Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma

Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart...

Full description

Saved in:
Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 51; no. 3; pp. 535 - 547.e9
Main Authors Meyer, Stefanie N., Scuoppo, Claudio, Vlasevska, Sofija, Bal, Elodie, Holmes, Antony B., Holloman, Mara, Garcia-Ibanez, Laura, Nataraj, Sarah, Duval, Romain, Vantrimpont, Thomas, Basso, Katia, Brooks, Nigel, Dalla-Favera, Riccardo, Pasqualucci, Laura
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 17.09.2019
Elsevier Limited
Subjects
acetyltransferase inhibitor
Acetyltransferases - genetics
Animal models
Animals
B-cell lymphoma
B-Lymphocytes - physiology
Cell Line
Clonal deletion
CREB-Binding Protein - genetics
CREBBP
dark zone
diffuse large cell lymphoma
E1A-Associated p300 Protein - genetics
Enzymes
EP300
Epigenesis, Genetic - genetics
Fitness
Genomes
Genomics
germinal center
Germinal Center - physiology
Germinal centers
HEK293 Cells
Humans
Inhibitors
light zone
Lymphocytes B
Lymphoma
Lymphoma, Follicular - etiology
Lymphoma, Large B-Cell, Diffuse - genetics
Mice
Mice, Inbred C57BL
Mutation
Reproductive fitness
Sequence Deletion - genetics
Software
synthetic lethality
Transcription
Transcription, Genetic - genetics
dark zone
diffuse large cell lymphoma
CREBBP
acetyltransferase inhibitor
synthetic lethality
EP300
light zone
germinal center
Online AccessGet full text
ISSN1074-7613
1097-4180
1097-4180
DOI10.1016/j.immuni.2019.08.006

Cover

Abstract Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart of FL and DLBCL, and in lymphomagenesis by using conditional GC-directed deletion mouse models targeting Crebbp or Ep300. We found that CREBBP and EP300 modulate common as well as distinct transcriptional programs implicated in separate anatomic and functional GC compartments. Consistently, deletion of Ep300 but not Crebbp impaired the fitness of GC B cells in vivo. Combined loss of Crebbp and Ep300 completely abrogated GC formation, suggesting that these proteins partially compensate for each other through common transcriptional targets. This synthetic lethal interaction was retained in CREBBP-mutant DLBCL cells and could be pharmacologically targeted with selective small molecule inhibitors of CREBBP and EP300 function. These data provide proof-of-principle for the clinical development of EP300-specific inhibitors in FL and DLBCL. [Display omitted] •CREBBP and EP300 control distinct as well as shared transcriptional targets in the GC•Deletion of Crebbp and Ep300 in B cells abrogates GC formation, revealing paralog lethality•CREBBP-mutant DLBCL cells are preferentially sensitive to EP300 deletion•EP300-dependency can be pharmacologically targeted by CREBBP and EP300 inhibitors Loss-of-function mutations of CREBBP and EP300 are frequent and early events in the pathogenesis of FL and DLBCL, the two most common lymphoma subtypes. Meyer et al. uncover distinct as well as compensatory roles for these acetyltransferases in separate compartments of the germinal center and exploit this notion to document an EP300-dependency in CREBBP-deficient lymphoma cells that can be targeted therapeutically.
AbstractList SummaryInactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart of FL and DLBCL, and in lymphomagenesis by using conditional GC-directed deletion mouse models targeting Crebbp or Ep300. We found that CREBBP and EP300 modulate common as well as distinct transcriptional programs implicated in separate anatomic and functional GC compartments. Consistently, deletion of Ep300 but not Crebbp impaired the fitness of GC B cells in vivo. Combined loss of Crebbp and Ep300 completely abrogated GC formation, suggesting that these proteins partially compensate for each other through common transcriptional targets. This synthetic lethal interaction was retained in CREBBP-mutant DLBCL cells and could be pharmacologically targeted with selective small molecule inhibitors of CREBBP and EP300 function. These data provide proof-of-principle for the clinical development of EP300-specific inhibitors in FL and DLBCL.
Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart of FL and DLBCL, and in lymphomagenesis by using conditional GC-directed deletion mouse models targeting Crebbp or Ep300. We found that CREBBP and EP300 modulate common as well as distinct transcriptional programs implicated in separate anatomic and functional GC compartments. Consistently, deletion of Ep300 but not Crebbp impaired the fitness of GC B cells in vivo. Combined loss of Crebbp and Ep300 completely abrogated GC formation, suggesting that these proteins partially compensate for each other through common transcriptional targets. This synthetic lethal interaction was retained in CREBBP-mutant DLBCL cells and could be pharmacologically targeted with selective small molecule inhibitors of CREBBP and EP300 function. These data provide proof-of-principle for the clinical development of EP300-specific inhibitors in FL and DLBCL.Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart of FL and DLBCL, and in lymphomagenesis by using conditional GC-directed deletion mouse models targeting Crebbp or Ep300. We found that CREBBP and EP300 modulate common as well as distinct transcriptional programs implicated in separate anatomic and functional GC compartments. Consistently, deletion of Ep300 but not Crebbp impaired the fitness of GC B cells in vivo. Combined loss of Crebbp and Ep300 completely abrogated GC formation, suggesting that these proteins partially compensate for each other through common transcriptional targets. This synthetic lethal interaction was retained in CREBBP-mutant DLBCL cells and could be pharmacologically targeted with selective small molecule inhibitors of CREBBP and EP300 function. These data provide proof-of-principle for the clinical development of EP300-specific inhibitors in FL and DLBCL.
Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart of FL and DLBCL, and in lymphomagenesis by using conditional GC-directed deletion mouse models targeting Crebbp or Ep300. We found that CREBBP and EP300 modulate common as well as distinct transcriptional programs implicated in separate anatomic and functional GC compartments. Consistently, deletion of Ep300 but not Crebbp impaired the fitness of GC B cells in vivo. Combined loss of Crebbp and Ep300 completely abrogated GC formation, suggesting that these proteins partially compensate for each other through common transcriptional targets. This synthetic lethal interaction was retained in CREBBP-mutant DLBCL cells and could be pharmacologically targeted with selective small molecule inhibitors of CREBBP and EP300 function. These data provide proof-of-principle for the clinical development of EP300-specific inhibitors in FL and DLBCL.
Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart of FL and DLBCL, and in lymphomagenesis by using conditional GC-directed deletion mouse models targeting Crebbp or Ep300. We found that CREBBP and EP300 modulate common as well as distinct transcriptional programs implicated in separate anatomic and functional GC compartments. Consistently, deletion of Ep300 but not Crebbp impaired the fitness of GC B cells in vivo. Combined loss of Crebbp and Ep300 completely abrogated GC formation, suggesting that these proteins partially compensate for each other through common transcriptional targets. This synthetic lethal interaction was retained in CREBBP-mutant DLBCL cells and could be pharmacologically targeted with selective small molecule inhibitors of CREBBP and EP300 function. These data provide proof-of-principle for the clinical development of EP300-specific inhibitors in FL and DLBCL. Loss-of-function mutations of CREBBP and EP300 are frequent and early events in the pathogenesis of FL and DLBCL, the two most common lymphoma subtypes. Meyer et al. uncover distinct as well as compensatory roles for these acetyltransferases in separate compartments of the germinal center and exploit this notion to document an EP300-dependency in CREBBP-deficient lymphoma cells that can be targeted therapeutically.
Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart of FL and DLBCL, and in lymphomagenesis by using conditional GC-directed deletion mouse models targeting Crebbp or Ep300. We found that CREBBP and EP300 modulate common as well as distinct transcriptional programs implicated in separate anatomic and functional GC compartments. Consistently, deletion of Ep300 but not Crebbp impaired the fitness of GC B cells in vivo. Combined loss of Crebbp and Ep300 completely abrogated GC formation, suggesting that these proteins partially compensate for each other through common transcriptional targets. This synthetic lethal interaction was retained in CREBBP-mutant DLBCL cells and could be pharmacologically targeted with selective small molecule inhibitors of CREBBP and EP300 function. These data provide proof-of-principle for the clinical development of EP300-specific inhibitors in FL and DLBCL. [Display omitted] •CREBBP and EP300 control distinct as well as shared transcriptional targets in the GC•Deletion of Crebbp and Ep300 in B cells abrogates GC formation, revealing paralog lethality•CREBBP-mutant DLBCL cells are preferentially sensitive to EP300 deletion•EP300-dependency can be pharmacologically targeted by CREBBP and EP300 inhibitors Loss-of-function mutations of CREBBP and EP300 are frequent and early events in the pathogenesis of FL and DLBCL, the two most common lymphoma subtypes. Meyer et al. uncover distinct as well as compensatory roles for these acetyltransferases in separate compartments of the germinal center and exploit this notion to document an EP300-dependency in CREBBP-deficient lymphoma cells that can be targeted therapeutically.
Author Vantrimpont, Thomas
Meyer, Stefanie N.
Vlasevska, Sofija
Scuoppo, Claudio
Pasqualucci, Laura
Duval, Romain
Holmes, Antony B.
Garcia-Ibanez, Laura
Dalla-Favera, Riccardo
Bal, Elodie
Nataraj, Sarah
Brooks, Nigel
Holloman, Mara
Basso, Katia
AuthorAffiliation 4 Department of Genetics & Development, Columbia University, New York, NY 10032, USA
1 Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
3 Cell Centric, Chesterford Research Park, Little Chesterford, Cambridge, CB10 1XL, UK
6 Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
7 Lead Contact
2 Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
5 Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA
AuthorAffiliation_xml – name: 7 Lead Contact
– name: 1 Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– name: 6 Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
– name: 3 Cell Centric, Chesterford Research Park, Little Chesterford, Cambridge, CB10 1XL, UK
– name: 2 Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
– name: 4 Department of Genetics & Development, Columbia University, New York, NY 10032, USA
– name: 5 Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA
Author_xml – sequence: 1
  givenname: Stefanie N.
  surname: Meyer
  fullname: Meyer, Stefanie N.
