling pathway in Ramos cells could inactivate prohibitin, but this had no effect on Rb function. Serum stimulation of quiescent Ramos cells inactivated Rb and prohibitin with different kinetics; further, while the serum-dependent inactivation of Rb was dependent on cyclin-dependent kinase activity, the inactivation of prohibitin was not. We believe that prohibitin is a novel regulator of E2F function which channels specific signaling cascades to the cell cycle regulatory machinery. Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology. For an alternate route to MCB .asm.org, visit: MCB
Author	Gina Fusaro Sheng Wang Niharika Nath Srikumar Chellappan
AuthorAffiliation	Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
AuthorAffiliation_xml	– name: Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Author_xml	– sequence: 1 givenname: Sheng surname: Wang fullname: Wang, Sheng organization: Department of Pathology, College of Physicians and Surgeons, Columbia University – sequence: 2 givenname: Niharika surname: Nath fullname: Nath, Niharika organization: Department of Pathology, College of Physicians and Surgeons, Columbia University – sequence: 3 givenname: Gina surname: Fusaro fullname: Fusaro, Gina organization: Department of Pathology, College of Physicians and Surgeons, Columbia University – sequence: 4 givenname: Srikumar surname: Chellappan fullname: Chellappan, Srikumar email: spc10@columbia.edu organization: Department of Pathology, College of Physicians and Surgeons, Columbia University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/10523633$$D View this record in MEDLINE/PubMed
BookMark	eNqFkk1v1DAQhi3Uim4LV44o4sBtt3acxLbEBZYWkIpAS3u2nGSy6yqxU9vLav89U1KJfqjiYM94_D7WfPiYHDjvgJA3jC4Yy-Xp9-WnBVPoL0RRiBdkxqiS87Is1AGZ0VzQueC0OiLHMV5TSitF-UtyxGiZ84rzGble1ZlxbfYz-I2tbbIuuzRhDSn7bCOempStYG29i5nvsrP8nGWdDxgbA8SI8b_0CuLo0SaPWNdBAJeyqzGmAGbIftm1M318RQ47NPD6zp6Qq_Ozy-XX-cWPL9-WHy_mTVnKNGcSKK_yomJ1rgQXjBeGQmlYXuVCqlqyVihWtriDBAa1qJtatrTlUBlc_IScTu9u3Wj2O9P3egx2MGGvGdW3XdNDU2um0Ne3XUPiw0SM23qAtsHsg_lHeWP1wxtnN3rtf2uJsET8_R0e_M0WYtKDjQ30vXHgt1ELKnOFFf1XyAQvSpUrFL69n9C9_Ke5oWAxCZrgYwzQPSkRP8bDEotHQGOTSThALMj2z2NqwqzDsQ9m50Pf6mT2vQ9dMK6xUfNn2XcTu7Hrzc4G0CYOj1v_B3Go2VE
CitedBy_id	crossref_primary_10_1242_dev_053405 crossref_primary_10_1016_j_bbabio_2010_12_011 crossref_primary_10_1038_sj_emboj_7600231 crossref_primary_10_1038_sj_onc_1205944 crossref_primary_10_1080_15384101_2020_1801190 crossref_primary_10_1371_journal_pgen_0020167 crossref_primary_10_1016_j_bbagrm_2010_07_004 crossref_primary_10_1016_j_ejmech_2018_06_052 crossref_primary_10_1021_pr9005316 crossref_primary_10_1186_1471_2105_11_S6_S22 crossref_primary_10_1002_jcp_24531 crossref_primary_10_1007_s12032_013_0614_8 crossref_primary_10_1016_j_bbrc_2003_10_148 crossref_primary_10_1073_pnas_1922535117 crossref_primary_10_1534_genetics_112_140152 crossref_primary_10_1038_sj_onc_1207444 crossref_primary_10_1186_s12885_015_1568_3 crossref_primary_10_1371_journal_pone_0109152 crossref_primary_10_1007_s13258_017_0580_1 crossref_primary_10_1007_s11010_006_9286_4 