Exploratory Analysis of iPSCS-Derived Neuronal Cells as Predictors of Diagnosis and Treatment of Alzheimer Disease

Alzheimer’s disease (AD) represents the most common neurodegenerative disorder, with 47 million affected people worldwide. Current treatment strategies are aimed at reducing the symptoms and do slow down the progression of the disease, but inevitably fail in the long-term. Induced pluripotent stem c...

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Published inBrain sciences Vol. 10; no. 3; p. 166
Main Authors Cavalli, Eugenio, Battaglia, Giuseppe, Basile, Maria Sofia, Bruno, Valeria, Petralia, Maria Cristina, Lombardo, Salvo Danilo, Pennisi, Manuela, Kalfin, Reni, Tancheva, Lyubka, Fagone, Paolo, Nicoletti, Ferdinando, Mangano, Katia
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.03.2020
MDPI
Subjects
alzheimer disease
Alzheimer's disease
Biomarkers
Cognitive ability
Datasets
Diagnosis
Disease
DNA microarrays
Drug development
drug repurposing
Drugs
Fibroblasts
Gene expression
Genotype & phenotype
induced pluripotent stem cells-derived neuronal cells
Inhibitory postsynaptic potentials
Muscular dystrophy
Neurodegeneration
Neurodegenerative diseases
Pluripotency
Principal components analysis
Statistical analysis
Stem cells
Induced pluripotent stem cells-derived neuronal cells
drug repurposing
Alzheimer disease
biomarkers
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ISSN2076-3425
2076-3425
DOI10.3390/brainsci10030166

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Abstract Alzheimer’s disease (AD) represents the most common neurodegenerative disorder, with 47 million affected people worldwide. Current treatment strategies are aimed at reducing the symptoms and do slow down the progression of the disease, but inevitably fail in the long-term. Induced pluripotent stem cells (iPSCs)-derived neuronal cells from AD patients have proven to be a reliable model for AD pathogenesis. Here, we have conducted an in silico analysis aimed at identifying pathogenic gene-expression profiles and novel drug candidates. The GSE117589 microarray dataset was used for the identification of Differentially Expressed Genes (DEGs) between iPSC-derived neuronal progenitor (NP) cells and neurons from AD patients and healthy donors. The Discriminant Analysis Module (DAM) algorithm was used for the identification of biomarkers of disease. Drugs with anti-signature gene perturbation profiles were identified using the L1000FWD software. DAM analysis was used to identify a list of potential biomarkers among the DEGs, able to discriminate AD patients from healthy people. Finally, anti-signature perturbation analysis identified potential anti-AD drugs. This study set the basis for the investigation of potential novel pharmacological strategies for AD. Furthermore, a subset of genes for the early diagnosis of AD is proposed.
AbstractList Alzheimer’s disease (AD) represents the most common neurodegenerative disorder, with 47 million affected people worldwide. Current treatment strategies are aimed at reducing the symptoms and do slow down the progression of the disease, but inevitably fail in the long-term. Induced pluripotent stem cells (iPSCs)-derived neuronal cells from AD patients have proven to be a reliable model for AD pathogenesis. Here, we have conducted an in silico analysis aimed at identifying pathogenic gene-expression profiles and novel drug candidates. The GSE117589 microarray dataset was used for the identification of Differentially Expressed Genes (DEGs) between iPSC-derived neuronal progenitor (NP) cells and neurons from AD patients and healthy donors. The Discriminant Analysis Module (DAM) algorithm was used for the identification of biomarkers of disease. Drugs with anti-signature gene perturbation profiles were identified using the L1000FWD software. DAM analysis was used to identify a list of potential biomarkers among the DEGs, able to discriminate AD patients from healthy people. Finally, anti-signature perturbation analysis identified potential anti-AD drugs. This study set the basis for the investigation of potential novel pharmacological strategies for AD. Furthermore, a subset of genes for the early diagnosis of AD is proposed.