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 2
  givenname: Claudio
  surname: Scuoppo
  fullname: Scuoppo, Claudio
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 3
  givenname: Sofija
  surname: Vlasevska
  fullname: Vlasevska, Sofija
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 4
  givenname: Elodie
  surname: Bal
  fullname: Bal, Elodie
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 5
  givenname: Antony B.
  surname: Holmes
  fullname: Holmes, Antony B.
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 6
  givenname: Mara
  surname: Holloman
  fullname: Holloman, Mara
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 7
  givenname: Laura
  surname: Garcia-Ibanez
  fullname: Garcia-Ibanez, Laura
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 8
  givenname: Sarah
  surname: Nataraj
  fullname: Nataraj, Sarah
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 9
  givenname: Romain
  surname: Duval
  fullname: Duval, Romain
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 10
  givenname: Thomas
  surname: Vantrimpont
  fullname: Vantrimpont, Thomas
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 11
  givenname: Katia
  surname: Basso
  fullname: Basso, Katia
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 12
  givenname: Nigel
  surname: Brooks
  fullname: Brooks, Nigel
  organization: Cell Centric, Chesterford Research Park, Little Chesterford, Cambridge, CB10 1XL, UK
– sequence: 13
  givenname: Riccardo
  surname: Dalla-Favera
  fullname: Dalla-Favera, Riccardo
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
– sequence: 14
  givenname: Laura
  orcidid: 0000-0001-6819-7370
  surname: Pasqualucci
  fullname: Pasqualucci, Laura
  email: lp171@cumc.columbia.edu
  organization: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31519498$$D View this record in MEDLINE/PubMed
BookMark eNqVkdtuEzEQhleoiB7gDRCyxA03CeM9LxdITUgLUiSiEq6tiXc2cbRrb21vUF6E563TlFMvQPjGlv3_v2e-OY9OtNEURS85jDnw_O12rLpu0GocA6_GUI4B8ifRGYeqGKW8hJPDuUhHRc6T0-jcuS0AT7MKnkWnCc94lVblWfT9q1a3AzHUNfuyQUs1m_VqTZq8kmxhzdpi55hpmN8Qm97MJpPFvXi2SADYpSS_b71F7Rqy6Mgxpdk12U5pbNmUtCfLJuHQto7d0I7C7RLtmjyuWmIfqCddk5bq6Jzvu35jOnwePW2wdfTiYb-Illez5fTjaP75-tP0cj6SWVb4UYyQ8NAJEK3SAmVKJUCdpgg11VnGi0ZSLTkmdUXU5LxehZWhbJDyUsrkIsqOsYPucf8N21b0VnVo94KDOGAWW3HELA6YBZQiYA6-90dfP6y68ENo0-Ivr0El_nzRaiPWZieKJI8LzkPAm4cAawJ-50WnnAyQUJMZnIjjCipIc4Agff1IujWDDXTvVTFAnJVVUL36vaKfpfyYdBC8OwqkNc5ZaoRUHr0yhwJV-69-00fm_8NEYYQ7RVa4MGgdZqIsSS9qo_4ecAecGurd
CitedBy_id crossref_primary_10_3389_fonc_2022_874645
crossref_primary_10_3390_cancers13061340
crossref_primary_10_1002_art_41188
crossref_primary_10_1182_bloodadvances_2020002944
crossref_primary_10_1139_bcb_2022_0288
crossref_primary_10_3389_fgene_2022_862803
crossref_primary_10_1016_j_tranon_2023_101779
crossref_primary_10_1039_D2MD00044J
crossref_primary_10_1016_j_cbpa_2020_04_008
crossref_primary_10_1038_s41467_022_30050_y
crossref_primary_10_3389_fcell_2021_805195
crossref_primary_10_3389_fonc_2021_780118
crossref_primary_10_1016_j_clim_2022_109105
crossref_primary_10_1158_2159_8290_CD_23_0111
crossref_primary_10_1038_s41392_020_00437_8
crossref_primary_10_3389_fimmu_2023_1288110
crossref_primary_10_1016_j_bbagrm_2022_194828
crossref_primary_10_1038_s41586_022_04906_8
crossref_primary_10_1080_17501911_2024_2447807
crossref_primary_10_1182_hematology_2020006908
crossref_primary_10_1016_j_ccell_2024_02_011
crossref_primary_10_1038_s41375_023_02013_9
crossref_primary_10_3389_fcell_2019_00272
crossref_primary_10_3390_cancers13092044
crossref_primary_10_1038_s41388_024_03065_6
crossref_primary_10_3389_fimmu_2021_710711
crossref_primary_10_1038_s41375_020_0908_8
crossref_primary_10_1111_bjh_19218
crossref_primary_10_1002_hon_3205
crossref_primary_10_3390_cancers12071869
crossref_primary_10_3390_cancers17020255
crossref_primary_10_1007_s00432_022_04067_1
crossref_primary_10_1016_j_blre_2020_100782
crossref_primary_10_1177_1758835919900856
crossref_primary_10_1186_s13046_021_02234_9
crossref_primary_10_1016_j_trecan_2025_02_001
crossref_primary_10_1097_HS9_0000000000000582
crossref_primary_10_1038_s41419_021_03695_8
crossref_primary_10_1186_s13045_022_01249_9
crossref_primary_10_1186_s13148_020_00948_9
crossref_primary_10_1038_s41375_021_01285_3
crossref_primary_10_1080_10428194_2020_1762883
crossref_primary_10_1038_s41467_023_43519_1
crossref_primary_10_3390_cancers15030835
crossref_primary_10_1016_j_cancergen_2022_07_006
crossref_primary_10_4103_jfmpc_jfmpc_2432_21
crossref_primary_10_3390_hemato5030020
crossref_primary_10_1093_nar_gkab950
crossref_primary_10_1182_bloodadvances_2020001879
crossref_primary_10_1158_2159_8290_CD_19_0116
crossref_primary_10_3390_cancers15041219
crossref_primary_10_1021_acs_jmedchem_1c00348
crossref_primary_10_3390_hemato3040041
crossref_primary_10_1080_17520363_2024_2389036
crossref_primary_10_1111_bjh_17383
crossref_primary_10_3389_fimmu_2021_683597
crossref_primary_10_1016_j_immuni_2019_08_018
crossref_primary_10_1038_s41568_021_00357_x
crossref_primary_10_1146_annurev_cancerbio_060820_125304
crossref_primary_10_1158_2159_8290_CD_20_0751
crossref_primary_10_1186_s12943_024_01953_9
crossref_primary_10_3390_ijms22158269
crossref_primary_10_1016_j_currproblcancer_2023_100955
crossref_primary_10_1186_s13578_024_01326_1
crossref_primary_10_1016_j_ijbiomac_2025_141533
crossref_primary_10_1182_hematology_2022000361
crossref_primary_10_1158_2643_3230_BCD_24_0020
crossref_primary_10_1182_blood_2020006908
crossref_primary_10_1073_pnas_2218330120
crossref_primary_10_1002_hon_3141
crossref_primary_10_1016_j_bioorg_2022_105803
crossref_primary_10_1136_jcp_2024_209848
crossref_primary_10_3389_fimmu_2022_813031
crossref_primary_10_1016_j_immuni_2021_07_015
crossref_primary_10_1007_s00277_024_05681_4
crossref_primary_10_2174_1568009620666210106122750
crossref_primary_10_1038_s41375_022_01774_z
crossref_primary_10_1101_cshperspect_a034827
crossref_primary_10_1007_s12032_021_01572_0
crossref_primary_10_1016_j_ccell_2023_11_001
crossref_primary_10_1016_j_chembiol_2023_11_014
crossref_primary_10_1126_sciadv_abl4618
crossref_primary_10_1038_s41379_020_0616_y
Cites_doi 10.1016/j.cell.2010.10.032
10.1158/2159-8290.CD-15-0754
10.1126/science.1247005
10.1038/s41591-018-0016-8
10.1056/NEJMoa1801445
10.1073/pnas.0506580102
10.1038/nm.3940
10.1038/nprot.2016.095
10.1038/s41590-018-0181-4
10.1093/bioinformatics/btt656
10.1016/j.immuni.2008.04.014
10.1186/s13059-014-0550-8
10.1038/ni.1609
10.1126/science.1246981
10.1038/nri3804
10.1186/1471-2105-12-277
10.1038/42981
10.1128/MCB.26.3.789-809.2006
10.1038/nprot.2008.211
10.1101/gad.14.13.1553
10.1186/s13059-015-0700-7
10.1038/nature09730
10.1146/annurev-immunol-020711-075032
10.1111/j.1600-065X.2012.01112.x
10.1038/nature10351
10.1182/blood-2012-03-415380
10.1093/bioinformatics/btp324
10.1016/j.cell.2018.04.033
10.1038/cr.2010.55
10.1016/S0092-8674(00)80521-8
10.1038/ng.892
10.1073/pnas.0804868105
10.1200/JCO.2017.35.15_suppl.11590
10.1084/jem.184.1.277
10.4161/epi.5.1.10449
10.1038/nbt.2951
10.1038/ng1018
10.1073/pnas.232568499
10.1038/383538a0
10.1038/ng.3167
10.1016/j.cell.2013.03.035
10.1093/bioinformatics/btp352
10.1038/nmeth.1923
10.1038/nature24028
10.1200/JCO.2006.09.3260
10.1073/pnas.0602353103
10.1016/S0092-8674(00)82001-2
10.1016/S0092-8674(00)80304-9
10.1002/mrd.22489
10.1038/386735a0
10.1038/srep28973
10.1016/j.immuni.2016.09.001
10.1242/jcs.114.13.2363
10.1016/S1535-6108(04)00022-4
10.1182/blood-2016-08-733469
10.1016/j.ccell.2018.08.006
10.1016/j.celrep.2013.12.027
10.1073/pnas.1501199112
10.1038/ng.2856
10.1038/s41467-018-06354-3
10.1200/JCO.2010.28.1618
10.1158/2159-8290.CD-16-0975
10.1182/blood-2005-08-3263
10.1182/blood-2018-03-837039
10.1093/nar/gku936
10.1021/cr500452k
10.1038/nmeth.3047
10.1073/pnas.1619555114
10.1158/2159-8290.CD-16-1417
10.1038/nature01062
10.1093/nar/27.1.209
10.1038/384641a0
ContentType Journal Article
Copyright 2019 Elsevier Inc.