crossref_primary_10_1016_j_chembiol_2013_02_006 crossref_primary_10_56093_ijas_v90i3_101498 crossref_primary_10_1016_j_fsi_2014_11_016 crossref_primary_10_1074_jbc_M110_164509 crossref_primary_10_1186_gb_2002_3_8_research0042 crossref_primary_10_1111_j_1600_0749_2005_00245_x crossref_primary_10_1038_onc_2013_447 crossref_primary_10_1111_j_1582_4934_2006_tb00404_x crossref_primary_10_1006_excr_2001_5166 crossref_primary_10_1074_jbc_M508669200 crossref_primary_10_1007_s00705_010_0728_7 crossref_primary_10_1097_WNR_0000000000000241 crossref_primary_10_1371_journal_pone_0011981 crossref_primary_10_1038_ncb1283 crossref_primary_10_1038_sj_onc_1205551 crossref_primary_10_1242_jcs_01142 crossref_primary_10_1530_ERC_12_0156 crossref_primary_10_1073_pnas_2111711119 crossref_primary_10_1242_jcs_037655 crossref_primary_10_1016_j_canlet_2012_02_027 crossref_primary_10_1016_j_chembiol_2005_02_014 crossref_primary_10_1038_sj_onc_1207987 crossref_primary_10_7314_APJCP_2012_13_10_5113 crossref_primary_10_1186_s13046_023_02695_0 crossref_primary_10_1016_S0925_4773_01_00297_0 crossref_primary_10_1371_journal_pone_0081552 crossref_primary_10_1093_jnci_djq541 crossref_primary_10_1186_1477_7827_1_66 crossref_primary_10_1371_journal_pone_0018765 crossref_primary_10_1089_thy_2008_0235 crossref_primary_10_1074_jbc_M305171200 crossref_primary_10_1074_jbc_M708232200 crossref_primary_10_1038_sj_onc_1210806 crossref_primary_10_31083_j_fbl2711318 crossref_primary_10_3748_wjg_14_5008 crossref_primary_10_1038_nm0604_581 crossref_primary_10_1074_jbc_M002598200 crossref_primary_10_3390_ijms19113384 crossref_primary_10_1021_pr1005718 crossref_primary_10_1007_s12192_008_0086_5 crossref_primary_10_1038_sj_onc_1208206 crossref_primary_10_1101_gad_1296405 crossref_primary_10_1006_abbi_2000_2278 crossref_primary_10_1093_nar_gkv885 crossref_primary_10_1038_sj_onc_1209099 crossref_primary_10_1002_hep4_1257 crossref_primary_10_1093_carcin_bgn117 crossref_primary_10_1038_sj_onc_1205455 crossref_primary_10_2147_OTT_S284182 crossref_primary_10_1080_21645698_2021_1872333 crossref_primary_10_1002_pros_21033 crossref_primary_10_1210_endo_142_9_8354 crossref_primary_10_1155_2020_7814628 crossref_primary_10_1016_j_bbrc_2007_06_118 crossref_primary_10_1002_prca_200900023 crossref_primary_10_1046_j_1474_9728_2002_00018_x crossref_primary_10_1155_2014_549719 crossref_primary_10_1006_mcbr_2001_0281 crossref_primary_10_1016_j_molmed_2005_02_004 crossref_primary_10_1139_O08_069 crossref_primary_10_1074_jbc_M605260200 crossref_primary_10_1073_pnas_0407536101 crossref_primary_10_1006_scbi_2000_0326 crossref_primary_10_1186_1476_4598_12_118 crossref_primary_10_1074_jbc_M116_744045 crossref_primary_10_1016_S0047_6374_01_00326_8 crossref_primary_10_1210_me_2007_0400 crossref_primary_10_1128_MCB_02142_05 crossref_primary_10_1292_jvms_14_0239 crossref_primary_10_1002_pmic_200300510 crossref_primary_10_1242_jcs_01227 crossref_primary_10_1016_j_bbrc_2008_12_103 crossref_primary_10_1111_j_1600_0749_2006_00321_x crossref_primary_10_1158_0008_5472_CAN_06_1004 crossref_primary_10_1016_j_ejogrb_2007_04_010 