高效液相色谱法测定~（18）F-FDG注射液中氨基聚醚含量
采用高效液相色谱法测定了18F-FDG注射液中氨基聚醚（K2.2.2）的含量,并对流动相、流速、检测波长进行了选择,确定检测条件为：V（50mmol/L乙酸铵）∶V（乙腈）=1∶1为流动相,流速为0.5mL/min,检测波长210nm,进样量为10μL。K2.2.2在1～50mg/L浓度范围内线性良好,线性回归方程：y=265 939.4x＋7 490.7,相关系数γ=0.999,回收率为96.0%～100.3%,精密度小于3.5%。本方法回收率较高,精密度较小,样品用量少,可用于18F-FDG注射液中微量K2.2.2的测定。...
Saved in:
| Published in | 同位素 Vol. 25; no. 3; pp. 171 - 174 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
原子高科股份有限公司,北京,102413
2012
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-7512 |
Cover
| Abstract | 采用高效液相色谱法测定了18F-FDG注射液中氨基聚醚（K2.2.2）的含量,并对流动相、流速、检测波长进行了选择,确定检测条件为：V（50mmol/L乙酸铵）∶V（乙腈）=1∶1为流动相,流速为0.5mL/min,检测波长210nm,进样量为10μL。K2.2.2在1～50mg/L浓度范围内线性良好,线性回归方程：y=265 939.4x＋7 490.7,相关系数γ=0.999,回收率为96.0%～100.3%,精密度小于3.5%。本方法回收率较高,精密度较小,样品用量少,可用于18F-FDG注射液中微量K2.2.2的测定。 |
|---|---|
| AbstractList | 采用高效液相色谱法测定了18F-FDG注射液中氨基聚醚（K2.2.2）的含量,并对流动相、流速、检测波长进行了选择,确定检测条件为：V（50mmol/L乙酸铵）∶V（乙腈）=1∶1为流动相,流速为0.5mL/min,检测波长210nm,进样量为10μL。K2.2.2在1～50mg/L浓度范围内线性良好,线性回归方程：y=265 939.4x＋7 490.7,相关系数γ=0.999,回收率为96.0%～100.3%,精密度小于3.5%。本方法回收率较高,精密度较小,样品用量少,可用于18F-FDG注射液中微量K2.2.2的测定。 R817.9%O657.72; 采用高效液相色谱法测定了18F- FDG注射液中氨基聚醚(K 2.2.2)的含量,并对流动相、流速、检测波长进行了选择,确定检测条件为:V(50 mmol/L乙酸铵)∶V(乙腈)=1∶1为流动相,流速为0.5mL/min,检测波长210 nm,进样量为10 μL.K2.2.2在1～50 mg/L浓度范围内线性良好,线性回归方程:y=265 939.4x+7 490.7,相关系数γ-0.999,回收率为96.0％～100.3％,精密度小于3.5％.本方法回收率较高,精密度较小,样品用量少,可用于18F-FDG注射液中微量K2.2,2的测定. |
| Author | 赵岩 王晓静 叶肇云 赵秀岩 姜华 |
| AuthorAffiliation | 原子高科股份有限公司,北京102413 |
| AuthorAffiliation_xml | – name: 原子高科股份有限公司,北京,102413 |
| Author_FL | YE Zhao-yun ZHAO Xiu-yan JIANG Hua ZHAO Yan WANG Xiao-jing |
| Author_FL_xml | – sequence: 1 fullname: ZHAO Yan – sequence: 2 fullname: WANG Xiao-jing – sequence: 3 fullname: YE Zhao-yun – sequence: 4 fullname: ZHAO Xiu-yan – sequence: 5 fullname: JIANG Hua |
| Author_xml | – sequence: 1 fullname: 赵岩 王晓静 叶肇云 赵秀岩 姜华 |
| BookMark | eNotzTFLw0AcBfAbKlhrP4TgGvjfXe6SjFJNFAou3UN6udSIJpooxUUQRFscdClIHFwLRYktSpF-HBOTqV_BQJ0ePH68t4FqQRjIGqpjAFA0hsk6asax3wWVc8LA0OvIKifP-WiQf01_X-bFcFqkH_lslH8-ZO_J9XIxwPpyMTQVc9fKZ-Msva3gz_wtT8fZ63dxk5R3SfY0Ke8fN9Ga55zEsvmfDdQx9zqtfaV9aB20dtqKYExXONMNT-OEMA1LwJJgLqnhYWBdgaWkLmdSCA6uQzSVCpd4XLhV5YLR5dTFtIG2V7N9J_CcoGcfh5dRUB3aF_2YACZAAfSKba2YOAqD3rlfwbPIP3WiK1ulVMMqpvQPsDVp5Q |
| ClassificationCodes | R817.9%O657.72 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W92 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库-工程技术 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| DocumentTitleAlternate | Quantification of Kryptofix2.2.2 in 18F-FDG by HPLC |