Copyright © 2019 Elsevier Inc. All rights reserved.
2019. Elsevier Inc.
Copyright_xml – notice: 2019 Elsevier Inc.
– notice: Copyright © 2019 Elsevier Inc. All rights reserved.
– notice: 2019. Elsevier Inc.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7T5
7T7
7TK
7TM
7U9
8FD
C1K
FR3
H94
K9.
M7N
NAPCQ
P64
RC3
7X8
5PM
ADTOC
UNPAY
DOI 10.1016/j.immuni.2019.08.006
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Nursing & Allied Health Premium
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Virology and AIDS Abstracts
Technology Research Database
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Nursing & Allied Health Premium
Genetics Abstracts
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
Immunology Abstracts
Engineering Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Calcium & Calcified Tissue Abstracts
MEDLINE - Academic
DatabaseTitleList Virology and AIDS Abstracts
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1097-4180
EndPage 547.e9
ExternalDocumentID 10.1016/j.immuni.2019.08.006
PMC7362711
31519498
10_1016_j_immuni_2019_08_006
S1074761319303322
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: P30 CA013696
– fundername: NCI NIH HHS
  grantid: P50 CA192937
– fundername: NCI NIH HHS
  grantid: R01 CA172492
GroupedDBID ---
--K
-DZ
0R~
1RT
1~5
2WC
4.4
457
4G.
53G
5GY
62-
6I.
7-5
7RV
7X7
8C1
8FE
8FH
AACTN
AAEDW
AAFTH
AAIAV
AAKRW
AALRI
AAUCE
AAVLU
AAXUO
ABMAC
ABMWF
ABOCM
ABVKL
ACGFO
ACGFS
ACIWK
ACPRK
ADBBV
ADEZE
ADFRT
ADJPV
AEFWE
AENEX
AEXQZ
AFKRA
AFRAH
AFTJW
AGGSO
AGKMS
AHMBA
AITUG
ALKID
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ASPBG
AVWKF
AZFZN
BAWUL
BBNVY
BENPR
BHPHI
BKEYQ
BPHCQ
BVXVI
C45
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
FCP
FDB
FIRID
HCIFZ
IH2
IHE
IXB
J1W
JIG
LK8
LX5
M2O
M3Z
M41
M7P
N9A
O-L
O9-
OK1
OVD
P2P
PQQKQ
PROAC
RCE
RIG
ROL
RPZ
SCP
SES
SSZ
TEORI
TR2
WQ6
ZA5
.55
.GJ
29I
5VS
AAEDT
AAIKJ
AAMRU
AAQFI
AAQXK
AAYWO
AAYXX
ABDGV
ABJNI
ABWVN
ACRPL
ACVFH
ADCNI
ADMUD
ADNMO
ADVLN
AEUPX
AFPUW
AGHFR
AGQPQ
AHHHB
AIGII
AKAPO
AKBMS
AKRWK
AKYEP
APXCP
CITATION
EFKBS
FEDTE
FGOYB
G-2
HVGLF
HZ~
OHT
OZT
R2-
UHS
X7M
Y6R
ZGI
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7T5
7T7
7TK
7TM
7U9
8FD
C1K
FR3
H94
K9.
M7N
NAPCQ
P64
RC3
7X8
5PM
ADTOC
UNPAY
ID FETCH-LOGICAL-c557t-2a0311940eeb47ac4e800d44a0ded5517fcedc1a3d9eef61dbbbb5acfae68cc3
IEDL.DBID IXB
ISSN 1074-7613
1097-4180
IngestDate Sun Oct 26 03:50:07 EDT 2025
Tue Sep 30 16:57:14 EDT 2025
Sun Sep 28 07:30:31 EDT 2025
Tue Oct 07 06:33:26 EDT 2025
Thu Apr 03 06:59:42 EDT 2025
Sat Oct 25 05:08:41 EDT 2025
Thu Apr 24 23:10:37 EDT 2025
Fri Feb 23 02:50:13 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords dark zone
diffuse large cell lymphoma
CREBBP
acetyltransferase inhibitor
synthetic lethality
EP300
light zone
germinal center
Language English
License Copyright © 2019 Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c557t-2a0311940eeb47ac4e800d44a0ded5517fcedc1a3d9eef61dbbbb5acfae68cc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
AUTHORS CONTRIBUTIONS
Conceptualization: L.P.; Methodology: L.P. and S.N.M.; Investigation: S.N.M., C.S., S.V., E.B, M.H., L.G.-I, R.D., T.V., and L.P.; Software: A.B.H. andK.B.; Validation: L.P.; Formal Analysis: S.N.M., A.B.H., and L.P.; Resources: N.B.; Data Curation: A.H. and L.P.; Writing – Original Draft: L.P., S.N.M.; Writing – Review & Editing: L.P., R.D.-F., S.N.M., S.V., E.B, M.H., K.B., C.S.; Visualization: L.P., S.N.M., S.V.; Supervision: L.P., R.D.-F.; Project administration: L.P.; Funding Acquisition: L.P., R.D.-F.
ORCID 0000-0001-6819-7370
OpenAccessLink https://proxy.k.utb.cz/login?url=http://www.cell.com/article/S1074761319303322/pdf
PMID 31519498
PQID 2292002589
PQPubID 2031079
ParticipantIDs unpaywall_primary_10_1016_j_immuni_2019_08_006
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7362711
proquest_miscellaneous_2290904600
proquest_journals_2292002589
pubmed_primary_31519498
crossref_citationtrail_10_1016_j_immuni_2019_08_006
crossref_primary_10_1016_j_immuni_2019_08_006
elsevier_sciencedirect_doi_10_1016_j_immuni_2019_08_006
PublicationCentury 2000
PublicationDate 2019-09-17
PublicationDateYYYYMMDD 2019-09-17
PublicationDate_xml – month: 09
  year: 2019
  text: 2019-09-17
  day: 17
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Cambridge
PublicationTitle Immunity (Cambridge, Mass.)
PublicationTitleAlternate Immunity
PublicationYear 2019
Publisher Elsevier Inc
Elsevier Limited
Publisher_xml – name: Elsevier Inc
– name: Elsevier Limited
References Huang, Sherman, Lempicki (bib25) 2009; 4
Weinert, Narita, Satpathy, Srinivasan, Hansen, Scholz, Hamilton, Zucconi, Wang, Liu (bib67) 2018; 174
Victora, Dominguez-Sola, Holmes, Deroubaix, Dalla-Favera, Nussenzweig (bib65) 2012; 120
Rebel, Kung, Tanner, Yang, Bronson, Livingston (bib54) 2002; 99
Subramanian, Tamayo, Mootha, Mukherjee, Ebert, Gillette, Paulovich, Pomeroy, Golub, Lander, Mesirov (bib61) 2005; 102
Bereshchenko, Gu, Dalla-Favera (bib6) 2002; 32
Pasqualucci, Dominguez-Sola, Chiarenza, Fabbri, Grunn, Trifonov, Kasper, Lerach, Tang, Ma (bib47) 2011; 471
Xu, Fukuyama, Ney, Wang, Rehg, Boyd, van Deursen, Brindle (bib70) 2006; 107
Dancy, Cole (bib12) 2015; 115
Green, Kihira, Liu, Nair, Salari, Gentles, Irish, Stehr, Vicente-Dueñas, Romero-Camarero (bib19) 2015; 112
Wang, Wei, Sabatini, Lander (bib66) 2014; 343
Giannopoulou, Elemento (bib16) 2011; 12
Basso, Dalla-Favera (bib73) 2012; 247
Dehairs, Talebi, Cherifi, Swinnen (bib14) 2016; 6
Bannister, Kouzarides (bib4) 1996; 384
Zhang, Dominguez-Sola, Hussein, Lee, Holmes, Bansal, Vlasevska, Mo, Tang, Basso (bib71) 2015; 21
Victora, Schwickert, Fooksman, Kamphorst, Meyer-Hermann, Dustin, Nussenzweig (bib64) 2010; 143
Montoto, Davies, Matthews, Calaminici, Norton, Amess, Vinnicombe, Waters, Rohatiner, Lister (bib42) 2007; 25
Zhang, Vlasevska, Wells, Nataraj, Holmes, Duval, Meyer, Mo, Basso, Brindle (bib72) 2017; 7
Mesin, Ersching, Victora (bib40) 2016; 45
Kwon, Hutter, Sun, Bilic, Cobaleda, Malin, Busslinger (bib31) 2008; 28
Schubart, Rolink, Kosco-Vilbois, Botteri, Matthias (bib59) 1996; 383
Sanjana, Shalem, Zhang (bib55) 2014; 11
Heckl, Kowalczyk, Yudovich, Belizaire, Puram, McConkey, Thielke, Aster, Regev, Ebert (bib23) 2014; 32
Bedford, Kasper, Fukuyama, Brindle (bib5) 2010; 5
Schmidt, Ramis-Zaldivar, Bonzheim, Steinhilber, Müller, Haake, Yu, Raffeld, Fend, Salaverria (bib57) 2018; 132
Shalem, Sanjana, Hartenian, Shi, Scott, Mikkelson, Heckl, Ebert, Root, Doench, Zhang (bib60) 2014; 343
Avantaggiati, Ogryzko, Gardner, Giordano, Levine, Kelly (bib3) 1997; 89
Gu, Roeder (bib20) 1997; 90
García-Ramírez, Tadros, González-Herrero, Martín-Lorenzo, Rodríguez-Hernández, Moore, Ruiz-Roca, Blanco, Alonso-López, Rivas (bib15) 2017; 129
Li, Durbin (bib75) 2009; 25
Victora, Nussenzweig (bib63) 2012; 30
Schmitz, Wright, Huang, Johnson, Phelan, Wang, Roulland, Kasbekar, Young, Shaffer (bib58) 2018; 378
Brinkman, Chen, Amendola, van Steensel (bib8) 2014; 42
Kasper, Fukuyama, Biesen, Boussouar, Tong, de Pauw, Murray, van Deursen, Brindle (bib29) 2006; 26
De Silva, Klein (bib13) 2015; 15
Kasper, Boussouar, Ney, Jackson, Rehg, van Deursen, Brindle (bib28) 2002; 419
