Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015
Clinical guidelines for interstitial cystitis and hypersensitive bladder have been updated as of 2015. The guidelines define interstitial cystitis by the presence of hypersensitive bladder symptoms (discomfort, pressure or pain in the bladder usually associated with urinary frequency and nocturia) a...
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| Published in | International journal of urology Vol. 23; no. 7; pp. 542 - 549 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Australia
Blackwell Publishing Ltd
01.07.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0919-8172 1442-2042 |
| DOI | 10.1111/iju.13118 |
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| Abstract | Clinical guidelines for interstitial cystitis and hypersensitive bladder have been updated as of 2015. The guidelines define interstitial cystitis by the presence of hypersensitive bladder symptoms (discomfort, pressure or pain in the bladder usually associated with urinary frequency and nocturia) and bladder pathology, after excluding other diseases explaining symptoms. Interstitial cystitis is further classified by bladder pathology; either Hunner type interstitial cystitis with Hunner lesions or non‐Hunner type interstitial cystitis with mucosal bleeding after distension in the absence of Hunner lesions. Hypersensitive bladder refers to a condition, where hypersensitive bladder symptoms are present, but bladder pathology or other explainable diseases are unproven. Interstitial cystitis and hypersensitive bladder severely affect patients' quality of life as a result of disabling symptoms and/or comorbidities. Reported prevalence suggestive of these disorders varies greatly from 0.01% to >6%. Pathophysiology would be an interaction of multiple factors including urothelial dysfunction, inflammation, neural hyperactivity, exogenous substances and extrabladder disorders. Definite diagnosis of interstitial cystitis and hypersensitive bladder requires cystoscopy with or without hydrodistension. Most of the therapeutic options lack a high level of evidence, leaving a few as recommended therapeutic options. |
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| AbstractList | Clinical guidelines for interstitial cystitis and hypersensitive bladder have been updated as of 2015. The guidelines define interstitial cystitis by the presence of hypersensitive bladder symptoms (discomfort, pressure or pain in the bladder usually associated with urinary frequency and nocturia) and bladder pathology, after excluding other diseases explaining symptoms. Interstitial cystitis is further classified by bladder pathology; either Hunner type interstitial cystitis with Hunner lesions or non‐Hunner type interstitial cystitis with mucosal bleeding after distension in the absence of Hunner lesions. Hypersensitive bladder refers to a condition, where hypersensitive bladder symptoms are present, but bladder pathology or other explainable diseases are unproven. Interstitial cystitis and hypersensitive bladder severely affect patients' quality of life as a result of disabling symptoms and/or comorbidities. Reported prevalence suggestive of these disorders varies greatly from 0.01% to >6%. Pathophysiology would be an interaction of multiple factors including urothelial dysfunction, inflammation, neural hyperactivity, exogenous substances and extrabladder disorders. Definite diagnosis of interstitial cystitis and hypersensitive bladder requires cystoscopy with or without hydrodistension. Most of the therapeutic options lack a high level of evidence, leaving a few as recommended therapeutic options. |
| Author | Oh, Seung-June Homma, Yukio Lee, Ming-Huei Lee, Kyu-Sung Tomoe, Hikaru Kim, Joon Chul Lin, Alex TL Kuo, Hann-Chorng Ueda, Tomohiro |