Alzheimer's disease (AD) represents the most common neurodegenerative disorder, with 47 million affected people worldwide. Current treatment strategies are aimed at reducing the symptoms and do slow down the progression of the disease, but inevitably fail in the long-term. Induced pluripotent stem cells (iPSCs)-derived neuronal cells from AD patients have proven to be a reliable model for AD pathogenesis. Here, we have conducted an in silico analysis aimed at identifying pathogenic gene-expression profiles and novel drug candidates. The GSE117589 microarray dataset was used for the identification of Differentially Expressed Genes (DEGs) between iPSC-derived neuronal progenitor (NP) cells and neurons from AD patients and healthy donors. The Discriminant Analysis Module (DAM) algorithm was used for the identification of biomarkers of disease. Drugs with anti-signature gene perturbation profiles were identified using the L1000FWD software. DAM analysis was used to identify a list of potential biomarkers among the DEGs, able to discriminate AD patients from healthy people. Finally, anti-signature perturbation analysis identified potential anti-AD drugs. This study set the basis for the investigation of potential novel pharmacological strategies for AD. Furthermore, a subset of genes for the early diagnosis of AD is proposed.Alzheimer's disease (AD) represents the most common neurodegenerative disorder, with 47 million affected people worldwide. Current treatment strategies are aimed at reducing the symptoms and do slow down the progression of the disease, but inevitably fail in the long-term. Induced pluripotent stem cells (iPSCs)-derived neuronal cells from AD patients have proven to be a reliable model for AD pathogenesis. Here, we have conducted an in silico analysis aimed at identifying pathogenic gene-expression profiles and novel drug candidates. The GSE117589 microarray dataset was used for the identification of Differentially Expressed Genes (DEGs) between iPSC-derived neuronal progenitor (NP) cells and neurons from AD patients and healthy donors. The Discriminant Analysis Module (DAM) algorithm was used for the identification of biomarkers of disease. Drugs with anti-signature gene perturbation profiles were identified using the L1000FWD software. DAM analysis was used to identify a list of potential biomarkers among the DEGs, able to discriminate AD patients from healthy people. Finally, anti-signature perturbation analysis identified potential anti-AD drugs. This study set the basis for the investigation of potential novel pharmacological strategies for AD. Furthermore, a subset of genes for the early diagnosis of AD is proposed.
Author Bruno, Valeria
Fagone, Paolo
Mangano, Katia
Cavalli, Eugenio
Basile, Maria Sofia
Petralia, Maria Cristina
Lombardo, Salvo Danilo
Battaglia, Giuseppe
Pennisi, Manuela
Nicoletti, Ferdinando
Kalfin, Reni
Tancheva, Lyubka
AuthorAffiliation 2 University Sapienza, Piazzale A. Moro, 5, 00185 Roma, Italy; giuseppe.battaglia@uniroma1.it (G.B.); valeria.bruno@uniroma1.it (V.B.)
1 Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 89, 95123 Catania, Italy; eugeniocavalli9@hotmail.it (E.C.); sofiabasile@hotmail.it (M.S.B.); salvo.lombardo.sdl@gmail.com (S.D.L.); manuela.pennisi@unict.it (M.P.); ferdinic@unict.it (F.N.); kmangano@unict.it (K.M.)
5 Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Block 23, 1113 Sofia, Bulgaria; reni_kalfin@abv.bg (R.K.); lyubkatancheva@gmail.com (L.T.)
4 Department of Educational Sciences, University of Catania, 95100 Catania, Italy; m.cristinapetralia@gmail.com
3 IRCCS Neuromed, Località Camerelle, 86077 Pozzilli (IS), Italy
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– name: 3 IRCCS Neuromed, Località Camerelle, 86077 Pozzilli (IS), Italy
– name: 1 Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 89, 95123 Catania, Italy; eugeniocavalli9@hotmail.it (E.C.); sofiabasile@hotmail.it (M.S.B.); salvo.lombardo.sdl@gmail.com (S.D.L.); manuela.pennisi@unict.it (M.P.); ferdinic@unict.it (F.N.); kmangano@unict.it (K.M.)