Ogryzko, Schiltz, Russanova, Howard, Nakatani (bib45) 1996; 87
Lasko, Jakob, Edalji, Qiu, Montgomery, Digiammarino, Hansen, Risi, Frey, Manaves (bib33) 2017; 550
Gisselbrecht, Glass, Mounier, Singh Gill, Linch, Trneny, Bosly, Ketterer, Shpilberg, Hagberg (bib17) 2010; 28
Jiang, Ortega-Molina, Geng, Ying, Hatzi, Parsa, McNally, Wang, Doane, Agirre (bib26) 2017; 7
Peled, Yu, Venkatesh, Bi, Ding, Krupski-Downs, Shaknovich, Sicinski, Diamond, Scharff, Ye (bib51) 2010; 20
Schindelin, Rueden, Hiner, Eliceiri (bib56) 2015; 82
Harrow, Denoeud, Frankish, Reymond, Chen, Chrast, Lagarde, Gilbert, Storey, Swarbreck (bib21) 2006; 1
Chapuy, Stewart, Dunford, Kim, Kamburov, Redd, Lawrence, Roemer, Li, Ziepert (bib11) 2018; 24
Okosun, Bödör, Wang, Araf, Yang, Pan, Boller, Cittaro, Bozek, Iqbal (bib46) 2014; 46
Love, Huber, Anders (bib39) 2014; 15
Chan, La Thangue (bib10) 2001; 114
Leiserson, Wu, Vandin, Raphael (bib34) 2015; 16
Morin, Mendez-Lago, Mungall, Goya, Mungall, Corbett, Johnson, Severson, Chiu, Field (bib43) 2011; 476
Goodman, Smolik (bib18) 2000; 14
Lill, Grossman, Ginsberg, DeCaprio, Livingston (bib37) 1997; 387
Hashwah, Schmid, Kasser, Bertram, Stelling, Manz, Müller (bib22) 2017; 114
Milpied, Cervera-Marzal, Mollichella, Tesson, Brisou, Traverse-Glehen, Salles, Spinelli, Nadel (bib41) 2018; 19
Pertea, Kim, Pertea, Leek, Salzberg (bib52) 2016; 11
Ogiwara, Sasaki, Mitachi, Oike, Higuchi, Tominaga, Kohno (bib44) 2016; 6
Akimaru, Chen, Dai, Hou, Nonaka, Smolik, Armstrong, Goodman, Ishii (bib1) 1997; 386
Li, Handsaker, Wysoker, Fennell, Ruan, Homer, Marth, Abecasis, Durbin (bib35) 2009; 25
Pegg, Brooks, Worthington, Young, Prosser, Lane, Taddei, Brown, Harbottle, Shannon (bib50) 2017; 35
Liao, Smyth, Shi (bib36) 2014; 30
Swerdlow, Harris, Jaffe, Pileri, Stein, Thiele (bib62) 2016
Casola, Cattoretti, Uyttersprot, Koralov, Seagal, Hao, Waisman, Egert, Ghitza, Rajewsky (bib9) 2006; 103
Lim, Lyashenko, Califano (bib38) 2009
Whyte, Orlando, Hnisz, Abraham, Lin, Kagey, Rahl, Lee, Young (bib68) 2013; 153
Pasqualucci, Khiabanian, Fangazio, Vasishtha, Messina, Holmes, Ouillette, Trifonov, Rossi, Tabbò (bib49) 2014; 6
Khiem, Cyster, Schwarz, Black (bib30) 2008; 105
Pasqualucci, Trifonov, Fabbri, Ma, Rossi, Chiarenza, Wells, Grunn, Messina, Elliot (bib48) 2011; 43
Lefranc, Giudicelli, Ginestoux, Bodmer, Muller, Bontrop, Lemaitre, Malik, Barbie, Chaume (bib74) 2018; 27
Kang-Decker, Tong, Boussouar, Baker, Xu, Leontovich, Taylor, Brindle, van Deursen (bib27) 2004; 5
Langmead, Salzberg (bib32) 2012; 9
Pott, Lieb (bib53) 2015; 47
Wilker, Kohyama, Sandau, Albring, Nakagawa, Schwarz, Murphy (bib69) 2008; 9
Arthur, Jiang, Grande, Alcaide, Cojocaru, Rushton, Mottok, Hilton, Lat, Zhao (bib2) 2018; 9
Brescia, Schneider, Holmes, Shen, Hussein, Pasqualucci, Basso, Dalla-Favera (bib7) 2018; 34
Hodgkin, Lee, Lyons (bib24) 1996; 184
García-Ramírez (10.1016/j.immuni.2019.08.006_bib15) 2017; 129
Schmitz (10.1016/j.immuni.2019.08.006_bib58) 2018; 378
Casola (10.1016/j.immuni.2019.08.006_bib9) 2006; 103
Whyte (10.1016/j.immuni.2019.08.006_bib68) 2013; 153
Zhang (10.1016/j.immuni.2019.08.006_bib72) 2017; 7
Zhang (10.1016/j.immuni.2019.08.006_bib71) 2015; 21
Wilker (10.1016/j.immuni.2019.08.006_bib69) 2008; 9
Dancy (10.1016/j.immuni.2019.08.006_bib12) 2015; 115
Wang (10.1016/j.immuni.2019.08.006_bib66) 2014; 343
Chan (10.1016/j.immuni.2019.08.006_bib10) 2001; 114
Hashwah (10.1016/j.immuni.2019.08.006_bib22) 2017; 114
Love (10.1016/j.immuni.2019.08.006_bib39) 2014; 15
Victora (10.1016/j.immuni.2019.08.006_bib64) 2010; 143
Swerdlow (10.1016/j.immuni.2019.08.006_bib62) 2016
De Silva (10.1016/j.immuni.2019.08.006_bib13) 2015; 15
Goodman (10.1016/j.immuni.2019.08.006_bib18) 2000; 14
Rebel (10.1016/j.immuni.2019.08.006_bib54) 2002; 99
Mesin (10.1016/j.immuni.2019.08.006_bib40) 2016; 45
Li (10.1016/j.immuni.2019.08.006_bib35) 2009; 25
Brescia (10.1016/j.immuni.2019.08.006_bib7) 2018; 34
Liao (10.1016/j.immuni.2019.08.006_bib36) 2014; 30
Lasko (10.1016/j.immuni.2019.08.006_bib33) 2017; 550
Gu (10.1016/j.immuni.2019.08.006_bib20) 1997; 90
Xu (10.1016/j.immuni.2019.08.006_bib70) 2006; 107
Pasqualucci (10.1016/j.immuni.2019.08.006_bib47) 2011; 471
Morin (10.1016/j.immuni.2019.08.006_bib43) 2011; 476
Sanjana (10.1016/j.immuni.2019.08.006_bib55) 2014; 11
Dehairs (10.1016/j.immuni.2019.08.006_bib14) 2016; 6
Gisselbrecht (10.1016/j.immuni.2019.08.006_bib17) 2010; 28
Kwon (10.1016/j.immuni.2019.08.006_bib31) 2008; 28
Lefranc (10.1016/j.immuni.2019.08.006_bib74) 2018; 27
Kasper (10.1016/j.immuni.2019.08.006_bib29) 2006; 26
Bannister (10.1016/j.immuni.2019.08.006_bib4) 1996; 384
Brinkman (10.1016/j.immuni.2019.08.006_bib8) 2014; 42
Chapuy (10.1016/j.immuni.2019.08.006_bib11) 2018; 24
Langmead (10.1016/j.immuni.2019.08.006_bib32) 2012; 9
Giannopoulou (10.1016/j.immuni.2019.08.006_bib16) 2011; 12
Schubart (10.1016/j.immuni.2019.08.006_bib59) 1996; 383
Pertea (10.1016/j.immuni.2019.08.006_bib52) 2016; 11
Huang (10.1016/j.immuni.2019.08.006_bib25) 2009; 4
Lim (10.1016/j.immuni.2019.08.006_bib38) 2009
Avantaggiati (10.1016/j.immuni.2019.08.006_bib3) 1997; 89
Shalem (10.1016/j.immuni.2019.08.006_bib60) 2014; 343
Li (10.1016/j.immuni.2019.08.006_bib75) 2009; 25
Victora (10.1016/j.immuni.2019.08.006_bib65) 2012; 120
Jiang (10.1016/j.immuni.2019.08.006_bib26) 2017; 7
Green (10.1016/j.immuni.2019.08.006_bib19) 2015; 112
Hodgkin (10.1016/j.immuni.2019.08.006_bib24) 1996; 184
Pott (10.1016/j.immuni.2019.08.006_bib53) 2015; 47
Arthur (10.1016/j.immuni.2019.08.006_bib2) 2018; 9
Bedford (10.1016/j.immuni.2019.08.006_bib5) 2010; 5
Okosun (10.1016/j.immuni.2019.08.006_bib46) 2014; 46
Kasper (10.1016/j.immuni.2019.08.006_bib28) 2002; 419
Lill (10.1016/j.immuni.2019.08.006_bib37) 1997; 387
Pegg (10.1016/j.immuni.2019.08.006_bib50) 2017; 35
Khiem (10.1016/j.immuni.2019.08.006_bib30) 2008; 105
Milpied (10.1016/j.immuni.2019.08.006_bib41) 2018; 19
Subramanian (10.1016/j.immuni.2019.08.006_bib61) 2005; 102
Schmidt (10.1016/j.immuni.2019.08.006_bib57) 2018; 132
Weinert (10.1016/j.immuni.2019.08.006_bib67) 2018; 174
Bereshchenko (10.1016/j.immuni.2019.08.006_bib6) 2002; 32
Victora (10.1016/j.immuni.2019.08.006_bib63) 2012; 30
Harrow (10.1016/j.immuni.2019.08.006_bib21) 2006; 1
Ogryzko (10.1016/j.immuni.2019.08.006_bib45) 1996; 87
Akimaru (10.1016/j.immuni.2019.08.006_bib1) 1997; 386
Basso (10.1016/j.immuni.2019.08.006_bib73) 2012; 247
Ogiwara (10.1016/j.immuni.2019.08.006_bib44) 2016; 6
Leiserson (10.1016/j.immuni.2019.08.006_bib34) 2015; 16
Heckl (10.1016/j.immuni.2019.08.006_bib23) 2014; 32
Schindelin (10.1016/j.immuni.2019.08.006_bib56) 2015; 82
Montoto (10.1016/j.immuni.2019.08.006_bib42) 2007; 25
Kang-Decker (10.1016/j.immuni.2019.08.006_bib27) 2004; 5
Pasqualucci (10.1016/j.immuni.2019.08.006_bib49) 2014; 6
Pasqualucci (10.1016/j.immuni.2019.08.006_bib48) 2011; 43
Peled (10.1016/j.immuni.2019.08.006_bib51) 2010; 20
31533053 - Immunity. 2019 Sep 17;51(3):420-423
References_xml – volume: 46
  start-page: 176
  year: 2014
  end-page: 181
  ident: bib46
  article-title: Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
  publication-title: Nat. Genet.