| Author_xml | – sequence: 1 givenname: Yukio surname: Homma fullname: Homma, Yukio email: homma-uro@umin.ac.jp organization: Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan – sequence: 2 givenname: Tomohiro surname: Ueda fullname: Ueda, Tomohiro organization: Department of Urology, Ueda Clinic, Kyoto, Japan – sequence: 3 givenname: Hikaru surname: Tomoe fullname: Tomoe, Hikaru organization: Department of Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan – sequence: 4 givenname: Alex TL surname: Lin fullname: Lin, Alex TL organization: Department of Urology, National Yang Ming University and Taipei Veterans General Hospital, Taipei, Taiwan – sequence: 5 givenname: Hann-Chorng surname: Kuo fullname: Kuo, Hann-Chorng organization: Department of Urology, Buddhist Tzu Chi General Hospital and School of Medicine, Tzu Chi University, HualienTaiwan – sequence: 6 givenname: Ming-Huei surname: Lee fullname: Lee, Ming-Huei organization: Department of Urology, Feng-Yuan Hospital, Taichung, Taiwan – sequence: 7 givenname: Seung-June surname: Oh fullname: Oh, Seung-June organization: Department of Urology, Seoul National University, Seoul, Korea – sequence: 8 givenname: Joon Chul surname: Kim fullname: Kim, Joon Chul organization: Department of Urology, The Catholic University of Korea, Seoul, Korea – sequence: 9 givenname: Kyu-Sung surname: Lee fullname: Lee, Kyu-Sung organization: Department of Urology, Sung Kyun Kwan University School of Medicine, Seoul, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27218442$$D View this record in MEDLINE/PubMed |
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Down regulation of vascular endothelial growth factor is associated with decreased inflammation after intravesical OnabotulinumtoxinA injections combined with hydrodistention for patients with interstitial cystitis-clinical results and immunohistochemistry analysis. Urology 2013; 82: e1-6. Pinto R, Lopes T, Costa D et al. Ulcerative and nonulcerative forms of bladder pain syndrome/in 2015; 34 2013; 24 2010; 17 2013; 20 2014; 25 2011; 11 2010; 183 2010; 184 2011; 17 2013; 8 2014; 21 2014; 20 2012; 51 2014; 1 2013; 16 2015; 85 2011; 22 2014; 9 2014; 8 2011; 29 2009; 16 2013; 190 2007; 26 2016; 195 2010; 76 2012; 80 2012; 187 2012; 188 2015; 4 2015; 10 2009; 297 2006; 7 2014; 191 2013; 90 2011; 77 2011; 78 2014; 192 2008; 53 2012; 79 2014; 83 2012; 109 2015; 193 2015; 26 2015; 194 2012; 110 2011; 108 2011; 107 2013; 32 2015; 22 2010; 298 2013; 82 2015 2011; 185 2009; 3 2012; 7 2016; 26 2014; 33 2009; 104 2014; 77 2014; 76 2011; 186 2012; 9 e_1_2_12_4_1 Yamada Y (e_1_2_12_53_1) 2015; 4 e_1_2_12_6_1 e_1_2_12_19_1 e_1_2_12_2_1 e_1_2_12_17_1 e_1_2_12_38_1 e_1_2_12_20_1 e_1_2_12_41_1 e_1_2_12_66_1 e_1_2_12_87_1 e_1_2_12_22_1 e_1_2_12_43_1 e_1_2_12_64_1 e_1_2_12_85_1 e_1_2_12_24_1 e_1_2_12_45_1 e_1_2_12_26_1 e_1_2_12_47_1 e_1_2_12_68_1 e_1_2_12_89_1 e_1_2_12_62_1 e_1_2_12_60_1 e_1_2_12_28_1 e_1_2_12_49_1 Tomoe H (e_1_2_12_74_1) 2015; 4 e_1_2_12_31_1 e_1_2_12_52_1 e_1_2_12_77_1 e_1_2_12_33_1 e_1_2_12_54_1 e_1_2_12_75_1 e_1_2_12_35_1 e_1_2_12_56_1 e_1_2_12_37_1 e_1_2_12_58_1 e_1_2_12_79_1 e_1_2_12_14_1 Lee MH (e_1_2_12_55_1) 2010; 17 e_1_2_12_90_1 e_1_2_12_12_1 Cox M (e_1_2_12_83_1) 2009; 16 e_1_2_12_8_1 e_1_2_12_10_1 e_1_2_12_73_1 e_1_2_12_94_1 e_1_2_12_50_1 e_1_2_12_71_1 e_1_2_12_92_1 e_1_2_12_3_1 e_1_2_12_5_1 e_1_2_12_18_1 e_1_2_12_16_1 e_1_2_12_39_1 e_1_2_12_42_1 e_1_2_12_65_1 e_1_2_12_88_1 e_1_2_12_21_1 e_1_2_12_44_1 e_1_2_12_63_1 e_1_2_12_86_1 e_1_2_12_23_1 e_1_2_12_46_1 e_1_2_12_69_1 e_1_2_12_25_1 e_1_2_12_48_1 e_1_2_12_67_1 e_1_2_12_80_1 e_1_2_12_61_1 e_1_2_12_84_1 e_1_2_12_40_1 e_1_2_12_82_1 e_1_2_12_27_1 e_1_2_12_29_1 e_1_2_12_30_1 e_1_2_12_76_1 e_1_2_12_32_1 e_1_2_12_34_1 e_1_2_12_57_1 e_1_2_12_36_1 e_1_2_12_59_1 e_1_2_12_78_1 e_1_2_12_15_1 e_1_2_12_91_1 e_1_2_12_13_1 e_1_2_12_11_1 e_1_2_12_72_1 e_1_2_12_7_1 Lee CL (e_1_2_12_81_1) 2013; 16 e_1_2_12_51_1 e_1_2_12_70_1 e_1_2_12_93_1 e_1_2_12_9_1 |
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| Title | Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015 |
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