crossref_primary_10_1042_BJ20060364 crossref_primary_10_1016_j_lfs_2009_05_012 crossref_primary_10_1038_s41598_019_44749_4 crossref_primary_10_1128_JVI_80_8_3884_3892_2006 crossref_primary_10_1007_s11802_015_2593_1 crossref_primary_10_1186_1471_2407_8_90 crossref_primary_10_1002_jcp_1075 crossref_primary_10_3390_biomedicines9121793 crossref_primary_10_1038_ja_2005_108 crossref_primary_10_1038_onc_2012_86 crossref_primary_10_1007_s10549_006_9389_3 crossref_primary_10_1074_jbc_M603800200 crossref_primary_10_1097_00008390_200206000_00001 crossref_primary_10_1007_s10571_013_9935_6 crossref_primary_10_1111_j_1365_313X_2006_02726_x crossref_primary_10_1095_biolreprod_103_024125 crossref_primary_10_1021_bi2008933 crossref_primary_10_1101_gad_1180204 crossref_primary_10_4103_jco_jco_10_21 crossref_primary_10_1007_s12015_014_9540_1 crossref_primary_10_1177_1535370217703976 crossref_primary_10_1074_jbc_M304877200 crossref_primary_10_1080_15384101_2017_1388970 crossref_primary_10_1007_s10725_013_9879_3 crossref_primary_10_1002_art_37837
Cites_doi	10.1016/S0959-437X(97)80111-6 10.1038/sj.onc.1202684 10.1073/pnas.95.16.9190 10.1073/pnas.95.6.2850 10.1074/jbc.273.38.24285 10.1016/S0092-8674(00)80940-X 10.1038/nsb0497-311 10.1042/bst0240054 10.1128/MCB.13.11.7170 10.1002/j.1460-2075.1994.tb06635.x 10.1016/0092-8674(92)90107-N 10.1038/35410 10.1073/pnas.93.4.1439 10.1016/S0960-9822(06)00261-2 10.1038/375812a0 10.1002/j.1460-2075.1995.tb00309.x 10.1016/S0092-8674(00)81255-6 10.1101/gad.8.13.1514 10.1016/0092-8674(89)90100-1 10.1038/sj.onc.1201975 10.1038/sj.onc.1201818 10.1016/0531-5565(94)00069-7 10.1093/nar/24.21.4139 10.1128/MCB.15.2.742 10.1038/358259a0 10.1128/jvi.69.4.2491-2500.1995 10.1002/j.1460-2075.1994.tb06689.x 10.1038/35404 10.1073/pnas.93.2.679 10.1016/0092-8674(95)90385-2 10.1016/S0968-0004(96)10070-0 10.1038/365349a0 10.1038/sj.onc.1202061 10.1074/jbc.272.18.12116 10.1128/MCB.14.12.8420 10.1016/0955-0674(94)90038-8 10.1073/pnas.94.14.7245 10.1074/jbc.273.16.10051 10.1093/emboj/18.6.1559 10.1128/MCB.16.10.5888 10.2741/A291 10.1038/375694a0 10.1073/pnas.91.9.3602 10.1128/MCB.18.7.4043 10.1128/MCB.19.5.3435 10.1101/gad.9.23.2873 10.1002/elps.1150190535 10.1101/gad.12.1.95 10.1016/0092-8674(91)90557-F 10.1128/MCB.18.12.7487 10.1016/S0021-9258(17)37320-9 10.1016/0092-8674(94)90582-7 10.1016/0092-8674(92)90108-O 10.1073/pnas.91.23.10918 10.1128/MCB.18.2.753 10.1128/MCB.11.3.1372 10.1128/MCB.15.6.3256 10.1002/j.1460-2075.1993.tb05932.x 10.1128/jvi.68.7.4213-4219.1994 10.1101/gad.12.15.2245
ContentType	Journal Article
Copyright	Copyright © 1999, American Society for Microbiology 1999
Copyright_xml	– notice: Copyright © 1999, American Society for Microbiology 1999
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TM 7X8 5PM ADTOC UNPAY
DOI	10.1128/MCB.19.11.7447
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nucleic Acids Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Nucleic Acids Abstracts MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Nucleic Acids Abstracts
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository
DeliveryMethod	fulltext_linktorsrc
Discipline	Chemistry Biology
EISSN	1098-5549
EndPage	7460
ExternalDocumentID	oai:pubmedcentral.nih.gov:84738 PMC84738 10523633 10_1128_MCB_19_11_7447 12288324 mcb_19_11_7447
Genre	Research Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S Journal Article
GrantInformation_xml	– fundername: NCI NIH HHS grantid: R01 CA063136 – fundername: NCI NIH HHS grantid: R0-1 CA63136
GroupedDBID	--- -DZ -~X .55 .GJ 0R~ 123 18M 29M 2WC 39C 3O- 4.4 53G 5RE 5VS 9M8 AAGFI ABJNI ACGFO ACKIV ACNCT ADBBV ADIYS ADXHL AENEX AEOZL AFFNX AGHSJ ALMA_UNASSIGNED_HOLDINGS AOIJS AQTUD BAWUL BTFSW C1A CS3 DIK DU5 E3Z EBS EJD F5P GX1 H13 HH5 HYE HZ~ IH2 KQ8 L7B M4Z MVM N9A O9- OK1 P2P RHI RNS RPM TASJS TDBHL TFL TFW TR2 UDS W8F WH7 WOQ X7M Y6R YYP ZCA ZGI ZXP AAYXX CITATION ABRLO ABTAH AGVNZ CGR CUY CVF ECM EIF EMOBN NPM PKN RHF RSF UCJ VQA WHG YIN ZY4 7TM 7X8 5PM ADTOC UNPAY
ID	FETCH-LOGICAL-c558t-18e0362461b29737134a0e5a1262789b81d7915dd79e8e1eb7bcb8d0d3e6a3e63
IEDL.DBID	UNPAY
ISSN	0270-7306 1098-5549 1067-8824
IngestDate	Sun Oct 26 02:05:47 EDT 2025 Thu Aug 21 13:38:37 EDT 2025 Thu Oct 02 12:14:45 EDT 2025 Fri Sep 05 09:36:01 EDT 2025 Wed Feb 19 02:36:26 EST 2025 Wed Oct 01 02:23:19 EDT 2025 Thu Apr 24 22:55:07 EDT 2025 Mon Oct 20 23:46:58 EDT 2025 Wed May 18 15:28:01 EDT 2016
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	11
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c558t-18e0362461b29737134a0e5a1262789b81d7915dd79e8e1eb7bcb8d0d3e6a3e63
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Corresponding author. Mailing address: Department of Pathology, College of Physicians and Surgeons, Columbia University, 630W 168th St., New York, NY 10032. Phone: (212) 305-3736. Fax: (212) 305-5498. E-mail: spc10@columbia.edu.
OpenAccessLink	https://proxy.k.utb.cz/login?url=https://www.ncbi.nlm.nih.gov/pmc/articles/84738
PMID	10523633
PQID	17345929
PQPubID	23462
PageCount	14
ParticipantIDs	pubmed_primary_10523633 crossref_primary_10_1128_MCB_19_11_7447 informaworld_taylorfrancis_310_1128_MCB_19_11_7447 pubmedcentral_primary_oai_pubmedcentral_nih_gov_84738 proquest_miscellaneous_70829624 highwire_asm_mcb_19_11_7447 proquest_miscellaneous_17345929 crossref_citationtrail_10_1128_MCB_19_11_7447 unpaywall_primary_10_1128_mcb_19_11_7447
ProviderPackageCode	CITATION AAYXX
PublicationCentury	1900
PublicationDate	1999-11-01
PublicationDateYYYYMMDD	1999-11-01
PublicationDate_xml	– month: 11 year: 1999 text: 1999-11-01 day: 01
PublicationDecade	1990
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Molecular and Cellular Biology
PublicationTitleAlternate	Mol Cell Biol
PublicationYear	1999
Publisher	American Society for Microbiology Taylor & Francis
Publisher_xml	– name: American Society for Microbiology – name: Taylor & Francis