– volume: 14
  start-page: 1553
  year: 2000
  end-page: 1577
  ident: bib18
  article-title: CBP/p300 in cell growth, transformation, and development
  publication-title: Genes Dev.
– volume: 9
  start-page: 603
  year: 2008
  end-page: 612
  ident: bib69
  article-title: Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation
  publication-title: Nat. Immunol.
– volume: 47
  start-page: 8
  year: 2015
  end-page: 12
  ident: bib53
  article-title: What are super-enhancers?
  publication-title: Nat. Genet.
– volume: 184
  start-page: 277
  year: 1996
  end-page: 281
  ident: bib24
  article-title: B cell differentiation and isotype switching is related to division cycle number
  publication-title: J. Exp. Med.
– volume: 30
  start-page: 429
  year: 2012
  end-page: 457
  ident: bib63
  article-title: Germinal centers
  publication-title: Annu. Rev. Immunol.
– volume: 387
  start-page: 823
  year: 1997
  end-page: 827
  ident: bib37
  article-title: Binding and modulation of p53 by p300/CBP coactivators
  publication-title: Nature
– volume: 384
  start-page: 641
  year: 1996
  end-page: 643
  ident: bib4
  article-title: The CBP co-activator is a histone acetyltransferase
  publication-title: Nature
– volume: 174
  start-page: 231
  year: 2018
  end-page: 244
  ident: bib67
  article-title: Time-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
  publication-title: Cell
– volume: 42
  start-page: e168
  year: 2014
  ident: bib8
  article-title: Easy quantitative assessment of genome editing by sequence trace decomposition
  publication-title: Nucleic Acids Res.
– volume: 15
  start-page: 550
  year: 2014
  ident: bib39
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
– volume: 87
  start-page: 953
  year: 1996
  end-page: 959
  ident: bib45
  article-title: The transcriptional coactivators p300 and CBP are histone acetyltransferases
  publication-title: Cell
– volume: 27
  start-page: 209
  year: 2018
  end-page: 212
  ident: bib74
  article-title: IMGT, the international ImMunoGeneTics database
  publication-title: Nucleic Acids Research
– volume: 153
  start-page: 307
  year: 2013
  end-page: 319
  ident: bib68
  article-title: Master transcription factors and mediator establish super-enhancers at key cell identity genes
  publication-title: Cell
– volume: 1
  start-page: 1
  year: 2006
  end-page: 9
  ident: bib21
  article-title: GENCODE: producing a reference annotation for ENCODE
  publication-title: Genome biology 7 Suppl.
– volume: 5
  start-page: 9
  year: 2010
  end-page: 15
  ident: bib5
  article-title: Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
  publication-title: Epigenetics
– volume: 378
  start-page: 1396
  year: 2018
  end-page: 1407
  ident: bib58
  article-title: Genetics and pathogenesis of diffuse large B-cell lymphoma
  publication-title: N. Engl. J. Med.
– volume: 45
  start-page: 471
  year: 2016
  end-page: 482
  ident: bib40
  article-title: Germinal center B cell dynamics
  publication-title: Immunity
– volume: 25
  start-page: 2426
  year: 2007
  end-page: 2433
  ident: bib42
  article-title: Risk and clinical implications of transformation of follicular lymphoma to diffuse large B-cell lymphoma
  publication-title: J. Clin. Oncol.
– volume: 4
  start-page: 44
  year: 2009
  end-page: 57
  ident: bib25
  article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
  publication-title: Nat. Protoc.
– volume: 476
  start-page: 298
  year: 2011
  end-page: 303
  ident: bib43
  article-title: Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
  publication-title: Nature
– volume: 28
  start-page: 4184
  year: 2010
  end-page: 4190
  ident: bib17
  article-title: Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era
  publication-title: J. Clin. Oncol.
– volume: 6
  start-page: 28973
  year: 2016
  ident: bib14
  article-title: CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing
  publication-title: Sci. Rep.
– volume: 19
  start-page: 1013
  year: 2018
  end-page: 1024
  ident: bib41
  article-title: Human germinal center transcriptional programs are de-synchronized in B cell lymphoma
  publication-title: Nat. Immunol.
– volume: 247
  start-page: 172
  year: 2012
  end-page: 183
  ident: bib73
  article-title: Roles of BCL6 in normal and transformed germinal center B cells
  publication-title: Immunol. Rev.
– volume: 32
  start-page: 606
  year: 2002
  end-page: 613
  ident: bib6
  article-title: Acetylation inactivates the transcriptional repressor BCL6
  publication-title: Nat. Genet.
– volume: 16
  start-page: 160
  year: 2015
  ident: bib34
  article-title: CoMEt: a statistical approach to identify combinations of mutually exclusive alterations in cancer
  publication-title: Genome Biol.
– volume: 6
  start-page: 430
  year: 2016
  end-page: 445
  ident: bib44
  article-title: Targeting p300 Addiction in CBP-deficient cancers causes synthetic lethality by apoptotic cell death due to abrogation of MYC expression
  publication-title: Cancer Discov.
– volume: 89
  start-page: 1175
  year: 1997
  end-page: 1184
  ident: bib3
  article-title: Recruitment of p300/CBP in p53-dependent signal pathways
  publication-title: Cell
– volume: 120
  start-page: 2240
  year: 2012
  end-page: 2248
  ident: bib65
  article-title: Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas
  publication-title: Blood
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: bib61
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 129
  start-page: 2645
  year: 2017
  end-page: 2656
  ident: bib15
  article-title: loss cooperates with
  publication-title: Blood
– volume: 105
  start-page: 17067
  year: 2008
  end-page: 17072
  ident: bib30
  article-title: A p38 MAPK-MEF2C pathway regulates B-cell proliferation
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 7
  start-page: 322
  year: 2017
  end-page: 337
  ident: bib72
  article-title: The CREBBP acetyltransferase is a haploinsufficient tumor suppressor in B-cell lymphoma
  publication-title: Cancer Discov.
– volume: 114
  start-page: 2363
  year: 2001
  end-page: 2373
  ident: bib10
  article-title: p300/CBP proteins: HATs for transcriptional bridges and scaffolds
  publication-title: J. Cell Sci.
– volume: 35
  start-page: 11590
  year: 2017
  ident: bib50
  article-title: Characterisation of CCS1477: A novel small molecule inhibitor of p300/CBP for the treatment of castration resistant prostate cancer
  publication-title: J. Clin. Oncol.
– volume: 107
  start-page: 4407
  year: 2006
  end-page: 4416
  ident: bib70
  article-title: Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells
  publication-title: Blood
– volume: 21
  start-page: 1190
  year: 2015
  end-page: 1198
  ident: bib71
  article-title: Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
  publication-title: Nat. Med.
– volume: 30
  start-page: 923
  year: 2014
  end-page: 930
  ident: bib36
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
– volume: 132
  start-page: 2687
  year: 2018
  end-page: 2690
  ident: bib57
  article-title: gene mutations are frequently detected in in situ follicular neoplasia
  publication-title: Blood
– volume: 343
  start-page: 80
  year: 2014
  end-page: 84
  ident: bib66
  article-title: Genetic screens in human cells using the CRISPR-Cas9 system
  publication-title: Science
– volume: 112
  start-page: E1116
  year: 2015
  end-page: E1125
  ident: bib19
  article-title: Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 32
  start-page: 941
  year: 2014
  end-page: 946
  ident: bib23
  article-title: Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing
  publication-title: Nat. Biotechnol.
– volume: 34
  start-page: 453
  year: 2018
  end-page: 465
  ident: bib7
  article-title: MEF2B instructs germinal center development and acts as an oncogene in B cell lymphomagenesis
  publication-title: Cancer Cell
– volume: 103
  start-page: 7396
  year: 2006
  end-page: 7401
  ident: bib9
  article-title: Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 5
  start-page: 177
  year: 2004
  end-page: 189
  ident: bib27
  article-title: Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency
  publication-title: Cancer Cell
– volume: 143
  start-page: 592
  year: 2010
  end-page: 605
  ident: bib64
  article-title: Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
  publication-title: Cell
– volume: 82
  start-page: 518
  year: 2015
  end-page: 529
  ident: bib56
  article-title: The ImageJ ecosystem: an open platform for biomedical image analysis
  publication-title: Mol. Reprod. Dev.