| DocumentTitle_FL | Quantification of Kryptofix2.2.2 in 18F-FDG by HPLC |
| EndPage | 174 |
| ExternalDocumentID | tws201203008 43371413 |
| GroupedDBID | -02 -05 2B. 2C0 2C~ 2RA 5VS 5XA 5XD 5XF 92H 92I 92L ACGFS ALMA_UNASSIGNED_HOLDINGS ARCSS CCEZO CEKLB CIEJG CQIGP CW9 GROUPED_DOAJ IPNFZ KQ8 RIG TCJ TGT U1G U5M W92 ~WA 4A8 93N ABJNI PSX |
| ID | FETCH-LOGICAL-c558-6589f7622571e01e216e39f105bc1ee3d65ecc60da2743cd2f6cd5ecd09b63d13 |
| ISSN | 1000-7512 |
| IngestDate | Thu May 29 04:03:57 EDT 2025 Wed Feb 14 10:45:36 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | 氨基聚醚(K2.2.2) 高效液相色谱法 18F-FDG注射液 |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c558-6589f7622571e01e216e39f105bc1ee3d65ecc60da2743cd2f6cd5ecd09b63d13 |
| Notes | 11-2566/TL 18 F-FDG injection; Kryptofix2.2.2; high performance liquid chromatography A high-performance liquid chromatograph method was used to quantify Krypto- fix2.2.2 （K2.2.2）in the radiopharmaceutical of 18F-FDG（2-Deoxy-2-[18F] fluoro-D-glucose）. A Waters C18 column （ XTerra RP18 150 mm×3. 9 mm,5 μm）was used as stationary phase, V（50 mmol/L ammonium acetate） ： V（acetonitrile）=1 ： 1 was used as mobile phase and the flow was 0.5 mL · min^-1, UV detection wavelength was performed at 210 nm. The calibration curve was established over the rang of 1-50 mg/L, the linear correlation co- efficient was 0. 999, and the recovery was in the rang of 96.0%-100.3%. The method was accurate and using less sample,and can be used for the quality control of K2.2.2 in 18F-FDG injection production. ZHAO Yan, WANG Xiao-jing, YE Zhao-yun, ZHAO Xiu-yan, JIANG Hua （HTA Co. , LTD. , Beijing 102413, China） |
| PageCount | 4 |
| ParticipantIDs | wanfang_journals_tws201203008 chongqing_primary_43371413 |
| PublicationCentury | 2000 |
| PublicationDate | 2012 |
| PublicationDateYYYYMMDD | 2012-01-01 |
| PublicationDate_xml | – year: 2012 text: 2012 |
| PublicationDecade | 2010 |
| PublicationTitle | 同位素 |
| PublicationTitleAlternate | Isotopes |
| PublicationTitle_FL | Journal of Isotopes |
| PublicationYear | 2012 |
| Publisher | 原子高科股份有限公司,北京,102413 |
| Publisher_xml | – name: 原子高科股份有限公司,北京,102413 |
| SSID | ssib046625098 ssj0039471 ssib051370769 ssib000862156 ssib038074670 |
| Score | 1.8884517 |
| Snippet | 采用高效液相色谱法测定了18F-FDG注射液中氨基聚醚（K2.2.2）的含量,并对流动相、流速、检测波长进行了选择,确定检测条件为：V（50mmol/L乙酸铵）∶V（乙腈）=1∶1为流动相,流... R817.9%O657.72; 采用高效液相色谱法测定了18F- FDG注射液中氨基聚醚(K 2.2.2)的含量,并对流动相、流速、检测波长进行了选择,确定检测条件为:V(50 mmol/L乙酸铵)∶V(乙... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 171 |