– name: 4 Department of Educational Sciences, University of Catania, 95100 Catania, Italy; m.cristinapetralia@gmail.com
– name: 5 Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Block 23, 1113 Sofia, Bulgaria; reni_kalfin@abv.bg (R.K.); lyubkatancheva@gmail.com (L.T.)
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Cites_doi 10.1515/REVNEURO.2008.19.6.395
10.1016/j.neurobiolaging.2003.12.026
10.3390/molecules25010020
10.1016/j.drudis.2012.08.005
10.18632/oncotarget.23862
10.1016/j.celrep.2019.01.023
10.1038/nature10821
10.2174/1389450111007011193
10.3390/brainsci9100284
10.1016/j.jad.2019.11.127
10.1126/scisignal.aap8734
10.1016/j.clim.2015.02.002
10.1038/s41467-019-09234-6
10.1016/j.cell.2010.10.016
10.1038/nrd3681
10.1016/j.bbadis.2017.07.033
10.1093/hmg/ddr394
10.3390/medicina55100667
10.1038/nrd4051
10.1177/2058738419838383
10.1038/nature09915
10.1126/science.1158799
10.3389/fendo.2019.00265
10.7150/ijbs.9224
10.1186/s13195-017-0241-2
10.1523/JNEUROSCI.4668-14.2015
10.3390/genes10110939
10.1002/jcp.26223
10.1093/bioinformatics/18.1.39
10.1016/j.bbi.2019.05.009
10.3390/molecules24132450
10.1007/s10637-019-00733-3
10.1016/j.stem.2013.01.009
10.1016/j.jneuroim.2019.05.006
10.1523/JNEUROSCI.2281-14.2014
10.3390/ijms20184323
10.3390/molecules25020291
10.1016/j.cell.2008.07.041
10.1002/wsbm.1337
10.1136/bmj.l6217
10.1016/j.drudis.2013.11.005
10.1242/dmm.031781
10.1111/bcpt.12414
10.1016/j.leukres.2015.06.013
10.1093/bioinformatics/bty060
10.3390/brainsci10010052
10.1093/hmg/ddu064
10.3390/medicina55110747
10.3390/brainsci9070172
10.1016/j.cell.2009.02.013
10.18632/oncotarget.24885
10.3390/molecules23102463
10.1186/2051-5960-2-4
10.3390/ijms19030831
10.1038/s41598-018-35645-4
10.1016/j.trci.2019.09.019
10.1155/2016/7147039
10.1016/j.neurobiolaging.2011.02.011
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Keywords Induced pluripotent stem cells-derived neuronal cells
drug repurposing
Alzheimer disease
biomarkers
Language English
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References Kan (ref_52) 2015; 35
Soldner (ref_14) 2009; 136
Lehrer (ref_59) 2017; 24
ref_53
Dimos (ref_13) 2008; 321
Israel (ref_7) 2012; 482
Mojic (ref_41) 2015; 39
Mangano (ref_30) 2018; 233
Desai (ref_58) 2019; 10
Mammana (ref_46) 2018; 9
Scannell (ref_23) 2012; 11
Fagone (ref_40) 2015; 117
Brennand (ref_16) 2011; 473
Hodos (ref_26) 2016; 8
Petralia (ref_37) 2019; 18
Lashley (ref_2) 2018; 11
Meyer (ref_1) 2019; 26
McManus (ref_56) 2017; 9
Muratore (ref_8) 2014; 23
Resende (ref_4) 2010; 11
Abarova (ref_5) 2017; 1863
Zhou (ref_18) 2019; 10
Kondo (ref_9) 2013; 12
Liu (ref_25) 2013; 18
Patel (ref_20) 2019; 80
Jadamba (ref_28) 2016; 2016
ref_29
Paskas (ref_44) 2019; 37
Conrad (ref_60) 2008; 19
Beeri (ref_55) 2012; 33
Shim (ref_24) 2014; 10
ref_36
Sproul (ref_10) 2014; 2
ref_35
Kazmi (ref_54) 2018; 8
Nicoletti (ref_33) 2019; 332
ref_34
Marchetto (ref_15) 2010; 143
ref_32
ref_31
Knoferle (ref_12) 2014; 34
Park (ref_17) 2008; 134
Fessel (ref_6) 2019; 5
Plenge (ref_22) 2013; 12
ref_39
ref_38
Nguyen (ref_19) 2002; 18
Joe (ref_3) 2019; 367
Petralia (ref_50) 2020; 263
Cole (ref_57) 2004; 25
Mangano (ref_47) 2018; 9
Fagone (ref_51) 2015; 157
ref_45
ref_43
ref_42
Yagi (ref_11) 2011; 20
Jin (ref_27) 2014; 19
ref_49
ref_48
Wang (ref_21) 2018; 34
References_xml – volume: 19
  start-page: 395
  year: 2008
  ident: ref_60
  article-title: Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis
  publication-title: Rev. Neurosci.