– volume: 24
  start-page: 679
  year: 2018
  end-page: 690
  ident: bib11
  article-title: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
  publication-title: Nat. Med.
– volume: 25
  start-page: 1754
  year: 2009
  end-page: 1760
  ident: bib75
  article-title: Fast and accurate short read alignment with Burrows-Wheeler transform
  publication-title: Bioinformatics
– volume: 99
  start-page: 14789
  year: 2002
  end-page: 14794
  ident: bib54
  article-title: Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 9
  start-page: 4001
  year: 2018
  ident: bib2
  article-title: Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
  publication-title: Nat. Commun.
– volume: 20
  start-page: 631
  year: 2010
  end-page: 646
  ident: bib51
  article-title: Requirement for cyclin D3 in germinal center formation and function
  publication-title: Cell Res.
– volume: 419
  start-page: 738
  year: 2002
  end-page: 743
  ident: bib28
  article-title: A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
  publication-title: Nature
– volume: 114
  start-page: 9701
  year: 2017
  end-page: 9706
  ident: bib22
  article-title: Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 11
  start-page: 1650
  year: 2016
  end-page: 1667
  ident: bib52
  article-title: Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
  publication-title: Nat. Protoc.
– volume: 6
  start-page: 130
  year: 2014
  end-page: 140
  ident: bib49
  article-title: Genetics of follicular lymphoma transformation
  publication-title: Cell Rep.
– volume: 90
  start-page: 595
  year: 1997
  end-page: 606
  ident: bib20
  article-title: Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
  publication-title: Cell
– volume: 25
  start-page: 2078
  year: 2009
  end-page: 2079
  ident: bib35
  article-title: The sequence alignment/map format and SAMtools
  publication-title: Bioinformatics
– volume: 11
  start-page: 783
  year: 2014
  end-page: 784
  ident: bib55
  article-title: Improved vectors and genome-wide libraries for CRISPR screening
  publication-title: Nat. Methods
– volume: 9
  start-page: 357
  year: 2012
  end-page: 359
  ident: bib32
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
– volume: 343
  start-page: 84
  year: 2014
  end-page: 87
  ident: bib60
  article-title: Genome-scale CRISPR-Cas9 knockout screening in human cells
  publication-title: Science
– year: 2016
  ident: bib62
  article-title: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Vol 2 Lyon: International Agency for Research on Cancer
– volume: 386
  start-page: 735
  year: 1997
  end-page: 738
  ident: bib1
  article-title: Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling
  publication-title: Nature
– volume: 15
  start-page: 137
  year: 2015
  end-page: 148
  ident: bib13
  article-title: Dynamics of B cells in germinal centres
  publication-title: Nat. Rev. Immunol.
– volume: 12
  start-page: 277
  year: 2011
  ident: bib16
  article-title: An integrated ChIP-seq analysis platform with customizable workflows
  publication-title: BMC Bioinformatics
– volume: 383
  start-page: 538
  year: 1996
  end-page: 542
  ident: bib59
  article-title: B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation
  publication-title: Nature
– volume: 471
  start-page: 189
  year: 2011
  end-page: 195
  ident: bib47
  article-title: Inactivating mutations of acetyltransferase genes in B-cell lymphoma
  publication-title: Nature
– volume: 550
  start-page: 128
  year: 2017
  end-page: 132
  ident: bib33
  article-title: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
  publication-title: Nature
– volume: 26
  start-page: 789
  year: 2006
  end-page: 809
  ident: bib29
  article-title: Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development
  publication-title: Mol. Cell. Biol.
– volume: 7
  start-page: 38
  year: 2017
  end-page: 53
  ident: bib26
  article-title: CREBBP inactivation promotes the development of HDAC3-dependent lymphomas
  publication-title: Cancer Discov.
– volume: 28
  start-page: 751
  year: 2008
  end-page: 762
  ident: bib31
  article-title: Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
  publication-title: Immunity
– volume: 115
  start-page: 2419
  year: 2015
  end-page: 2452
  ident: bib12
  article-title: Protein lysine acetylation by p300/CBP
  publication-title: Chem. Rev.
– start-page: 504
  year: 2009
  end-page: 515
  ident: bib38
  article-title: Master regulators used as breast cancer metastasis classifier
  publication-title: Pac. Symp. Biocomput.
– volume: 43
  start-page: 830
  year: 2011
  end-page: 837
  ident: bib48
  article-title: Analysis of the coding genome of diffuse large B-cell lymphoma
  publication-title: Nat. Genet.
– volume: 143
  start-page: 592
  year: 2010
  ident: 10.1016/j.immuni.2019.08.006_bib64
  article-title: Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
  publication-title: Cell
  doi: 10.1016/j.cell.2010.10.032
– volume: 6
  start-page: 430
  year: 2016
  ident: 10.1016/j.immuni.2019.08.006_bib44
  article-title: Targeting p300 Addiction in CBP-deficient cancers causes synthetic lethality by apoptotic cell death due to abrogation of MYC expression
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-15-0754
– volume: 343
  start-page: 84
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib60
  article-title: Genome-scale CRISPR-Cas9 knockout screening in human cells
  publication-title: Science
  doi: 10.1126/science.1247005
– volume: 24
  start-page: 679
  year: 2018
  ident: 10.1016/j.immuni.2019.08.006_bib11
  article-title: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0016-8
– start-page: 504
  year: 2009
  ident: 10.1016/j.immuni.2019.08.006_bib38
  article-title: Master regulators used as breast cancer metastasis classifier
  publication-title: Pac. Symp. Biocomput.
– volume: 378
  start-page: 1396
  year: 2018
  ident: 10.1016/j.immuni.2019.08.006_bib58
  article-title: Genetics and pathogenesis of diffuse large B-cell lymphoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1801445
– volume: 102
  start-page: 15545
  year: 2005
  ident: 10.1016/j.immuni.2019.08.006_bib61
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 21
  start-page: 1190
  year: 2015
  ident: 10.1016/j.immuni.2019.08.006_bib71
  article-title: Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
  publication-title: Nat. Med.
  doi: 10.1038/nm.3940
– volume: 11
  start-page: 1650
  year: 2016
  ident: 10.1016/j.immuni.2019.08.006_bib52
  article-title: Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.095
– volume: 19
  start-page: 1013
  year: 2018
  ident: 10.1016/j.immuni.2019.08.006_bib41
  article-title: Human germinal center transcriptional programs are de-synchronized in B cell lymphoma
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0181-4
– volume: 30
  start-page: 923
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib36
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
– volume: 28
  start-page: 751
  year: 2008
  ident: 10.1016/j.immuni.2019.08.006_bib31
  article-title: Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.04.014
– volume: 15
  start-page: 550
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib39
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 9
  start-page: 603
  year: 2008
  ident: 10.1016/j.immuni.2019.08.006_bib69
  article-title: Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1609
– volume: 343
  start-page: 80
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib66
  article-title: Genetic screens in human cells using the CRISPR-Cas9 system
  publication-title: Science
  doi: 10.1126/science.1246981
– volume: 15
  start-page: 137
  year: 2015
  ident: 10.1016/j.immuni.2019.08.006_bib13
  article-title: Dynamics of B cells in germinal centres
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3804
– volume: 12
  start-page: 277
  year: 2011
  ident: 10.1016/j.immuni.2019.08.006_bib16
  article-title: An integrated ChIP-seq analysis platform with customizable workflows
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-12-277
– volume: 387
  start-page: 823
  year: 1997
  ident: 10.1016/j.immuni.2019.08.006_bib37
  article-title: Binding and modulation of p53 by p300/CBP coactivators
  publication-title: Nature
  doi: 10.1038/42981
– volume: 26
  start-page: 789
  year: 2006
  ident: 10.1016/j.immuni.2019.08.006_bib29
  article-title: Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.26.3.789-809.2006
– volume: 4
  start-page: 44
  year: 2009
  ident: 10.1016/j.immuni.2019.08.006_bib25
  article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.211
– volume: 14
  start-page: 1553
  year: 2000
  ident: 10.1016/j.immuni.2019.08.006_bib18
  article-title: CBP/p300 in cell growth, transformation, and development
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.13.1553
– volume: 16
  start-page: 160
  year: 2015
  ident: 10.1016/j.immuni.2019.08.006_bib34
  article-title: CoMEt: a statistical approach to identify combinations of mutually exclusive alterations in cancer
  publication-title: Genome Biol.
  doi: 10.1186/s13059-015-0700-7
– volume: 471
  start-page: 189
  year: 2011
  ident: 10.1016/j.immuni.2019.08.006_bib47
  article-title: Inactivating mutations of acetyltransferase genes in B-cell lymphoma
  publication-title: Nature
  doi: 10.1038/nature09730
– volume: 30
  start-page: 429
  year: 2012
  ident: 10.1016/j.immuni.2019.08.006_bib63
  article-title: Germinal centers
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-020711-075032
– volume: 247
  start-page: 172
  year: 2012
  ident: 10.1016/j.immuni.2019.08.006_bib73
  article-title: Roles of BCL6 in normal and transformed germinal center B cells
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2012.01112.x
– volume: 476
  start-page: 298
  year: 2011
  ident: 10.1016/j.immuni.2019.08.006_bib43
  article-title: Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
  publication-title: Nature
  doi: 10.1038/nature10351
– volume: 120
  start-page: 2240
  year: 2012
  ident: 10.1016/j.immuni.2019.08.006_bib65
  article-title: Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas
  publication-title: Blood
  doi: 10.1182/blood-2012-03-415380
– volume: 25
  start-page: 1754
  year: 2009
  ident: 10.1016/j.immuni.2019.08.006_bib75
  article-title: Fast and accurate short read alignment with Burrows-Wheeler transform
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp324
– volume: 174
  start-page: 231
  year: 2018
  ident: 10.1016/j.immuni.2019.08.006_bib67
  article-title: Time-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
  publication-title: Cell
  doi: 10.1016/j.cell.2018.04.033
– volume: 20
  start-page: 631
  year: 2010
  ident: 10.1016/j.immuni.2019.08.006_bib51
  article-title: Requirement for cyclin D3 in germinal center formation and function
  publication-title: Cell Res.