| SubjectTerms | 18F-FDG注射液 氨基聚醚（K2.2.2） 高效液相色谱法 |
| Title | 高效液相色谱法测定~（18）F-FDG注射液中氨基聚醚含量 |
| URI | http://lib.cqvip.com/qk/96299X/201203/43371413.html https://d.wanfangdata.com.cn/periodical/tws201203008 |
| Volume | 25 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library issn: 1000-7512 databaseCode: KQ8 dateStart: 19880101 customDbUrl: isFulltext: true dateEnd: 99991231 titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html omitProxy: true ssIdentifier: ssj0039471 providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals issn: 1000-7512 databaseCode: DOA dateStart: 20060101 customDbUrl: isFulltext: true dateEnd: 99991231 titleUrlDefault: https://www.doaj.org/ omitProxy: true ssIdentifier: ssj0039471 providerName: Directory of Open Access Journals |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NaxQxFA-lF72In9hqpQffqYxMNpNMcpzZnW1RFIQKvS07X-1pq3aL0IMgiLZ40EtB6sFroShri1Kkf467bk_9F3wvM7tORUSFYXi8eXl5mZdJfskkeYzdjAXBiix1ctdrOzj-SpxYxLFjYuOLTHmpSmhz8t17auGBd3tJLk1M9Cqrlta78a1k47f7Sv7Hq8hDv9Iu2X_w7FgpMpBG_-IdPYz3v_IxRAaCEIyGSIGRoC0R4lWDyAcTQogcDdpYjobQhZBbGUHyRGCqECIJQQQmAD-CqAlhHVVxPSJN02k25stkgSZpVKS9SmYe5RQ0LMctZQymDmz2nFSjrVpZAh-5ZDdxfNCnVhaWT3Xd6myAblBJQg-C8X8VWxBJFxlSg8DMkYyObEkwCwNGkHLTQHqOpHSTDCVTapQlqQ7A8LmKKh8Cn5Z9VHRKYpm6VYCWRNUZEl6ZLqWfF44v-an2vthoXdZrUWm8eREMpsQBvIge9Mtp3J6gIw5tmGSEdhQr5M79Kp5VCKHG-I4O88eOaNwgegpHm-7P8a3kwnd9ivBeQAdhyhmCkdl04MfKamf5EcIYu6usk7c7yxUAtHienStHLrNBUQ0vsImNlYvsTH0UMPASmz_eezvY3hx82f_-7nC4tT_sfRocbA8-v-p_3Hl6crTJ9cnRlq1Kg4Pdfu85Cn47_DDo7fbffx0-2zl-sdN_s3f88vVlttiMFusLThmnw0mk1A5iWJNjn4qNP89cntW4yoTJEbjHCc8ykSqJ7YRy03YN4WqS1nKVpMhKXRMrkXJxhU12VjvZVTaLPR6NCYySben5MouTPEvyXFMUA0_xeIpNj99H62FxHEtr5JIpNlO-oFb5ja61uk_WqEZgT-bq6T8lvsbOkmAxuXadTXYfr2czCDe78Q3r4h9udGTJ |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E9%AB%98%E6%95%88%E6%B6%B2%E7%9B%B8%E8%89%B2%E8%B0%B1%E6%B3%95%E6%B5%8B%E5%AE%9A%7E%EF%BC%8818%EF%BC%89F-FDG%E6%B3%A8%E5%B0%84%E6%B6%B2%E4%B8%AD%E6%B0%A8%E5%9F%BA%E8%81%9A%E9%86%9A%E5%90%AB%E9%87%8F&rft.jtitle=%E5%90%8C%E4%BD%8D%E7%B4%A0&rft.au=%E8%B5%B5%E5%B2%A9+%E7%8E%8B%E6%99%93%E9%9D%99+%E5%8F%B6%E8%82%87%E4%BA%91+%E8%B5%B5%E7%A7%80%E5%B2%A9+%E5%A7%9C%E5%8D%8E&rft.date=2012&rft.issn=1000-7512&rft.volume=25&rft.issue=3&rft.spage=171&rft.epage=174&rft.externalDocID=43371413 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F96299X%2F96299X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Ftws%2Ftws.jpg |