  doi: 10.1515/REVNEURO.2008.19.6.395
– volume: 25
  start-page: 675
  year: 2004
  ident: ref_57
  article-title: The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2003.12.026
– ident: ref_34
  doi: 10.3390/molecules25010020
– volume: 18
  start-page: 110
  year: 2013
  ident: ref_25
  article-title: In silico drug repositioning–What we need to know
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2012.08.005
– volume: 9
  start-page: 8263
  year: 2018
  ident: ref_46
  article-title: Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.23862
– volume: 26
  start-page: 1112
  year: 2019
  ident: ref_1
  article-title: REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.01.023
– volume: 482
  start-page: 216
  year: 2012
  ident: ref_7
  article-title: Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
  publication-title: Nature
  doi: 10.1038/nature10821
– volume: 11
  start-page: 1193
  year: 2010
  ident: ref_4
  article-title: Multiple Defects in Energy Metabolism in Alzheimers Disease
  publication-title: Curr. Drug Targets
  doi: 10.2174/1389450111007011193
– ident: ref_38
  doi: 10.3390/brainsci9100284
– volume: 263
  start-page: 15
  year: 2020
  ident: ref_50
  article-title: Pathogenic contribution of the Macrophage migration inhibitory factor family to major depressive disorder and emerging tailored therapeutic approaches
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2019.11.127
– ident: ref_53
  doi: 10.1126/scisignal.aap8734
– volume: 157
  start-page: 198
  year: 2015
  ident: ref_51
  article-title: Carbon monoxide-releasing molecule-A1 (CORM-A1) improves clinical signs of experimental autoimmune uveoretinitis (EAU) in rats
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2015.02.002
– volume: 10
  start-page: 1523
  year: 2019
  ident: ref_18
  article-title: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09234-6
– volume: 143
  start-page: 527
  year: 2010
  ident: ref_15
  article-title: A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
  publication-title: Cell
  doi: 10.1016/j.cell.2010.10.016
– volume: 11
  start-page: 191
  year: 2012
  ident: ref_23
  article-title: Diagnosing the decline in pharmaceutical R&D efficiency
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3681
– volume: 1863
  start-page: 2934
  year: 2017
  ident: ref_5
  article-title: A novel DSC approach for evaluating protectant drugs efficacy against dementia
  publication-title: Biochim. Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2017.07.033
– volume: 20
  start-page: 4530
  year: 2011
  ident: ref_11
  article-title: Modeling familial Alzheimer’s disease with induced pluripotent stem cells
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddr394
– ident: ref_31
  doi: 10.3390/medicina55100667
– volume: 12
  start-page: 581
  year: 2013
  ident: ref_22
  article-title: Validating therapeutic targets through human genetics
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd4051
– ident: ref_43
  doi: 10.1177/2058738419838383
– volume: 473
  start-page: 221
  year: 2011
  ident: ref_16
  article-title: Modelling schizophrenia using human induced pluripotent stem cells
  publication-title: Nature
  doi: 10.1038/nature09915
– volume: 321
  start-page: 1218
  year: 2008
  ident: ref_13
  article-title: Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
  publication-title: Science
  doi: 10.1126/science.1158799
– volume: 10
  start-page: 265
  year: 2019
  ident: ref_58
  article-title: Autoimmune Disease in Women: Endocrine Transition and Risk across the Lifespan
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2019.00265
– volume: 10
  start-page: 654
  year: 2014
  ident: ref_24
  article-title: Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.9224
– volume: 9
  start-page: 14
  year: 2017
  ident: ref_56
  article-title: Role of neuroinflammation in neurodegeneration: New insights
  publication-title: Alzheimer Res. Ther.