  doi: 10.1038/cr.2010.55
– volume: 90
  start-page: 595
  year: 1997
  ident: 10.1016/j.immuni.2019.08.006_bib20
  article-title: Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80521-8
– volume: 43
  start-page: 830
  year: 2011
  ident: 10.1016/j.immuni.2019.08.006_bib48
  article-title: Analysis of the coding genome of diffuse large B-cell lymphoma
  publication-title: Nat. Genet.
  doi: 10.1038/ng.892
– volume: 105
  start-page: 17067
  year: 2008
  ident: 10.1016/j.immuni.2019.08.006_bib30
  article-title: A p38 MAPK-MEF2C pathway regulates B-cell proliferation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0804868105
– volume: 35
  start-page: 11590
  year: 2017
  ident: 10.1016/j.immuni.2019.08.006_bib50
  article-title: Characterisation of CCS1477: A novel small molecule inhibitor of p300/CBP for the treatment of castration resistant prostate cancer
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2017.35.15_suppl.11590
– volume: 184
  start-page: 277
  year: 1996
  ident: 10.1016/j.immuni.2019.08.006_bib24
  article-title: B cell differentiation and isotype switching is related to division cycle number
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.184.1.277
– volume: 5
  start-page: 9
  year: 2010
  ident: 10.1016/j.immuni.2019.08.006_bib5
  article-title: Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
  publication-title: Epigenetics
  doi: 10.4161/epi.5.1.10449
– volume: 32
  start-page: 941
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib23
  article-title: Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2951
– volume: 32
  start-page: 606
  year: 2002
  ident: 10.1016/j.immuni.2019.08.006_bib6
  article-title: Acetylation inactivates the transcriptional repressor BCL6
  publication-title: Nat. Genet.
  doi: 10.1038/ng1018
– volume: 99
  start-page: 14789
  year: 2002
  ident: 10.1016/j.immuni.2019.08.006_bib54
  article-title: Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.232568499
– volume: 383
  start-page: 538
  year: 1996
  ident: 10.1016/j.immuni.2019.08.006_bib59
  article-title: B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation
  publication-title: Nature
  doi: 10.1038/383538a0
– volume: 47
  start-page: 8
  year: 2015
  ident: 10.1016/j.immuni.2019.08.006_bib53
  article-title: What are super-enhancers?
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3167
– volume: 153
  start-page: 307
  year: 2013
  ident: 10.1016/j.immuni.2019.08.006_bib68
  article-title: Master transcription factors and mediator establish super-enhancers at key cell identity genes
  publication-title: Cell
  doi: 10.1016/j.cell.2013.03.035
– volume: 25
  start-page: 2078
  year: 2009
  ident: 10.1016/j.immuni.2019.08.006_bib35
  article-title: The sequence alignment/map format and SAMtools
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp352
– volume: 9
  start-page: 357
  year: 2012
  ident: 10.1016/j.immuni.2019.08.006_bib32
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 550
  start-page: 128
  year: 2017
  ident: 10.1016/j.immuni.2019.08.006_bib33
  article-title: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
  publication-title: Nature
  doi: 10.1038/nature24028
– volume: 25
  start-page: 2426
  year: 2007
  ident: 10.1016/j.immuni.2019.08.006_bib42
  article-title: Risk and clinical implications of transformation of follicular lymphoma to diffuse large B-cell lymphoma
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2006.09.3260
– volume: 103
  start-page: 7396
  year: 2006
  ident: 10.1016/j.immuni.2019.08.006_bib9
  article-title: Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0602353103
– volume: 87
  start-page: 953
  year: 1996
  ident: 10.1016/j.immuni.2019.08.006_bib45
  article-title: The transcriptional coactivators p300 and CBP are histone acetyltransferases
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)82001-2
– volume: 89
  start-page: 1175
  year: 1997
  ident: 10.1016/j.immuni.2019.08.006_bib3
  article-title: Recruitment of p300/CBP in p53-dependent signal pathways
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80304-9
– volume: 82
  start-page: 518
  year: 2015
  ident: 10.1016/j.immuni.2019.08.006_bib56
  article-title: The ImageJ ecosystem: an open platform for biomedical image analysis
  publication-title: Mol. Reprod. Dev.
  doi: 10.1002/mrd.22489
– volume: 386
  start-page: 735
  year: 1997
  ident: 10.1016/j.immuni.2019.08.006_bib1
  article-title: Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling
  publication-title: Nature
  doi: 10.1038/386735a0
– volume: 6
  start-page: 28973
  year: 2016
  ident: 10.1016/j.immuni.2019.08.006_bib14
  article-title: CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing
  publication-title: Sci. Rep.
  doi: 10.1038/srep28973
– volume: 45
  start-page: 471
  year: 2016
  ident: 10.1016/j.immuni.2019.08.006_bib40
  article-title: Germinal center B cell dynamics
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.09.001
– volume: 114
  start-page: 2363
  year: 2001
  ident: 10.1016/j.immuni.2019.08.006_bib10
  article-title: p300/CBP proteins: HATs for transcriptional bridges and scaffolds
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.114.13.2363
– volume: 5
  start-page: 177
  year: 2004
  ident: 10.1016/j.immuni.2019.08.006_bib27
  article-title: Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(04)00022-4
– volume: 129
  start-page: 2645
  year: 2017
  ident: 10.1016/j.immuni.2019.08.006_bib15
  article-title: Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice
  publication-title: Blood
  doi: 10.1182/blood-2016-08-733469
– volume: 34
  start-page: 453
  year: 2018
  ident: 10.1016/j.immuni.2019.08.006_bib7
  article-title: MEF2B instructs germinal center development and acts as an oncogene in B cell lymphomagenesis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2018.08.006
– volume: 6
  start-page: 130
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib49
  article-title: Genetics of follicular lymphoma transformation
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.12.027
– volume: 112
  start-page: E1116
  year: 2015
  ident: 10.1016/j.immuni.2019.08.006_bib19
  article-title: Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1501199112
– volume: 46
  start-page: 176
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib46
  article-title: Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2856
– volume: 9
  start-page: 4001
  year: 2018
  ident: 10.1016/j.immuni.2019.08.006_bib2
  article-title: Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06354-3
– volume: 28
  start-page: 4184
  year: 2010
  ident: 10.1016/j.immuni.2019.08.006_bib17
  article-title: Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2010.28.1618
– volume: 7
  start-page: 38
  year: 2017
  ident: 10.1016/j.immuni.2019.08.006_bib26
  article-title: CREBBP inactivation promotes the development of HDAC3-dependent lymphomas
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-16-0975
– volume: 107
  start-page: 4407
  year: 2006
  ident: 10.1016/j.immuni.2019.08.006_bib70
  article-title: Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells
  publication-title: Blood
  doi: 10.1182/blood-2005-08-3263
– volume: 132
  start-page: 2687
  year: 2018
  ident: 10.1016/j.immuni.2019.08.006_bib57
  article-title: CREBBP gene mutations are frequently detected in in situ follicular neoplasia
  publication-title: Blood
  doi: 10.1182/blood-2018-03-837039
– volume: 42
  start-page: e168
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib8
  article-title: Easy quantitative assessment of genome editing by sequence trace decomposition
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku936
– volume: 115
  start-page: 2419
  year: 2015
  ident: 10.1016/j.immuni.2019.08.006_bib12
  article-title: Protein lysine acetylation by p300/CBP
  publication-title: Chem. Rev.
  doi: 10.1021/cr500452k
– volume: 11
  start-page: 783
  year: 2014
  ident: 10.1016/j.immuni.2019.08.006_bib55
  article-title: Improved vectors and genome-wide libraries for CRISPR screening
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3047
– volume: 1
  start-page: 1
  year: 2006
  ident: 10.1016/j.immuni.2019.08.006_bib21
  article-title: GENCODE: producing a reference annotation for ENCODE
  publication-title: Genome biology 7 Suppl.
– volume: 114
  start-page: 9701
  year: 2017
  ident: 10.1016/j.immuni.2019.08.006_bib22
  article-title: Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1619555114
– volume: 7
  start-page: 322
  year: 2017
  ident: 10.1016/j.immuni.2019.08.006_bib72
  article-title: The CREBBP acetyltransferase is a haploinsufficient tumor suppressor in B-cell lymphoma
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-16-1417
– volume: 419
  start-page: 738
  year: 2002
  ident: 10.1016/j.immuni.2019.08.006_bib28
  article-title: A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
  publication-title: Nature
  doi: 10.1038/nature01062
– volume: 27
  start-page: 209
  year: 2018
  ident: 10.1016/j.immuni.2019.08.006_bib74
  article-title: IMGT, the international ImMunoGeneTics database
  publication-title: Nucleic Acids Research
  doi: 10.1093/nar/27.1.209
– year: 2016
  ident: 10.1016/j.immuni.2019.08.006_bib62
– volume: 384
  start-page: 641
  year: 1996
  ident: 10.1016/j.immuni.2019.08.006_bib4
  article-title: The CBP co-activator is a histone acetyltransferase
  publication-title: Nature
  doi: 10.1038/384641a0
– reference: 31533053 - Immunity. 2019 Sep 17;51(3):420-423
SSID ssj0014590
Score 2.6015267
Snippet Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and...
SummaryInactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL)...
Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and...