References	B64 B65 B22 B66 B23 B67 B24 B68 B25 B69 B28 B29 B70 B30 B31 Slansky J. E. (B50) 1996; 208 B33 B34 B35 B36 Adams P. D. (B1) 1996; 208 B37 B38 B39 Helin K. (B21) 1992; 70 Beijersbergen R. L. (B3) 1996; 1287 B2 B4 B5 B6 B7 B8 B9 Cress W. D. (B12) 1996; 208 B40 Zhang Y. (B71) 1995; 10 B42 B43 B44 B45 B47 B48 Cress W. D. (B11) 1994; 68 B49 Tordai A. (B57) 1994; 269 Kowalik T. F. (B27) 1998; 9 Kitagawa M. (B26) 1995; 10 B51 Hamel P. A. (B20) 1992; 12 B52 B54 B55 Nevins J. R. (B41) 1998; 9 B56 B13 B14 B58 B15 B59 B16 B17 B18 B19 Rasmussen R. K. (B46) 1998; 19 La Thangue N. B. (B32) 1994; 6 Strom D. K. (B53) 1998; 9 Cobrinik D. (B10) 1996; 208 B60 B61 B62 B63
References_xml	– ident: B17 doi: 10.1016/S0959-437X(97)80111-6 – ident: B62 doi: 10.1038/sj.onc.1202684 – ident: B19 doi: 10.1073/pnas.95.16.9190 – volume: 9 start-page: 585 year: 1998 ident: B41 publication-title: Cell Growth Differ. – volume: 208 start-page: 32 year: 1996 ident: B10 publication-title: Curr. Top. Microbiol. Immunol. – ident: B58 doi: 10.1073/pnas.95.6.2850 – ident: B39 doi: 10.1074/jbc.273.38.24285 – ident: B36 doi: 10.1016/S0092-8674(00)80940-X – ident: B56 doi: 10.1038/nsb0497-311 – ident: B33 doi: 10.1042/bst0240054 – volume: 1287 start-page: 103 year: 1996 ident: B3 publication-title: Biochim. Biophys. Acta – ident: B16 doi: 10.1128/MCB.13.11.7170 – ident: B49 doi: 10.1002/j.1460-2075.1994.tb06635.x – volume: 10 start-page: 229 year: 1995 ident: B26 publication-title: Oncogene – volume: 70 start-page: 337 year: 1992 ident: B21 publication-title: Cell doi: 10.1016/0092-8674(92)90107-N – ident: B37 doi: 10.1038/35410 – ident: B60 doi: 10.1073/pnas.93.4.1439 – ident: B9 doi: 10.1016/S0960-9822(06)00261-2 – ident: B65 doi: 10.1038/375812a0 – ident: B43 doi: 10.1002/j.1460-2075.1995.tb00309.x – ident: B18 doi: 10.1016/S0092-8674(00)81255-6 – ident: B23 doi: 10.1101/gad.8.13.1514 – volume: 12 start-page: 3431 year: 1992 ident: B20 publication-title: Mol. Cell. Biol. – ident: B40 doi: 10.1016/0092-8674(89)90100-1 – ident: B7 doi: 10.1038/sj.onc.1201975 – ident: B34 doi: 10.1038/sj.onc.1201818 – ident: B38 doi: 10.1016/0531-5565(94)00069-7 – ident: B59 doi: 10.1093/nar/24.21.4139 – volume: 10 start-page: 2085 year: 1995 ident: B71 publication-title: Oncogene – ident: B44 doi: 10.1128/MCB.15.2.742 – ident: B66 doi: 10.1038/358259a0 – ident: B28 doi: 10.1128/jvi.69.4.2491-2500.1995 – ident: B55 doi: 10.1002/j.1460-2075.1994.tb06689.x – ident: B5 doi: 10.1038/35404 – ident: B48 doi: 10.1073/pnas.93.2.679 – ident: B64 doi: 10.1016/0092-8674(95)90385-2 – ident: B54 doi: 10.1016/S0968-0004(96)10070-0 – volume: 208 start-page: 79 year: 1996 ident: B1 publication-title: Curr. Top. Microbiol. Immunol. – ident: B22 doi: 10.1038/365349a0 – volume: 9 start-page: 113 year: 1998 ident: B27 publication-title: Cell Growth Differ. – ident: B2 doi: 10.1038/sj.onc.1202061 – volume: 9 start-page: 59 year: 1998 ident: B53 publication-title: Cell Growth Differ. – ident: B70 doi: 10.1074/jbc.272.18.12116 – ident: B69 doi: 10.1128/MCB.14.12.8420 – volume: 6 start-page: 443 year: 1994 ident: B32 publication-title: Curr. Opin. Cell. Biol. doi: 10.1016/0955-0674(94)90038-8 – ident: B13 doi: 10.1073/pnas.94.14.7245 – ident: B30 doi: 10.1074/jbc.273.16.10051 – ident: B63 doi: 10.1093/emboj/18.6.1559 – ident: B51 doi: 10.1128/MCB.16.10.5888 – ident: B24 doi: 10.2741/A291 – ident: B68 doi: 10.1038/375694a0 – ident: B67 doi: 10.1073/pnas.91.9.3602 – ident: B4 doi: 10.1128/MCB.18.7.4043 – ident: B52 doi: 10.1128/MCB.19.5.3435 – ident: B14 doi: 10.1101/gad.9.23.2873 – volume: 19 start-page: 809 year: 1998 ident: B46 publication-title: Electrophoresis doi: 10.1002/elps.1150190535 – ident: B47 doi: 10.1101/gad.12.1.95 – ident: B8 doi: 10.1016/0092-8674(91)90557-F – ident: B61 doi: 10.1128/MCB.18.12.7487 – volume: 208 start-page: 1 year: 1996 ident: B50 publication-title: Curr. Top. Microbiol. Immunol. – volume: 208 start-page: 63 year: 1996 ident: B12 publication-title: Curr. Top. Microbiol. Immunol. – volume: 269 start-page: 7538 year: 1994 ident: B57 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)37320-9 – ident: B29 doi: 10.1016/0092-8674(94)90582-7 – ident: B25 doi: 10.1016/0092-8674(92)90108-O – ident: B45 doi: 10.1073/pnas.91.23.10918 – ident: B35 doi: 10.1128/MCB.18.2.753 – ident: B42 doi: 10.1128/MCB.11.3.1372 – ident: B6 doi: 10.1128/MCB.15.6.3256 – ident: B31 doi: 10.1002/j.1460-2075.1993.tb05932.x – volume: 68 start-page: 4213 year: 1994 ident: B11 publication-title: J. Virol. doi: 10.1128/jvi.68.7.4213-4219.1994 – ident: B15 doi: 10.1101/gad.12.15.2245
SSID	ssj0006903
Score	2.024266
Snippet	Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... E2F transcription factor is subject to stringent regulation by a variety of molecules. We recently observed that prohibitin, a potential tumor suppressor...
SourceID	unpaywall pubmedcentral proquest pubmed crossref informaworld highwire
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	7447
SubjectTerms	Binding Sites Carrier Proteins Cell Cycle Proteins Cell Growth and Development Colony-Forming Units Assay Cyclin-Dependent Kinases - metabolism DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor Gene Expression Regulation Protein Binding Proteins - metabolism Proto-Oncogene Proteins c-raf - metabolism Receptor Cross-Talk Receptors, Fc - metabolism Recombinant Fusion Proteins - metabolism Repressor Proteins Retinoblastoma Protein - metabolism Retinoblastoma-Binding Protein 1 Signal Transduction Transcription Factors - metabolism Transcription, Genetic
Title	Rb and Prohibitin Target Distinct Regions of E2F1 for Repression and Respond to Different Upstream Signals
URI	http://mcb.asm.org/content/19/11/7447.abstract https://www.tandfonline.com/doi/abs/10.1128/MCB.19.11.7447 https://www.ncbi.nlm.nih.gov/pubmed/10523633 https://www.proquest.com/docview/17345929 https://www.proquest.com/docview/70829624 https://pubmed.ncbi.nlm.nih.gov/PMC84738 https://www.ncbi.nlm.nih.gov/pmc/articles/84738
UnpaywallVersion	submittedVersion
Volume	19