  doi: 10.1186/s13195-017-0241-2
– volume: 35
  start-page: 5969
  year: 2015
  ident: ref_52
  article-title: Arginine deprivation and immune suppression in a mouse model of Alzheimer’s disease
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4668-14.2015
– ident: ref_29
  doi: 10.3390/genes10110939
– volume: 233
  start-page: 4156
  year: 2018
  ident: ref_30
  article-title: Involvement of the Nrf2/HO-1/CO axis and therapeutic intervention with the CO-releasing molecule CORM-A1, in a murine model of autoimmune hepatitis
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.26223
– volume: 18
  start-page: 39
  year: 2002
  ident: ref_19
  article-title: Tumor classification by partial least squares using microarray gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/18.1.39
– volume: 80
  start-page: 644
  year: 2019
  ident: ref_20
  article-title: Transcriptomic analysis of probable asymptomatic and symptomatic alzheimer brains
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2019.05.009
– ident: ref_39
  doi: 10.3390/molecules24132450
– volume: 37
  start-page: 1014
  year: 2019
  ident: ref_44
  article-title: Lopinavir-NO, a nitric oxide-releasing HIV protease inhibitor, suppresses the growth of melanoma cells in vitro and in vivo
  publication-title: Investig. New Drugs
  doi: 10.1007/s10637-019-00733-3
– volume: 12
  start-page: 487
  year: 2013
  ident: ref_9
  article-title: Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.01.009
– volume: 332
  start-page: 224
  year: 2019
  ident: ref_33
  article-title: Prevention of clinical and histological signs of MOG-induced experimental allergic encephalomyelitis by prolonged treatment with recombinant human EGF
  publication-title: J. Neuroimmunol.
  doi: 10.1016/j.jneuroim.2019.05.006
– volume: 34
  start-page: 14069
  year: 2014
  ident: ref_12
  article-title: Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2281-14.2014
– ident: ref_36
  doi: 10.3390/ijms20184323
– ident: ref_49
  doi: 10.3390/molecules25020291
– volume: 134
  start-page: 877
  year: 2008
  ident: ref_17
  article-title: Disease-specific induced pluripotent stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2008.07.041
– volume: 8
  start-page: 186
  year: 2016
  ident: ref_26
  article-title: In silico methods for drug repurposing and pharmacology
  publication-title: Wiley Interdiscip. Rev. Syst. Biol. Med.
  doi: 10.1002/wsbm.1337
– volume: 367
  start-page: l6217
  year: 2019
  ident: ref_3
  article-title: Cognitive symptoms of Alzheimer’s disease: Clinical management and prevention
  publication-title: BMJ
  doi: 10.1136/bmj.l6217
– volume: 19
  start-page: 637
  year: 2014
  ident: ref_27
  article-title: Toward better drug repositioning: Prioritizing and integrating existing methods into efficient pipelines
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2013.11.005
– volume: 11
  start-page: dmm031781
  year: 2018
  ident: ref_2
  article-title: Molecular biomarkers of Alzheimer’s disease: Progress and prospects
  publication-title: Dis. Model. Mech.
  doi: 10.1242/dmm.031781
– volume: 117
  start-page: 306
  year: 2015
  ident: ref_40
  article-title: Effects of NO-Hybridization on the Immunomodulatory Properties of the HIV Protease Inhibitors Lopinavir and Ritonavir
  publication-title: Basic Clin. Pharmacol. Toxicol.