SourceID unpaywall
pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 535
SubjectTerms acetyltransferase inhibitor
Acetyltransferases - genetics
Animal models
Animals
B-cell lymphoma
B-Lymphocytes - physiology
Cell Line
Clonal deletion
CREB-Binding Protein - genetics
CREBBP
dark zone
diffuse large cell lymphoma
E1A-Associated p300 Protein - genetics
Enzymes
EP300
Epigenesis, Genetic - genetics
Fitness
Genomes
Genomics
germinal center
Germinal Center - physiology
Germinal centers
HEK293 Cells
Humans
Inhibitors
light zone
Lymphocytes B
Lymphoma
Lymphoma, Follicular - etiology
Lymphoma, Large B-Cell, Diffuse - genetics
Mice
Mice, Inbred C57BL
Mutation
Reproductive fitness
Sequence Deletion - genetics
Software
synthetic lethality
Transcription
Transcription, Genetic - genetics
SummonAdditionalLinks – databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3bbtNAEB2VVFxeuJRboKBF4tWtN17b8WNSUipEqygkUnmy1t6xCBgnShxQ-BC-l5n1RVRBaslTop2N7M3J7LF95gzAWyORSEiUOBLDnqNMph2tE7pwNRhpT3k0ysXJ5xfB2Ux9uPQv96BpXMiqSr5jbXN0vXbHn1g0SJfbhBZKuITA46XJbsF-4BP97sD-7GI8-NxqCwNZieqj0FGy7zblclbTNbc1FyzoiqxxJ_c5-vd2tEs3d1WTdzfFUm9_6jz_a0s6fQCTprCnUqJ8O9qUyVH6a9fn8eZn-xDu1wRVDKq4R7CHxQHcrlpWbg_gznn9MP4x_J5Z81ehCyPY9xmNGC3Z3JPrIsW4En6txSITRDLFyWQ0HI5t8Gjsua4YpFhu89ISZ1zRZroW80K8r8Q5ueDbzrgSQ3qT52sxwR9EacXUCte53Eu8q9v3UnKyMz9uCZiL7_oJTE9H05Mzp27z4KS-H5ZOT1NikZFyERMV6lQhkVijlCa8GCJ0YZbSokvtmQgxC6RJ6OXrNNMY9NPUewqdYlHgcxA6DEyA7FgXGJUhfY_P_mVas8u8VNgFr_mx47S2QOdOHHncaN2-xhVEYoZIzA063aALTjtrWVmAXBMfNjiKaxpT0ZOYdqlrZh42sIvrVLKOe9xPjJhpP-rCm3aYkgAjRxe42NgYN-JH3G4XnlUobQ_VI04XqahPh3UFv20AG4xfHSnmX6zReEjsJpSyC0ct0m-0Ai_-d8JLuMefWIcjw0PolKsNviKyVyav67_3H9_uUxE
  priority: 102
  providerName: Unpaywall
Title Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma
URI https://dx.doi.org/10.1016/j.immuni.2019.08.006
https://www.ncbi.nlm.nih.gov/pubmed/31519498
https://www.proquest.com/docview/2292002589
https://www.proquest.com/docview/2290904600
https://pubmed.ncbi.nlm.nih.gov/PMC7362711
http://www.cell.com/article/S1074761319303322/pdf
UnpaywallVersion publishedVersion
Volume 51
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVESC
  databaseName: Elsevier Free Content
  customDbUrl:
  eissn: 1097-4180
  dateEnd: 20241105
  omitProxy: true
  ssIdentifier: ssj0014590
  issn: 1074-7613
  databaseCode: IXB
  dateStart: 19950101
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
– providerCode: PRVBFR
  databaseName: Free Medical Journals - Free Access to All
  customDbUrl:
  eissn: 1097-4180
  dateEnd: 20241105
  omitProxy: true
  ssIdentifier: ssj0014590
  issn: 1074-7613
  databaseCode: DIK
  dateStart: 19950101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVLSH
  databaseName: Elsevier Journals
  customDbUrl:
  mediaType: online
  eissn: 1097-4180
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0014590
  issn: 1074-7613
  databaseCode: AKRWK
  dateStart: 19940401
  isFulltext: true
  providerName: Library Specific Holdings
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELamTfx4mcaAEdgqI_EamjROUj-2pWMDNlWjlcpT5MQXERTSqk039R_h7-XO-SGqIQ3Rp7a2K8t3OX-uv_uOsXfaBQQhMrZdCHu20KmylYrx4KpBKk942ErJyVfXwcVMfJr78z02anJhiFZZx_4qpptoXX_TrVezu8yy7leiEuIhHH0IwzD6JcZhT_SpfMPlfNjeJAhfOi3vEHs36XOG45WZHAwieEkj5El1j_6-Pd2Hn_dZlE82xVJt71Se_7FFnR-xwxpb8kE1_WdsD4pj9qiqNrk9Zo-v6nv05-zXzOi2clVoTpLNoPl4SbqclNLIJxVna80XKUd8yEc34-FwYjqPJ57j8EEC5TYvDeaFFe6Da54V_GPFq8k5_WMMKz7EN3m-5jdwi2iUTw3nnDK1-Ie68i6utxn5ZYs-tfipXrDp-Xg6urDrCg124vthafcUxgRXCgcgFqFKBCD-1EIoNLVGLBamaMbEVZ6WAGng6hhfvkpSBUE_SbyXbL9YFPCKcRUGOgASmwu0SAF_xyfpMaVIIN4VYDGvsUuU1OrlVEQjjxqa2o-osmZE1oyotqYTWMxuRy0r9Y4H-oeNyaMdL4xwg3lg5GnjIVEdBdZRj0qBIajsS4u9bZvx-aVLGVXAYmP6OJJupx2LnVQO1U7VQzgmhezjtHZcre1A2uC7LUX23WiEhwhMQte12PvWKf9pBV7_9wq8YU_pE3Fp3PCU7ZerDZwhYCvjDh5VLj93zHPZYQez68ng228Rp0QD
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbGEIwXBOOywAAj8RqaNE5SP66lo0A7VaOT-mY58YkIytKqF1D_CL-Xc5yLqIY0RJ-i2o4sn5PjL_F3vsPYO-MDghCZuD7EXVeYTLtaJ_jiakDqQATYSsnJk4todCU-z8P5ARs0uTBEq6xjfxXTbbSu_-nUq9lZ5nnnK1EJ8SUcfQjDMPrlHXZXhIhOKItv3m-PEkQovZZ4iN2b_DlL8sptEgYxvKRV8qTCR3_fn27iz5s0yqNtudS7n7oo_tijzh-xhzW45GfV_B-zAyiP2b2q3OTumN2f1AfpT9ivKyvcynVpOGk2g-HDJQlzUk4jn1akrTVfZBwBIh9cDvv9qe08nAaex89S2OyKjQW9sMKNcM3zkn-siDUFp0_GsOJ9vCiKNb-EHwhH-cySzilVi3-oS-_igtuR4x061eJaP2Wz8-FsMHLrEg1uGobxxu1qDAq-FB5AImKdCkAAaoTQaGuDYCzO0I6prwMjAbLINwn-Qp1mGqJemgbP2GG5KOGEcR1HJgJSm4uMyADvE5L2mNakEO8LcFjQ2EWltXw5VdEoVMNT-64qayqypqLiml7kMLcdtazkO27pHzcmV3tuqHCHuWXkaeMhqg4Da9WlWmCIKnvSYW_bZnyA6VRGl7DY2j6epONpz2HPK4dqpxogHpNC9nBae67WdiBx8P2WMv9mRcJjRCax7zvsfeuU_7QCL_57Bd6wo9FsMlbjTxdfXrIH1ELEGj8-ZYeb1RZeIXrbJK_t0_kbnk1EgA
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3bbtNAEB2VVFxeuJRboKBF4tWtN17b8WNSUipEqygkUnmy1t6xCBgnShxQ-BC-l5n1RVRBaslTop2N7M3J7LF95gzAWyORSEiUOBLDnqNMph2tE7pwNRhpT3k0ysXJ5xfB2Ux9uPQv96BpXMiqSr5jbXN0vXbHn1g0SJfbhBZKuITA46XJbsF-4BP97sD-7GI8-NxqCwNZieqj0FGy7zblclbTNbc1FyzoiqxxJ_c5-vd2tEs3d1WTdzfFUm9_6jz_a0s6fQCTprCnUqJ8O9qUyVH6a9fn8eZn-xDu1wRVDKq4R7CHxQHcrlpWbg_gznn9MP4x_J5Z81ehCyPY9xmNGC3Z3JPrIsW4En6txSITRDLFyWQ0HI5t8Gjsua4YpFhu89ISZ1zRZroW80K8r8Q5ueDbzrgSQ3qT52sxwR9EacXUCte53Eu8q9v3UnKyMz9uCZiL7_oJTE9H05Mzp27z4KS-H5ZOT1NikZFyERMV6lQhkVijlCa8GCJ0YZbSokvtmQgxC6RJ6OXrNNMY9NPUewqdYlHgcxA6DEyA7FgXGJUhfY_P_mVas8u8VNgFr_mx47S2QOdOHHncaN2-xhVEYoZIzA063aALTjtrWVmAXBMfNjiKaxpT0ZOYdqlrZh42sIvrVLKOe9xPjJhpP-rCm3aYkgAjRxe42NgYN-JH3G4XnlUobQ_VI04XqahPh3UFv20AG4xfHSnmX6zReEjsJpSyC0ct0m-0Ai_-d8JLuMefWIcjw0PolKsNviKyVyav67_3H9_uUxE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Unique+and+Shared+Epigenetic+Programs+of+the+CREBBP+and+EP300+Acetyltransferases+in+Germinal+Center+B+Cells+Reveal+Targetable+Dependencies+in+Lymphoma&rft.jtitle=Immunity+%28Cambridge%2C+Mass.%29&rft.au=Meyer%2C+Stefanie+N&rft.au=Scuoppo%2C+Claudio&rft.au=Vlasevska%2C+Sofija&rft.au=Bal%2C+Elodie&rft.date=2019-09-17&rft.pub=Elsevier+Limited&rft.issn=1074-7613&rft.eissn=1097-4180&rft.volume=51&rft.issue=3&rft.spage=535&rft_id=info:doi/10.1016%2Fj.immuni.2019.08.006&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1074-7613&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1074-7613&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1074-7613&client=summon