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 1098-5549 dateEnd: 20250501 omitProxy: true ssIdentifier: ssj0006903 issn: 1098-5549 databaseCode: HH5 dateStart: 19810101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1098-5549 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006903 issn: 1098-5549 databaseCode: KQ8 dateStart: 19890101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1098-5549 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006903 issn: 1098-5549 databaseCode: KQ8 dateStart: 19810101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1098-5549 dateEnd: 20250501 omitProxy: true ssIdentifier: ssj0006903 issn: 1098-5549 databaseCode: DIK dateStart: 19810101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1098-5549 dateEnd: 20250501 omitProxy: true ssIdentifier: ssj0006903 issn: 1098-5549 databaseCode: GX1 dateStart: 19810101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVAQN databaseName: PubMed Open Access customDbUrl: eissn: 1098-5549 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006903 issn: 1098-5549 databaseCode: RPM dateStart: 19810101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFD7aOqHxwmXcymD4AQlekiZxnMvjKJsm0KZSVmk8WbHjsUDjVGsqNH49x05StRuV4CFRFJ9Esf3FPk6-8x2At4yJSAZBjm-aSJ0wzoWTMMYcFSmEkEplqkxw8ulZdDIJP12wiy0YdLEwlrQvReHqaenq4spyK2elHHQ8sQEOpzTZhp2IofPdg53J2ejwm_2SEnsO4tXGE-EY7KDvaP8pG8VMnDTTVrIRB-RBKYXrp3jsxqFJrLI6JXUywbe0S__mgd4lUu4u9Cy7-ZVNpyuz1PFDGHX1a8gpP91FLVz5-5b04380wCN40Hqs5LApeAxbSu_BvSaH5c0e7A67lHFP4MdYkEznZHRdXRWiqAtNzi3TnHw0Q4mWNRkrQ4Cek-qSHOFqnmDV8VzLxtX26rGl7eakrvCyJn1LTSYzE9WSleRr8d1IPj-FyfHR-fDEaZM5OJKxpHb8RJnJMox8YdJlmRDWzFMs84PIBOMK9Jvj1Gc57lWifCViIUWSezlVUYYbfQY9XWn1AogUYS5YECuaiNATgaCepHnAEpWFOaWqD07Xn1y2Sucm4caU2xVPkPDT4Qfup3jMTf_34d3SftZofGy03O_gwbN5yRFHa6XBKmJ4bb-5XDYJUjjddMs3Ha449pb5XZNpVS3m3I9pyNB73WwRm8BobNM-PG9wuPL4LKARpX1gawhdGhhV8fUSxJpVF7fw6sP7JZLvtMl6rV_-u-k-3LeqFzaU8xX06uuFeo0-XS0OYPvzl-SgfZv_AO2uSXM
linkProvider	Unpaywall
linkToUnpaywall	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb5swFD7qUk3dyy7djXUXP0zaXiCAMZfHLmtVTWoVZY3UPVnYuCtbMFFDNHW_fscGoqRdpO0BhPABYfvDPobvfAfgPWMilmFY4JsmMjdKCuGmjDFXxQohpDKZKROcfHoWn0yjLxfsYgeGfSyMJe1LUXp6Vnm6vLLcynklhz1PbIjDKU3vwW7M0PkewO70bHz4zX5JSXwX8WrjiXAMdtF3tP-UjWImTppZJ9mIA_KwksILMjz2ksgkVlmfknqZ4FvapX_zQO8SKfeWep7f_Mpns7VZ6vgRjPv6teSUn96yEZ78fUv68T8a4DE87DxWctgWPIEdpffhfpvD8mYf9kZ9yrin8GMiSK4LMr6ur0pRNqUm55ZpTj6boUTLhkyUIUAvSH1JjnA1T7DqeK5j42p79cTSdgvS1HhZm76lIdO5iWrJK_K1_G4kn5_B9PjofHTidskcXMlY2rhBqsxkGcWBMOmyTAhr7iuWB2FsgnEF-s1JFrAC9ypVgRKJkCIt_IKqOMeNPoeBrrV6CUSKqBAsTBRNReSLUFBf0iJkqcqjglLlgNv3J5ed0rlJuDHjdsUTpvx09IkHGR5z0_8OfFjZz1uNj62WBz08eL6oOOJoozRcRwxv7DeXyzZBCqfbbvmuxxXH3jK_a3Kt6uWCBwmNGHqv2y0SExiNberAixaHa4_PQhpT6gDbQOjKwKiKb5Yg1qy6uIWXAx9XSL7TJpu1fvXvpgfwwKpe2FDO1zBorpfqDfp0jXjbvcd_ADqoSH4
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rb+and+prohibitin+target+distinct+regions+of+E2F1+for+repression+and+respond+to+different+upstream+signals&rft.jtitle=Molecular+and+cellular+biology&rft.au=Wang%2C+S&rft.au=Nath%2C+N&rft.au=Fusaro%2C+G&rft.au=Chellappan%2C+S&rft.date=1999-11-01&rft.issn=0270-7306&rft.volume=19&rft.issue=11&rft.spage=7447&rft_id=info:doi/10.1128%2FMCB.19.11.7447&rft_id=info%3Apmid%2F10523633&rft.externalDocID=10523633
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-7306&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-7306&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-7306&client=summon