  doi: 10.1111/bcpt.12414
– volume: 39
  start-page: 1088
  year: 2015
  ident: ref_41
  article-title: The NO-modified HIV protease inhibitor as a valuable drug for hematological malignancies: Role of p70S6K
  publication-title: Leuk. Res.
  doi: 10.1016/j.leukres.2015.06.013
– volume: 34
  start-page: 2150
  year: 2018
  ident: ref_21
  article-title: L1000FWD: Fireworks visualization of drug-induced transcriptomic signatures
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bty060
– ident: ref_35
  doi: 10.3390/brainsci10010052
– volume: 24
  start-page: 147
  year: 2017
  ident: ref_59
  article-title: Nasal steroids as a possible treatment for Alzheimer’s disease
  publication-title: Discov. Med.
– volume: 23
  start-page: 3523
  year: 2014
  ident: ref_8
  article-title: The familial Alzheimer’s disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddu064
– ident: ref_42
  doi: 10.3390/medicina55110747
– ident: ref_32
  doi: 10.3390/brainsci9070172
– volume: 136
  start-page: 964
  year: 2009
  ident: ref_14
  article-title: Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors
  publication-title: Cell
  doi: 10.1016/j.cell.2009.02.013
– volume: 9
  start-page: 17951
  year: 2018
  ident: ref_47
  article-title: Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.24885
– ident: ref_45
  doi: 10.3390/molecules23102463
– volume: 18
  start-page: 2055
  year: 2019
  ident: ref_37
  article-title: Retrospective follow-up analysis of the transcriptomic patterns of cytokines, cytokine receptors and chemokines at preconception and during pregnancy, in women with post-partum depression
  publication-title: Exp. Ther. Med.
– volume: 2
  start-page: 4
  year: 2014
  ident: ref_10
  article-title: Generation of iPSC lines from archived non-cryoprotected biobanked dura mater
  publication-title: Acta Neuropathol. Commun.
  doi: 10.1186/2051-5960-2-4
– ident: ref_48
  doi: 10.3390/ijms19030831
– volume: 8
  start-page: 1
  year: 2018
  ident: ref_54
  article-title: Cyclic undecapeptide Cyclosporin A mediated inhibition of amyloid synthesis: Implications in alleviation of amyloid induced neurotoxicity
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-35645-4
– volume: 5
  start-page: 780
  year: 2019
  ident: ref_6
  article-title: Prevention of Alzheimer’s disease by treating mild cognitive impairment with combinations chosen from eight available drugs
  publication-title: Alzheimer Dement.
  doi: 10.1016/j.trci.2019.09.019
– volume: 2016
  start-page: 7147039
  year: 2016
  ident: ref_28
  article-title: A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network
  publication-title: BioMed Res. Int.
  doi: 10.1155/2016/7147039
– volume: 33
  start-page: 1258
  year: 2012
  ident: ref_55
  article-title: Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2011.02.011
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Snippet Alzheimer’s disease (AD) represents the most common neurodegenerative disorder, with 47 million affected people worldwide. Current treatment strategies are...
Alzheimer's disease (AD) represents the most common neurodegenerative disorder, with 47 million affected people worldwide. Current treatment strategies are...
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StartPage 166
SubjectTerms alzheimer disease
Alzheimer's disease
Biomarkers
Cognitive ability
Datasets
Diagnosis
Disease
DNA microarrays
Drug development
drug repurposing
Drugs
Fibroblasts
Gene expression
Genotype & phenotype
induced pluripotent stem cells-derived neuronal cells
Inhibitory postsynaptic potentials
Muscular dystrophy
Neurodegeneration
Neurodegenerative diseases
Pluripotency
Principal components analysis
Statistical analysis
Stem cells
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Title Exploratory Analysis of iPSCS-Derived Neuronal Cells as Predictors of Diagnosis and Treatment of Alzheimer Disease
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