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Keywords: 13/1; 13/106; 13/51; 13/89; 14; 14/63; 140/58; 38; 631/67/1922; 631/67/2327; 631/67/327; Acetone - analogs & derivatives; Acetone - metabolism; Acetone - toxicity; Animals; Brain Neoplasms - blood supply; Brain Neoplasms - enzymology; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Brain tumors; Cancer; Cancer cells; Carbon; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Enzymes; Female; Glioblastoma - blood supply; Glioblastoma - enzymology; Glioblastoma - metabolism; Glioblastoma - pathology; Gliomas; Glycine; Glycine - metabolism; Glycine Dehydrogenase (Decarboxylating) - antagonists & inhibitors; Glycine Dehydrogenase (Decarboxylating) - metabolism; Glycine Hydroxymethyltransferase - metabolism; Health aspects; Humanities and Social Sciences; Humans; Hypoxia; Ischemia; Ischemia - enzymology; Ischemia - metabolism; Ischemia - pathology; Kinases; letter; Metabolism; Metabolites; Mice; multidisciplinary; Necrosis; Oxygen Consumption; Physiological aspects; Pyruvaldehyde - metabolism; Pyruvaldehyde - toxicity; Pyruvate Kinase - metabolism; Science; Survival; Tumor Microenvironment; Xenograft Model Antitumor Assays